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Bioconjugate Techniques

Bioconjugate Techniques

by Greg T. Hermanson

  • Publisher : Academic Press
  • Release : 2013-07-25
  • Pages : 1200
  • ISBN : 0123822408
  • Language : En, Es, Fr & De
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Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates Features full color illustrations Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented

Bioconjugate Techniques

Bioconjugate Techniques

by Greg T. Hermanson

  • Publisher : Academic Press
  • Release : 2010-07-26
  • Pages : 1323
  • ISBN : 9780080568720
  • Language : En, Es, Fr & De
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Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticles Silane coupling agents Dendrimers and dendrons Chemoselective ligation Quantum dots Lanthanide chelates Cyanine dyes Discrete PEG compounds Buckyballs,fullerenes, and carbon nanotubes Mass tags and isotope tags Bioconjugation in the study of protein interactions

Drug-like Properties: Concepts, Structure Design and Methods

Drug-like Properties: Concepts, Structure Design and Methods
from ADME to Toxicity Optimization

by Li Di,Edward H Kerns

  • Publisher : Elsevier
  • Release : 2010-07-26
  • Pages : 552
  • ISBN : 0080557619
  • Language : En, Es, Fr & De
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Bioconjugation Protocols

Bioconjugation Protocols
Strategies and Methods

by Sonny S. Mark

  • Publisher : Humana Press
  • Release : 2016-08-23
  • Pages : 605
  • ISBN : 9781493960965
  • Language : En, Es, Fr & De
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Contemporary approaches to the synthesis of chemically modified biomacromolecules (proteins, nucleic acids, lipids, and carbohydrates) not only require efficient means to control conjugation and the specific site of attachment of the conjugated moiety but also the effective use of recent developments in the fields of pharmaceutical chemistry, biomolecular/polymer engineering, and nanobiotechnology. In this second edition of Bioconjugation Protocols: Strategies and Methods, expert researchers update the classic methods and introduce valuable new approaches that go beyond basic conjugation techniques to include elements from advanced organic synthesis, molecular biology, surface biotechnology, materials science, and nanobioscience/engineering. These readily reproducible methods cover the preparation of biomolecular conjugates using a variety of labeling techniques and semisynthetic approaches. Additional chapters address the biofunctionalization of surface structures, including organic/inorganic thin films, as well as various types of nanostructures (magnetic nanoparticles, quantum dots, carbon nanotubes, and silicon nanowire devices). All the protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioconjugation Protocols: Strategies and Methods, Second Edition offers both novice and experienced researchers access to the broad array of techniques needed to carry out the semisynthesis of functional biomolecular reagents and/or the biofunctionalization of surfaces and structures of unique interest for a wide variety of applications, ranging from novel biomedical diagnostics to powerful new therapeutics to advanced biomaterials.

Chemistry of Bioconjugates

Chemistry of Bioconjugates
Synthesis, Characterization, and Biomedical Applications

by Ravin Narain

  • Publisher : John Wiley & Sons
  • Release : 2013-12-02
  • Pages : 496
  • ISBN : 1118776372
  • Language : En, Es, Fr & De
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Explores bioconjugate properties and applications ofpolymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas ofindustry and biomedicine. With its emphasis on synthesis,properties and applications, this book enables readers tounderstand the connection between chemistry and the biologicalapplication of bioconjugated materials. Its detailed descriptionsof methods make it possible for researchers to fabricate and takefull advantage of bioconjugates for a broad range of applications.Moreover, the book sets the foundation for the development of newapplications, including assays, imaging, biosensors, drug delivery,and diagnostics. Chemistry of Bioconjugates features contributions from aninternational team of leading experts and pioneers in the field.These contributions reflect the authors’ firsthand laboratoryexperience as well as a thorough review of the current literature.The book’s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle-based bioconjugates Inorganic nanomaterial bioconjugates, including metals andmetal oxides Cell-based, hydrogel/microgel, and glyco-bioconjugates Characterization, physico-(bio)chemical properties, andapplications of bioconjugates This comprehensive exploration of bioconjugates includesdiscussions of polymers, dendrimers, lipids, nanoparticles, andnanotubes. References at the end of each chapter serve as a gatewayto the most important original research findings and reviews in thefield. By drawing together and analyzing all the latest chemicalmethods and research findings on the physico-chemical andbiochemical properties of bioconjugates, Chemistry ofBioconjugates sheds new light on the significance and potentialof bioconjugation. The book is recommended for organic and polymerchemists, biochemists, biomaterial scientists, carbohydratechemists, biophysicists, bioengineers, and drug and gene deliveryscientists.

