Download Behavioral and Neural Genetics of Zebrafish Ebook PDF

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish
A Book

by Robert T. Gerlai

  • Publisher : Academic Press
  • Release : 2020-04-03
  • Pages : 614
  • ISBN : 012817529X
  • Language : En, Es, Fr & De
GET BOOK

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Psychophysics and Genetics of Zebrafish Visual Behavior

Psychophysics and Genetics of Zebrafish Visual Behavior
A Book

by Michael Brian Orger

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 134
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

A central goal of neuroscience is to understand the neural basis of behavior. The zebrafish is a vertebrate model system that allows behavior to be studied using both systems and molecular genetic approaches. Here we present a psychophysical and genetic analysis of optomotor behavior in zebrafish larvae. By applying psychophysical methods developed for primates to zebrafish we have demonstrated than motion detection in zebrafish uses mechanisms that are broadly similar to humans. The larvae are susceptible to visual illusions that indicate that they detect Fourier motion energy in visual scenes. They also respond to non-Fourier motion, an ability that is believed to depend on visual cortex in humans. Different visual behaviors in the fish use different chromatic information. The optomotor response, in particular, is colorblind and pools signals from longer wavelength cones, while excluding shorter wavelength inputs. Motion processing seems to be functionally similar between higher and lower vertebrates despite large differences in neuroanatomy. Using an automated assay, we have conducted a large-scale genetic screen for recessive mutants affecting the optomotor response. Testing these mutants with a battery of behavioral assays allows us to categorize them into motor and visual system mutants, as well as some that are specific to the optomotor response. Many have normal visual system anatomy, but some are missing specific cell-types or have defects in axon target selection.

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research
A Book

by Robert T. Gerlai

  • Publisher : Academic Press
  • Release : 2018-04-24
  • Pages : 708
  • ISBN : 0128041161
  • Language : En, Es, Fr & De
GET BOOK

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Laboratory Fish in Biomedical Research

Laboratory Fish in Biomedical Research
Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Cavefish, Stickleback, Goldfish and Danionella Translucida

by Livia d'Angelo,Paolo de Girolamo

  • Publisher : Academic Press
  • Release : 2021-08-28
  • Pages : 474
  • ISBN : 0128212454
  • Language : En, Es, Fr & De
GET BOOK

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

The Orexin System. Basic Science and Role in Sleep Pathology

The Orexin System. Basic Science and Role in Sleep Pathology
A Book

by M.A. Steiner,M. Yanagisawa,M. Clozel

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2021-05-28
  • Pages : 154
  • ISBN : 3318068446
  • Language : En, Es, Fr & De
GET BOOK

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Handbook of Psychology, Behavioral Neuroscience

Handbook of Psychology, Behavioral Neuroscience
A Book

by Irving B. Weiner,Randy J. Nelson,Sheri Mizumori

  • Publisher : John Wiley & Sons
  • Release : 2012-10-16
  • Pages : 768
  • ISBN : 0470890592
  • Language : En, Es, Fr & De
GET BOOK

Psychology is of interest to academics from many fields, as well as to the thousands of academic and clinical psychologists and general public who can't help but be interested in learning more about why humans think and behave as they do. This award-winning twelve-volume reference covers every aspect of the ever-fascinating discipline of psychology and represents the most current knowledge in the field. This ten-year revision now covers discoveries based in neuroscience, clinical psychology's new interest in evidence-based practice and mindfulness, and new findings in social, developmental, and forensic psychology.

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes
A Book

by Wim E. Crusio

  • Publisher : Cambridge University Press
  • Release : 2013-04-25
  • Pages : 357
  • ISBN : 1107034817
  • Language : En, Es, Fr & De
GET BOOK

A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse.

Genetic Dissection of Neural Circuits and Behavior

Genetic Dissection of Neural Circuits and Behavior
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2009-08-21
  • Pages : 216
  • ISBN : 9780123748362
  • Language : En, Es, Fr & De
GET BOOK

Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. * Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future prospects

The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish

The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish
A Book

by Allan V. Kalueff

  • Publisher : Springer
  • Release : 2017-02-06
  • Pages : 327
  • ISBN : 3319337742
  • Language : En, Es, Fr & De
GET BOOK

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

Genetic Dissection of Neural Circuits and Behavior

Genetic Dissection of Neural Circuits and Behavior
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2009-07-14
  • Pages : 216
  • ISBN : 9780080951157
  • Language : En, Es, Fr & De
GET BOOK

