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Alginates in Drug Delivery

Alginates in Drug Delivery
A Book

by Amit Kumar Nayak,Md Saquib Hasnain

  • Publisher : Academic Press
  • Release : 2020-07-23
  • Pages : 434
  • ISBN : 0128176415
  • Language : En, Es, Fr & De
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Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations, along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields

Alginates

Alginates
Versatile Polymers in Biomedical Applications and Therapeutics

by Md Saquib Hasnain,Amit Kumar Nayak

  • Publisher : CRC Press
  • Release : 2019-04-01
  • Pages : 626
  • ISBN : 042965748X
  • Language : En, Es, Fr & De
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This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.

Alginates

Alginates
Applications in the Biomedical and Food Industries

by Shakeel Ahmed

  • Publisher : John Wiley & Sons
  • Release : 2019-03-12
  • Pages : 336
  • ISBN : 1119487919
  • Language : En, Es, Fr & De
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Alginate is a hydrophilic, biocompatible, biodegradable, and relatively economical polymer generally found in marine brown algae. The modification in the alginate molecule after polymerization has shown strong potential in biomedical, pharmaceutical and biotechnology applications such as wound dressing, drug delivery, dental treatment, in cell culture and tissue engineering. Besides this, alginates have industrial applications too in the paper and food industries as plasticizers and additives. The few books that have been published on alginates focus more on their biology. This current book focuses on the exploration of alginates and their modification, characterization, derivatives, composites, hydrogels as well as the new and emerging applications.

Alginates and Their Biomedical Applications

Alginates and Their Biomedical Applications
A Book

by Bernd H.A. Rehm,M. Fata Moradali

  • Publisher : Springer
  • Release : 2017-11-29
  • Pages : 268
  • ISBN : 9811069107
  • Language : En, Es, Fr & De
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This book presents a comprehensive review of the latest advances in developing alginate-based biomaterials and derivatives as well as their biomedical and pharmaceutical applications. It covers the physiochemical properties of alginates, production and formulation methods, derivatizations and characterization methods, the fundamental work on optimizing alginate polymers for defined biomedical purposes as well as the scope and effectiveness of their applications in medicine and therapeutic approaches. The book brings together new concepts and advances in harnessing alginate-based biomaterials in combination with applied technological advances to tailor their applications to medical needs. The contributions by leading academics, clinicians and researchers not only cover the fundamentals, but also open new avenues for meeting future challenges in research and clinical applications.

Use of Alginate/montmorillonite Nanocomposites as Drug Delivery System for Curcumin

Use of Alginate/montmorillonite Nanocomposites as Drug Delivery System for Curcumin
A Book

by Marwa Fathy Abdelfattah Ahmed

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 162
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility and rapid metabolism are main obstacles. Different techniques were used to overcome the drawbacks of curcumin, with recent attention focusing on approaches based on nanotechnology. Clay-polymer nanocomposites are getting to play a role in nanoformulations for drug delivery. This is due to their improved rheological and mechanical properties, and controlled drug release characteristics compared to their individual components, clays and polymers. Alginate/ montmorillonite (MMT) nanocomposites are used as drug delivery system for a wide variety of drugs due to numerous advantages of both components such as the high loading capacity of MMT and the ability of alginate release encapsulated drugs in a controlled manner. Accordingly, this study aimed at the preparation of curcumin loaded alginate/MMT nanocomposites and the investigation of their release properties. Exfoliated MMT clay was first prepared by stirring the clay in an aqueous suspension for 4 hours, followed by filtration and drying at 70 °C. Exfoliation was confirmed by X-ray diffraction (XRD) and Fourier Transform infrared (FTIR) spectroscopy. Curcumin loaded MMT was then prepared by dispersing the exfoliated clay into an ethanoic curcumin solution. Different parameters were tested, namely stirring time, curcumin solution concentration and ratio of MMT to curcumin, in order to find out the maximum loading conditions. Stirring exfoliated MMT into curcumin solution of 1 mg/ml for 1 hour and in 5% W/V ratio was found to be the best condition for maximum loading (6.56 mg/g, corresponding to entrapment efficiency of 25.62 %). The hybrid sample (curcumin loaded MMT) was thus prepared. Visible spectrophotometric measurements of the curcumin solution were used to determine the amount of curcumin loaded by measuring the absorbance of curcumin solution before and after the dispersion of the clay. The hybrid sample was then encapsulated into alginate beads with different hybrid to alginate ratios (W/W) using the ionotropic technique. XRD and FTIR analysis were used for the characterization of the prepared hybrid and nanocomposites. They revealed the increase in the degree of clay exfoliation upon drug loading and encapsulation into the alginate beads and the loss of the crystalline nature of curcumin upon v adsorption onto the clay surface without any chemical interaction between the clay and curcumin. The release of curcumin from different alginate/MMT nanocomposites was studied in different biorelevent media: fast gastric (FaSSGF), fast intestinal (FaSSIF) and fed intestinal media (FeSSIF). The curcumin release in gastric media was negligible and this was attributed to its low solubility in these media and to the shrinkage of alginate beads in the acidic pH environment. Curcumin release in intestinal media was significantly higher and was found to be affected by both the feeding state and the ratio of hybrid to alginate. Increasing the hybrid to alginate ratio decreased the percentage of curcumin release because of the decrease of the swelling ratio of alginate due to the crosslinking effect of the clay. Consequently, the 1:20 (W/W) hybrid to alginate ratio nanocomposite sample (NC 1) showed the highest release percentage in both fast and fed intestinal media (71% in the FaSSIF and 15.5 % in the FeSSIF). On the other hand, the 1:2 (W/W) hybrid to alginate ratio nanocomposite sample (NC 4) demonstrated the lowest release percentage in both media (17.4% in FaSSIF and 6.6 % in FeSSIF). The feeding state played additional role in the percentage of curcumin released as it was found to affect both the pH and the concentration of the natural solubilizing components such as phospholipids and bile salts of the intestine. Accordingly, the percentage of curcumin released was higher in the fasting state than in the fed state due to the higher pH of the former media (88.4% in the FaSSIF and 16.6% in the FeSSIF for NC 1. Curcumin release in both intestinal media demonstrated different behaviors: in FaSSIF sustained release behavior was found to occur for 24 hours, while curcumin release reached a plateau by 8 hours in the FeSSIF. This study reveals the promising use of alginate/MMT nanocomposites as sustained release drug delivery system for curcumin through surface adsorption of curcumin onto the surface of exfoliated clay and encapsulation of the loaded clay into alginate beads. The release of curcumin would be hindered into the gastric environment and start into the intestine. For maximum and sustained release behavior a fasting state is preferred.

Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery

Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery
A Book

by Amit Kumar Nayak,Md Saquib Hasnain

  • Publisher : Springer
  • Release : 2019-03-27
  • Pages : 129
  • ISBN : 9811067848
  • Language : En, Es, Fr & De
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This book explores the use of various plant polysaccharides for pharmaceutical purposes, including drug delivery. It examines the exploitation of plant polysaccharides’ auxiliary functions to enhance drug release, stability, bioavailability and target specificity. Plant-derived materials are at the center of drug-delivery research thanks to their non-toxicity, biodegradability, ready availability, eco-friendliness and low extraction costs. These materials include polysaccharides, a class of naturally occurring polymers consisting of glucose monomers, which serve as storage carbohydrates in cereals, root vegetables, rhizomes, seeds, fruits, etc.

Advanced Biopolymeric Systems for Drug Delivery

Advanced Biopolymeric Systems for Drug Delivery
A Book

by Amit Kumar Nayak,Md Saquib Hasnain

  • Publisher : Springer Nature
  • Release : 2020-07-11
  • Pages : 386
  • ISBN : 3030469239
  • Language : En, Es, Fr & De
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This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Natural Polysaccharides in Drug Delivery and Biomedical Applications

Natural Polysaccharides in Drug Delivery and Biomedical Applications
A Book

by Md Saquib Hasnain,Amit Kumar Nayak

  • Publisher : Academic Press
  • Release : 2019-07-23
  • Pages : 654
  • ISBN : 0128170565
  • Language : En, Es, Fr & De
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Natural Polysaccharides in Drug Delivery and Biomedical Applications provides a fundamental overview of natural polysaccharides, their sources, extraction methodologies, and characterizations. It covers specific natural polysaccharides and their effective application in drug delivery and biomedical use. Additionally, chapters in the book discuss key topics including the sources and extraction methodologies of natural polysaccharides, their role in tissue engineering applications, polysaccharide-based nanoparticles in biomedical applications, and their role in the delivery of anticancer drugs. Written by industry leaders and edited by experts, this book emphasizes recent advances made in the field. Natural Polysaccharides in Drug Delivery and Biomedical Applications provides academics, researchers, and pharmaceutical health care professionals with a comprehensive book on polysaccharides in pharmaceutical delivery process. Provides fundamental concepts of natural polysaccharides as it applies to the pharmaceutical, biomedical, and biotechnology industries Includes contributions from global leaders and experts from academia, industry, and regulatory agencies in the application of natural polysaccharides in pharmaceutical products and biomedical utilization Offers practical examples, illustrations, chemical structures, and research case studies to help explain natural polysaccharides concepts in drug delivery and biomedical applications

Alginates

Alginates
Production, Types and Applications

by Manuel E. Molina,Andres J. Quiroga

  • Publisher : Nova Science Pub Incorporated
  • Release : 2012
  • Pages : 272
  • ISBN : 9781619425460
  • Language : En, Es, Fr & De
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Alginate is extracted from brown algae and some bacteria. It is an abundant natural polysaccharide and usually exists as sodium salt. In this book, the authors present topical research in the study of the production, types and applications of alginate. Topics discussed include the application of alginates in cell and enzyme immobilization; alginate based materials in environmental applications; cross-linked alginates for modified drug delivery applications; bacterial alginate production by fermentation and the preparation and functionalization of alginate-based hydrogels.

