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Supercritical Fluid Extraction of Nutraceuticals and Bioactive Compounds

Supercritical Fluid Extraction of Nutraceuticals and Bioactive Compounds
A Book

by Jose L. Martinez

  • Publisher : CRC Press
  • Release : 2007-11-28
  • Pages : 424
  • ISBN : 1420006517
  • Language : En, Es, Fr & De
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Enhanced concern for the quality and safety of food products, increased preference for natural products, and stricter regulations on the residual level of solvents, all contribute to the growing use of supercritical fluid technology as a primary alternative for the extraction, fractionation, and isolation of active ingredients. As a solvent-free p

The Search for Bioactive Compounds from Microorganisms

The Search for Bioactive Compounds from Microorganisms
A Book

by Satoshi Omura

  • Publisher : Springer Science & Business Media
  • Release : 1992-10-22
  • Pages : 352
  • ISBN : 9780387977553
  • Language : En, Es, Fr & De
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Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.

Extracting Bioactive Compounds for Food Products

Extracting Bioactive Compounds for Food Products
Theory and Applications

by M. Angela A. Meireles

  • Publisher : CRC Press
  • Release : 2008-12-16
  • Pages : 464
  • ISBN : 9781420062397
  • Language : En, Es, Fr & De
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The demand for functional foods and neutraceuticals is on the rise, leaving product development companies racing to improve bioactive compound extraction methods – a key component of functional foods and neutraceuticals development. From established processes such as steam distillation to emerging techniques like supercritical fluid technology, Extracting Bioactive Compounds for Food Products: Theory and Applications details the engineering aspects of the processes used to extract bioactive compounds from their food sources. Covers Bioactive Compounds Found in Foods, Cosmetics, and Pharmaceuticals Each well-developed chapter provides the fundamentals of transport phenomena and thermodynamics as they relate to the process described, a state-of-the-art literature review, and replicable case studies of extraction processes. This authoritative reference examines a variety of established and groundbreaking extraction processes including: Steam distillation Low-pressure solvent extraction Liquid-liquid extraction Supercritical and pressurized fluid extraction Adsorption and desorption The acute view of thermodynamic, mass transfer, and economical engineering provided in this book builds a foundation in the processes used to obtain high-quality bioactive extracts and purified compounds. Going beyond the information traditionally found in unit operations reference books, Extracting Bioactive Compounds for Food Products: Theory and Applications demonstrates how to successfully optimize bioactive compound extraction methods and use them to create new and better natural food options.

Bioactive Compounds from Natural Sources

Bioactive Compounds from Natural Sources
Isolation, Characterization and Biological Properties

by Corrado Tringali

  • Publisher : CRC Press
  • Release : 2003-09-02
  • Pages : 693
  • ISBN : 9780203212318
  • Language : En, Es, Fr & De
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Interest in obtaining biologically active compounds from natural sources has recently spiked due to their low toxicity, complete biodegradability, availability from renewable sources, and in most cases, low cost. Taking an interdisciplinary approach, Bioactive Compounds from Natural Sources: Isolation, Characterization, and Biological Properties covers general methods and main topics in the research field of bioactive natural products. The book describes general screening methods, modern HPLC hyphenated techniques, and NMR methods in the structural elucidation of compounds and devotes individual chapters to specific topics of research. Surveys on compounds displaying important pharmacological activities are presented in chapters devoted to Mexican medicinal plants, anti-tumor drugs of natural origin, cancer chemopreventive flavonoids, and metabolites displaying anti-HIV, antioxidative, antimalarial, and anti-inflammatory activity. The final chapters are devoted to representative examples of research into marine metabolites: immunomodulating marine glycolipids and surveys of bioactive compounds from marine opisthobranchs and Japanese soft corals. With its focus on modern approaches to the isolation of biologically active natural products, this book encourages interdisciplinary work among chemists, pharmacologists, biologists, botanists, and agronomists with an interest in bioactive natural products.

