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Bioinformatics for Biomedical Science and Clinical Applications

Bioinformatics for Biomedical Science and Clinical Applications
A Book

by K-H Liang

  • Publisher : Elsevier
  • Release : 2013-07-31
  • Pages : 170
  • ISBN : 1908818239
  • Language : En, Es, Fr & De
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Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications. Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical questions. The first two chapters consider Bioinformatics and analysis of the human genome. The subsequent three chapters cover the introduction of Transcriptomics, Proteomics and Systems biomedical science. The remaining chapters move on to critical developments, clinical information and conclude with domain knowledge and adaptivity. A coherent presentation of concepts, methodologies and practical tools that systematically lead to significant discoveries in the biomedical and clinical area Real examples of cutting edge discoveries The introduction of study types and technologies for all the DNA, RNA and protein levels

Computational Methods With Applications In Bioinformatics Analysis

Computational Methods With Applications In Bioinformatics Analysis
A Book

by Tsai Jeffrey J P,Ng Ka-lok

  • Publisher : World Scientific
  • Release : 2017-06-09
  • Pages : 232
  • ISBN : 981320799X
  • Language : En, Es, Fr & De
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This compendium contains 10 chapters written by world renowned researchers with expertise in semantic computing, genome sequence analysis, biomolecular interaction, time-series microarray analysis, and machine learning algorithms. The salient feature of this book is that it highlights eight types of computational techniques to tackle different biomedical applications. These techniques include unsupervised learning algorithms, principal component analysis, fuzzy integral, graph-based ensemble clustering method, semantic analysis, interolog approach, molecular simulations and enzyme kinetics. The unique volume will be a useful reference material and an inspirational read for advanced undergraduate and graduate students, computer scientists, computational biologists, bioinformatics and biomedical professionals.

Application of Clinical Bioinformatics

Application of Clinical Bioinformatics
A Book

by Xiangdong Wang,Christian Baumgartner,Denis C. Shields,Hong-Wen Deng,Jacques S Beckmann

  • Publisher : Springer
  • Release : 2016-03-31
  • Pages : 398
  • ISBN : 9401775435
  • Language : En, Es, Fr & De
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This book elucidates how genetic, biological and medical information can be applied to the development of personalized healthcare, medication and therapies. Focusing on aspects of the development of evidence-based approaches in bioinformatics and computational medicine, including data integration, methodologies, tools and models for clinical and translational medicine, it offers an essential introduction to clinical bioinformatics for clinical researchers and physicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. Xiangdong Wang is a distinguished Professor of Medicine. He is Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Deputy Director of Shanghai Respiratory Research Institute, Director of Biomedical Research Center, Fudan University Zhongshan Hospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of Health Care and Biomedical Engineering at Institute of Health Care Engineering with European Notified Body of Medical Devices, Graz University of Technology, Graz, Austria; Dr. Denis Shields is a Professor of Clinical Bioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Deng is a Professor at Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, USA; Dr. Jacques S Beckmann is a Professor and Director of Section of Clinical Bioinformatics, Swiss Institute of Bioinformatics, Switzerland.

11th Asian-Pacific Conference on Medical and Biological Engineering

11th Asian-Pacific Conference on Medical and Biological Engineering
Proceedings of the Online Conference APCMBE 2020, May 25-27, 2020

by Yasuyuki Shiraishi,Ichiro Sakuma,Keiji Naruse,Akinori Ueno

  • Publisher : Springer Nature
  • Release : 2021-06-04
  • Pages : 343
  • ISBN : 3030661695
  • Language : En, Es, Fr & De
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This book presents cutting-edge research and developments in the field of medical and biological engineering, which a special emphasis on activities carried out in the Asian-Pacific region. Gathering the proceedings of the 11th Asian-Pacific Conference on Medical and Biological Engineering, organized in Japan and held online on May 25-27, 2020, the book both fundamental research and clinical applications relating to medical instrumentations, bioimaging, bioinformatics and computational biomedicine, AI and data science in healthcare, as well as regenerative medicine and rehabilitation. It aims at informing on new trends, challenges and solutions, and fosters communication and collaboration between medical scientists, engineers, and researchers dealing with cutting-edge themes in broad field of biomedical and clinical engineering.

