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Biopharmaceutics and Pharmacokinetics Considerations

Biopharmaceutics and Pharmacokinetics Considerations
A Book

by Rakesh Tekade

  • Publisher : Elsevier
  • Release : 2021-07-29
  • Pages : 752
  • ISBN : 0128144254
  • Language : En, Es, Fr & De
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Biopharmaceutics and Pharmacokinetics Considerations examines the history as well as the current state of the field within pharmaceutical sciences and concisely explains the history of biopharmaceutics and pharmacokinetics including key developments. It provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce as well as the movement of drugs within the body. This book provides a comprehensive examination suitable for researchers working in the pharmaceutical, cosmetics, biotechnology, and related industries as well as advanced students in these fields.

Biopharmaceutics and Pharmacokinetics Considerations

Biopharmaceutics and Pharmacokinetics Considerations
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2021-07-15
  • Pages : 752
  • ISBN : 0128144262
  • Language : En, Es, Fr & De
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Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics
A Book

by Milo Gibaldi

  • Publisher : Lippincott Williams & Wilkins
  • Release : 1991
  • Pages : 406
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.

Pharmacokinetics and Toxicokinetic Considerations

Pharmacokinetics and Toxicokinetic Considerations
A Book

by Rakesh Tekade

  • Publisher : Academic Press
  • Release : 2021-12-15
  • Pages : 670
  • ISBN : 9780323983679
  • Language : En, Es, Fr & De
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Biopharmaceutics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. Part of the Advances in Pharmaceutical Product Development and Research series, it provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It will expound strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. It also offers focused elaborations on various bioanalytical methods for Bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. This book will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists Allows readers to integrate up-to-date research findings into designing their laboratory work systematically Presents focused explorations of bioanalytical methods for Bioavailability and bioequivalence assessment Provides clinical applications of concepts

Biopharmaceutics Applications in Drug Development

Biopharmaceutics Applications in Drug Development
A Book

by Rajesh Krishna,Lawrence Yu

  • Publisher : Springer Science & Business Media
  • Release : 2007-09-20
  • Pages : 396
  • ISBN : 038772379X
  • Language : En, Es, Fr & De
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The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Biopharmaceutics & Pharmacokinetics

Biopharmaceutics & Pharmacokinetics
A Book

by Dr. A. R. Paradkar

  • Publisher : Pragati Books Pvt. Ltd.
  • Release : 2008-10-06
  • Pages : 150
  • ISBN : 9788185790374
  • Language : En, Es, Fr & De
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Biotechnology and Biopharmaceuticals

Biotechnology and Biopharmaceuticals
Transforming Proteins and Genes into Drugs

by Anonim

  • Publisher : John Wiley & Sons
  • Release : 2013-12-16
  • Pages : 744
  • ISBN : 111817979X
  • Language : En, Es, Fr & De
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Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Dosage Form Design Considerations

Dosage Form Design Considerations
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-07-28
  • Pages : 820
  • ISBN : 0128144246
  • Language : En, Es, Fr & De
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Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. Examines the history and recent developments in drug dosage forms for pharmaceutical sciences Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics
An Introduction, Fourth Edition,

by Notari

  • Publisher : Routledge
  • Release : 2017-11-22
  • Pages : 440
  • ISBN : 1351463845
  • Language : En, Es, Fr & De
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For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics.Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses.Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics.As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.

Essentials of Biopharmaceutics and Pharmacokinetics - E-Book

Essentials of Biopharmaceutics and Pharmacokinetics - E-Book
A Book

by Ashutosh Kar

  • Publisher : Elsevier Health Sciences
  • Release : 2010-09-15
  • Pages : 368
  • ISBN : 813123262X
  • Language : En, Es, Fr & De
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Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.

Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems

Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems
A Book

by Loyd V. Allen,Nicholas G. Popovich,Howard C. Ansel

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 710
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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"Thanks to its comprehensive coverage, clear explanations, and logical organization, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems has been a core pharmaceutics text in the pharmacy curriculum for more than 40 years. As you progress through this thoroughly updated Ninth Edition, you'll master all the principles, practices, and technologies essential for the preparation of pharmaceutical dosage forms and drug delivery systems. The text's integrated approach will help you understand the interrelationships among pharmaceutical and biopharmaceutical principles, product design, formulation, manufacturing, compounding, and the clinical application of dosage forms for effective patient care." --Book Jacket.