Immobilized Affinity Ligand Techniques

Immobilized Affinity Ligand Techniques

by Greg T. Hermanson,A. Krishna Mallia,Paul K. Smith

  • Publisher : Academic Press
  • Release : 1992-09-10
  • Pages : 454
  • ISBN :
  • Language : En, Es, Fr & De
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This book is a practical guide to the preparation and use of immobilized affinity ligands for purification, catalysis, and analysis. Special emphasis is given to immunochemical techniques including antibody isolation, preparation of antibody fragments using immobilized enzymes, and immunoaffinity chromatography. The book provides easy-to-follow, well-tested protocols to allow the uninitiated to use these techniques to the maximum advantage with minimum hassle. In addition, it shows researchers how to save money by making their own optimized affinity supports. Matrix activation: Ligand immobilization, Binding and elution of target molecules, Enzyme catalysis on solid supports, Analytical affinity chromatography, Isolation/purification of antibodies, Preparation of antibody fragments, Immunoaffinity chromatography, Immobilization of nucleic acids, Use of immobilized ligands for removal of trace contaminants Practical advice on choosing: Matrices, Spacers, Methods of activation and coupling Background information and insights on: Affinity interactions, The ease and power of affinity chromatography, Attaching molecules to insoluble supports, Matrices currently in use, Over 20 methods of activation, Spacers, Extensive References

Bioconjugation

Bioconjugation
Methods and Protocols

by Sam Massa,Nick Devoogdt

  • Publisher : Humana
  • Release : 2019-07-23
  • Pages : 317
  • ISBN : 9781493996537
  • Language : En, Es, Fr & De
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This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.

Network Intrusion Analysis

Network Intrusion Analysis
Methodologies, Tools, and Techniques for Incident Analysis and Response

by Joe Fichera,Steven Bolt

  • Publisher : Newnes
  • Release : 2012-12-17
  • Pages : 252
  • ISBN : 1597499714
  • Language : En, Es, Fr & De
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Nearly every business depends on its network to provide information services to carry out essential activities, and network intrusion attacks have been growing increasingly frequent and severe. When network intrusions do occur, it’s imperative that a thorough and systematic analysis and investigation of the attack is conducted to determine the nature of the threat and the extent of information lost, stolen, or damaged during the attack. A thorough and timely investigation and response can serve to minimize network downtime and ensure that critical business systems are maintained in full operation. Network Intrusion Analysis teaches the reader about the various tools and techniques to use during a network intrusion investigation. The book focuses on the methodology of an attack as well as the investigative methodology, challenges, and concerns. This is the first book that provides such a thorough analysis of network intrusion investigation and response. Network Intrusion Analysis addresses the entire process of investigating a network intrusion by: *Providing a step-by-step guide to the tools and techniques used in the analysis and investigation of a network intrusion. *Providing real-world examples of network intrusions, along with associated workarounds. *Walking you through the methodology and practical steps needed to conduct a thorough intrusion investigation and incident response, including a wealth of practical, hands-on tools for incident assessment and mitigation. Network Intrusion Analysis addresses the entire process of investigating a network intrusion Provides a step-by-step guide to the tools and techniques used in the analysis and investigation of a network intrusion Provides real-world examples of network intrusions, along with associated workarounds Walks readers through the methodology and practical steps needed to conduct a thorough intrusion investigation and incident response, including a wealth of practical, hands-on tools for incident assessment and mitigation

