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A Paradigm Shift to Prevent and Treat Alzheimer's Disease

A Paradigm Shift to Prevent and Treat Alzheimer's Disease
From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols

by Howard Friel,Sally A. Frautschy

  • Publisher : Academic Press
  • Release : 2017-07-18
  • Pages : 290
  • ISBN : 012812279X
  • Language : En, Es, Fr & De
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A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

Prevention of Alzheimer’s Disease: From Cognitive Reserve to Precision Medicine

Prevention of Alzheimer’s Disease: From Cognitive Reserve to Precision Medicine
A Book

by Hyun Kook Lim,Howard Aizenstein

  • Publisher : Frontiers Media SA
  • Release : 2020-08-05
  • Pages : 329
  • ISBN : 2889639177
  • Language : En, Es, Fr & De
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The End of Alzheimer's

The End of Alzheimer's
The First Program to Prevent and Reverse Cognitive Decline

by Dale Bredesen

  • Publisher : Penguin
  • Release : 2017-08-22
  • Pages : 320
  • ISBN : 0735216223
  • Language : En, Es, Fr & De
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The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Index Medicus

Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Impacts of Stress Management in Reversing Heart Disease

Impacts of Stress Management in Reversing Heart Disease
Hearing Before a Subcommittee of the Committee on Appropriations, United States Senate, One Hundred Seventh Congress, Second Session : Special Hearing, May 16, 2002, Washington, DC.

by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 53
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Lomborg Deception

The Lomborg Deception
Setting the Record Straight About Global Warming

by Howard Friel

  • Publisher : Yale University Press
  • Release : 2010-03-16
  • Pages : 288
  • ISBN : 0300161344
  • Language : En, Es, Fr & De
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In this major assessment of leading climate-change skeptic Bjørn Lomborg, Howard Friel meticulously deconstructs the Danish statistician’s claim that global warming is “no catastrophe” by exposing the systematic misrepresentations and partial accounting that are at the core of climate skepticism. His detailed analysis serves not only as a guide to reading the global warming skeptics, but also as a model for assessing the state of climate science. With attention to the complexities of climate-related phenomena across a range of areas—from Arctic sea ice to the Antarctic ice sheet—The Lomborg Deception also offers readers an enlightening review of some of today’s most urgent climate concerns. Friel’s book is the first to respond directly to Lomborg’s controversial research as published in The Skeptical Environmentalist (2001) and Cool It: The Skeptical Environmentalist’s Guide to Global Warming (2007). His close reading of Lomborg’s textual claims and supporting footnotes reveals a lengthy list of findings that will rock climate skeptics and their allies in the government and news media, demonstrating that the published peer-reviewed climate science, as assessed mainly by the U.N.’s Intergovernmental Panel on Climate Change, has had it mostly right—even if somewhat conservatively right—all along. Friel’s able defense of Al Gore’s An Inconvenient Truth against Lomborg’s repeated attacks is by itself worth an attentive reading.

Alzheimer's Disease

Alzheimer's Disease
Modernizing Concept, Biological Diagnosis and Therapy

by Harald Hampel,Maria C. Carrillo

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2012
  • Pages : 193
  • ISBN : 3805598025
  • Language : En, Es, Fr & De
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How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Psychological Abstracts

Psychological Abstracts
A Book

by American psychological association

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Animal Experimentation

Animal Experimentation
Working Towards a Paradigm Change

by Kathrin Herrmann,Kimberley Jayne

  • Publisher : Human-Animal Studies
  • Release : 2019
  • Pages : 714
  • ISBN : 9789004356184
  • Language : En, Es, Fr & De
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Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

The Tell

The Tell
The Little Clues That Reveal Big Truths about Who We Are

by Matthew Hertenstein

  • Publisher : Basic Books
  • Release : 2013-11-12
  • Pages : 288
  • ISBN : 0465069886
  • Language : En, Es, Fr & De
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Every day we make predictions based on limited information, in business and at home. Will this company’s stock performance continue? Will the job candidate I just interviewed be a good employee? What kind of adult will my child grow up to be? We tend to dismiss our predictive minds as prone to bias and mistakes, but in The Tell, psychologist Matthew Hertenstein reveals that our intuition is surprisingly good at using small clues to make big predictions, and shows how we can make better decisions by homing in on the right details. Just as expert poker players use their opponents’ tells to see through their bluffs, Hertenstein shows that we can likewise train ourselves to read physical cues to significantly increase our predictive acumen. By looking for certain clues, we can accurately call everything from election results to the likelihood of marital success, IQ scores to sexual orientation--even from flimsy evidence, such as an old yearbook photo or a silent one-minute video. Moreover, by understanding how people read our body language, we can adjust our own behavior so as to ace our next job interview or tip the dating scales in our favor. Drawing on rigorous research in psychology and brain science, Hertenstein shows us how to hone our powers of observation to increase our predictive capacities. A charming testament to the power of the human mind, The Tell will, to paraphrase Sherlock Holmes, show us how to notice what we see.

