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Adverse Effects of Engineered Nanomaterials

Adverse Effects of Engineered Nanomaterials
Exposure, Toxicology, and Impact on Human Health

by Bengt Fadeel,Antonio Pietroiusti,Anna A. Shvedova

  • Publisher : Academic Press
  • Release : 2012-01-25
  • Pages : 360
  • ISBN : 0123869765
  • Language : En, Es, Fr & De
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Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety. This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients. The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

Potential Adverse Effects of Engineered Nanomaterials Commonly Used in Food on the MiRNome

Potential Adverse Effects of Engineered Nanomaterials Commonly Used in Food on the MiRNome
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: The emergence of nanotechnology has greatly impacted our daily lives. Multiple products, including cosmetics, pharmaceuticals, electronics and food, are produced with incorporation of nanomaterials (NMs). Nanotechnology has yielded many promising benefits, yet, there remains much uncertainty about the hazards of NMs to humans. Hence, it is important to ensure safety of the users. Although many invitro and invivo studies have been carried out on the potential toxicity generated by NMs in food, its effects on the microRNA genome (miRNome) involved in the regulation of gene expression have been poorly understood. Therefore, this review focuses on the types of commonly used NMs (containing silicon dioxide, titanium dioxide, silver or zinc oxide) in food products and their potential toxic effects, including how NMs can induce epigenetic toxicity mediated via altered miRNA expression. Highlights: General toxicity and potential effects on the miRNome induced by SiO2 NPs, TiO2 NPs, AgNPs and ZnO NPs (commonly used in food) are discussed. Specific miRNAs are altered by the different types of NMs. There is a lack of studies on the epigenetic effects of NMs administered orally.

Handbook of Immunological Properties of Engineered Nanomaterials

Handbook of Immunological Properties of Engineered Nanomaterials
A Book

by Marina A. Dobrovolskaia,Scott E. McNeil

  • Publisher : World Scientific
  • Release : 2013
  • Pages : 692
  • ISBN : 9814390259
  • Language : En, Es, Fr & De
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The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Engineered Nanoparticles

Engineered Nanoparticles
Structure, Properties and Mechanisms of Toxicity

by Ashok K Singh

  • Publisher : Academic Press
  • Release : 2015-11-24
  • Pages : 554
  • ISBN : 012801492X
  • Language : En, Es, Fr & De
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Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects. Provides state-of-the-art physicochemical descriptions and methodologies for the characterization of engineered nanomaterials (ENM) Describes the potential toxicological effects of ENM and the nanotoxicological mechanisms of action Presents how to apply theory to practice in a public health and risk assessment setting

Journal of the National Cancer Institute

Journal of the National Cancer Institute
JNCI.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanotoxicity

Nanotoxicity
From In Vivo and In Vitro Models to Health Risks

by Saura C. Sahu,Daniel A. Casciano

  • Publisher : John Wiley & Sons
  • Release : 2009-08-04
  • Pages : 630
  • ISBN : 047074779X
  • Language : En, Es, Fr & De
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Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Nanotechnology - Toxicological Issues and Environmental Safety

Nanotechnology - Toxicological Issues and Environmental Safety
A Book

by P.P. Simeonova,N. Opopol,M.I. Luster

  • Publisher : Springer Science & Business Media
  • Release : 2007-05-08
  • Pages : 276
  • ISBN : 1402060769
  • Language : En, Es, Fr & De
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This book provides a summary of the state-of-art knowledge on nanomaterials and nanoparticles. It examines toxicological issues, risk assessment and control measures, public participation and educational/ethical issues, as well as institutional mechanisms and status reports from various countries. Coverage also details collaborations in the field of nanotechnology regarding safe application and development.

Nanotoxicology

Nanotoxicology
Characterization, Dosing and Health Effects

by Nancy A. Monteiro-Riviere,C. Lang Tran

  • Publisher : CRC Press
  • Release : 2007-07-25
  • Pages : 392
  • ISBN : 9781420045154
  • Language : En, Es, Fr & De
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Nanomaterials - structures with characteristic dimensions between 1 and 100 nm -exhibit a variety of unique and tunable chemical and physical properties that have made engineered nanoparticles central components in an array of emerging technologies. The use of nanotechnology is increasing; however its potential adverse effects on human health are n

Phytotoxicity of Nanoparticles

Phytotoxicity of Nanoparticles
A Book

by Mohammad Faisal,Quaiser Saquib,Abdulrahman A. Alatar,Abdulaziz A. Al-Khedhairy

  • Publisher : Springer
  • Release : 2018-06-28
  • Pages : 407
  • ISBN : 3319767089
  • Language : En, Es, Fr & De
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This book provides relevant findings on nanoparticles’ toxicity, their uptake, translocation and mechanisms of interaction with plants at cellular and sub-cellular level. The small size and large specific surface area of nanoparticles endow them with high chemical reactivity and intrinsic toxicity. Such unique physicochemical properties draw global attention of scientists to study potential risks and adverse effects of nanoparticles in the environment. Their toxicity has pronounced effects and consequences for plants and ultimately the whole ecosystem. Plants growing in nanomaterials-polluted sites may exhibit altered metabolism, growth reduction, and lower biomass production. Nanoparticles can adhere to plant roots and exert physicochemical toxicity and subsequently cell death in plants. On the other hand, plants have developed various defense mechanisms against this induced toxicity. This books discusses recent findings as well as several unresolved issues and challenges regarding the interaction and biological effects of nanoparticles. Only detailed studies of these processes and mechanisms will allow researchers to understand the complex plant-nanomaterial interactions.