Biochemical Targets of Plant Bioactive Compounds

Biochemical Targets of Plant Bioactive Compounds
A Pharmacological Reference Guide to Sites of Action and Biological Effects

by Gideon Polya

  • Publisher : CRC Press
  • Release : 2003-05-15
  • Pages : 860
  • ISBN : 9780203013717
  • Language : En, Es, Fr & De
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When introduced to the human body, bioactive metabolites produced by plants for self defense bind to particular biochemical targets, most notably to proteins involved in signaling by hormones and neurotransmitters. This, essentially, is the basis for the effects of herbal medicine. While herbal medicine preparations may act by complex synergistic interactions, molecular explanations of herbal medicine efficacy and side effects ultimately require definition of the biochemical targets of individual plant bioactive constituents. Biochemical Targets of Plant Bioactive Compounds is a comprehensive and user-friendly reference guide to biochemical targets of plant defensive compounds. With 500 pages of tables, it presents a mine of succinctly summarized information relating to bioactive compound structures, plant sources, biochemical targets and physiological effects that can be readily accessed via chemical compound, plant genus, plant common name and subject indexes. With introductory chapters providing reviews of the structural diversity of plant defensive compounds and biochemistry, this book is an invaluable reference for biomedical professionals in the fields of alternative/complementary medicine, natural product chemistry, toxicology, pharmacology, and botany.

Bioactive Compounds

Bioactive Compounds
Health Benefits and Potential Applications

by Maira Rubi Segura Campos

  • Publisher : Woodhead Publishing
  • Release : 2018-12-01
  • Pages : 308
  • ISBN : 012814775X
  • Language : En, Es, Fr & De
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Bioactive Compounds: Health Benefits and Potential Applications provides information about different bioactive compounds including their sources, biological effects, health benefits and, potential applications which could contribute as alternatives in the prevention or treatment of multifactorial diseases for vulnerable population groups. Going beyond the basics to include discussion of bioaccessibility and the legislative aspects of marketing of bioactive compounds as nutraceuticals or food supplements, this book presents insights from a global perspective. Written for researchers, professors and graduate students, this book is sure to be a welcomed reference for all who work in food chemistry, new product development and nutritional science. Highlights potential contributions of bioactive compounds as alternatives in the prevention or treatment of disease Investigates the world of bioactive compounds and the many activities associated with them Contains information relevant to food chemistry, new product development and nutritional science

Biotechnological Production of Bioactive Compounds

Biotechnological Production of Bioactive Compounds
A Book

by Madan L. Verma,Anuj Chandel

  • Publisher : Elsevier
  • Release : 2019-07-20
  • Pages : 508
  • ISBN : 0444643249
  • Language : En, Es, Fr & De
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Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits “bioactives’’ from plants and microbes and explains how the extraction efficiency of bioactives molecules improves significantly with the recent advances in nanobiotechnology. Researchers in the fields of biochemical engineering, biotechnology, bioremediation, environmental sustainability and those in pharma industries will find the information in this book very helpful and illuminating. Outlines technological advances in bioactives extraction Covers bioflavonoids, biopigments, omega-3-fatty acids and low sugar substitutes Explains the mechanisms of Green cargo (biogenic nanoparticles) for the delivery of bioactive molecules

Biotechnology of Bioactive Compounds

Biotechnology of Bioactive Compounds
Sources and Applications

by Vijai Kumar Gupta,Maria G. Tuohy,Anthonia O'Donovan,Mohtashim Lohani

  • Publisher : John Wiley & Sons
  • Release : 2015-01-22
  • Pages : 736
  • ISBN : 1118733479
  • Language : En, Es, Fr & De
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Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Water Extraction of Bioactive Compounds

Water Extraction of Bioactive Compounds
From Plants to Drug Development

by Herminia Dominguez,Maria Jesus Gonzalez Munoz

  • Publisher : Elsevier
  • Release : 2017-09-20
  • Pages : 530
  • ISBN : 0128096152
  • Language : En, Es, Fr & De
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Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. The book is a detailed guide to the fundamental concepts and necessary equipment needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Part 1 begins with a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals, the need for standardization and a move toward more rational and greener techniques in the field, the development of plant-based extraction processes and pretreatments for the efficient extraction. Part 2 then reviews a broad range of available techniques, including sections on conventional hot water extraction and pressurized hot water extraction in a range of settings. Intensified processes are then discussed in detail, including sections on microwave-assisted processes, ultrasound-assisted processes and enzyme assisted extraction. Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needs Presents up-to-date and cutting edge applications by international experts Highlights current use and future potential for industrial scale applications Offers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals

Marine Bioactive Compounds

Marine Bioactive Compounds
Sources, Characterization and Applications

by Maria Hayes

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-19
  • Pages : 232
  • ISBN : 9781461412472
  • Language : En, Es, Fr & De
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The aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries. It discusses sustainable marine resources of macroalgal origin and gives examples of bioactive compounds isolated from these and other resources, including marine by-product and fisheries waste streams. In addition, it looks at the importance of correct taxonomic characterization.

