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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
A Book

by Allan Matte

  • Publisher : Elsevier
  • Release : 2020-09-07
  • Pages : 222
  • ISBN : 0081030193
  • Language : En, Es, Fr & De
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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Development of Antibody-Based Therapeutics

Development of Antibody-Based Therapeutics
Translational Considerations

by Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp

  • Publisher : Springer Science & Business Media
  • Release : 2012-04-24
  • Pages : 426
  • ISBN : 1441959556
  • Language : En, Es, Fr & De
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Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

Monoclonal Antibodies

Monoclonal Antibodies
A Practical Approach

by Philip Shepherd,Christopher J. Dean

  • Publisher : Practical Approach (Paperback)
  • Release : 2000
  • Pages : 479
  • ISBN : 9780199637225
  • Language : En, Es, Fr & De
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Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Subject Index of Current Extramural Research Administered by the National Cancer Institute

Subject Index of Current Extramural Research Administered by the National Cancer Institute
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Research Awards Index

Research Awards Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Science

Science
A Book

by John Michels

  • Publisher : Unknown Publisher
  • Release : 2001-09
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Federation Proceedings

Federation Proceedings
A Book

by Federation of American Societies for Experimental Biology

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Vols. for 1942- include proceedings of the American Physiological Society.

Bibliography of Agriculture

Bibliography of Agriculture
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Current Research on Pre-clinical Aspects of Cancer Therapy

Current Research on Pre-clinical Aspects of Cancer Therapy
A Book

by Smithsonian Science Information Exchange. Current Cancer Research Project Analysis Center

  • Publisher : Unknown Publisher
  • Release : 1975
  • Pages : 259
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.

Scientific Report

Scientific Report
A Book

by Ohio State University. Comprehensive Cancer Center

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Government Reports Announcements & Index

Government Reports Announcements & Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989-10
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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1987 Abstracts

1987 Abstracts
The Pittsburgh Conference & Exposition on Analytical Chemistry and Applied Spectroscopy, March 9-13, 1987, Atlantic City, New Jersey

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cancer Research

Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009-07
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of Chromatography

Journal of Chromatography
A.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cambridge Scientific Biochemistry Abstracts

Cambridge Scientific Biochemistry Abstracts
Amino-acids, peptides & proteins. Part 3

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Therapeutic Proteins

Therapeutic Proteins
Methods and Protocols

by C. Mark Smales,David Cameron James

  • Publisher : Springer Science & Business Media
  • Release : 2005
  • Pages : 482
  • ISBN : 1592599222
  • Language : En, Es, Fr & De
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This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, formulation and viral inactivation who cover all aspects of protein drug production downstream of the discovery stage. Protocols for the production of therapeutic proteins using a variety of sources are covered. including bacterial and yeast expression systems, insect and mammalian cells. Therapeutic Proteins: Methods and Protocols will prove an invaluable resourse to all those working in the field of therapeutic protein production.

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability
Natcher Building, National Institutes of Health (NIH), Bethesda, MD, USA, June 10-13, 2003

by Anthony R. Mire-Sluis

  • Publisher : S Karger Ag
  • Release : 2005
  • Pages : 213
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.

The Journal of Immunology

The Journal of Immunology
Official Journal of the American Association of Immunologists

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genetic Engineering & Biotechnology News

Genetic Engineering & Biotechnology News
GEN.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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