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Progress in Biological Chirality

Progress in Biological Chirality
A Book

by Gyula Palyi,Claudia Zucchi,Luciano Caglioti

  • Publisher : Elsevier
  • Release : 2004-12-13
  • Pages : 444
  • ISBN : 9780080474038
  • Language : En, Es, Fr & De
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Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Biological Chirality

Biological Chirality
A Book

by Gyula Palyi

  • Publisher : Academic Press
  • Release : 2019-11-06
  • Pages : 268
  • ISBN : 0128123389
  • Language : En, Es, Fr & De
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Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Advances in BioChirality

Advances in BioChirality
A Book

by C. Zucchi,L. Caglioti,Gyula Palyi

  • Publisher : Elsevier
  • Release : 1999-09-08
  • Pages : 407
  • ISBN : 9780080526621
  • Language : En, Es, Fr & De
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Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
A Book

by Roger J. Crossley

  • Publisher : CRC Press
  • Release : 1995-09-11
  • Pages : 208
  • ISBN : 9780849391408
  • Language : En, Es, Fr & De
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This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Reactions in Active Sites

by Nilashis Nandi

  • Publisher : CRC Press
  • Release : 2011-07-27
  • Pages : 209
  • ISBN : 1439840024
  • Language : En, Es, Fr & De
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Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chiral Drugs

Chiral Drugs
Chemistry and Biological Action

by Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng

  • Publisher : John Wiley & Sons
  • Release : 2011-08-08
  • Pages : 472
  • ISBN : 9781118075630
  • Language : En, Es, Fr & De
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An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Asymmetry in Biological Homochirality

Asymmetry in Biological Homochirality
A Book

by David Hochberg

  • Publisher : MDPI
  • Release : 2021-06-04
  • Pages : 102
  • ISBN : 3036504427
  • Language : En, Es, Fr & De
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Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

Second International Symposium on Biological Chirality

Second International Symposium on Biological Chirality
A Book

by International Symposium on Biological Chirality

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 133
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chirality and Biological Activity

Chirality and Biological Activity
A Book

by Hartmut Frank,Bo Holmstedt,Bernard Testa

  • Publisher : Wiley-Liss
  • Release : 1990
  • Pages : 283
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Biochirality

Biochirality
Origins, Evolution and Molecular Recognition

by Pedro Cintas

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 316
  • ISBN : 3642376266
  • Language : En, Es, Fr & De
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Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY (POLARIZED POSITRONS, POSITRONIUM, SLOW).

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY (POLARIZED POSITRONS, POSITRONIUM, SLOW).
A Book

by JAMES CHRISTOPHER VAN HOUSE

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 169
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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an asymmetry in the rate of orthopositronium formation, Ap(,s), when low energy positron beams with a net helicity form positronium in optically active molecules, and quantitatively connect Ap(,s) to asymmetric radiolysis.

Current Topics in Chirality

Current Topics in Chirality
From Chemistry to Biology

by Takashiro Akitsu

  • Publisher : BoD – Books on Demand
  • Release : 2021-09-01
  • Pages : 196
  • ISBN : 1839689536
  • Language : En, Es, Fr & De
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Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Comprehensive Chirality: Biological significance -- pharmacology, pharmaceutical, agrochemical

Comprehensive Chirality: Biological significance -- pharmacology, pharmaceutical, agrochemical
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems

Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems
A Book

by Jie Song

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 332
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chirality and Molecular Interactions

Chirality and Molecular Interactions
A Book

by Thirumoorthy Krishnan

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2010-10
  • Pages : 248
  • ISBN : 9783843356862
  • Language : En, Es, Fr & De
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This book discusses the influence of chirality and intermolecular interactions in biomimetic (amphiphilic and peptide systems) and biological (amino acids and model biological reactions involving amino acids and peptides) systems using computational chemical methods. Generation and retention of homochirality are fundamentally important in biology. The difference in intermolecular interactions between enantiomeric and racemic pairs (homochiral and heterochiral interactions) and their interactions with the surrounding molecular structures leading to chiral discrimination, which could be responsible for homochiral preference, is also discussed. The nature of intermolecular energy surfaces as a function of molecular mutual orientations dictates the chiral discrimination in biology. The knowledge gained in the biomimetic systems is employed to understand more complex biological reactions like synthesis of amino acids by transamination reaction, synthesis of aminoacyl-tRNA in the aminoacylation process and synthesis of peptides in ribosome. The molecular recognition process in biomimetic amphiphiles and peptides are correlated with the nature of the intermolecular energy surfaces.

Organometallic Chirality

Organometallic Chirality
A Book

by Gyula Pályi,Claudia Zucchi,Luciano Caglioti

  • Publisher : Mucchi Editore
  • Release : 2008
  • Pages : 276
  • ISBN : 8870004910
  • Language : En, Es, Fr & De
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Encyclopedia of Astrobiology

Encyclopedia of Astrobiology
A Book

by Muriel Gargaud,Ricardo Amils,Henderson James Cleaves

  • Publisher : Springer Science & Business Media
  • Release : 2011-05-26
  • Pages : 1853
  • ISBN : 3642112714
  • Language : En, Es, Fr & De
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Astrobiology is a remarkably interdisciplinary field. This reference serves as a key to understanding technical terms from the different subfields of astrobiology, including astronomy, biology, chemistry, the geosciences and the space sciences.

Encyclopedia of Biocolloid and Biointerface Science, 2 Volume Set

Encyclopedia of Biocolloid and Biointerface Science, 2 Volume Set
A Book

by Hiroyuki Ohshima

  • Publisher : John Wiley & Sons
  • Release : 2016-09-26
  • Pages : 1200
  • ISBN : 1118542762
  • Language : En, Es, Fr & De
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This encyclopedia uniquely concentrates on biocolloids and biointerfaces rather than the broader field of colloid and interface science. Biocolloids and biointerfaces are the youngest but increasingly prominent studied area of colloid and interface science, and this encyclopedia uses "soft particles" and "soft interface" as surface models in observing phenomena in biological systems. Provides a detailed description of the fundamental theories, dealing with the physicochemical and theoretical aspects of biocolloid and biointerface science Offers a detailed description of soft interfaces or surfaces Includes detailed description of applications of fundamental biocolloid and biointerface theories to nano-, bio, and environmental sciences A useful and timely resource for researchers and graduates in the field of biocolloid and biointerface science, as well as engineers in the field of nanotechnology, bioscience, and environmental science.

Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products

Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products
A Book

by Kimberley Jade Powell

  • Publisher : Springer
  • Release : 2015-08-12
  • Pages : 136
  • ISBN : 3319220691
  • Language : En, Es, Fr & De
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This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs – the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.

On Chirality and the Universal Asymmetry

On Chirality and the Universal Asymmetry
Reflections on Image and Mirror Image

by Georges H. Wagnière

  • Publisher : John Wiley & Sons
  • Release : 2008-09-26
  • Pages : 256
  • ISBN : 3906390608
  • Language : En, Es, Fr & De
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Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.