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. * Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future prospects

Encyclopedia of Animal Behavior

Encyclopedia of Animal Behavior
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-01-21
  • Pages : 3048
  • ISBN : 0128132523
  • Language : En, Es, Fr & De
GET BOOK

Encyclopedia of Animal Behavior, Second Edition, the latest update since the 2010 release, builds upon the solid foundation established in the first edition. Updated sections include Host-parasite interactions, Vertebrate social behavior, and the introduction of ‘overview essays’ that boost the book's comprehensive detail. The structure for the work is modified to accommodate a better grouping of subjects. Some chapters have been reshuffled, with section headings combined or modified. Represents a one-stop resource for scientifically reliable information on animal behavior Provides comparative approaches, including the perspective of evolutionary biologists, physiologists, endocrinologists, neuroscientists and psychologists Includes multimedia features in the online version that offer accessible tools to readers looking to deepen their understanding

Behavioral Neurogenetics

Behavioral Neurogenetics
A Book

by John F. Cryan,Andreas Reif

  • Publisher : Springer Science & Business Media
  • Release : 2012-05-04
  • Pages : 636
  • ISBN : 3642278590
  • Language : En, Es, Fr & De
GET BOOK

This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio

Behavioral Genetic Analysis of the Spatial and Temporal Resolution of Vision in the Zebrafish, Danio Rerio
A Book

by Matt Smear

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 114
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

It is unclear whether the properties of neuronal circuits beyond the retina limit the spatial and temporal resolution of vision. The kinetics of neurotransmission at central synapses should limit an animal's ability to see rapid movements. Accurate retinotopy should be essential for the perception of fine spatial detail. We have tested these predictions using the zebrafish blumenkohl (blu) mutant. Positional cloning revealed that the blu gene encodes vglut2a, a vesicular glutamate transporter expressed by retinal ganglion cells. blu mutants' retinotectal synapses show diminished responses to high frequency electrical stimulation, which should reduce the visibility of fast-moving visual stimuli. Single retinal axons in blu mutants arborize over a larger area in the tectum, blurring the fine detail of the retinotopic map, which should compromise spatial acuity. We tested these hypotheses using assays for optomotor responses and prey capture. Our study provides experimental support for previously untested principles of sensory coding.

Biological Research on Addiction

Biological Research on Addiction
Chapter 5. Zebrafish and Alcohol

by Robert Gerlai

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-05-17
  • Pages : 758
  • ISBN : 0128064633
  • Language : En, Es, Fr & De
GET BOOK

Aggression

Aggression
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2011-11-30
  • Pages : 304
  • ISBN : 9780123808585
  • Language : En, Es, Fr & De
GET BOOK

Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Mouse Brain Development

Mouse Brain Development
A Book

by Andre M. Goffinet,Pasko Rakic

  • Publisher : Springer Science & Business Media
  • Release : 2012-08-10
  • Pages : 339
  • ISBN : 3540480021
  • Language : En, Es, Fr & De
GET BOOK

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Handbook of Neurobehavioral Genetics and Phenotyping

Handbook of Neurobehavioral Genetics and Phenotyping
A Book

by Valter Tucci

  • Publisher : John Wiley & Sons
  • Release : 2017-03-06
  • Pages : 632
  • ISBN : 1118540719
  • Language : En, Es, Fr & De
GET BOOK

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research
Biology, Husbandry, Diseases, and Research Applications

by Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders

  • Publisher : Academic Press
  • Release : 2019-11-22
  • Pages : 718
  • ISBN : 0128124326
  • Language : En, Es, Fr & De
GET BOOK

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

The world according to zebrafish: How neural circuits generate behaviour

The world according to zebrafish: How neural circuits generate behaviour

by Gonzalo G. De Polavieja,German Sumbre

  • Publisher : Frontiers E-books
  • Release : 2014-11-07
  • Pages : 129
  • ISBN : 2889193284
  • Language : En, Es, Fr & De
GET BOOK

Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

Decoding Neural Circuit Structure and Function

Decoding Neural Circuit Structure and Function
Cellular Dissection Using Genetic Model Organisms

by Arzu Çelik,Mathias F. Wernet

  • Publisher : Springer
  • Release : 2017-07-24
  • Pages : 518
  • ISBN : 3319573632
  • Language : En, Es, Fr & De
GET BOOK

This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.