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Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
A Book

by Svetlana Dambinova,Ronald L Hayes,Kevin K.W. Wang

  • Publisher : Royal Society of Chemistry
  • Release : 2012-05-24
  • Pages : 246
  • ISBN : 1849734747
  • Language : En, Es, Fr & De
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Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students.

On Biomarkers in Traumatic Brain Injury

On Biomarkers in Traumatic Brain Injury
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 96
  • ISBN : 9789175498645
  • Language : En, Es, Fr & De
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Biomarkers of Traumatic Brain Injury with a Focus on Blast Injury

Biomarkers of Traumatic Brain Injury with a Focus on Blast Injury
A Book

by Stuart Edward Harrisson,University of Newcastle upon Tyne. Institute of Cellular Medicine

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 195
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Blood Biomarkers for Traumatic Brain Injury

Blood Biomarkers for Traumatic Brain Injury
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 70
  • ISBN : 9789162896706
  • Language : En, Es, Fr & De
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MRI Data Harmonization for Multi-center Comparison of Quantitative Biomarkers in Traumatic Brain Injury

MRI Data Harmonization for Multi-center Comparison of Quantitative Biomarkers in Traumatic Brain Injury
A Book

by Charlotte Timmermans

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biomarkers of Brain Damage – A Complex Challenge with Great Potential

Biomarkers of Brain Damage – A Complex Challenge with Great Potential
A Book

by Olli Tenovuo,Jean-charles Sanchez,Damir Janigro,Johan Undén

  • Publisher : Frontiers Media SA
  • Release : 2021-05-10
  • Pages : 129
  • ISBN : 2889667545
  • Language : En, Es, Fr & De
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Olli Tenovuo is consultant and member of SAB for NeuroTrauma Sciences LLC (Georgia, USA) and ABCDx SA (Geneva, Switzerland). Jean-Charles Sanchez has a research grant to disclose from ABCDx SA, (Geneva, Switzerland). Damir Janigro is the CEO of FloTBI Inc. (Cleveland, USA), a company interested in biomarkers of neurological diseases.

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders
A Book

by Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy

  • Publisher : CRC Press
  • Release : 2014-10-28
  • Pages : 650
  • ISBN : 1482239825
  • Language : En, Es, Fr & De
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This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Neurotrauma

Neurotrauma
A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury

by Kevin Wang

  • Publisher : Oxford University Press, USA
  • Release : 2018-12-05
  • Pages : 528
  • ISBN : 0190279435
  • Language : En, Es, Fr & De
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Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Neurotrauma

Neurotrauma
A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury

by Kevin Wang

  • Publisher : Oxford University Press
  • Release : 2018-11-07
  • Pages : 624
  • ISBN : 0190279451
  • Language : En, Es, Fr & De
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Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Biomarkers of Brain Injury in Children-Potential Uses and Limitations

Biomarkers of Brain Injury in Children-Potential Uses and Limitations
A Book

by Jirí Zurek

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2011-02
  • Pages : 120
  • ISBN : 9783844311808
  • Language : En, Es, Fr & De
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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Clinical examination has limited ability to assess injury severity or predict outcome. The identification of pathology- specific biomarkers can assist in the diagnosis and estimation of prognosis, and can serve as surrogate markers for monitoring the effectiveness of a treatment. Most of these biomarkers are mediators of responses to injury and subsequent cell damage or cell death. For patients with severe TBI, a biomarker may be helpful to predict which patients are likely to experience secondary insults and help prognosticate. The aims of this study were the correlations amongs biomarkers of brain injury in children with severity of brain injury, mortality and prediction of the final outcome.

Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury

Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury

by Stefania Mondello, Ronald L Hayes,András Büki, Frank C Tortella, Kevin K W Wang

  • Publisher : Frontiers Media SA
  • Release : 2015-02-25
  • Pages : 129
  • ISBN : 2889193918
  • Language : En, Es, Fr & De
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Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers

Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers
A Book

by Firas Kobeissy

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2014-09-30
  • Pages : 152
  • ISBN : 9783659614941
  • Language : En, Es, Fr & De
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Brain injury can exist in different forms; such conditions occur after mechanical trauma, such as traumatic brain injury (TBI) or after exposure to a number of recreational drugs such as MDMA, methamphetamine, or cocaine. Recent findings have provided some preliminary data showing that brain injury and drug abuse insults may share common pathway(s)leading to neuronal cell injury. Such pathways may be mediated by the activation of the protease families: the pronecrotic calpain and the proapoptotic caspase systems. These proteases can act on a number of substrates including the cytoskeletal proteins resulting in the breakdown products of such proteins can be used as biomarkers for brain injury insult (mechanical and chemical). The field of proteomics has been introduced as a new discipline for biomarker identification that allows for deciphering protein expression at very low concentrations. Having this in mind, neuroproteomics approach has been applied to identify the differential alterations of protein markers involved in two models of experimental traumatic brain injury as well as in drug abuse which showed high similarity in the underlying mechanisms leading to neuronal injury.

Imaging Biomarkers in the Hyper-acute Phase Following Traumatic Brain Injury

Imaging Biomarkers in the Hyper-acute Phase Following Traumatic Brain Injury
A Book

by Tim Lawrence

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Textbook of Traumatic Brain Injury, Third Edition

Textbook of Traumatic Brain Injury, Third Edition
A Book

by Jonathan M. Silver, M.D.,Thomas W. McAllister, M.D.,David B. Arciniegas, M.D.

  • Publisher : American Psychiatric Pub
  • Release : 2018-12-05
  • Pages : 985
  • ISBN : 1615371125
  • Language : En, Es, Fr & De
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Despite the increased public awareness of traumatic brain injury (TBI), the complexities of the neuropsychiatric, neuropsychological, neurological, and other physical consequences of TBI of all severities across the lifespan remain incompletely understood by patients, their families, healthcare providers, and the media. Keeping pace with advances in the diagnosis, treatment, and science of TBI, the Textbook of Traumatic Brain Injury, Third Edition, comprehensively fills this gap in knowledge. Nearly all 50 chapters feature new authors, all of them experts in their field. Chapters new to this edition include biomechanical forces, biomarkers, neurodegenerative dementias, suicide, endocrine disorders, chronic disease management, and social cognition. An entirely new section is devoted to the evaluation and treatment of mild TBI, including injuries in athletes, military service members and veterans, and children and adolescents. These chapters join newly updated sections on the assessment and treatment of the cognitive, emotional, behavioral, and other physical sequelae of TBI. The Textbook of Traumatic Brain Injury is a must-read for all of those working in any of the multitude of disciplines that contribute to the care and rehabilitation of persons with brain injury. This new volume is also a potentially useful reference for policymakers in both the public and private sectors.

Traumatic Brain Injury

Traumatic Brain Injury
Neurobiology, Diagnosis and Treatment

by Yongxia Zhou

  • Publisher : BoD – Books on Demand
  • Release : 2019-09-11
  • Pages : 166
  • ISBN : 1789842956
  • Language : En, Es, Fr & De
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Traumatic brain injury (TBI) is a significant public health problem. There are several advanced techniques available for the investigation of disease neurobiology, diagnosis, and treatment. This book covers many topics in the active TBI research field such as cumulative mild head injury review, brain changes, and risk factors, as well as post-concussion syndrome (PCS) definition, classification, and association with brain dysfunction. Brain changes, including blood flow, intracranial pressure, and neuroinflammation, the neurobiological basis of neuroprotective activation, as well as correlation with PCS, including sleep, are illustrated further. Furthermore, multiple biomarkers, including S-100?, UCH-L1, and GFAP for blood-brain barrier breakdown and neuronal injury, are reviewed thoroughly. Lastly, well-evaluated neuroprotective agents, hypothermia as a neuroprotective effect in TBI, and effects investigation, as well as sedation in TBI as a neurocritical and therapeutic strategy with different assessments, are reported. This book introduces readers to a number of perspectives, including TBI disease pathophysiology and post-concussion syndrome classification, associated brain changes, imaging diagnosis, and several useful biomarkers with high sensitivities, as well as multiple therapeutic strategies. Various advanced technical developments, upfront neuroimaging, and clinical data are presented together with comprehensive, up-to-date, and interesting examples. Detailed reviews and accurate illustrations together with objective and informative discussions of several challenging problems such as PCS and neuroprotective treatments are the advantages of this book. Finally, this book will hopefully convey the clinical aspects of TBI and help guide diagnosis and therapeutic research in this field.