Handbook of Pharmaceutical Excipients

Handbook of Pharmaceutical Excipients
A Book

by Arthur H. Kibbe

  • Publisher : Amer Pharmacists Assn
  • Release : 2000
  • Pages : 665
  • ISBN : 9780917330964
  • Language : En, Es, Fr & De
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Describes the chemical and physical properties of pharmaceutical excipients. Each monograph contains nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology, description, pharmacopeial specifications, typical propertics, stability and storage conditions, incompatibilities, method of manufacture, safety, handling precautions, regulatory status, pharmacopeias, related substances, comments, specific references, general references, and authors.

Advances in Material Design for Regenerative Medicine, Drug Delivery, and Targeting/imaging

Advances in Material Design for Regenerative Medicine, Drug Delivery, and Targeting/imaging
Symposium Held December 1-3, 2008, Boston, Massachusetts, U.S.A.

by V. Prasad Shastri

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 223
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Controlled Drug Delivery

Controlled Drug Delivery
Designing Technologies for the Future

by Kinam Park,Randall J. Mrsny

  • Publisher : Amer Chemical Society
  • Release : 2000
  • Pages : 459
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Controlled Drug Delivery examines the current state of drug deliverytechnologies and discusses the future directions of drug delivery development.Topics include advances for increasing the uptake of orally delivered drugs,modulating blood levels for better drug safety/efficacy profiles, targetingdrugs and genes for cellular and intracellular delivery, improving the deliveryof poorly soluble drugs and recent advances in polymer-based drug deliverytechnologies.

Biomaterials for Drug Delivery and Tissue Engineering: Volume 662

Biomaterials for Drug Delivery and Tissue Engineering: Volume 662
A Book

by Surya Mallapragada,Mark Tracy,Balaji Narasimhan,Richard Korsmeyer,Edith Mathiowitz

  • Publisher : Materials Research Society
  • Release : 2001-09-14
  • Pages : 324
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The MRS Symposium Proceeding series is an internationally recognised reference suitable for researchers and practitioners.

Controlled Growth Factor Delivery to Engineer Vascular Networks and Enhance Transplanted Cell Survival

Controlled Growth Factor Delivery to Engineer Vascular Networks and Enhance Transplanted Cell Survival
A Book

by Martin Craswell Peters

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Future Strategies for Drug Delivery with Particulate Systems

Future Strategies for Drug Delivery with Particulate Systems
A Book

by Julia E. Diederichs,Rainer H. Müller

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 194
  • ISBN : 9783887630614
  • Language : En, Es, Fr & De
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Drug Release Profile Libraries for Ciprofloxacin-loaded Alginate- and Chitosan-based Electrospun Nanofibers

Drug Release Profile Libraries for Ciprofloxacin-loaded Alginate- and Chitosan-based Electrospun Nanofibers
A Thesis Submitted in Partial Fulfillment of the Requirements for the Masters of Science in Natural Science in Chemistry, Delta State University, Cleveland, Mississippi

by Kathryn Elizabeth Penton

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 198
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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As an alternative to traditional wound dressings, the electrospinning of natural polymers alginate and chitosan were explored, each with various concentrations of each of the co-polymers poly (vinyl alcohol) and agarose, with multi-walled carbon nanotubes incorporated into the polymer solution once ideal fibers were formed. Ciprofloxacin was introduced to the solution to create drug-loaded nanofibers, which were analyzed through scanning electron microscopy and confocal imaging to create a catalog of small molecule release profiles that can aid in development of biomaterials used in drug delivery and modern wound healing dressings.

Chemistry and Industry

Chemistry and Industry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of Scientific & Industrial Research

Journal of Scientific & Industrial Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biodegradable Polymers

Biodegradable Polymers
A Book

by Reza Arshady

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 396
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Microspheres and Drug Therapy

Microspheres and Drug Therapy
Pharmaceutical, Immunological, and Medical Aspects

by Stanley S. Davis

  • Publisher : Elsevier Publishing Company
  • Release : 1984
  • Pages : 448
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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