Applications of Nanoscience in Photomedicine

Applications of Nanoscience in Photomedicine
A Book

by Michael R. Hamblin,Pinar Avci

  • Publisher : Elsevier
  • Release : 2015-02-17
  • Pages : 220
  • ISBN : 1908818786
  • Language : En, Es, Fr & De
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Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of photomedicine. In the past commercial applications of nanoscience have been limited to materials science research only, however, in recent years nanoparticles are rapidly being incorporated into industrial and consumer products. This is mainly due to the expansion of biomedical related research and the burgeoning field of nanomedicine. Applications of Nanoscience in Photomedicine covers a wide range of nanomaterials including nanoparticles used for drug delivery and other emerging fields such as optofluidics, imaging and SERS diagnostics. Introductory chapters are followed by a section largely concerned with imaging, and finally a section on nanoscience-enabled therapeutics. Covers a comprehensive up-to-date information on nanoscience Focuses on the combination of photomedicine with nanotechnology to enhance the diversity of applications Pioneers in the field have written their respective chapters Opens a plethora of possibilities for developing future nanomedicine Easy to understand and yet intensive coverage chapter by chapter

SOFSEM 2018: Theory and Practice of Computer Science

SOFSEM 2018: Theory and Practice of Computer Science
44th International Conference on Current Trends in Theory and Practice of Computer Science, Krems, Austria, January 29 - February 2, 2018, Proceedings

by A Min Tjoa,Ladjel Bellatreche,Stefan Biffl,Jan van Leeuwen,Jiří Wiedermann

  • Publisher : Springer
  • Release : 2018-01-12
  • Pages : 698
  • ISBN : 3319731173
  • Language : En, Es, Fr & De
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This book constitutes the refereed proceedings of the 44th International Conference on Current Trends in Theory and Practice of Computer Science, SOFSEM 2018, held in Krems, Austria, in January/February 2018. The 48 papers presented in this volume were carefully reviewed and selected from 97 submissions. They were organized in topical sections named: foundations of computer science; software engineering: advances methods, applications, and tools; data, information and knowledge engineering; network science and parameterized complexity; model-based software engineering; computational models and complexity; software quality assurance and transformation; graph structure and computation; business processes, protocols, and mobile networks; mobile robots and server systems; automata, complexity, completeness; recognition and generation; optimization, probabilistic analysis, and sorting; filters, configurations, and picture encoding; machine learning; text searching algorithms; and data model engineering.

Clinical Research in Asia

Clinical Research in Asia
Opportunities and Challenges

by U Sahoo

  • Publisher : Elsevier
  • Release : 2012-05-25
  • Pages : 412
  • ISBN : 1908818131
  • Language : En, Es, Fr & De
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Asia is increasingly taking on a leading role in the fields of Good Clinical Practice (GCP) and ethics, two areas that are central to clinical research practices worldwide. Clinical research in Asia examines the evolution of these key sectors in the Asian countries where the greatest developments are taking place, offering valuable perspectives on a wide range of issues affecting clinical research. Following an introduction that provides an overview of the topic and its strengths and weaknesses, each chapter of the book is devoted to clinical research in a specific country, focusing on issues including the history and evolution of clinical research, clinical trials and regulatory aspects. The chapters also offer a perspective on future trends in clinical research in each country. The book concludes with a discussion of the importance of political, economic, socio-cultural, technological, legal and environmental factors (PESTLE analysis). Analysis from a leading and highly respected professional in the sector An overview of country-specific regulatory environments Discussion of challenges and solutions for clinical research

Computer-Aided Applications in Pharmaceutical Technology

Computer-Aided Applications in Pharmaceutical Technology
A Book

by Jelena Djuris

  • Publisher : Elsevier
  • Release : 2013-04-10
  • Pages : 300
  • ISBN : 1908818328
  • Language : En, Es, Fr & De
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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

An Introduction to Pharmaceutical Sciences

An Introduction to Pharmaceutical Sciences
Production, Chemistry, Techniques and Technology