Potential Biomarkers for Mild Traumatic Brain Injury

Potential Biomarkers for Mild Traumatic Brain Injury
Identification of Synaptic Proteins that are Differentially Regulated Following Exposure to Mild Shock Waves in Cultured Neurons and Intact Retina

by Vanessa Sarah Obourn

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 142
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gender Budgeting

Gender Budgeting
neueste Entwicklungen und Umsetzungsbeispiele

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 40
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Traumatic Brain Injury

Traumatic Brain Injury
Studies on Serum Biomarkers for Diagnosis and Single Nucleotide Polymorphisms to Predict Outcome

by Anada Raj Poovindran

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 364
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Concussions in Athletics

Concussions in Athletics
From Brain to Behavior

by Semyon M. Slobounov,Wayne J. Sebastianelli

  • Publisher : Springer Nature
  • Release : 2021-09-19
  • Pages : 442
  • ISBN : 3030755649
  • Language : En, Es, Fr & De
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Now in a fully revised and expanded second edition, this comprehensive text remains a timely and major contribution to the literature that addresses the neuromechanisms, predispositions, and latest developments in the evaluation and management of concussive injuries. Concussion, also known as mild traumatic brain injury, continues to be a significant public health concern with increased attention focusing on treatment and management of this puzzling epidemic as well as controversies within the field. The book is comprised of five thematic sections: current developments in evaluation; biomechanical mechanisms; neural substrates, biomarkers, genetics and brain imaging; pediatric considerations; and clinical management and rehabilitation. Since the publication of the original edition in 2014, much has changed regarding the current understanding of mild traumatic brain injury including development of more precise imaging modalities, development and classification of new biomarkers, and updates to clinical treatment and management of athletic concussion. This new edition will include new chapters targeting the influence of genetics on concussive injury, as well as an expansion on the knowledge of pediatric response to concussion and the influence of repetitive subconcussive impacts on athlete health. An invaluable contribution to the literature, Concussions in Athletics: From Brain to Behavior reestablishes itself as a state-of-the-art reference that will be of significant interest to a wide range of clinicians, researchers, administrators, and policy makers, and this updated version aims to narrow the gap between research findings and clinical management of sports-related concussion and other mild traumatic brain injury. The second edition also attempts to broaden the scope of the knowledge to apply to more professionals and pre-professionals in the fields of neuroscience, neuropsychology, and other allied health professionals that closely work with athletes and sports medicine professionals.

Leveraging Biomedical and Healthcare Data

Leveraging Biomedical and Healthcare Data
Semantics, Analytics and Knowledge

by Firas Kobeissy,Kevin Wang,Fadi A. Zaraket,Ali Alawieh

  • Publisher : Academic Press
  • Release : 2018-11-23
  • Pages : 225
  • ISBN : 012809561X
  • Language : En, Es, Fr & De
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Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research. Includes at each section resource pages containing a list of available curated raw and processed data that can be used by researchers in the field Provides demonstrative and relevant examples that serve as a general tutorial Presents a list of algorithm names and computational tools available for basic and clinical researchers