Data Mining: Practical Machine Learning Tools and Techniques

Data Mining: Practical Machine Learning Tools and Techniques

by Ian H. Witten,Eibe Frank,Mark A. Hall

  • Publisher : Elsevier
  • Release : 2011-02-03
  • Pages : 664
  • ISBN : 0080890369
  • Language : En, Es, Fr & De
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Data Mining: Practical Machine Learning Tools and Techniques, Third Edition, offers a thorough grounding in machine learning concepts as well as practical advice on applying machine learning tools and techniques in real-world data mining situations. This highly anticipated third edition of the most acclaimed work on data mining and machine learning will teach you everything you need to know about preparing inputs, interpreting outputs, evaluating results, and the algorithmic methods at the heart of successful data mining. Thorough updates reflect the technical changes and modernizations that have taken place in the field since the last edition, including new material on Data Transformations, Ensemble Learning, Massive Data Sets, Multi-instance Learning, plus a new version of the popular Weka machine learning software developed by the authors. Witten, Frank, and Hall include both tried-and-true techniques of today as well as methods at the leading edge of contemporary research. The book is targeted at information systems practitioners, programmers, consultants, developers, information technology managers, specification writers, data analysts, data modelers, database R&D professionals, data warehouse engineers, data mining professionals. The book will also be useful for professors and students of upper-level undergraduate and graduate-level data mining and machine learning courses who want to incorporate data mining as part of their data management knowledge base and expertise. Provides a thorough grounding in machine learning concepts as well as practical advice on applying the tools and techniques to your data mining projects Offers concrete tips and techniques for performance improvement that work by transforming the input or output in machine learning methods Includes downloadable Weka software toolkit, a collection of machine learning algorithms for data mining tasks—in an updated, interactive interface. Algorithms in toolkit cover: data pre-processing, classification, regression, clustering, association rules, visualization

Interview Techniques for UX Practitioners

Interview Techniques for UX Practitioners
A User-Centered Design Method

by Chauncey Wilson

  • Publisher : Newnes
  • Release : 2013-11-23
  • Pages : 100
  • ISBN : 0124104509
  • Language : En, Es, Fr & De
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Much of the work of user-centered design practitioners involves some type of interviewing. While interviewing is an important skill, many colleagues have little or no formal training in interviewing methods and often learn on the job with limited feedback on the quality of their interviews. This book teaches readers about the three basic interview methods: structured interviews, semi-structured interviews, and unstructured interviews. The author discusses the various strengths, weaknesses, issues with each type of interview, and includes best practices and procedures for conducing effective and efficient interviews. The book dives into the detailed information about interviews that haven’t been discussed before – readers learn how and when to ask the "how" and "why" questions to get a deeper understanding of problems, concepts, and processes, as well as discussions on laddering and critical incident techniques. Because so much of what UX practitioners do involves good interviewing skills, this is your one-stop resource with the definitions, processes, procedures and best practices on the basic approaches.

Chemical Reagents for Protein Modification, Fourth Edition

Chemical Reagents for Protein Modification, Fourth Edition

by Roger L. Lundblad

  • Publisher : CRC Press
  • Release : 2014-07-22
  • Pages : 684
  • ISBN : 1466571918
  • Language : En, Es, Fr & De
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The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics. Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters: Alkylating Agents Acylating Agents Nitration and Nitrosylation Oxidation Modification of Proteins with Reducing Agents There is greatly increased coverage of the chemical modification of cysteine, which is critical for bioconjugate synthesis. The chapter on reduction also provides information necessary for bioconjugate synthesis as well as for the processing of inclusion bodies. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. This new version has increased significance to biopharmaceuticals. Much of the information is in tabular form, which enables the rapid location of cited material.

15-Minute Counseling Techniques That Work

15-Minute Counseling Techniques That Work
What You Didn't Learn in Grad School

by Allison Edwards

  • Publisher : 15-Minute Focus
  • Release : 2020-05-21
  • Pages : 80
  • ISBN : 9781937870690
  • Language : En, Es, Fr & De
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The counselor is not the strategy. The counselor teaches strategies. As counselors, we spend our days helping kids. Kids come to us with a variety of problems, searching for answers. They want us to listen. And they need us to give them solutions for the issues they are facing. While these solutions may work temporarily, we really never help kids until we give them tools"¬‚¬"or techniques"¬‚¬"to manage thoughts and feelings on their own. Our job is not to do it for them. Our job is to teach them how to do it themselves! This is the greatest gift we can give. In 15-Minute Counseling Techniques, Allison Edwards provides tools to use in individual or group counseling sessions with children in grades K"¬‚¬"12. Children will learn how to calm their mind and body with Square Breathing, let go of negative thoughts by Changing the Channel, identify their unique gifts by creating a "What I'm Good At" Jar, and so much more. The techniques in this book will help children feel empowered to face everyday challenges and equipped to manage their stress and emotions. And, best of all, you will give them the confidence they need to handle challenges throughout their lives.

