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Ambient Ionization Mass Spectrometry in Life Sciences

Ambient Ionization Mass Spectrometry in Life Sciences
Principles and Applications

by Kei Zaitsu

  • Publisher : Elsevier
  • Release : 2019-11-06
  • Pages : 292
  • ISBN : 0128172215
  • Language : En, Es, Fr & De
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Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications is a systematic introduction to this rapidly expanding area of study. Underlying principles of each technique are explained in detail, along with discussions on their applications across life science disciplines. Ambient ionization has recently emerged as one of the hottest and fastest growing topics in mass spectrometry, hence this book is not just for analysts and researchers who use and study mass spectrometry. This volume would be of interest to anyone who works in or studies analytical chemistry, omics sciences (including metabolomics), pharmacokinetics, forensic science or drug analysis. Covers the most up-to-date techniques, including DART, DCBI, DESI, PESI, PSI, REIMS and laser-based ambient ionization Includes easy-to-understand pros and cons of each ionization technique to aid in decision-making Provides plentiful examples of life science applications

Mass Spectrometry in Life Sciences and Clinical Laboratory

Mass Spectrometry in Life Sciences and Clinical Laboratory
A Book

by Goran Mitulović

  • Publisher : BoD – Books on Demand
  • Release : 2021-06-02
  • Pages : 154
  • ISBN : 1838818618
  • Language : En, Es, Fr & De
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Mass spectrometry is a state-of-the-art tool for basic biological research and applied clinical diagnostics. This book covers sample preparation for mass spectrometric analysis for proteomics, clinical studies, and food analysis. In addition, it explores possible directions for further developing the technology and its potential applications.

Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book

Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book
A Book

by Sankha (Bobby) Basu

  • Publisher : Elsevier Health Sciences
  • Release : 2021-05-31
  • Pages : 240
  • ISBN : 0323813305
  • Language : En, Es, Fr & De
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Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book

Ambient Laser Ablation Electrospray Ionization Mass Spectrometry Imaging

Ambient Laser Ablation Electrospray Ionization Mass Spectrometry Imaging
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 164
  • ISBN : 9789463439220
  • Language : En, Es, Fr & De
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Identification and confirmation of (bio)chemical entities in ambient MS mostly involves accurate mass determination, often in combination with MS/MS work flows. However, an accurate mass only provides the elemental composition of the (bio)molecule, still resulting in numerous possible structures. MS/MS procedures are often insufficient in differentiating between the hundreds possible candidate substances in database searches. Obtaining additional information and thereby improving structural assignment as well as reducing the vast number of possible candidates is thus of high importance in any ambient MS(I) study. In Chapter 5 we present an ambient hydrogen/deuterium exchange (HDX) LAESI-MS method for structure elucidation and confirmation of (bio)molecules. The concept was demonstrated with small molecules, peptides, and proteins. Moreover, the same approach could be applied to MSI as shown by the ambient MSI of arginine and oligosaccharides on an orange slice. Eventually, this approach will allow spatially resolved MSI of different protein conformers and may have a major impact in the life sciences.

Time-Resolved Mass Spectrometry

Time-Resolved Mass Spectrometry
From Concept to Applications

by Pawel L. Urban,Yu-Chie Chen,Yi-Sheng Wang

  • Publisher : John Wiley & Sons
  • Release : 2016-03-21
  • Pages : 280
  • ISBN : 1118887328
  • Language : En, Es, Fr & De
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Time is an important factor in physical and natural sciences. It characterizes the progress of chemical and biochemical processes. Mass spectrometry provides the means to study molecular structures by detecting gas-phase ions with the unique mass-to-charge ratios. Time-resolved mass spectrometry (TRMS) allows one to differentiate between chemical states that can be observed sequentially at different time points. Real-time mass spectrometric monitoring enables recording data continuously with a specified temporal resolution. The TRMS approaches – introduced during the past few decades – have shown temporal resolutions ranging from hours down to microseconds and beyond. This text covers the key aspects of TRMS. It introduces ion sources, mass analyzers, and interfaces utilized in time-resolved measurements; discusses the influence of data acquisition and treatment; finally, it reviews most prominent applications of TRMS – in the studies of reaction kinetics and mechanism, physicochemical phenomena, protein structure dynamics, biocatalysis, and metabolic profiling. It will assist science and engineering students to gain a basic understanding of the TRMS concept, and to recognize its usefulness. In addition, it may benefit scientists who conduct molecular studies in the areas of chemistry, physics and biology.

