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A History of Modern Immunology

A History of Modern Immunology
The Path Toward Understanding

by Zoltan A. Nagy

  • Publisher : Academic Press
  • Release : 2013-10-11
  • Pages : 356
  • ISBN : 0124201083
  • Language : En, Es, Fr & De
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A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

A History of Immunology

A History of Immunology
A Book

by Arthur M. Silverstein

  • Publisher : Elsevier
  • Release : 2012-12-02
  • Pages : 422
  • ISBN : 0080925839
  • Language : En, Es, Fr & De
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This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye The only complete history of immunology available

Crafting Immunity

Crafting Immunity
Working Histories of Clinical Immunology

by Jennifer Keelan

  • Publisher : Routledge
  • Release : 2017-03-02
  • Pages : 318
  • ISBN : 1351947893
  • Language : En, Es, Fr & De
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Immunity is as old as illness itself, yet historians have only just begun to take up the challenge of reconstructing the modern transformation of attempts to protect against disease. Crafting Immunity assembles in one volume the most recent efforts of an international group of scholars to place the diverse practices of immunity in their historical contexts. It is this diversity that provides the book with its greatest source of strength. Collectively, the papers in this volume suggest that it was the craft-like, small-scale, and local conditions of clinical medicine that turned the immunity of individuals and populations into biomedical objects. That is to say, the modern conception of immunity was at least as much the product of the work of healing as it was the systematic result of discoveries about the immune system. Working outside the narrow confines of laboratory histories, Crafting Immunity is the first attempt to set the problems of immunity into a variety of social, technological, institutional and intellectual contexts. It will appeal not only to historians and sociologists of health, but also to social and cultural historians interested in the biomedical creation of modern health regimens.

A History of Transplantation Immunology

A History of Transplantation Immunology
A Book

by Leslie Brent

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 482
  • ISBN : 9780121317706
  • Language : En, Es, Fr & De
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Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Key Features * Describes landmarks in immunology and places them in historical context * Beautifully written by one of the founding fathers of the field * Portrays the surprising history of events in a colorful and readable manner * Contains biographical sketches of some of the pioneers * Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation * Foreword by Ray Owen

Metchnikoff and the Origins of Immunology

Metchnikoff and the Origins of Immunology
From Metaphor to Theory

by Alfred I. Tauber,Leon Chernyak

  • Publisher : Oxford University Press
  • Release : 1991-07-25
  • Pages : 280
  • ISBN : 9780195345100
  • Language : En, Es, Fr & De
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This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. His program developed from comparative embryological studies that sought to establish genealogical relations between species at the dawn of the Darwinian revolution. In this scientific biography, Tauber and Chernyak explore ore Metchnikoff's development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on Metchnikoff's progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural and philosophic sources. Immunologists and historians of science and medicine will find it an absorbing and accessible account of a remarkable individual.

Immunology: The Making of a Modern Science

Immunology: The Making of a Modern Science
The Making of a Modern Science

by Richard B. Gallagher,Jean Gilder,Gustav J.V. Nossal,Gaetano Salvatore

  • Publisher : Elsevier
  • Release : 1995-07-14
  • Pages : 246
  • ISBN : 0080534538
  • Language : En, Es, Fr & De
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Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity. The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein. Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.

A History of Organ Transplantation

A History of Organ Transplantation
Ancient Legends to Modern Practice

by David Hamilton

  • Publisher : University of Pittsburgh Pre
  • Release : 2012
  • Pages : 576
  • ISBN : 0822977842
  • Language : En, Es, Fr & De
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"The first book of its kind, A History of Organ Transplantation examines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included."--Project Muse.

Immunity

Immunity
The Evolution of an Idea

by Alfred I. Tauber

  • Publisher : Oxford University Press
  • Release : 2017-01-02
  • Pages : 304
  • ISBN : 0190651253
  • Language : En, Es, Fr & De
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Modern immunology traditionally conceives of the immune system as providing defense against pathogens. Alfred I. Tauber criticizes this conception of immunity as too narrow, because it discounts much of the immune system's other normal functions. These include active tolerance of nutritional exchanges with the environment and the stabilization of cooperative relationships with resident micro-organisms. An expanded account extends immunity's functional role from singular 'defense' to broadened discernment of environmental 'exchange.' This ecological perspective has profound theoretical implications, for the basic notion of immune identity is reconfigured: highlighting the organism as a holobiont (a consortium of diverse organisms living in cooperative relationships) challenges prevailing concepts of individuality and the self/nonself dichotomy heretofore organizing immune theory. Indeed, if theoretical interest is focused on the challenges of maintaining immune balance in the full ecological context of the organism, then immune regulation assumes new complexity. Tauber maintains that the key to unravelling that puzzle requires a critical re-assessment of the cognitive processes that underlie immune effector functions. Accordingly, he provides the outline of a re-formulated 'cognitive paradigm' that dispenses with agent-based models and adopts an ecologically conceived understanding of perception and information processing. The implications of this revised configuration of immunity and its deconstructed notions of individuality and selfhood have wide significance for philosophers and life scientists working in immunology, ecology, and the cognitive sciences.