by Jiben Roy

  • Publisher : Elsevier
  • Release : 2011-07-25
  • Pages : 446
  • ISBN : 1908818042
  • Language : En, Es, Fr & De
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This textbook is written as a unified approach to various topics, ranging from drug discovery to manufacturing, techniques and technology, regulation and marketing. The key theme of the book is pharmaceuticals - what every student of pharmaceutical sciences should know: from the active pharmaceutical ingredients to the preparation of various dosage forms along with the relevant chemistry, this book makes pharmaceuticals relevant to undergraduate students of pharmacy and pharmaceutical sciences. This book explains how a particular drug was discovered and then converted from lab-scale to manufacturing scale, to the market. It explains the motivation for drug discovery, the reaction chemistry involved, experimental difficulties, various dosage forms and the reasoning behind them, mechanism of action, quality assurance and role of regulatory agencies. After having a course based on this book, the student will be able to understand: 1) the career prospects in the pharmaceutical industry, 2) the need for interdisciplinary teamwork in science, 3) the techniques and technology involved in making pharmaceuticals starting from bulk drugs, and 4) different dosage forms and critical factors in the development of pharmaceutical formulations in relation to the principles of chemistry. A few blockbuster drugs including atorvastatin, sildanefil, ranitidine, ciprofloxacin, amoxicillin, and the longest serving drugs such as aspirin and paracetamol are discussed in detail. Finally, the book also covers the important current pharmaceutical issues like quality control, safety, counterfeiting and abuse of drugs, and future prospects for pharmaceutical industry. Unified approach explaining drug discovery, bulk drug manufacturing, formulation of dosage forms, with pharmacological and therapeutic actions Manufacturing processes of representative active pharmaceutical ingredients and their chemistry plus formulation of dosage forms presented in this book are based on actual industrial processes Covers many aspects relevant to students of the pharmaceutical sciences or newly employed pharmaceutical researchers/employees. It contains summary information about regulatory agencies of different countries

Statistical Advances in the Biomedical Sciences

Statistical Advances in the Biomedical Sciences
Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics

by Atanu Biswas,Sujay Datta,Jason P. Fine,Mark R. Segal

  • Publisher : John Wiley & Sons
  • Release : 2007-12-14
  • Pages : 616
  • ISBN : 9780470181195
  • Language : En, Es, Fr & De
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The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.

Commercializing the Stem Cell Sciences

Commercializing the Stem Cell Sciences
A Book

by Olivia Harvey

  • Publisher : Elsevier
  • Release : 2012-10-16
  • Pages : 212
  • ISBN : 190881814X
  • Language : En, Es, Fr & De
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Promising new developments in biomedical technology such as stem cell science are widely endorsed by governments keen to reduce spiralling healthcare costs, clinicians focused on patient care, and patients demanding revolutionary new treatments. Commercializing the stem cell sciences offers a comparative analysis of the commercial methods adopted in the global stem cell industries. It seeks to establish whether there is an optimum commercial model and to examine what emerging companies can learn from their predecessors. Following an introduction to stem cell sciences and the problems involved in their commercialization, the book begins with a discussion of stem cell treatments from a global perspective, and the role of innovation in the commercialization of biotechnology in general. In the second half of the book, chapters focus on the different strategies that can be employed and their relative risks and values, before a conclusion that looks at potential new developments in the field. In-depth discussion of case studies of products undergoing development Focus on commercial optimization of stem cell treatments Analysis in a global context and covering a diverse range of countries

Gene therapy

Gene therapy
Potential Applications of Nanotechnology

by Surendra Nimesh

  • Publisher : Elsevier
  • Release : 2013-10-31
  • Pages : 380
  • ISBN : 1908818646
  • Language : En, Es, Fr & De
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Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome

Allergens and Respiratory Pollutants

Allergens and Respiratory Pollutants
The Role of Innate Immunity

by Marc A. Williams

  • Publisher : Elsevier
  • Release : 2011-07-18
  • Pages : 312
  • ISBN : 1908818069
  • Language : En, Es, Fr & De
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Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease. Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material

Outsourcing Biopharma R&D to India

Outsourcing Biopharma R&D to India
A Book

by P R Chowdhury

  • Publisher : Elsevier
  • Release : 2011-05-05
  • Pages : 130
  • ISBN : 1908818018
  • Language : En, Es, Fr & De
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The trend of outsourcing to India for research and development is catching on fast. Over the last decade, worldwide pharmaceutical and biotechnology companies have made India their choice for a research destination. Initially R&D was inclined more towards developing products for the Indian market within the country. This led to several multinational companies opening up production plants in India, primarily due to the globalization of the Indian economy and offshoring jobs to India. Alongside, several global pharma-biotech majors ascertained large market requirements within the country and capitalized on the advantage of serving Indian customers. Strategies were devised to optimize operational expenses with the setting up of on-site R&D to develop products for local requirements. In view of this, this book seeks to explore various nuances of the outsourcing sector with respect to biopharma in India. Constitutes the first ever comprehensive insight on the Indian biopharma sector Provides a perspective based on practical hands-on legal experience Simply structured, clearly presented and free from excessive legal jargon

