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Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases
From Molecular Mechanisms to Translational Medicine

by Jun Ren,James R. Sowers,Yingmei Zhang

  • Publisher : Academic Press
  • Release : 2018-04-12
  • Pages : 340
  • ISBN : 0128054425
  • Language : En, Es, Fr & De
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Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Autophagy: Biology and Diseases

Autophagy: Biology and Diseases
Clinical Science

by Weidong Le

  • Publisher : Springer Nature
  • Release : 2020-07-15
  • Pages : 736
  • ISBN : 9811542724
  • Language : En, Es, Fr & De
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This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Oxidative Stress in Heart Diseases

Oxidative Stress in Heart Diseases
A Book

by Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit

  • Publisher : Springer Nature
  • Release : 2019-11-06
  • Pages : 596
  • ISBN : 9811382735
  • Language : En, Es, Fr & De
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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Myocardial Energy Metabolism

Myocardial Energy Metabolism
A Book

by J.W. de Jong

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 310
  • ISBN : 9400913192
  • Language : En, Es, Fr & De
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Autophagy in Immune Response: Impact on Cancer Immunotherapy

Autophagy in Immune Response: Impact on Cancer Immunotherapy
A Book

by Salem Chouaib

  • Publisher : Academic Press
  • Release : 2020-05
  • Pages : 400
  • ISBN : 0128196092
  • Language : En, Es, Fr & De
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Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
A Book

by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran

  • Publisher : Frontiers Media SA
  • Release : 2019-08-08
  • Pages : 89
  • ISBN : 2889459381
  • Language : En, Es, Fr & De
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Mitochondrial Diseases

Mitochondrial Diseases
A Book

by Eylem Taskin,Celal Guven,Yusuf Sevgiler

  • Publisher : BoD – Books on Demand
  • Release : 2018-08-29
  • Pages : 496
  • ISBN : 1789236746
  • Language : En, Es, Fr & De
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Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
A Book

by M. A. Hayat

  • Publisher : Academic Press
  • Release : 2016-12-28
  • Pages : 430
  • ISBN : 0128094273
  • Language : En, Es, Fr & De
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Autophagy in Current Trends in Cellular Physiology and Pathology

Autophagy in Current Trends in Cellular Physiology and Pathology
A Book

by Nikolai Gorbunov,E. Marion Schneider

  • Publisher : BoD – Books on Demand
  • Release : 2016-11-10
  • Pages : 526
  • ISBN : 9535127268
  • Language : En, Es, Fr & De
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Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Autophagy in Health and Disease

Autophagy in Health and Disease
A Book

by Roberta A. Gottlieb

  • Publisher : Academic Press
  • Release : 2012-12-31
  • Pages : 240
  • ISBN : 0123851025
  • Language : En, Es, Fr & De
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Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Cardiorespiratory Fitness in Cardiometabolic Diseases

Cardiorespiratory Fitness in Cardiometabolic Diseases
Prevention and Management in Clinical Practice

by Peter Kokkinos,Puneet Narayan

  • Publisher : Springer
  • Release : 2019-03-18
  • Pages : 443
  • ISBN : 3030048160
  • Language : En, Es, Fr & De
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This book examines the links between physical activity (PA), cardiorespiratory fitness (CRF), and cardiovascular and metabolic diseases. It presents an overview of the role of PA and CRF in the prevention and management of risk factors associated with cardiometabolic diseases such as hypertension, peripheral vascular disease, stroke, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, and atherosclerosis. In addition, it explores how these risks vary with different populations such as the elderly and people of various racial backgrounds. The book also highlights risks associated with exercise and presents a prescription for appropriate and efficacious exercise to minimize risk and maximize health benefits for the heart. Cardiorespiratory Fitness in Prevention and Management of Cardiometabolic Disease is an essential resource for physicians, exercise physiologists, medical students, residents, fellows, nurses, and researchers in cardiology, cardiorespiratory fitness, exercise science, health promotion and disease prevention, public health, and epidemiology.

Autophagy and Cancer

Autophagy and Cancer
A Book

by Hong-Gang Wang

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-30
  • Pages : 261
  • ISBN : 1461465613
  • Language : En, Es, Fr & De
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With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Manual of Research Techniques in Cardiovascular Medicine

Manual of Research Techniques in Cardiovascular Medicine
A Book

by Hossein Ardehali,Roberto Bolli,Douglas W. Losordo

  • Publisher : John Wiley & Sons
  • Release : 2013-12-16
  • Pages : 472
  • ISBN : 1118495136
  • Language : En, Es, Fr & De
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While some research methods or techniques are applicable in severalareas of medicine, research in cardiovascular diseases requiresknowledge of an increasing array of procedures, techniques andmeasurements that are highly specialized and unique to this area ofinvestigation. Edited by senior clinical investigators who arerecognized leaders in cardiovascular medicine worldwide, this bookprovides readers with a comprehensive, practical“how-to-do-it” review of best-practice techniques forcardiovascular research.

