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Biomarkers in Cardiovascular Diseases

Biomarkers in Cardiovascular Diseases
A Book

by Dimitris Tousoulis,Christodoulos Stefanadis

  • Publisher : CRC Press
  • Release : 2013-07-29
  • Pages : 450
  • ISBN : 1466587148
  • Language : En, Es, Fr & De
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The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.

Biomarkers in Cardiovascular Disease

Biomarkers in Cardiovascular Disease
A Book

by Vijay Nambi

  • Publisher : Elsevier Health Sciences
  • Release : 2018-11-27
  • Pages : 400
  • ISBN : 0323548369
  • Language : En, Es, Fr & De
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Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.

Novel Biomarkers for Heart Disease

Novel Biomarkers for Heart Disease
A Book

by Michael Lichtenauer

  • Publisher : MDPI
  • Release : 2020-12-28
  • Pages : 420
  • ISBN : 3039438832
  • Language : En, Es, Fr & De
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Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.

Cardiac Biomarkers

Cardiac Biomarkers
Case Studies and Clinical Correlations

by Alan S. Maisel,Allan S. Jaffe

  • Publisher : Springer
  • Release : 2016-10-24
  • Pages : 370
  • ISBN : 3319429825
  • Language : En, Es, Fr & De
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This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know. The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.​

Circulating Biomarkers in Cardiovascular Disease - Book Edition of Disease Markers

Circulating Biomarkers in Cardiovascular Disease - Book Edition of Disease Markers
A Book

by E. Ingelsson

  • Publisher : Ios PressInc
  • Release : 2009-11-15
  • Pages : 94
  • ISBN : 9781607500575
  • Language : En, Es, Fr & De
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This publication gives a comprehensive overview of the current state of knowledge regarding circulating biomarkers in cardiovascular disease (CVD), a field which has a long history of using biomarkers for risk stratification. The blood lipid profile, including cholesterol fractions, was one of the first biomarkers to be established as a risk factor for CVD. The main focus of this work is the use of biomarkers in the risk stratification of healthy individuals and the early detection of subclinical disease.

Biomarkers in Disease: Methods, Discoveries and Applications

Biomarkers in Disease: Methods, Discoveries and Applications
Cardiovascular Disease

by Victor R. Preedy,Vinood B. Patel

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 600
  • ISBN : 9789400776791
  • Language : En, Es, Fr & De
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Cardiac Biomarkers

Cardiac Biomarkers
Expert Advice for Clinicians

by Alan S Maisel

  • Publisher : JP Medical Ltd
  • Release : 2012-01-01
  • Pages : 239
  • ISBN : 9350255642
  • Language : En, Es, Fr & De
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Cardiac Biomarkers describes the most recent developments in the field of biomarkers, providing best practice and current guidelines. It also discusses how these guidelines may alter in the future. With contributions from internationally-based clinicians and scientists, this book includes almost 100 detailed images and illustrations. Topics covered include: Markers of Cardiac Arrest, Markers of Cardiac Ischemia, Natriuretic Peptides for Heart Failure, Biomarkers in Cardio Renal Disease and Future Developments.

Cardiovascular Biomarkers

Cardiovascular Biomarkers
Pathophysiology and Disease Management

by David A. Morrow

  • Publisher : Springer Science & Business Media
  • Release : 2010-04-28
  • Pages : 640
  • ISBN : 9781597450515
  • Language : En, Es, Fr & De
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In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.

Biomarkers in Heart Disease

Biomarkers in Heart Disease
A Book

by James de Lemos

  • Publisher : John Wiley & Sons
  • Release : 2009-01-26
  • Pages : 256
  • ISBN : 1444300210
  • Language : En, Es, Fr & De
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Biomarkers in Heart Disease is the first title in the AHAClinical Series and is aimed at meeting the needs of clinicians,providing cardiologists, internists, emergency physicians,laboratorians, and other healthcare providers with a clearunderstanding of the role of biomarkers in contemporarycardiovascular medicine. The book covers both the strengths and pitfalls of currentlyavailable markers, and provides information on the most promisingbiomarkers that are likely to impact practice in the next fewyears. It is divided into four parts, organized around clinicalscenarios rather than individual biomarkers. This book will help the practicing physician decide whichbiomarkers to measure, when to measure them, how to interpret theresults and how to make decisions based on the test result.

Cardiac Biomarkers in Clinical Practice

Cardiac Biomarkers in Clinical Practice
A Book

by James L. Januzzi

  • Publisher : Jones & Bartlett Learning
  • Release : 2011
  • Pages : 892
  • ISBN : 0763761613
  • Language : En, Es, Fr & De
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Cardiac Biomarkers in Clinical Practice was just honored with 4 Stars from Doody's Book Review! Cardiac Biomarkers in Clinical Practice presents a case based approach to biomarkers in heart diseases including heart failure, ischemic heart disease, and outpatient. Divided into six sections, this book provides physicians and other health care providers with a clear understanding of the role of biomarkers in clinical cardiovascular medicine.

Circulating Cells as Biomarkers in Cardiovascular Disease

Circulating Cells as Biomarkers in Cardiovascular Disease
The Difference Between Men and Women

by Thijs Jan Zweers

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 237
  • ISBN : 9789462039582
  • Language : En, Es, Fr & De
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Integrated Biomarkers in Cardiovascular Disease

Integrated Biomarkers in Cardiovascular Disease
Third International Symposium

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 3
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biomarkers and cardiovascular disease in HIV infection

Biomarkers and cardiovascular disease in HIV infection
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Exosomes in Cardiovascular Diseases

Exosomes in Cardiovascular Diseases
Biomarkers, Pathological and Therapeutic Effects

by Junjie Xiao,Sanda Cretoiu

  • Publisher : Springer
  • Release : 2017-09-19
  • Pages : 307
  • ISBN : 9811043973
  • Language : En, Es, Fr & De
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The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Quantification of Imaging Biomarkers for Cardiovascular Disease in CT(A).