Bioassay Techniques for Drug Development

Bioassay Techniques for Drug Development

by Atta-ur-Rahman,M. Iqbal Choudhary,William J. Thomsen

  • Publisher : CRC Press
  • Release : 2001-10-04
  • Pages : 240
  • ISBN : 1135287228
  • Language : En, Es, Fr & De
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The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

Key Engineering Materials

Key Engineering Materials
Current State-of-the-Art on Novel Materials

by Devrim Balköse,Daniel Horak,Ladislav Šoltés

  • Publisher : CRC Press
  • Release : 2014-02-14
  • Pages : 584
  • ISBN : 1926895738
  • Language : En, Es, Fr & De
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With coverage of a broad range of key engineering materials, this book provides a single, comprehensive book summarizing all aspects involved in the functional materials production chain. It introduces state-of-the-art technology in key engineering materials, emphasizing the rapidly growing technologies. It takes a unique approach by presenting specific materials, then progresses into a discussion of the ways in which these novel materials and processes are integrated into today's functioning manufacturing industry. The book follows a more quantitative and design-oriented approach than other texts in the market, helping readers gain a better understanding of important concepts. They’ll also discover how material properties relate to the process variables in a given process as well as how to perform quantitative engineering analysis of manufacturing processes.

Biomedical Applications of Nanotechnology

Biomedical Applications of Nanotechnology

by Vinod Labhasetwar,Diandra L. Leslie-Pelecky

  • Publisher : John Wiley & Sons
  • Release : 2007-09-28
  • Pages : 272
  • ISBN : 9780470152911
  • Language : En, Es, Fr & De
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An overview of nanotechnology and its potential The field of nanotechnology is undergoing rapid developments on many fronts. This reference provides a comprehensive review of various nanotechnologies with a view to their biomedical applications. With chapters contributed by distinguished scientists from diverse disciplines, Biomedical Applications of Nanotechnology : Reviews recent advances in the designing of various nanotechnologies based on nucleic acids, polymers, biomaterials, and metals Discusses biomedical nanotechnology in areas such as drug and gene delivery Covers advanced aspects of imaging and diagnostics Includes a chapter on the issue of nanotoxicology Complete with figures and tables, this is a practical, hands-on reference book for researchers in pharmaceutical and biotech industries, biomedical engineers, pharmaceutical scientists, pharmacologists, and materials scientists as well as for the policymakers who need to understand the potential of nanotechnology. It is also an excellent resource book for graduate-level students in pharmaceutical sciences, biomedical engineering, and other fields in which nanotechnology is playing an increasingly important role.

Enzyme Immunoassays

Enzyme Immunoassays
From Concept to Product Development

by S.S. Deshpande

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 464
  • ISBN : 1461311691
  • Language : En, Es, Fr & De
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This unique reference provides a pragmatic approach to the development of successful commercial immunodiagnostic products based on enzyme immunoessay technology. Presenting both the basic and applied principles, Enzyme Immunoassays gathers information on all aspects of this process, from the initial conceptualization to the introduction of the product to the market.

Engineered Carbohydrate-Based Materials for Biomedical Applications

Engineered Carbohydrate-Based Materials for Biomedical Applications
Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels

by Ravin Narain

  • Publisher : John Wiley & Sons
  • Release : 2011-03-01
  • Pages : 416
  • ISBN : 1118002245
  • Language : En, Es, Fr & De
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This book addresses the need for a comprehensive book on the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles and hydrogels. While these chapters comprehensively review the synthetic and characterization methods of those carbohydrate-based materials, their biological applications are discussed in detail.

Nanoanalytics

Nanoanalytics
Nanoobjects and Nanotechnologies in Analytical Chemistry

by Sergei Shtykov

  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 2018-03-19
  • Pages : 463
  • ISBN : 311054024X
  • Language : En, Es, Fr & De
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Nanoanalytics is a novel branch of analytical chemistry which explores applications of nanotechnologies in chemical analysis. This comprehensive publication gives an overview of the analytical techniques used to study nanoobjects and nanoparticles as well as the application of nanomaterials themselves in the development of new methods of analysis. The authors also address important metrology aspects and give future prospects of the area.

Viruses and Nanotechnology

Viruses and Nanotechnology

by Marianne Manchester,Nicole F. Steinmetz

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-02
  • Pages : 147
  • ISBN : 3540693793
  • Language : En, Es, Fr & De
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Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.

Radiopharmaceutical Chemistry

Radiopharmaceutical Chemistry

by Jason S. Lewis,Albert D. Windhorst,Brian M. Zeglis

  • Publisher : Springer
  • Release : 2019-04-02
  • Pages : 651
  • ISBN : 3319989472
  • Language : En, Es, Fr & De
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This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.