Pharmacology and Pharmacologists

Pharmacology and Pharmacologists
An International Directory

by Oxford University Press

  • Publisher : Oxford University Press, USA
  • Release : 1981
  • Pages : 387
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Essentials Of Biopharmaceutics And Pharmacokinetics

Essentials Of Biopharmaceutics And Pharmacokinetics
A Book

by Kar

  • Publisher : Elsevier Health Sciences
  • Release : 2010
  • Pages : 329
  • ISBN : 8131226395
  • Language : En, Es, Fr & De
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Introduction to Biopharmaceutics

Introduction to Biopharmaceutics
A Book

by Milo Gibaldi

  • Publisher : Unknown Publisher
  • Release : 1971
  • Pages : 80
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics
A Book

by Leon Shargel,Andrew B. C. Yu

  • Publisher : McGraw-Hill/Appleton & Lange
  • Release : 1993
  • Pages : 625
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition
A Book

by Leon Shargel,Susanna Wu-Pong,Andrew Yu

  • Publisher : McGraw Hill Professional
  • Release : 2004-09-09
  • Pages : 892
  • ISBN : 0071501878
  • Language : En, Es, Fr & De
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The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics! 4 STAR DOODY'S REVIEW! "The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Applied Biopharmaceutics & Pharmacokinetics

Applied Biopharmaceutics & Pharmacokinetics
A Book

by Leon Shargel,Susanna Wu-Pong,Andrew B. C. Yu

  • Publisher : McGraw-Hill Medical Publishing
  • Release : 2005
  • Pages : 892
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Annotation The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Suppositories

Suppositories
A Book

by Loyd V. Allen,Dennis B. Worthen,Bill Mink

  • Publisher : Unknown Publisher
  • Release : 2007-10-26
  • Pages : 245
  • ISBN : 9780853696469
  • Language : En, Es, Fr & De
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This is an essential resource for all those involved in the formulation, development, manufacture and testing of suppositories.The administration of drugs using a suppository base formulation is particularly useful in paediatrics, debilitated patients and 'non-oral' patients. Depending on the excipient used, it is possible to control the release of the active pharmaceutical ingredient, thus offering some advantages in specific drug regimens over other dosage forms.Many suppository formulations have been developed for a number of therapeutic aims, however comprehensive reliable information on suppository formulation is not always readily available. "Suppositories" resolves this situation by providing up-to-date, comprehensive information in one point of reference."Suppositories" provides a detailed review of suppository dosage forms with chapters covering: the history and development of the suppository; suppository bases and their characteristics; pharmaceutical, biopharmaceutical and pharmacokinetic factors; formulation considerations; manufacturing and compounding suppositories; special types of suppositories; quality control; packaging and labelling; stability and storage; and clinical considerations.This book is an essential resource for all those involved in the formulation, development, manufacture and testing of suppositories.

Preclinical Safety Evaluation of Biopharmaceuticals

Preclinical Safety Evaluation of Biopharmaceuticals
A Science-Based Approach to Facilitating Clinical Trials

by Joy A. Cavagnaro

  • Publisher : John Wiley & Sons
  • Release : 2013-03-07
  • Pages : 1064
  • ISBN : 1118679385
  • Language : En, Es, Fr & De
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"The goal is to provide a comprehensive reference book for thepreclinicaldiscovery and development scientist whoseresponsibilities span target identification, lead candidateselection, pharmacokinetics, pharmacology, and toxicology, and forregulatory scientists whose responsibilities include the evaluationof novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictivevalue, lessen the time and cost of launching newbiopharmaceuticals, and speed potentially lifesaving drugs tomarket. This guide covers topics ranging from lead candidateselection to establishing proof of concept and toxicity testing tothe selection of the first human doses. With chapters contributedby experts in their specific areas, Preclinical SafetyEvaluation of Biopharmaceuticals: A Science-Based Approach toFacilitating Clinical Trials: Includes an overview of biopharmaceuticals with information onregulation and methods of production Discusses the principles of ICH S6 and their implementation inthe U.S., Europe, and Japan Covers current practices in preclinical development andincludes a comparison of safety assessments for small moleculeswith those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process,including: the selection of relevant species; safety/toxicityendpoints; specific considerations based upon class; and practicalconsiderations in the design, implementation, and analysis ofbiopharmaceuticals Covers transitioning from preclinical development to clinicaltrials This is a hands-on, straightforward reference for professionalsinvolved in preclinical drug development, including scientists,toxicologists, project managers, consultants, and regulatorypersonnel.

Pharmacokinetics in Drug Development

Pharmacokinetics in Drug Development
Advances and Applications

by Peter L. Bonate,Danny R. Howard

  • Publisher : Springer
  • Release : 2011-02-23
  • Pages : 319
  • ISBN : 9781441979360
  • Language : En, Es, Fr & De
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The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling. Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection. Important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.