Concepts and Techniques in Genomics and Proteomics

Concepts and Techniques in Genomics and Proteomics
A Book

by N Saraswathy,P Ramalingam

  • Publisher : Elsevier
  • Release : 2011-07-01
  • Pages : 268
  • ISBN : 1908818050
  • Language : En, Es, Fr & De
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Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to illustrate ideas Important points to remember are noted

Drug-Biomembrane Interaction Studies

Drug-Biomembrane Interaction Studies
The Application of Calorimetric Techniques

by Rosario Pignatello

  • Publisher : Elsevier
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 1908818344
  • Language : En, Es, Fr & De
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The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

String Processing and Information Retrieval

String Processing and Information Retrieval
25th International Symposium, SPIRE 2018, Lima, Peru, October 9-11, 2018, Proceedings

by Travis Gagie,Alistair Moffat,Gonzalo Navarro,Ernesto Cuadros-Vargas

  • Publisher : Springer
  • Release : 2018-10-01
  • Pages : 364
  • ISBN : 3030004791
  • Language : En, Es, Fr & De
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This book constitutes the refereed proceedings of the 25th International Symposium on String Processing and Information Retrieval, SPIRE 2018, held in Lima, Peru, in October 2018. The 22 full papers and 6 short papers presented were carefully reviewed and selected from 51 submissions. They focus on fundamental studies on string processing and information retrieval, as well as on computational biology.

Orphan Drugs

Orphan Drugs
Understanding the Rare Disease Market and its Dynamics

by Elizabeth Hernberg-Ståhl,Miroslav Reljanović

  • Publisher : Elsevier
  • Release : 2013-11-15
  • Pages : 334
  • ISBN : 1908818395
  • Language : En, Es, Fr & De
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This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups. The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey. After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs. The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs. A comprehensive overview of strategy, key activities and considerations of how to bring an orphan drug from concept to the market and make it available to patients A source of updated information, news and trends for those who are already active in this fast-evolving field Covers the global definitions and the criteria for getting an orphan drug designation in, for example, the US and Europe

Practical Leadership for Biopharmaceutical Executives

Practical Leadership for Biopharmaceutical Executives
A Book

by Jane Y Chin

  • Publisher : Elsevier
  • Release : 2011-05-05
  • Pages : 216
  • ISBN : 1908818026
  • Language : En, Es, Fr & De
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The biohealthcare executive in upper-middle management confronts leadership challenges unique to their industry: they manage highly specialized knowledge workers and innovators, compete at the speed of technology, work in a highly regulated environment where "free speech" often does not apply due to patient safety and privacy concerns, and increasingly are leading virtual teams who may be located in different parts of the world. Practical leadership for biopharmaceutical executives is a guide that strips away the theory and meets head-on the practical leadership challenges these executives face on a daily basis, and provides these "innovator leaders" with the tools to lead effectively in the face of technological complexity. Focuses on personal leadership, where the executive has an opportunity to manage his/her own effectiveness as a leader and manager, and engage with their own career development and method of contribution within their chosen industry Discusses particularly the unique leadership challenges in biohealthcare: an industry that is at once highly innovative and emotive. Biohealthcare companies are often viewed with suspicion by the consumers who question corporate motives, and product marketing and sales practices. The effective biohealthcare leaders are well aware of these emotive features, and embody ethics through action - not just lip service Includes real life examples, including a series of both phone-based and email-based interviews of executives

A Biotech Manager's Handbook

A Biotech Manager's Handbook
A Practical Guide

by M O'Neill,M M Hopkins

  • Publisher : Elsevier
  • Release : 2012-05-02
  • Pages : 414
  • ISBN : 1908818158
  • Language : En, Es, Fr & De
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A biotech manager's handbook lays out - in a simple, straightforward manner - for the manager or would-be entrepreneur the basic principles of running a biotech company. Most managers in biotechnology companies are working in their first company or in their first managerial role. Their expertise and experience in the scientific part of the work can be taken as a given but there is a whole range of other skills to be learned and areas of expertise to come to terms with. Small companies do not have big budgets to hire people or time to become an expert in so many areas. The book starts by outlining the state of the biopharmaceutical industry and goes on to explain the importance of planning (no matter what the size of the company). Succeeding chapters deal with the basics of intellectual property, perspectives from a university technology transfer office and how to raise some initial funding from an investor and entrepreneur. No other 'how to' manual exists for this sector Written by a range of expert professionals in each area, all in one book Is the only 'bench to bedside' book covering the whole spectrum of development