Bioactive Compounds from Plants

Bioactive Compounds from Plants
A Book

by Derek J. Chadwick,Joan Marsh

  • Publisher : John Wiley & Sons
  • Release : 2008-04-30
  • Pages : 254
  • ISBN : 0470514019
  • Language : En, Es, Fr & De
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Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to environmental factors. The isolation and characterization of plant products, the identification of their role in the plant, and ways of synthesizing identical compounds or more potent analogues are covered. Also includes methods of culturing plant tissues and genetic engineering as a means of increasing the yield of desired substances from plants. Special emphasis is placed on plants previously unknown to Western scientists.

Bioactive Compounds and Cancer

Bioactive Compounds and Cancer
A Book

by John A. Milner,Donato F. Romagnolo

  • Publisher : Springer Science & Business Media
  • Release : 2010-06-08
  • Pages : 882
  • ISBN : 1607616262
  • Language : En, Es, Fr & De
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Because of the wealth of new information generated by the scientific community during the last decade on the role of nutrition on cancer risk, this book provides a forum for presentation and discussion of recent scientific data and highlights a set of dietary recommendations. Bioactive Compounds and Cancer presents chapters that highlight laboratory and clinical findings on how selected nutrients function as signaling molecules and, as such, influence cellular behavior and cancer predisposition. This important compendium focuses on understanding the role of nutrition in cancer biology, the molecular action of bioactive food components and xenobiotics on cancer risk, the role of dietary components in cancer prevention and/or treatment, and nutrition education with the most up to date dietary recommendations that may reduce cancer risk. This volume will be of interest to specialized health professionals, clinicians, nurses, basic and clinical researchers, graduate students, and health officials of public and private organizations.

Analysis of Marine Samples in Search of Bioactive Compounds

Analysis of Marine Samples in Search of Bioactive Compounds
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2014-08-26
  • Pages : 312
  • ISBN : 0444633812
  • Language : En, Es, Fr & De
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Seas and oceans offer a wide range of temperature, pressure, light and chemical conditions thus allowing a wide diversity of marine organisms from shallow coastal waters to the deep ocean. These resources can be used to obtain new products and develop services, and in turn help to provide solutions to the challenges that affect our planet, including offering a sustainable supply of food and energy, new industrial materials and processes, new bioactive compounds, and new health treatments. Marine compounds have been identified as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. The major sources of these bioactive compounds are marine sponges, coelenterates, and microorganisms, followed by algae, echinoderms, tunicates, molluscs, and bryozoans. The discovery of bioactive compounds from marine samples is a hot topic considering the current need for sustainable use of marine resources. This book is a comprehensive overview of the analytical techniques employed in the discovery and characterization of bioactive compounds isolated from (all possible) marine samples and gives future perspectives of analytical methodologies. This overview includes an assessment of the sampling and preparation of extracts, the separation and isolation of bioactive compounds, their structural characterization and the application of bioassays in the discovery of bioactive compounds. Comprehensive coverage of analytical techniques and applications Clear diagrams to adequately support important topics Real examples of applications of analytical techniques in the search for new bioactive compounds

Bioactive Compounds from Extremophiles

Bioactive Compounds from Extremophiles
Genomic Studies, Biosynthetic Gene Clusters, and New Dereplication Methods

by Lesley-Ann Giddings,David J. Newman

  • Publisher : Springer
  • Release : 2015-01-07
  • Pages : 58
  • ISBN : 3319148362
  • Language : En, Es, Fr & De
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​This SpringerBrief sheds new light on bioactive materials from extremophiles with the focus on the biosynthesis processes and related genomics. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.

Naturally Occurring Bioactive Compounds

Naturally Occurring Bioactive Compounds
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2006-09-25
  • Pages : 514
  • ISBN : 9780080464923
  • Language : En, Es, Fr & De
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This timely book provides an overview of natural products/botanicals used for the management of insect-pest and diseases. It will help readers to update and widen their knowledge about natural products and their bio-activities against plant pathogens. The volume explores activity, chemistry, toxicity and geographic distribution of plants. Discussions concerning the methodology used for the detection of active principles, their mode of action and commercial prospects are of utmost importance and worthy of note. Focuses on recent achievements in natural bio-actives Global coverage of natural products / plants Targets the most important issues of natural botanicals/ biocides Includes innovative ideas with lucid explanations Contains specialized chapters, such as, natural control of multi-drug resistant organisms, anti-salmonella agents, natural house-dust-mite control agents, and naturally occurring anti-insect proteins, etc. Covers research on bioactives: From Lab to Field and Field to Market Includes eco-friendly and economically viable herbal technology

Bioactive Compounds from Marine Extremophiles

Bioactive Compounds from Marine Extremophiles
A Book

by Lesley-Ann Giddings,David J. Newman

  • Publisher : Springer
  • Release : 2015-01-06
  • Pages : 150
  • ISBN : 3319143611
  • Language : En, Es, Fr & De
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​This SpringerBrief sheds new light on bioactive materials from marine extremophiles. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.