A History of Transplantation Immunology

A History of Transplantation Immunology
A Book

by Leslie Brent

  • Publisher : Academic Press
  • Release : 1996-11-18
  • Pages : 482
  • ISBN : 9780080533995
  • Language : En, Es, Fr & De
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Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen

A History of Medical Bacteriology and Immunology

A History of Medical Bacteriology and Immunology
A Book

by W. D. Foster

  • Publisher : Butterworth-Heinemann
  • Release : 2014-05-20
  • Pages : 244
  • ISBN : 1483162451
  • Language : En, Es, Fr & De
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A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

The Foundations of Immunology and their Pertinence to Medicine

The Foundations of Immunology and their Pertinence to Medicine
A Book

by Peter Bretscher

  • Publisher : FriesenPress
  • Release : 2016-12-05
  • Pages : 200
  • ISBN : 1460296567
  • Language : En, Es, Fr & De
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In The Foundations of Immunology and their Pertinence to Medicine, Peter Bretscher describes how the few foundational concepts of immunology came about. He traces Jenner's development of safe vaccination against small pox in the 1700's, and how it led to the recognition of infectious disease by Koch and Pasteur in the 1880's, and to the discovery of the Principles of Vaccination. The formulation of the Clonal Selection Theory in the 1950's still provides a foundation for contemporary analysis of the immune system. Peter describes the main, and sometimes conflicting concepts, proposed in the last 50 years as to how immune responses are regulated. He develops a unique framework, and employs this to justify some tested and some speculative strategies to prevent and treat clinical conditions in five areas of medicine: Infectious Diseases, Cancer, Autoimmunity, Allergies and Transplantation. This book provides a platform for discussing contemporary immunological issues accessible to the non-specialist, medical students and medical practitioners. The platform challenges some of todays most popular paradigms. Foundations is written in a clear and jargon-free style.

The Historiography of Contemporary Science, Technology, and Medicine

The Historiography of Contemporary Science, Technology, and Medicine
Writing Recent Science

by Ronald E. Doel,Thomas Söderqvist

  • Publisher : Routledge
  • Release : 2006-10-02
  • Pages : 336
  • ISBN : 1134482973
  • Language : En, Es, Fr & De
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As historians of science increasingly turn to work on recent (post 1945) science, the historiographical and methodological problems associated with the history of contemporary science are debated with growing frequency and urgency. Bringing together authorities on the history, historiography and methodology of recent and contemporary science, this book reviews the problems facing historians of technology, contemporary science and medicine, and explores new ways forward. With contributions from key researchers in the field, the text covers topics that will be of ever increasing interest to historians of post-war science, including the difficulties of accessing and using secret archival material, the interactions between archivists, historians and scientists, and the politics of evidence and historical accounts.

Immunology

Immunology
A Short Course

by Richard Coico,Geoffrey Sunshine

  • Publisher : John Wiley & Sons
  • Release : 2009-01-14
  • Pages : 391
  • ISBN : 0470081589
  • Language : En, Es, Fr & De
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"Each chapter is complemented with bulleted summaries and review questions with detailed answers. The book also contains an extensive glossary. Written in a clear, user-friendly style, this text is suitable for integrated courses that cover microbiology, immunology, and pathology, as well as focused immunology courses."--BOOK JACKET.

Immunology, a Synthesis

Immunology, a Synthesis
A Book

by Edward S. Golub,Douglas R. Green

  • Publisher : Sinauer Associates, Incorporated
  • Release : 1991
  • Pages : 744
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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In this second, revised edition of a textbook, E.S. Golub joins forces with D.R. Green to provide an up-to-date synthesis of modern immunology, spanning the full range of molecular, cellular and clinical immunology. Continuing in the tradition of the first edition and of The Cellular Basis of the Immune Response, Golub and Green describe immunology as a process by using experimental design and by following the sequence of experiments that have led to the current state of knowledge in the field.