Ambient Ionization Mass Spectrometry

Ambient Ionization Mass Spectrometry
A Book

by Marek Domin,Robert Cody

  • Publisher : Royal Society of Chemistry
  • Release : 2014-11-14
  • Pages : 508
  • ISBN : 1782628029
  • Language : En, Es, Fr & De
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Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

Issues in Life Sciences: Molecular Biology: 2011 Edition

Issues in Life Sciences: Molecular Biology: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 3330
  • ISBN : 1464963487
  • Language : En, Es, Fr & De
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Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Plant Single Cell Type Systems Biology

Plant Single Cell Type Systems Biology

by Marc Libault,Sixue Chen

  • Publisher : Frontiers Media SA
  • Release : 2016-09-06
  • Pages : 129
  • ISBN : 2889199487
  • Language : En, Es, Fr & De
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The phenotype of a plant in response to a stress condition is the reflection of the molecular responses in different cell-types composing the plant. The multicellular complexity represents a challenge when accessing specific responses of each cell or cell type composing the plant. To overcome this difficulty and allow the clear characterization of the plant cell molecular mechanisms, the research community is now focusing on studying a single cell and single cell-types. The isolation of plant single cells is limited by the cell wall that confers the rigidity of the plant and its overall structure. Various methods have been developed for isolating plant cells (e.g. laser capture microdissection; cell sorting of Green Fluorescent Protein (GFP)-tagged protoplasts, differential protoplastization of cells such as guard cells, isolation of easily accessible cell types such as cotton fiber, pollen cells, trichomes and root hair cells). The development of these innovative approaches to isolate single plant cells or cell-types combined with the application of sensitive and high-throughput technologies allows a better analysis of the developmental processes and response to environmental stresses. Ultimately, single plant cell and cell-type biology will lead to establishment of more reliable and accurate -molecular regulatory networks at the resolution of basic life unit. The goal of this Research Topic is to cover new technological and biological advances in the study of plant single cell, cell-type and systems biology.

Applications of Mass Spectrometry Imaging to Cancer

Applications of Mass Spectrometry Imaging to Cancer
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2017-01-19
  • Pages : 312
  • ISBN : 0128054409
  • Language : En, Es, Fr & De
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Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Chemical Analysis of Food

Chemical Analysis of Food
Techniques and Applications

by Yolanda Pico

  • Publisher : Academic Press
  • Release : 2020-06-16
  • Pages : 916
  • ISBN : 0128132671
  • Language : En, Es, Fr & De
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Chemical Analysis of Food: Techniques and Applications, Second Edition, reviews the latest technologies and challenges in all stages of food analysis, from selecting the right approach, how to perform analytic procedures, and how to measure and report the results. The book is structured in two parts: the first describes the role of the latest developments in analytical and bio-analytical techniques, with the second reviewing innovative applications and issues in food analysis. The techniques discussed range from the non-invasive and non-destructive, such as infrared spectroscopy and ultrasound, to newly emerging areas, such as nanotechnology, biosensors and electronic noses and tongues. This thoroughly updated edition includes new chapters on ambient mass spectrometry, imaging techniques, omics approaches in food analysis, natural toxins analysis, food contact materials, nanomaterials and organic foods. All chapters are updated or rewritten to bring the content completely up-to-date. Reviews the attributes, benefits, limits and potential of all relevant analytic modalities, including spectroscopy, ultrasound and nanotechnology applications Provides in-depth coverage of each technology, including near-infrared, mid-infrared, and Raman spectroscopy, low intensity ultrasound, microfluidic devices and biosensors, electronic noses and tongues, mass spectrometry and molecular techniques Outlines practical solutions to challenging problems in food analysis, including how to combine techniques for improved efficacy Covers all relevant applications of food analysis, such as traceability, authenticity and fraud, biologically-active food components, novel food and nutritional supplements, flavors and fragrances, and contaminants and allergens Provides researchers with a single source of current research and includes contributions from internationally renowned experts in food science and technology and nutrition

Characterization of Impurities and Degradants Using Mass Spectrometry

Characterization of Impurities and Degradants Using Mass Spectrometry
A Book

by Guodong Chen

  • Publisher : John Wiley & Sons
  • Release : 2011-04-27
  • Pages : 496
  • ISBN : 0470922974
  • Language : En, Es, Fr & De
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The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products. Both general practitioners in pharmaceutical research and specialists in analytical chemistry field will benefit from this book that will detail step-by-step approaches and new strategies to solve challenging problems related to pharmaceutical research.