Bioactive Compounds from Terrestrial Extremophiles

Bioactive Compounds from Terrestrial Extremophiles
A Book

by Lesley-Ann Giddings,David J. Newman

  • Publisher : Springer
  • Release : 2014-11-21
  • Pages : 90
  • ISBN : 3319132601
  • Language : En, Es, Fr & De
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A discussion of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or leads to novel drugs for human use. This SpringerBrief deals with bioactive materials from terrestrial extremophiles.

Bioactive Compounds in Foods

Bioactive Compounds in Foods
A Book

by John Gilbert,Hamide Şenyuva

  • Publisher : John Wiley & Sons
  • Release : 2009-01-21
  • Pages : 432
  • ISBN : 1444302299
  • Language : En, Es, Fr & De
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Inherent toxicants and processing contaminants are bothnon-essential, bioactive substances whose levels in foods can bedifficult to control. This volume covers both types of compound forthe first time, examining their beneficial as well as theirundesirable effects in the human diet. Chapters have been writtenas individually comprehensive reviews, and topics have beenselected to illustrate recent scientific advances in understandingof the occurrence and mechanism of formation, exposure/riskassessment and developments in the underpinning analyticalmethodology. A wide range of contaminants are examined in detail,including pyrrolizidine alkaloids, glucosinolates, phycotoxins, andmycotoxins. Several process contaminants (eg acrylamide and furan),which are relatively new but which have a rapidly growingliterature, are also covered. The book provides a practical reference for a wide range ofexperts: specialist toxicologists (chemists and food chemists),hygienists, government officials and anyone who needs to be awareof the main issues concerning toxicants and process contaminants infood. It will also be a valuable introduction to the subject forpost-graduate students.

Bioactive Compounds from Natural Sources, Second Edition

Bioactive Compounds from Natural Sources, Second Edition
Natural Products as Lead Compounds in Drug Discovery

by Corrado Tringali

  • Publisher : CRC Press
  • Release : 2011-09-27
  • Pages : 648
  • ISBN : 1439822298
  • Language : En, Es, Fr & De
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The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Microwave-assisted Extraction for Bioactive Compounds

Microwave-assisted Extraction for Bioactive Compounds
Theory and Practice

by Farid Chemat,Giancarlo Cravotto

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-12
  • Pages : 240
  • ISBN : 1461448301
  • Language : En, Es, Fr & De
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With increasing energy prices and the drive to reduce CO2 emissions, food industries are challenged to find new technologies in order to reduce energy consumption, to meet legal requirements on emissions, product/process safety and control, and for cost reduction and increased quality as well as functionality. Extraction is one of the promising innovation themes that could contribute to sustainable growth in the chemical and food industries. For example, existing extraction technologies have considerable technological and scientific bottlenecks to overcome, such as often requiring up to 50% of investments in a new plant and more than 70% of total process energy used in food, fine chemicals and pharmaceutical industries. These shortcomings have led to the consideration of the use of new "green" techniques in extraction, which typically use less solvent and energy, such as microwave extraction. Extraction under extreme or non-classical conditions is currently a dynamically developing area in applied research and industry. Using microwaves, extraction and distillation can now be completed in minutes instead of hours with high reproducibility, reducing the consumption of solvent, simplifying manipulation and work-up, giving higher purity of the final product, eliminating post-treatment of waste water and consuming only a fraction of the energy normally needed for a conventional extraction method. Several classes of compounds such as essential oils, aromas, anti-oxidants, pigments, colours, fats and oils, carbohydrates, and other bioactive compounds have been extracted efficiently from a variety of matrices (mainly animal tissues, food, and plant materials). The advantages of using microwave energy, which is a non-contact heat source, includes more effective heating, faster energy transfer, reduced thermal gradients, selective heating, reduced equipment size, faster response to process heating control, faster start-up, increased production, and elimination of process steps. This book will present a complete picture of the current knowledge on microwave-assisted extraction (MAE) of bioactive compounds from food and natural products. It will provide the necessary theoretical background and details about extraction by microwaves, including information on the technique, the mechanism, protocols, industrial applications, safety precautions, and environmental impacts.