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Progress in Biological Chirality

Progress in Biological Chirality
A Book

by Gyula Palyi,Claudia Zucchi,Luciano Caglioti

  • Publisher : Elsevier
  • Release : 2004-12-13
  • Pages : 444
  • ISBN : 9780080474038
  • Language : En, Es, Fr & De
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Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Biological Chirality

Biological Chirality
A Book

by Gyula Palyi

  • Publisher : Academic Press
  • Release : 2019-11-06
  • Pages : 268
  • ISBN : 0128123389
  • Language : En, Es, Fr & De
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Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Biological Chirality

Biological Chirality
A Book

by Gyula Palyi

  • Publisher : Academic Press
  • Release : 2019-11-06
  • Pages : 268
  • ISBN : 0128123389
  • Language : En, Es, Fr & De
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Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Reactions in Active Sites

by Nilashis Nandi

  • Publisher : CRC Press
  • Release : 2011-07-27
  • Pages : 209
  • ISBN : 1439840024
  • Language : En, Es, Fr & De
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Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
A Book

by Roger J. Crossley

  • Publisher : CRC Press
  • Release : 1995-09-11
  • Pages : 208
  • ISBN : 9780849391408
  • Language : En, Es, Fr & De
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This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Chiral Drugs

Chiral Drugs
Chemistry and Biological Action

by Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng

  • Publisher : John Wiley & Sons
  • Release : 2011-08-08
  • Pages : 472
  • ISBN : 9781118075630
  • Language : En, Es, Fr & De
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An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Chirality and Biological Activity

Chirality and Biological Activity
A Book

by Hartmut Frank,Bo Holmstedt,Bernard Testa

  • Publisher : Wiley-Liss
  • Release : 1990
  • Pages : 283
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Advances in BioChirality

Advances in BioChirality
A Book

by C. Zucchi,L. Caglioti,Gyula Palyi

  • Publisher : Elsevier
  • Release : 1999-09-08
  • Pages : 407
  • ISBN : 9780080526621
  • Language : En, Es, Fr & De
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Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Biological Pigments: Advances in Research and Application: 2011 Edition

Biological Pigments: Advances in Research and Application: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 368
  • ISBN : 1464922128
  • Language : En, Es, Fr & De
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Biological Pigments: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological Pigments. The editors have built Biological Pigments: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological Pigments in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Biological Pigments: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems

Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems
A Book

by Jie Song

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 332
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Analysis of Drugs in Biological Fluids

The Analysis of Drugs in Biological Fluids
A Book

by Joseph Chamberlain

  • Publisher : CRC Press
  • Release : 2018-02-06
  • Pages : 368
  • ISBN : 1351411438
  • Language : En, Es, Fr & De
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This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth.

Chirality from Dynamic Kinetic Resolution

Chirality from Dynamic Kinetic Resolution
A Book

by Hélène Pellissier

  • Publisher : Royal Society of Chemistry
  • Release : 2011
  • Pages : 299
  • ISBN : 1849731977
  • Language : En, Es, Fr & De
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The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.

Chirotechnology

Chirotechnology
Industrial Synthesis of Optically Active Compounds

by Roger A. Sheldon

  • Publisher : CRC Press
  • Release : 1993-05-27
  • Pages : 423
  • ISBN : 9780824791438
  • Language : En, Es, Fr & De
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This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.

Amplification of Chirality

Amplification of Chirality
A Book

by Kenso Soai

  • Publisher : Springer Science & Business Media
  • Release : 2009-11-04
  • Pages : 205
  • ISBN : 3540778691
  • Language : En, Es, Fr & De
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Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.