Tumor Immunology and Immunotherapy - Integrated Methods Part B

Tumor Immunology and Immunotherapy - Integrated Methods Part B
A Book

by Nils-Petter Rudqvist

  • Publisher : Academic Press
  • Release : 2020-04
  • Pages : 412
  • ISBN : 0128206675
  • Language : En, Es, Fr & De
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Tumor Immunology and Immunotherapy - Integrated Methods Part B, Volume 636 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this update include Quantification methods of Transforming Growth Factor beta (TGF˗β) activity in the setting of cancer immunotherapy, Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses, Tracking and interrogating tissue-resident and recruited microglia in brain tumors, Metabolomics and lipidomics of the tumor microenvironment, Monitoring abscopal responses to radiation in mice, and much more.

Analytical Geomicrobiology

Analytical Geomicrobiology
A Book

by Janice P. L. Kenney,Harish Veeramani,Daniel S. Alessi

  • Publisher : Cambridge University Press
  • Release : 2019-07-31
  • Pages : 468
  • ISBN : 1107070333
  • Language : En, Es, Fr & De
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A comprehensive handbook outlining state-of-the-art analytical techniques used in geomicrobiology, for advanced students, researchers and professional scientists.

Proceedings of 4th World Congress on Mass Spectrometry 2017

Proceedings of 4th World Congress on Mass Spectrometry 2017
Journal of Chromatography & Separation Techniques : Volume 8

by ConferenceSeries

  • Publisher : ConferenceSeries
  • Release : 2022
  • Pages : 151
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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June 19-21, 2017 London, UK Key Topics : Applications of Mass Spectrometry, New Approaches in Mass Spectrometry, Recent Advances and Development in Mass Spectrometry, Mass spectrometry Imaging, Fundamentals of Mass Spectrometry, Ionization Techniques, Mass Spectrometry Configurations and Separation Techniques, Chromatography and High Performance Liquid Chromatography (HPLC), Maintenance, Troubleshooting, Data Analysis and Experimentation in Mass Spectrometry, Mass Spectrometry in Proteome Research, Proteomics and its applications, Mass Spectrometry in Metabolomics and Lipidomics, Hyphenated Techniques (LC-NMR-MS, HPLC-ESI-MS, MC-ICP-MS, HPLC-ICP-MS, UPLC-Q-TOF/MS), Mass spectrometry in environmental analysis, Spectroscopy, Clinical application of mass spectrometry, UV, IR and Ion Spectroscopy, Nuclear Magnetic Resonance(NMR) Spectroscopy, Mass Spectrometry in Toxicology, Mass spectrometry in Analytical Science, Mass Spectrometry in Pharmaceutical Analysis,

Advances in Chromatography

Advances in Chromatography
Volume 54

by Nelu Grinberg,Eli Grushka

  • Publisher : CRC Press
  • Release : 2017-08-15
  • Pages : 200
  • ISBN : 1351652974
  • Language : En, Es, Fr & De
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For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 54, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Ion Mobility-Mass Spectrometry

Ion Mobility-Mass Spectrometry
Methods and Protocols

by Giuseppe Paglia,Giuseppe Astarita

  • Publisher : Humana
  • Release : 2020-11-15
  • Pages : 312
  • ISBN : 9781071600320
  • Language : En, Es, Fr & De
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This book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as an ideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.

Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production

Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production
A Book

by Dimitrios Kontogiannatos,Anna Kourti,Kassio Ferreira Mendes

  • Publisher : BoD – Books on Demand
  • Release : 2020-12-23
  • Pages : 268
  • ISBN : 1789238277
  • Language : En, Es, Fr & De
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This book highlights some of the most recent research with respect to emerging pest challenges in agricultural crop and animal husbandry production: analytical methods for glyphosate detection in foods, biopesticides and essential oils, environmental safety in pest control, herbicide and glyphosate resistance, herbicides and weed management, integrated pest management, mass spectrometry for insect physiology studies, pheromones and chemical communication, pasteurellosis outbreaks, and tick identification and management.

