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Adverse Events and Oncotargeted Kinase Inhibitors

Adverse Events and Oncotargeted Kinase Inhibitors
A Book

by Giuseppe Tridente

  • Publisher : Academic Press
  • Release : 2017-05-08
  • Pages : 736
  • ISBN : 0128094451
  • Language : En, Es, Fr & De
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Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events. Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Immunotherapy for Gastrointestinal Malignancies

Immunotherapy for Gastrointestinal Malignancies
A Book

by Ramakrishna Vadde

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 9811564876
  • Language : En, Es, Fr & De
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Williams Hematology, 10th Edition

Williams Hematology, 10th Edition
A Book

by Kenneth Kaushansky,Marshall A. Lichtman,Josef T. Prchal,Marcel M. Levi,Linda J. Burns

  • Publisher : McGraw Hill Professional
  • Release : 2021-01-14
  • Pages : 2528
  • ISBN : 126046413X
  • Language : En, Es, Fr & De
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The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources

Williams Hematology, 9E

Williams Hematology, 9E
A Book

by Kenneth Kaushansky,Marshall A. Lichtman,Josef Prchal,Marcel M. Levi,Oliver W Press,Linda J Burns,Michael Caligiuri

  • Publisher : McGraw Hill Professional
  • Release : 2015-12-23
  • Pages : 2528
  • ISBN : 0071833013
  • Language : En, Es, Fr & De
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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2019! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Maingot's Abdominal Operations. 13th edition

Maingot's Abdominal Operations. 13th edition
A Book

by Michael J. Zinner,Stanley W. Ashley

  • Publisher : McGraw Hill Professional
  • Release : 2018-09-22
  • Pages : 1600
  • ISBN : 0071844295
  • Language : En, Es, Fr & De
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The best edition yet of the cornerstone text on abdominal operations—enhanced by thousands of full-color photographs and illustrations and thoroughly updated content Edition after edition, Maingot’s Abdominal Operations has been hailed as the most complete, current, and trusted resource among general, colorectal, and gastrointestinal surgeons. Presented in full color, this classic textbook carefully details common and important abdominal procedures, offering a concise, yet complete, survey of the diagnosis and management of benign and malignant digestive disorders. Bolstered by more than 650 photographs and 1,250 full color illustrations, Maingot’s 78 chapters deliver everything you need to understand congenital, acquired, and neoplastic disorders – and optimize surgical outcomes for any type of abdominal disorder. FEATURES: •Contemporary focus on operative procedures, and new concepts in the diagnosis and management of abdominal disease•Convenient organ/procedure presentation provides a seamless review of surgical protocols, as well as pre- and postoperative strategies and techniques•Added chapters on quality metrics, ERAS, and robotic surgery; and an increased number of “Perspective” commentaries by experts in the field•Disease-focused and organ/procedure presentation provides a seamless review of surgical protocols, as well as pre- and postoperative strategies and techniques•More than 650 photographs and 1,250 full color illustrations, many new to this edition