Comprehensive Chirality

Comprehensive Chirality
A Book

by Anonim

  • Publisher : Newnes
  • Release : 2012-12-31
  • Pages : 5648
  • ISBN : 0080951686
  • Language : En, Es, Fr & De
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Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Chirality in Transition Metal Chemistry

Chirality in Transition Metal Chemistry
Molecules, Supramolecular Assemblies and Materials

by Hani Amouri,Michel Gruselle

  • Publisher : John Wiley & Sons
  • Release : 2008-11-20
  • Pages : 260
  • ISBN : 047072160X
  • Language : En, Es, Fr & De
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Chirality in Transition Metal Chemistry is an essential introduction to this increasingly important field for students and researchers in inorganic chemistry. Emphasising applications and real-world examples, the book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers. The subsequent chapters deal with the the specifics of chirality as it applies to transition metals. Some reviews of Chirality in Transition Metal Chemistry "...useful to students taking an advanced undergraduate course and particularly to postgraduates and academics undertaking research in the areas of chiral inorganic supramolecular complexes and materials." Chemistry World, August 2009 “...the book offers an extremely exciting new addition to the study of inorganic chemistry, and should be compulsory reading for students entering their final year of undergraduate studies or starting a Ph.D. in structural inorganic chemistry.” Applied Organometallic Chemistry Volume 23, Issue 5, May 2009 “...In conclusion the book gives a wonderful overview of the topic. It is helpful for anyone entering the field through systematic and detailed introduction of basic information. It was time to publish a new and topical text book covering the important aspect of coordination chemistry. It builds bridges between Inorganic, organic and supramolecular chemistry. I can recommend the book to everybody who is interested in the chemistry of chiral coordination compounds .” Angew. chem. Volume 48, Issue 18, April 2009 About the Series Chirality in Transition Metal Chemistry is the latest addition to the Wiley Inorganic Chemistry Advanced Textbook series. This series reflects the pivotal role of modern inorganic and physical chemistry in a whole range of emerging areas such as materials chemistry, green chemistry and bioinorganic chemistry, as well as providing a solid grounding in established areas such as solid state chemistry, coordination chemistry, main group chemistry and physical inorganic chemistry.

Chirality in Drug Design and Development

Chirality in Drug Design and Development
A Book

by Indra K. Reddy,Reza Mehvar

  • Publisher : CRC Press
  • Release : 2004-03-15
  • Pages : 1200
  • ISBN : 0824751094
  • Language : En, Es, Fr & De
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Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
A Book

by Satinder Ahuja

  • Publisher : John Wiley & Sons
  • Release : 2011-03-31
  • Pages : 400
  • ISBN : 9781118097755
  • Language : En, Es, Fr & De
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Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Physical Chemistry for the Biological Sciences

Physical Chemistry for the Biological Sciences
A Book

by Gordon G. Hammes

  • Publisher : John Wiley & Sons
  • Release : 2007-04-10
  • Pages : 363
  • ISBN : 0470122021
  • Language : En, Es, Fr & De
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Gain a practical, working knowledge of the physical chemistry essential for the biological sciences Physical Chemistry for the Biological Sciences is an excellent resource for biochemistry and biology/health science professionals and students who need a basic understanding of thermodynamics, kinetics, hydrodynamics of macromolecules, and spectroscopy in order to explore molecular structure and chemical reactions. Approachable, yet thorough, the book presents physical chemistry in conceptual terms with a minimum of mathematics. Providing the basic knowledge and tools that every biologist should have to understand the quantitative interpretation of biological phenomena, it covers: Fundamentals of thermodynamics and chemical kinetics Fundamentals of spectroscopy and structure determination Ligand binding to macromolecules, hydrodynamics, and mass spectrometry All techniques and concepts are clearly illustrated with relevant applications and examples from the biological sciences. Problems at the end of each chapter reinforce the principles. This is a succinct reference for practitioners, including bioorganic chemists, medicinal chemists, biochemists, pharmaceutical chemists, biologists, and professionals in fields such as pharmaceuticals, agriculture, and biotechnology. It's also an excellent textbook for graduate and upper-level undergraduate students in biochemistry, biology, and related fields.

Bioorganometallic Chemistry

Bioorganometallic Chemistry
Applications in Drug Discovery, Biocatalysis, and Imaging

by Gérard Jaouen,Michèle Salmain

  • Publisher : John Wiley & Sons
  • Release : 2015-04-20
  • Pages : 424
  • ISBN : 3527335277
  • Language : En, Es, Fr & De
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An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term "bioorganometallics", and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.