Another Person’s Poison

Another Person’s Poison
A History of Food Allergy

by Matthew Smith

  • Publisher : Columbia University Press
  • Release : 2015-05-26
  • Pages : 304
  • ISBN : 0231539193
  • Language : En, Es, Fr & De
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To some, food allergies seem like fabricated cries for attention. To others, they pose a dangerous health threat. Food allergies are bound up with so many personal and ideological concerns that it is difficult to determine what is medical and what is myth. Another Person's Poison parses the political, economic, cultural, and genuine health factors of a phenomenon that dominates our interactions with others and our understanding of ourselves. For most of the twentieth century, food allergies were considered a fad or junk science. While many physicians and clinicians argued that certain foods could cause a range of chronic problems, from asthma and eczema to migraines and hyperactivity, others believed that allergies were psychosomatic. 'This book traces the trajectory of this debate and its effect on public-health policy and the production, manufacture, and consumption of food. Are rising allergy rates purely the result of effective lobbying and a booming industry built on self-diagnosis and expensive remedies? Or should physicians become more flexible in their approach to food allergies and more careful in their diagnoses? Exploring the issue from scientific, political, economic, social, and patient-centered perspectives, this book is the first to engage fully with the history of a major modern affliction, illuminating society's troubled relationship with food, disease, nature, and the creation of medical knowledge.

A Historical Perspective on Evidence-Based Immunology

A Historical Perspective on Evidence-Based Immunology
A Book

by Edward J. Moticka

  • Publisher : Newnes
  • Release : 2015-11-25
  • Pages : 394
  • ISBN : 0123983754
  • Language : En, Es, Fr & De
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A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Rats, Lice and History

Rats, Lice and History
A Book

by Hans Zinsser

  • Publisher : Transaction Publishers
  • Release : 2011-12-31
  • Pages : 332
  • ISBN : 1412815711
  • Language : En, Es, Fr & De
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When Rats, Lice and History appeared in 1935, Hans Zinsser was a highly regarded Harvard biologist who had never written about historical events. Although he had published under a pseudonym, virtually all of his previous writings had dealt with infections and immunity and had appeared either in medical and scientific journals or in book format. Today he is best remembered as the author of Rats, Lice, and History, which gone through multiple editions and remains a masterpiece of science writing for a general readership. To Zinsser, scientific research was high adventure and the investigation of infectious disease, a field of battle. Yet at the same time he maintained a love of literature and philosophy. His goal in Rats, Lice and History was to bring science, philosophy, and literature together to establish the importance of disease, and especially epidemic infectious disease, as a major force in human affairs. Zinsser cast his work as the "biography" of a disease. In his view, infectious disease simply represented an attempt of a living organism to survive. From a human perspective, an invading pathogen was abnormal; from the perspective of the pathogen it was perfectly normal. This book is devoted to a discussion of the biology of typhus and history of typhus fever in human affairs. Zinsser begins by pointing out that the louse was the constant companion of human beings. Under certain conditions–to wash or to change clothing–lice proliferated. The typhus pathogen was transmitted by rat fleas to human beings, who then transmitted it to other humans and in some strains from human to human. Rats, Lice and History is a tour de force. It combines Zinsser's expertise in biology with his broad knowledge of the humanities

Allergy

Allergy
The History of a Modern Malady

by Mark Jackson

  • Publisher : Reaktion Books
  • Release : 2007-08-15
  • Pages : 288
  • ISBN : 9781861893338
  • Language : En, Es, Fr & De
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Mark Jackson investigates how allergy has become the archetypal “disease of civilization,” transforming from a fringe malady of the wealthy into one of the greatest medical disorders of the twentieth century.

A History of Biology

A History of Biology
A Book

by Michel Morange

  • Publisher : Princeton University Press
  • Release : 2021-06
  • Pages : 448
  • ISBN : 0691175403
  • Language : En, Es, Fr & De
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"This book presents a complete, global history of the biological sciences from ancient times to today-introducing a long-term perspective to the history of biological thought, while showing its fractures and upheavals through the ages. The history of biology often neglects certain areas, such as ecology, ethology (the study of non-human animal behavior), and plant biology-areas which are covered in this work. The broad, global perspective offered here will allow the reader to better appreciate the nature of the interdisciplinary exchanges that have shaped the biological sciences, perhaps more than any other discipline. Much attention is also given to the contribution of technology, the role of experimentation, and, more generally, the social and technological environment within which scientific transformations develop"--

Advances in Immunology

Advances in Immunology
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-02-15
  • Pages : 172
  • ISBN : 0128155302
  • Language : En, Es, Fr & De
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Advances in Immunology, Volume 137, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including sections on Notch and T-Cell signaling/T-Cell memory, Single Cell Analysis of CD8+ and CD4+ T Cell Differentiation, New Developments in the Chemokine Field, the Role of Caveolin-1 in BCR and TCR Receptors, The Unusual Biochemistry of Bovine Immunoglobulins, and the Molecular Aspects of Allergens and Allergy. Contains contributions from leading authorities in immunology Informs and updates on all the latest developments in the field of immunology