Applications in High Resolution Mass Spectrometry

Applications in High Resolution Mass Spectrometry
Food Safety and Pesticide Residue Analysis

by Roberto Romero-González,Antonia Garrido Frenich

  • Publisher : Elsevier
  • Release : 2017-03-07
  • Pages : 360
  • ISBN : 0128096489
  • Language : En, Es, Fr & De
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Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field. Arms researchers with an in-depth resource devoted to the rapid advances in HRMS tools and strategies for pesticide residue analysis in food Provides a complete overview of analytical methodologies and applications of HRMS, including UHPLC-HRMS, HRMS coupled with time of flight (TOF) and/or GC-Orbitrap, and flow injection-HRMS Discusses the current international regulations and legislation related to the use of HRMS in pesticide residue analysis Features a chapter on the hardware and software available for HRMS implementation Offers separate chapters on HRMS applied to pesticide residue analysis in fruits and vegetables and in food from animal origin

UHPLC in Life Sciences

UHPLC in Life Sciences
A Book

by Davy Guillarme,Jean-Luc Veuthey

  • Publisher : Royal Society of Chemistry
  • Release : 2015-11-09
  • Pages : 484
  • ISBN : 1782626158
  • Language : En, Es, Fr & De
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Since its commercial introduction in 2004, UHPLC (Ultra-High Performance Liquid Chromatography) has begun to replace conventional HPLC in academia and industry and interest in this technique continues to grow. Both the increases in speed and resolution make this an attractive method; particularly to the life sciences and more than 1500 papers have been written on this strongly-evolving topic to date. This book provides a solid background on how to work with UHPLC and its application to the life sciences. The first part of the book covers the basics of this approach and the specifics of a UHPLC system, providing the reader with a solid background to working properly with such a system. The second part examines the application of UHPLC to the life sciences, with a focus on drug analysis strategies. UHPLC-MS, a key technique in pharmaceutical and toxicological analyses, is also examined in detail. The editors (Davy Guillarme and Jean-Luc Veuthey) were some of the earliest adopters of UHPLC and have published and lectured extensively on this topic. Between them they have brought together an excellent team of contributors from Europe and the United States, presenting a wealth of expertise and knowledge. This book is an essential handbook for anyone wishing to adopt an UHPLC system in either an academic or industrial setting and will benefit postgraduate students and experienced workers alike.

Determining Core Capabilities in Chemical and Biological Defense Science and Technology

Determining Core Capabilities in Chemical and Biological Defense Science and Technology
A Book

by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Determining Core Capabilities in Chemical and Biological Defense Research and Development

  • Publisher : National Academies Press
  • Release : 2013-01-13
  • Pages : 150
  • ISBN : 0309265355
  • Language : En, Es, Fr & De
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The goal of the U.S. Department of Defense's (DoD's) Chemical and Biological Defense Program (CBDP) is to provide support and world-class capabilities enabling he U.S. Armed Forces to fight and win decisively in chemical, biological, radiological, and nuclear (CBRN) environments. To accomplish this objective, the CBDP must maintain robust science and technology capabilities to support the research, development, testing, and evaluation required for the creation and validation of the products the program supplies. The threat from chemical and biological attack evolves due to the changing nature of conflict and rapid advances in science and technology (S&T), so the core S&T capabilities that must be maintained by the CBDP must also continue to evolve. In order to address the challenges facing the DoD, the Deputy Assistant Secretary of Defense (DASD) for Chemical and Biological Defense (CBD) asked the National Research Council (NRC) to conduct a study to identify the core capabilities in S&T that must be supported by the program. The NRC Committee on Determining Core Capabilities in Chemical and Biological Defense Research and Development examined the capabilities necessary for the chemical and biological defense S&T program in the context of the threat and of the program's stated mission and priorities. Determining Core Capabilities in Chemical and Biological Defense Science and Technology contains the committee's findings and recommendations. It is intended to assist the DASD CBD in determining the best strategy for acquiring, developing, and/or maintaining the needed capabilities.