The Biology of Alzheimer Disease

The Biology of Alzheimer Disease
A Book

by Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 511
  • ISBN : 9781936113446
  • Language : En, Es, Fr & De
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Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer Disease, is also an intense area of research.

The Best American Essays 2002

The Best American Essays 2002
A Book

by Stephen Jay Gould,Robert Atwan

  • Publisher : Houghton Mifflin Harcourt
  • Release : 2002
  • Pages : 376
  • ISBN : 9780618213887
  • Language : En, Es, Fr & De
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Edited by the award-winning late author of The Mismeasure of Man a new collection of the finest nonfiction essays published over the past year incorporates the work of distinguished masters of the essay genre on topics ranging from pathology to the boxing arena to growing up.

Cool It

Cool It
A Book

by Bjorn Lomborg

  • Publisher : Vintage
  • Release : 2007-09-11
  • Pages : 272
  • ISBN : 0307267792
  • Language : En, Es, Fr & De
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Bjorn Lomborg argues that many of the elaborate and staggeringly expensive actions now being considered to meet the challenges of global warming ultimately will have little impact on the world’s temperature. He suggests that rather than focusing on ineffective solutions that will cost us trillions of dollars over the coming decades, we should be looking for smarter, more cost-effective approaches (such as massively increasing our commitment to green energy R&D) that will allow us to deal not only with climate change but also with other pressing global concerns, such as malaria and HIV/AIDS. And he considers why and how this debate has fostered an atmosphere in which dissenters are immediately demonized. From the Trade Paperback edition.

Summary of The End of Alzheimer's: The First Program to ...

Summary of The End of Alzheimer's: The First Program to ...
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Record of the Paper

The Record of the Paper
How the New York Times Misreports US Foreign Policy

by Howard Friel,Richard A. Falk

  • Publisher : Verso
  • Release : 2004
  • Pages : 304
  • ISBN : 9781844670192
  • Language : En, Es, Fr & De
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In this meticulously researched study--the first part of a two-volume work--Friel and Falk demonstrate their assertion that the "New York Times" has consistently, over the last 50 years, misreported the facts related to the wars waged by the United States.

Health Professional and Patient Interaction

Health Professional and Patient Interaction
A Book

by Ruth B. Purtilo,Amy Marie Haddad

  • Publisher : W.B. Saunders Company
  • Release : 1996
  • Pages : 409
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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On doctor-patient interaction

The Alzheimer's Disease Challenge

The Alzheimer's Disease Challenge
A Book

by Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf

  • Publisher : Frontiers Media SA
  • Release : 2019-12-04
  • Pages : 329
  • ISBN : 2889631281
  • Language : En, Es, Fr & De
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Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

The End of Alzheimer's Program

The End of Alzheimer's Program
The First Protocol to Enhance Cognition and Reverse Decline at Any Age

by Dale Bredesen

  • Publisher : Penguin
  • Release : 2020-08-18
  • Pages : 352
  • ISBN : 052553850X
  • Language : En, Es, Fr & De
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The instant New York Times bestseller The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower. In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone's needs and will enhance cognitive ability at any age. What we call Alzheimer's disease is actually a protective response to a wide variety of insults to the brain: inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. Bredesen starts by having us figure out which of these insults we need to address and continues by laying out a personalized lifestyle plan. Focusing on the Ketoflex 12/3 Diet, which triggers ketosis and lets the brain restore itself with a minimum 12-hour fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. He also examines the tricky question of toxic exposure and provides workarounds for many difficult problems. The takeaway is that we do not need to do the program perfectly but will see tremendous results if we can do it well enough. With inspiring stories from patients who have reversed cognitive decline and are now thriving, this book shifts the treatment paradigm and offers a new and effective way to enhance cognition as well as unprecedented hope to sufferers of this now no longer deadly disease.

Chemistry and Molecular Aspects of Drug Design and Action

Chemistry and Molecular Aspects of Drug Design and Action
A Book

by E. A. Rekka,P. N. Kourounakis

  • Publisher : CRC Press
  • Release : 2008-04-28
  • Pages : 384
  • ISBN : 1420008277
  • Language : En, Es, Fr & De
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An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve