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Antifungal Compounds Discovery

Antifungal Compounds Discovery
Natural and Synthetic Approaches

by Marina Sokovic,Konstantinos Liaras

  • Publisher : Elsevier
  • Release : 2020-09-30
  • Pages : 290
  • ISBN : 0128158255
  • Language : En, Es, Fr & De
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Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Agents

Antifungal Agents
Discovery and Mode of Action

by G. K. Dixon,Leonard G. Copping,Derek W. Hollomon

  • Publisher : Bios Scientific Pub Limited
  • Release : 1995
  • Pages : 292
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Antifungal Drug Discovery: New Theories and New Therapies

Antifungal Drug Discovery: New Theories and New Therapies

by Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa

  • Publisher : Frontiers Media SA
  • Release : 2016-09-13
  • Pages : 329
  • ISBN : 2889199509
  • Language : En, Es, Fr & De
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Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Anti-fungal Drug Discovery

Anti-fungal Drug Discovery
Identification and Characterization of Potent, Broad-spectrum Antifungal Compounds Via a Yeast Reporter Bioassay

by Bradley Mark Tebbets

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 208
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents
Proceedings of an International Telesymposium, May 1987

by Robert A. Fromtling

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 641
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Emerging Strategies

by George Tegos,Eleftherios Mylonakis

  • Publisher : CABI
  • Release : 2012
  • Pages : 357
  • ISBN : 1845939433
  • Language : En, Es, Fr & De
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Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

New Antifungal Compounds from Marine Fungi

New Antifungal Compounds from Marine Fungi
A Book

by Akkharawit Kanjana-opas

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 360
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery: Chemotherapeutic agents
A Book

by Alfred Burger

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Discovery of Natural Products with Therapeutic Potential

The Discovery of Natural Products with Therapeutic Potential
A Book

by Vincent Philip Gullo

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 461
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

Antifungal Drugs

Antifungal Drugs
A Book

by New York Academy of Sciences

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 613
  • ISBN : 9780897665100
  • Language : En, Es, Fr & De
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Current Topics in Marine Biotechnology

Current Topics in Marine Biotechnology
Proceedings of the First International Marine Biotechnology Conference, September 3-6, 1989, Tokyo, Japan

by Shigetō Miyaji,I. Karube,Y. Ishida

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 437
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Canadian Journal of Botany

Canadian Journal of Botany
Journal Canadien de Botanique

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Encyclopedia of Microbiology

Encyclopedia of Microbiology
A Book

by Joshua Lederberg

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 329
  • ISBN : 9780122268915
  • Language : En, Es, Fr & De
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V.1. A-C. v.2. D-L. v.3. M-R. v.4. S-Z, Index.

Discovery and Isolation of Microbial Products

Discovery and Isolation of Microbial Products
A Book

by M. S. Verrall

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 198
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Antimicrobial Compounds

Antimicrobial Compounds
Current Strategies and New Alternatives

by Tomás G. Villa,Patricia Veiga-Crespo

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-19
  • Pages : 316
  • ISBN : 3642404448
  • Language : En, Es, Fr & De
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Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Breakthrough

Breakthrough
The Discovery of Modern Medicines at Janssen

by Harry Schwartz

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 181
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Natural Products

Natural Products
Rapid Utilization of Sources for Drug Discovery and Development

by Nancy Mulford,Carol Sussman

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 339
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Discovery and Innovation

Discovery and Innovation
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Synthesis and Chemistry of Agrochemicals VI

Synthesis and Chemistry of Agrochemicals VI
A Book

by Don R. Baker

  • Publisher : Amer Chemical Society
  • Release : 2002
  • Pages : 364
  • ISBN : 9780841237834
  • Language : En, Es, Fr & De
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This 30-chapter volume is a complete reference book that includes current updates and trends in the field of agrochemicals. Topics in the book include herbicides in agriculture, control of insects and acrids in agriculture, and control of fungal disease in agriculture.

Indian Journal of Experimental Biology

Indian Journal of Experimental Biology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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