The Longevity Solution

The Longevity Solution
Rediscovering Centuries-Old Secrets to a Healthy, Long Life

by Dr. James DiNicolantonio,Dr. Jason Fung

  • Publisher : Victory Belt Publishing
  • Release : 2019-02-26
  • Pages : 304
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Getting older doesn't have to mean experiencing more pain and illness, becoming less mobile, or developing disease. Renowned cardiovascular research scientist and doctor of pharmacy Dr. James DiNicolantonio partners with leading physician and bestselling author Dr. Jason Fung to deliver The Longevity Solution, a groundbreaking new book that unlocks the secrets of healthy aging. Using evidence drawn from their years of medical research and clinical practice, Dr. DiNicolantonio and Dr. Fung lay out five simple, easy-to-follow steps you can take now for a longer, fuller, healthier life. "The Longevity Solution" explains how to incorporate time-honored wellness traditions while doing away with fads, unnecessary supplements, and unsubstantiated wellness practices. It investigates the dietary habits and other practices of the healthiest, longest-lived humans on the planet, who live in regions known as Blue Zones, as a model for what and how we should eat. It teaches the benefits of intermittent fasting and calorie restriction, which have been shown to slow the aging process, while consuming proper ratios of protein and healthy fats. It also looks at how red wine, tea, and coffee play key roles in optimizing health and why salt is an ally, not an enemy, in the longevity equation. In this comprehensive guide, Dr. DiNicolantonio and Dr. Fung unveil cutting-edge science in an approachable format that is easy to understand and can be put into practice immediately. Simple dietary changes can help you break the cycle of carbohydrate dependence, kick your metabolism into high gear, and jump-start your longevity genes. The Longevity Solution puts healthy aging back in your control!

Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition

Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 760
  • ISBN : 1464921016
  • Language : En, Es, Fr & De
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Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cardiovascular Diseases. The editors have built Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Prevent and Reverse Heart Disease

Prevent and Reverse Heart Disease
The Revolutionary, Scientifically Proven, Nutrition-based Cure

by Caldwell B. Esselstyn

  • Publisher : Penguin
  • Release : 2008
  • Pages : 308
  • ISBN : 1583333002
  • Language : En, Es, Fr & De
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ESSELSTYN/PREVENT AND REVERSE

Mitochondrial Dynamics in Cardiovascular Medicine

Mitochondrial Dynamics in Cardiovascular Medicine
A Book

by Gaetano Santulli

  • Publisher : Springer
  • Release : 2017-05-25
  • Pages : 646
  • ISBN : 3319553305
  • Language : En, Es, Fr & De
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This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Primer on Cerebrovascular Diseases

Primer on Cerebrovascular Diseases
A Book

by Louis R. Caplan,José Biller,Megan C. Leary,Eng H. Lo,Ajith J Thomas,Midori Yenari,John H. Zhang

  • Publisher : Academic Press
  • Release : 2017-02-10
  • Pages : 968
  • ISBN : 0128030593
  • Language : En, Es, Fr & De
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Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner. Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more. Provides concise chapters on topics in cerebral blood flow and metabolism, pathogenesis of cerebrovascular disorders, diagnostic testing, and management in a comprehensive and accessible format Written by international leading authorities on cerebral vasculature Provides up-to-date information on practical applications of basic research and the main clinical issues facing the community, such as axonal transport and proteomics

Cardiovascular Diseases

Cardiovascular Diseases
Nutritional and Therapeutic Interventions

by Nilanjana Maulik, Ph.D.

  • Publisher : CRC Press
  • Release : 2013-04-09
  • Pages : 614
  • ISBN : 1439882002
  • Language : En, Es, Fr & De
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With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases. Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect. Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.

Aldehyde Dehydrogenases

Aldehyde Dehydrogenases
From Alcohol Metabolism to Human Health and Precision Medicine

by Jun Ren,Yingmei Zhang,Junbo Ge

  • Publisher : Springer
  • Release : 2019-07-31
  • Pages : 253
  • ISBN : 9811362602
  • Language : En, Es, Fr & De
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This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.