Journal of the National Cancer Institute

Journal of the National Cancer Institute
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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"Summaries of papers" contained in the journal accompany each issue, 19--

Case Studies in Nanotoxicology and Particle Toxicology

Case Studies in Nanotoxicology and Particle Toxicology
A Book

by Antonietta M Gatti,Stefano Montanari

  • Publisher : Academic Press
  • Release : 2015-05-29
  • Pages : 276
  • ISBN : 0128012544
  • Language : En, Es, Fr & De
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Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment. This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration. Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices to prevent these effects. The text is an essential reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians. Presents real-life cases showing the potential risks to human health following exposure to nanoparticles An ideal reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians Provides examples to help assess risks of handling engineered nanomaterials Advises on the best forms of protection and the safest nanotechnological products

Safe Nanotechnology

Safe Nanotechnology
A Book

by Arthur J. Cornwelle

  • Publisher : Nova Science Pub Incorporated
  • Release : 2009
  • Pages : 77
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Developed by the National Institute for Occupational Safety and Health.

Mechatronic Systems and Materials Application

Mechatronic Systems and Materials Application
A Book

by Liang Zhong Jiang

  • Publisher : Trans Tech Publications Ltd
  • Release : 2012-11-12
  • Pages : 590
  • ISBN : 3038139106
  • Language : En, Es, Fr & De
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These proceedings of the International Conference on Mechatronic Systems and Materials Application, held on the 8 and 9th September 2012 in Qingdao, China, comprise papers grouped under the rubrics: Alloy and Nanometer Materials Technology; Chemical, Biological, Composites and Functional Materials Science; Electromechanical Integration and Control; Machinery, Automation and Design Technology; Intelligent Production.

C L

C L

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Daily Labor Report

Daily Labor Report
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007-12
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanotechnologies - Occupational Risk Management Applied to Engineered Nanomaterials

Nanotechnologies - Occupational Risk Management Applied to Engineered Nanomaterials
Part 2: Use of controlled banding approach

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 31
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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"This standard 'describes the use of a control banding approach for controlling the risks associated with occupational exposures to nano-objects, and their aggregates and agglomerates greater than 100nm (NOAA), even if knowledge regarding their toxicity and quantitative exposure estimations is limited or lacking'. ISO/TS 12901-2: 2014 is 'focused on intentionally produced nano-objects' either in 'their original form or incorporated in materials or preparations from which they could be released during their lifecycle'. The control banding approach is meant to limit exposure 'in order to prevent any possible adverse effects on workers' health'. This version focuses on inhalation control. This standard 'is intended to help businesses and others [...] engaged in the manufacturing, processing or handling of NOAA, by providing an easy-to-understand, pragmatic approach for the control of occupational exposures'." --Publisher's note.

Progress in Genotoxicity Evaluation of Engineered Nanomaterials

Progress in Genotoxicity Evaluation of Engineered Nanomaterials
A Book

by Xiaoqing Guo

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Engineered nanomaterials (ENMs) are being produced at an increasing rate. Because of their unique physicochemical properties, ENMs have been used in a wide variety of commercial products. The specific properties of ENMs, such as their relatively larger surface area, however, could also cause adverse biological effects different from their bulk counterparts. Nanomaterials can be genotoxic while their bulk counterparts are not, or vice versa, due to these specific characteristics. Also, the differences between nanomaterials and bulk materials can generate uncertainty when measuring the genotoxic potential of ENMs using current genotoxicity assays that were developed for conventional chemicals or bulk materials. In this chapter, we summarize current progress in evaluating the genotoxicity of ENMs with a focus on results from the standard genotoxicity assays, possible mechanisms underlying the genotoxicity of ENMs, the suitability of current genotoxicity assays for evaluation of ENMs, and application of ENM genotoxicity data for risk assessment. Future perspectives for the evaluation of ENM genotoxicity are also addressed.

Journal of the Air & Waste Management Association

Journal of the Air & Waste Management Association
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Interaction of Nanomaterials with the Immune System

Interaction of Nanomaterials with the Immune System
A Book

by James C. Bonner,Jared M. Brown

  • Publisher : Springer Nature
  • Release : 2020-01-30
  • Pages : 223
  • ISBN : 3030339629
  • Language : En, Es, Fr & De
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This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

The Environmental Applications and Implications of Nanotechnology in Membrane-based Separations for Water Treatment

The Environmental Applications and Implications of Nanotechnology in Membrane-based Separations for Water Treatment
A Book

by Wenqian Shan

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 256
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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