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Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
A Book

by Subhas Kundu,Rui L. Reis

  • Publisher : Elsevier
  • Release : 2020-08-22
  • Pages : 772
  • ISBN : 012818129X
  • Language : En, Es, Fr & De
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Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models
A Book

by J. Miguel Oliveira,Rui L. Reis

  • Publisher : Springer Nature
  • Release : 2020-04-13
  • Pages : 175
  • ISBN : 3030365883
  • Language : En, Es, Fr & De
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This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Cell-derived Matrices

Cell-derived Matrices
A Book

by Rui L. Reis

  • Publisher : Academic Press
  • Release : 2020-05
  • Pages : 312
  • ISBN : 0128201746
  • Language : En, Es, Fr & De
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Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell-Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more.

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics
Evolution and Innovation

by Kinam Park

  • Publisher : Woodhead Publishing
  • Release : 2020-03-05
  • Pages : 782
  • ISBN : 0081029845
  • Language : En, Es, Fr & De
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Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Covers synthetic vaccines, proteins and polymers for cancer therapeutics

Biomaterials Science

Biomaterials Science
An Introduction to Materials in Medicine

by William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski

  • Publisher : Academic Press
  • Release : 2020-05-23
  • Pages : 1616
  • ISBN : 0128161388
  • Language : En, Es, Fr & De
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The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for each chapter

Cell-Derived Matrices Part B

Cell-Derived Matrices Part B
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-04-23
  • Pages : 264
  • ISBN : 0128201754
  • Language : En, Es, Fr & De
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Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics surrounding the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as the quantification of mechanical properties, decellularization protocols, and innovative matrix engineering methods

Cell-derived Matrices Part A

Cell-derived Matrices Part A
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-03-26
  • Pages : 350
  • ISBN : 0128201738
  • Language : En, Es, Fr & De
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Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics on the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as quantification of the mechanical properties, decellularization protocols, and innovative matrix engineering methods

The Investigation of Regulation of Glioma Cell Migration in a Three-dimensional Model

The Investigation of Regulation of Glioma Cell Migration in a Three-dimensional Model
A Book

by Pranita Kaphle

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 71
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The invasion of glioblastoma is a complex process that involves coordinated interactions between tumor cells and the extracellular matrix. Biomaterial scaffolds now show promise in forming in vitro and in vivo three-dimensional (3D) cancer models and can generate an in vitro micro-environmental context that mimics the complexity of the tumor tissue in vivo. Higher expression of MMP-2 and MMP-9 and plasminogen activator in tumor cells is correlated with an increased grade of glioblastoma malignancy. In this study, we fabricated a microtumor and investigated the effect of viscosity of collagen hydrogel and the inhibitors of MMPs and plasminogen activators on migration of glioblastoma cells in collagen hydrogel. The cell viability and proliferation of microtumors were studied by LIVE/DEAD assay and AlamarBlue assay respectively. qRT-PCR was performed to study MMP-2, MMP-9 and plasminogen activator gene expression in collagen hydrogels. Time-lapse imaging was recorded to quantify tumor cell migration speed and distance in collagen hydrogel and in collagen hydrogels containing inhibitors of MMP-2, MMP-9 and plasminogen activator. Crosslinking of collagen hydrogels increased the viscosity of collagen hydrogel and decreased tumor cell migration distance and velocity. Crosslinking reduced the tumor cell-mediated degradation rate of the hydrogels. The inhibitors of MMP-2 and MMP-9 reduced tumor cell migration speed on cell culture dishes or in hydrogels. Although tranexamic acid and aprotinin did not change the tumor cell migration on cell culture dish, they significantly reduced the cell migration in collagen hydrogels. The similar inhibition effect of MMP-2 and MMP-9 inhibitors on tumor cell migration on cell culture dish and in hydrogels was observed in this study. This study demonstrated that the increased ECM viscosity can limit glioma cell migration and demonstrates the different functions of pharmacologic inhibitors on glioma cell motility in a 3D matrix against a 2D environment.

