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Basic Fundamentals of Drug Delivery

Basic Fundamentals of Drug Delivery
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-11-30
  • Pages : 810
  • ISBN : 0128179104
  • Language : En, Es, Fr & De
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Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. Provides up-to-date information on translating the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as orally, parenterally, transdermally or through inhalation Contains extensive references and further reading for course and self-study

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
A Book

by Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone

  • Publisher : Springer Science & Business Media
  • Release : 2011-12-14
  • Pages : 592
  • ISBN : 1461408806
  • Language : En, Es, Fr & De
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Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Drug Delivery

Drug Delivery
Fundamentals and Applications, Second Edition

by Anya M Hillery,Kinam Park

  • Publisher : CRC Press
  • Release : 2016-09-15
  • Pages : 614
  • ISBN : 1482217740
  • Language : En, Es, Fr & De
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This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
Fundamentals, Design, and Applications

by Saurabh Bhatia

  • Publisher : CRC Press
  • Release : 2017-03-03
  • Pages : 390
  • ISBN : 1771883618
  • Language : En, Es, Fr & De
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This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

Drug Delivery Systems

Drug Delivery Systems
Fundamentals and Techniques

by Peter Johnson,J. G. Lloyd-Jones

  • Publisher : John Wiley & Sons
  • Release : 1987
  • Pages : 282
  • ISBN : 9783527265589
  • Language : En, Es, Fr & De
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New drug delivery systems have been the focus of attention for the past 20 years. With a range of international contributions, this book summarizes current knowledge of site-specific, implantable, oral and other noninvasive (i.e. transdermal, nasal and ocular) systems, providing a comprehensive overview of the latest approaches to controlled release technology from both academic and industrial viewpoints. The authors not only present clear and concise accounts of current thinking, but additionally offer the reader some appropriate glimpses into the future, where the combination of drug delivery technology and advancing techniques in molecular biology and genetic engineering holds particular promise.

Drug Delivery

Drug Delivery
Materials Design and Clinical Perspective

by Eric P. Holowka,Sujata K. Bhatia

  • Publisher : Springer
  • Release : 2014-11-22
  • Pages : 355
  • ISBN : 1493919989
  • Language : En, Es, Fr & De
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Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Advanced Drug Delivery

Advanced Drug Delivery
A Book

by Ashim Mitra,Chi H. Lee,Kun Cheng

  • Publisher : John Wiley & Sons
  • Release : 2013-08-26
  • Pages : 530
  • ISBN : 1118662849
  • Language : En, Es, Fr & De
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Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical sciences,chemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases. Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts: Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stability,transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell research,cell-based therapeutics, tissue engineering, and molecularimaging Each chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book. Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.

Biodrug Delivery Systems

Biodrug Delivery Systems
Fundamentals, Applications and Clinical Development

by Mariko Morishita,Kinam Park

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 488
  • ISBN : 1420086715
  • Language : En, Es, Fr & De
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Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development presents the work of an international group of leading experts in drug development and biopharmaceutical science who discuss the latest advances in biodrug delivery systems and associated techniques. The book discusses components of successful formulation, delivery, and p

Bioadhesive Drug Delivery Systems

Bioadhesive Drug Delivery Systems
Fundamentals, Novel Approaches, and Development

by Edith Mathiowitz,Donald E. Chickering III,Claus-Michael Lehr

  • Publisher : CRC Press
  • Release : 1999-07-13
  • Pages : 696
  • ISBN : 9781420001341
  • Language : En, Es, Fr & De
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This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Drug Delivery

Drug Delivery
Principles and Applications

by Binghe Wang,Longqin Hu,Teruna J. Siahaan

  • Publisher : John Wiley & Sons
  • Release : 2016-03-09
  • Pages : 720
  • ISBN : 1118833309
  • Language : En, Es, Fr & De
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Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Drug Delivery

Drug Delivery
A Book

by Monika Schäfer-Korting

  • Publisher : Springer Science & Business Media
  • Release : 2010-03-10
  • Pages : 501
  • ISBN : 9783642004773
  • Language : En, Es, Fr & De
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In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.

The Future of Pharmaceutical Product Development and Research

The Future of Pharmaceutical Product Development and Research
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-09-02
  • Pages : 976
  • ISBN : 0128144556
  • Language : En, Es, Fr & De
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The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques

Controlled Drug Delivery

Controlled Drug Delivery
Fundamentals and Applications, Second Edition

by Joseph Robinson,Vincent H. L. Lee

  • Publisher : CRC Press
  • Release : 1987-01-30
  • Pages : 744
  • ISBN : 9780824775889
  • Language : En, Es, Fr & De
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Targeted Drug Delivery : Concepts and Design

Targeted Drug Delivery : Concepts and Design
A Book

by Padma V. Devarajan,Sanyog Jain

  • Publisher : Springer
  • Release : 2014-12-08
  • Pages : 790
  • ISBN : 3319113550
  • Language : En, Es, Fr & De
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This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Drug Delivery Systems

Drug Delivery Systems
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-10-23
  • Pages : 792
  • ISBN : 0128145080
  • Language : En, Es, Fr & De
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Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Nervous System Drug Delivery

Nervous System Drug Delivery
Principles and Practice

by Russell R. Lonser,Malisa Sarntinoranont,Kristof Bankiewicz

  • Publisher : Academic Press
  • Release : 2019-06-25
  • Pages : 556
  • ISBN : 0128139986
  • Language : En, Es, Fr & De
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Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques. Offers an up-to-date, comprehensive resource on drug delivery to the nervous system Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application) Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery
A Book

by Rebecca A. Bader,David A. Putnam

  • Publisher : John Wiley & Sons
  • Release : 2014-01-17
  • Pages : 496
  • ISBN : 1118747801
  • Language : En, Es, Fr & De
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Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Enhancement in Drug Delivery

Enhancement in Drug Delivery
A Book

by Elka Touitou,Brian W. Barry

  • Publisher : CRC Press
  • Release : 2006-11-27
  • Pages : 656
  • ISBN : 9781420004816
  • Language : En, Es, Fr & De
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Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes fo

Alginates in Drug Delivery

Alginates in Drug Delivery
A Book

by Amit Kumar Nayak,Md Saquib Hasnain

  • Publisher : Academic Press
  • Release : 2020-07-23
  • Pages : 434
  • ISBN : 0128176415
  • Language : En, Es, Fr & De
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Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations, along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields