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An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
From Etiopathogenesis to New Therapeutic Avenues

by Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey

  • Publisher : Academic Press
  • Release : 2020-01-16
  • Pages : 574
  • ISBN : 0128190604
  • Language : En, Es, Fr & De
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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

Cancer Research Program Annual Report to the California State Legislature ...

Cancer Research Program Annual Report to the California State Legislature ...
A Book

by Cancer Research Program (Calif.)

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Prostate Cancer Metabolism

Prostate Cancer Metabolism
From Biochemistry to Therapeutics

by Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel

  • Publisher : Academic Press
  • Release : 2021-07-01
  • Pages : 200
  • ISBN : 032390551X
  • Language : En, Es, Fr & De
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Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice Discusses new drugs and nutraceuticals with a metabolism-centered approach Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

Wiley Encyclopedia of Chemical Biology, Volume 3

Wiley Encyclopedia of Chemical Biology, Volume 3
A Book

by Tadhg P. Begley

  • Publisher : Wiley
  • Release : 2009-02-03
  • Pages : 828
  • ISBN : 9780470470190
  • Language : En, Es, Fr & De
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The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Genetic Engineering News

Genetic Engineering News
GEN.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Scientist

New Scientist
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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International Journal of Oncology

International Journal of Oncology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts

Abstracts
A Book

by American Public Health Association. Annual Meeting

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive Dissertation Index

Comprehensive Dissertation Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Acta Cytologica

Acta Cytologica
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Includes abstracts of papers of various symposia

Advances in Breast Cancer Research

Advances in Breast Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Health Psychology

Health Psychology
Biopsychosocial Interactions

by Edward P. Sarafino

  • Publisher : John Wiley & Sons Incorporated
  • Release : 2008-01-02
  • Pages : 556
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Edward P. Sarafino's Health Psychology: Biopsychosocial Interactions, 6e integrates research and theory from many disciplines-- such as, psychology, sociology, medicine, allied health, and health and physical education--to describe the interconnectedness between psychology and health. The psychological research cited in the text reflects an eclectic orientation and supports a variety of behavioral, physiological, cognitive, and social/personality viewpoints. Sarafino integrates a focus on lifespan development in health and illness throughout the text. Emphasis is also placed on health and prevention while integrating gender, ethnic, and age differences and similarities. In addition, the book has an internationalized content, giving health information from 14 countries around the world.

Annual Meeting of the American Public Health Association and Related Organizations

Annual Meeting of the American Public Health Association and Related Organizations
A Book

by American Public Health Association

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts ... Annual Meeting of the American Public Health Association and Related Organizations

Abstracts ... Annual Meeting of the American Public Health Association and Related Organizations
A Book

by American Public Health Association. Annual Meeting

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cancer Research

Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002-04
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Ladies' Home Journal

The Ladies' Home Journal
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005-07
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bibliomed-SM 2

Bibliomed-SM 2
1980-1986

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 278
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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