Tumor Organoids

Tumor Organoids
A Book

by Shay Soker,Aleksander Skardal

  • Publisher : Humana Press
  • Release : 2017-10-20
  • Pages : 213
  • ISBN : 3319605119
  • Language : En, Es, Fr & De
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Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

3D microtissue models to target tumor dormancy and invasion processes

3D microtissue models to target tumor dormancy and invasion processes
Novel high-content application of 3D cell culture models for early drug discovery and screening

by Carsten Wenzel

  • Publisher : GRIN Verlag
  • Release : 2016-07-04
  • Pages : 142
  • ISBN : 366825172X
  • Language : En, Es, Fr & De
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Doctoral Thesis / Dissertation from the year 2014 in the subject Medicine - Biomedical Engineering, grade: 1,0, Technical University of Berlin (Biotechnologie), language: English, abstract: Despite all efforts to discover novel therapeutic options to treat cancer the disease remains devastating causing more than 14 million deaths in 2012 - and the trend is rising. Some parts of the preclinical drug discovery process rely on cell culture models to reproduce the pathophysiological features of cancer in in vitro experiments. These cellular models are then used in screening campaigns that aim to identify substances such as small molecules, peptides, or interfering RNA that alter the phenotype of a cancer cell in a desired manner. One of the main properties of cancer cells is their uncontrolled cell division. Accordingly, the cell cycle is a major target for chemotherapy, but resistance to chemotherapy frequently causes treatment failure in patients with advanced and inoperable cancer. As the distance from supplying blood vessels increases, oxygen and nutrient concentrations decrease and cancer cells react by halting cell cycle progression and entering a dormant state. As cytostatic drugs mainly target proliferating cells, cancer cell dormancy is considered a major resistance mechanism to this class of anti-cancer drugs. Therefore, substances that target cancer cells in poorly vascularized tumor regions have the potential to enhance cytostatic-based chemotherapy in solid tumors. Multicellular tumor spheroids (MCTS) allow for three-dimensional growth conditions, thus reproducing several parameters of the tumor microenvironment, including oxygen and nutrient gradients as well as the development of dormant tumor regions. Here, the evaluation of a 3D cell culture high-content screening system led to the identification of nine substances from two commercially available drug libraries that specifically target cells in inner MCTS core regions. Subsequently, the mode of action of the identified compounds could be identified as respiratory chain inhibitors. Ultimately, benefits in combinational treatment with commonly used cytostatics in MCTS were proven. The data suggest a rationale to find and evaluate new substances that target the altered metabolism of tumor cells in dormant tumor regions to enhance cytostaticbased therapies. In a second approach the combination of different cell types in a 3D cell co-culture model was evaluated, which allows monitoring of invasion processes in different malignancies. Among them idiopathic pulmonary fibrosis (IPF) currently affects 50.000 people per year with high mortality rates. [...]

Bioinspired Materials Science and Engineering

Bioinspired Materials Science and Engineering
A Book

by Guang Yang,Lin Xiao,Lallepak Lamboni

  • Publisher : John Wiley & Sons
  • Release : 2018-08-21
  • Pages : 400
  • ISBN : 111939032X
  • Language : En, Es, Fr & De
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An authoritative introduction to the science and engineering of bioinspired materials Bioinspired Materials Science and Engineering offers a comprehensive view of the science and engineering of bioinspired materials and includes a discussion of biofabrication approaches and applications of bioinspired materials as they are fed back to nature in the guise of biomaterials. The authors also review some biological compounds and shows how they can be useful in the engineering of bioinspired materials. With contributions from noted experts in the field, this comprehensive resource considers biofabrication, biomacromolecules, and biomaterials. The authors illustrate the bioinspiration process from materials design and conception to application of bioinspired materials. In addition, the text presents the multidisciplinary aspect of the concept, and contains a typical example of how knowledge is acquired from nature, and how in turn this information contributes to biological sciences, with an accent on biomedical applications. This important resource: Offers an introduction to the science and engineering principles for the development of bioinspired materials Includes a summary of recent developments on biotemplated formation of inorganic materials using natural templates Illustrates the fabrication of 3D-tumor invasion models and their potential application in drug assessments Explores electroactive hydrogels based on natural polymers Contains information on turning mechanical properties of protein hydrogels for biomedical applications Written for chemists, biologists, physicists, and engineers, Bioinspired Materials Science and Engineering contains an indispensible resource for an understanding of bioinspired materials science and engineering.

Evaluation of a Biomaterial-based Three-dimensional Model of Breast Cancer Metastasis

Evaluation of a Biomaterial-based Three-dimensional Model of Breast Cancer Metastasis
A Book

by Jenna Evelyn Al-Saleh

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 224
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Breast cancer metastasis (BCM) remains one of the leading causes of death in women with cancer. Research over the last several decades has indicated that the microenvironment plays a critical role in the activation of the metastatic cascade. Inflammatory cytokines secreted by adipocytes in the tumor microenvironment, such as leptin, can play key roles in metastasis and are of interest as predictive diagnostic indicators. In this work, three-dimensional (3D) chitosan-collagen scaffolds were created and evaluated to characterize their mechanical properties. Studies were performed to assess cell viability and metastatic protein expression to determine the scaffold efficacy for mimicking BCM. Leptin was then incorporated into the 3D models to study the effects of leptin on BCM. Expression of metastasis-related cytokines was measured towards building a proof-of-concept statistical model for predicting BCM based on varying levels of biomarkers, such as leptin.