Quantification of Imaging Biomarkers for Cardiovascular Disease in CT(A).
A Book

by Rahil Shahzad

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 129
  • ISBN : 9789064647055
  • Language : En, Es, Fr & De
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Proteomic, Circulating and Functional Biomarkers of Cardiovascular Disease

Proteomic, Circulating and Functional Biomarkers of Cardiovascular Disease
A Book

by Ulf Neisius

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Trends in Biomarkers and Diseases: An Overview

New Trends in Biomarkers and Diseases: An Overview
A Book

by Juan Antonio Vílchez,María Dolores Albaladejo-Otón

  • Publisher : Bentham Science Publishers
  • Release : 2017-09-29
  • Pages : 568
  • ISBN : 1681084953
  • Language : En, Es, Fr & De
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Biomarkers are any measurable biochemical characteristics of an organism that reflect a particular physiological state. Biomarkers can take many different forms including particular proteins or peptides, antibodies, cell types, metabolites, hormones, enzyme levels, compounds related to genomics, etc. A biomarker can also be a substance introduced into a patient to assess the internal organ systems role. In medicine, biomarkers considered as compounds isolated from serum, urine, or other fluids, can be used as an indicator of the presence or severity of a particular disease state. The use of biomarkers is becoming a fundamental practice in medicine, Biomarker research involves a significantly greater scope of laboratory medicine. This monograph presents information on several types of biomarkers for general pathologies (preeclampsia, metabolic syndrome, iron metabolism, bone disease, liver function, renal function), cardiovascular pathology (including atrial fibrillation, peripheral artery disease, thrombotic disorders) and sepsis. Additional information on endocrine and salivary biomarkers is also presented. New Trends in Biomarkers and Diseases: An Overview is an ideal reference for medical students, pathology trainees and clinical researchers seeking information on biomarkers in medicine.

Integrin Activation on Circulating Inflammatory Monocytes

Integrin Activation on Circulating Inflammatory Monocytes
Biomarkers of Cardiovascular Disease Risk

by Greg Allen Foster

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 129
  • ISBN : 9781339542508
  • Language : En, Es, Fr & De
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Coronary artery disease (CAD) results in the narrowing of the small blood vessels that supply oxygen to the heart and is the major cause of morbidity and mortality in the U.S. Since CAD is largely asymptomatic, clinicians rely on biomarkers in the blood (e.g., low- and high-density lipoprotein cholesterol, C-reactive protein, and triglyceride levels) to determine cardiovascular risk and to guide therapy for an individual patient. However, these conventional biomarkers lack in specificity to inform on vascular health, as they fail to identify >20% of subjects at risk for future complications resulting from coronary blockage. Atherosclerosis underlying CAD is dependent on the recruitment of circulating monocytes to inflamed endothelium expressing vascular cell adhesion molecule-1 (VCAM-1). Therefore, the objectives of this work were: 1) develop unique assays to assess the functional phenotype of circulating monocytes during inflammation associated with atherogenesis, 2) characterize the relationship between activated monocytes and cardiovascular risk, and 3) elucidate the mechanism through which activated blood monocytes recruit to inflamed endothelium. To address the objectives of this dissertation, we fabricated a microfluidic based lab-on-a-chip to quantify the adhesion efficiency of monocytes sheared in whole blood on VCAM-1. The lab-chip device, combined with fluorescent antibody labeling against CD14 and CD16, allowed us to characterize the recruitment efficiency of monocyte subsets, in particular the inflammatory CD14++CD16+ (Mon2). We found that Mon2 adhered with 7-fold higher efficiency than other subsets and capture was dependent on integrins CD11c/CD18 and very late antigen-4 (VLA-4). To characterize the relationship between capture of inflammatory Mon2 and cardiovascular risk, we studied a range of subjects that included otherwise healthy individuals with elevated serum triglyceride levels to patients presenting with acute myocardial infarction resulting from coronary disease. We found that Mon2 from hypertriglyceridemic subjects exhibited increased CD11c expression and capture on VCAM-1 compared to subjects with normal serum triglyceride levels. CD11c expression and capture efficiency was further elevated in patients with known CAD suggesting a hierarchal relationship between activation of Mon2 and cardiovascular disease risk. Upregulation of CD11c in blood was attributable to Mon2 uptake of triglyceride rich lipoproteins and subsequent signaling via a phospholipase C (PLC)-dependent mechanism to increase CD11c expression, VLA-4 function, and integrin co-clustering within focal adhesive sites on VCAM-1. Using a unique antibody that allosterically binds CD11c and induces a high affinity conformation, we found that outside-in activation of CD11c on the membrane directly activated VLA-4 adhesion via phospho-spleen tyrosine kinase (pSyk) and paxillin within focal adhesion complexes. In summary, this work reveals that CD11c is an inducible integrin on inflammatory Mon2, whose expression correlates with monocyte inflammatory state in subjects at risk for atherogenesis and in patients with CAD. Therefore CD11c on Mon2 is a biomarker of cardiovascular risk and a potential target for drug therapy to ameliorate the recruitment of inflammatory monocytes during atherogenesis.

Exploring the Associations Between Diabetes, Fibrosis-related Biomarkers, and Cardiovascular Disease

Exploring the Associations Between Diabetes, Fibrosis-related Biomarkers, and Cardiovascular Disease
A Book

by Isha Agarwal

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 198
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Circulating MicroRNAs

Circulating MicroRNAs
Methodological Solutions to Identify Biomarkers for Cardiovascular Disease

by Maurice Wilhelmus Jacobus Ronde

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 275
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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