Mathematical Models for Glioma Invasion in 3d Collagen-I Gel

Mathematical Models for Glioma Invasion in 3d Collagen-I Gel
A Book

by Andrew M. Stein

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biofabrication and 3D Tissue Modeling

Biofabrication and 3D Tissue Modeling
A Book

by Dong-Woo Cho

  • Publisher : Royal Society of Chemistry
  • Release : 2019-01-02
  • Pages : 369
  • ISBN : 1788011988
  • Language : En, Es, Fr & De
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3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Biomaterials for Brain Therapy and Repair

Biomaterials for Brain Therapy and Repair
A Book

by Sara Pedron,Brendan A.C. Harley

  • Publisher : Frontiers Media SA
  • Release : 2019-02-06
  • Pages : 329
  • ISBN : 2889457478
  • Language : En, Es, Fr & De
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Prevalence of brain related diseases is expected to increase significantly in the next decades. Therefore, there is a vital need to develop effective, personalized models of human brain that can provide information about brain development, and the unique neurobiology of brain disorders. The use of biomaterials can play a strategic role for the future understanding and treatment of complex CNS diseases. Three-dimensional brain cultures have shown promise in disease modelling, cell transplantation and modulation of tissue repair.

Multi-Parametric Live Cell Microscopy of 3D Tissue Models

Multi-Parametric Live Cell Microscopy of 3D Tissue Models
A Book

by Ruslan I. Dmitriev

  • Publisher : Springer
  • Release : 2017-10-26
  • Pages : 172
  • ISBN : 3319673580
  • Language : En, Es, Fr & De
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This book provides an essential overview of existing state-of-the-art quantitative imaging methodologies and protocols (intensity-based ratiometric and FLIM/ PLIM). A variety of applications are covered, including multi-parametric quantitative imaging in intestinal organoid culture, autofluorescence imaging in cancer and stem cell biology, Ca2+ imaging in neural ex vivo tissue models, as well as multi-parametric imaging of pH and viscosity in cancer biology. The current state-of-the-art of 3D tissue models and their compatibility with live cell imaging is also covered. This is an ideal book for specialists working in tissue engineering and designing novel biomaterial.

Cell Culture Technology

Cell Culture Technology
A Book

by Cornelia Kasper,Verena Charwat,Antonina Lavrentieva

  • Publisher : Springer
  • Release : 2018-10-10
  • Pages : 168
  • ISBN : 3319748548
  • Language : En, Es, Fr & De
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This textbook provides an overview on current cell culture techniques, conditions, and applications specifically focusing on human cell culture. This book is based on lectures, seminars and practical courses in stem cells, tissue engineering, regenerative medicine and 3D cell culture held at the University of Natural Resources and Life Sciences Vienna BOKU and the Gottfried Wilhelm Leibniz University Hannover, complemented by contributions from international experts, and therefore delivers in a compact and clear way important theoretical, as well as practical knowledge to advanced graduate students on cell culture techniques and the current status of research. The book is written for Master students and PhD candidates in biotechnology, tissue engineering and biomedicine working with mammalian, and specifically human cells. It will be of interest to doctoral colleges, Master- and PhD programs teaching courses in this area of research.

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies
A Book

by Hasan Uludag,Abhay Pandit,Liisa Kuhn

  • Publisher : Frontiers Media SA
  • Release : 2020-07-14
  • Pages : 329
  • ISBN : 2889638537
  • Language : En, Es, Fr & De
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Comparison of 2D and 3D Iterative Watershed Segmentation Methods in Hepatic Tumor Volumetrics

Comparison of 2D and 3D Iterative Watershed Segmentation Methods in Hepatic Tumor Volumetrics
A Book

by Shonket Ray

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 192
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Deformable Models

Deformable Models
Theory and Biomaterial Applications

by Aly Farag

  • Publisher : Springer Science & Business Media
  • Release : 2007-08-02
  • Pages : 581
  • ISBN : 0387312048
  • Language : En, Es, Fr & De
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This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. The book focuses on the core image processing techniques, theory and biomaterials useful to research and industry. Contributors are all pioneers in the field.