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Bioreactor Modeling

Bioreactor Modeling
Interactions between Hydrodynamics and Biology

by Jerome Morchain

  • Publisher : Elsevier
  • Release : 2017-10-06
  • Pages : 218
  • ISBN : 0081011660
  • Language : En, Es, Fr & De
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Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).
A Book

by CRAIG REED HALBERSTADT

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 123
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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antibody production. Whether the increase in antibody production is due to autocrine/paracrine factors, local pH concentrations, pulsatile delivery of growth factors or some other mechanism is unknown and requires further study.

Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
Fundamentals of Design and Operation

by David A. Mitchell,Nadia Krieger,Marin Berovic

  • Publisher : Springer Science & Business Media
  • Release : 2006-08-02
  • Pages : 448
  • ISBN : 3540312862
  • Language : En, Es, Fr & De
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This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Development of a Multicompartmental, Multiple Cell Type Bioreactor and Corresponding Pharmacokinetic Model for Naphthalene

Development of a Multicompartmental, Multiple Cell Type Bioreactor and Corresponding Pharmacokinetic Model for Naphthalene
A Book

by Lisa Marie Sweeney

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 278
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modeling Analysis of and Human-human Hybridoma Culture in an Intercalated-spiral Alternate-dead-ended Hollow Fiber Bioreactor

Modeling Analysis of and Human-human Hybridoma Culture in an Intercalated-spiral Alternate-dead-ended Hollow Fiber Bioreactor
A Book

by John D. Brotherton

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 438
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Model of a Split-flow Airlift Bioreactor for Attachment-dependent Baculovirus Infected Insect Cells

A Model of a Split-flow Airlift Bioreactor for Attachment-dependent Baculovirus Infected Insect Cells
A Book

by Arun Kumar

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 144
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modeling and Simulation of Bioreactor Process Dynamics

Modeling and Simulation of Bioreactor Process Dynamics
A Book

by C. Kleinstreuer,T. Poweigha

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 56
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recombinant DNA Technology and Applications

Recombinant DNA Technology and Applications
A Book

by Aleš Prokop,Rakesh K. Bajpai

  • Publisher : McGraw-Hill Companies
  • Release : 1991
  • Pages : 619
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioreactors

Bioreactors
Design, Operation and Novel Applications

by Carl-Fredrik Mandenius

  • Publisher : John Wiley & Sons
  • Release : 2016-02-16
  • Pages : 520
  • ISBN : 3527683372
  • Language : En, Es, Fr & De
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In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Ethanol Production in a Multimembrane Bioreactor

Ethanol Production in a Multimembrane Bioreactor
Cell and Reactor Modeling and Continuous Fermentation

by David Ethan Steinmeyer

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 552
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioreactors

Bioreactors
Animal Cell Culture Control for Bioprocess Engineering

by Goutam Saha,Alok Barua,Satyabroto Sinha

  • Publisher : CRC Press
  • Release : 2017-12-01
  • Pages : 136
  • ISBN : 1498736025
  • Language : En, Es, Fr & De
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Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

The Third Pacific Chemical Engineering Congress: Energy & resource, process modeling, process simulation, process dynamics & control, computer applications

The Third Pacific Chemical Engineering Congress: Energy & resource, process modeling, process simulation, process dynamics & control, computer applications
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 1717
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings: Energy & resource. Process modeling. Process simulation. Process dynamics & control. Computer applications

Proceedings: Energy & resource. Process modeling. Process simulation. Process dynamics & control. Computer applications
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modeling and Control of Biotechnical Processes 1992, (2nd IFAC Symposium) and Computer Applications in Fermentation Technology (5th International Conference)

Modeling and Control of Biotechnical Processes 1992, (2nd IFAC Symposium) and Computer Applications in Fermentation Technology (5th International Conference)
Selected Papers from the IFAC and ICCAFT 5 Meetings, Keystone, Colorado, USA, 29 March - 2 April 1992

by Mohammed Nazmul Karim,G. Stephanopoulos

  • Publisher : Pergamon
  • Release : 1992
  • Pages : 482
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Hardbound. This volume provides the state-of-the-art findings of control theory and applications of biotechnical processes. Topics covered include neural networks and their applications, modeling, identification, AI and expert systems.

Recombinant DNA Technology I

Recombinant DNA Technology I
A Book

by Aleš Prokop,Rakesh K. Bajpai

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 386
  • ISBN : 9780897666732
  • Language : En, Es, Fr & De
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This volume contains 46 papers, the proceedings of a conference sponsored by the Engineering Foundation in June 1990. The research of geneticists, molecular biologists, biochemists and cell biologists involved in cloning and cell culturing is integrated with reports from technologists and engineers in large scale bioprocessing, manufacturing and facility design. There are sections on cloning; optimisation of gene expression; protein recovery and purification; bio-reactor design, monitoring, control and scale-up.

Modeling Methods for Predicting Polymer Process Dynamics and Product Properties

Modeling Methods for Predicting Polymer Process Dynamics and Product Properties
The Effects of Mixing and Catalyst Characteristics

by Gary James Wells

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 396
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biotechnology

Biotechnology
A Multi-volume Comprehensive Treatise. Index

by Hans-Jürgen Rehm,Gerald Reed

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings of the ... European Simulation Multiconference

Proceedings of the ... European Simulation Multiconference
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Design of a Bioreactor System for the Study of the Interactions of Trace Metals and Microbial Cells at the Solid-solution Interface

Design of a Bioreactor System for the Study of the Interactions of Trace Metals and Microbial Cells at the Solid-solution Interface
A Book

by Ke Ming Hsieh

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 294
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioprocess Parameter Control

Bioprocess Parameter Control
A Book

by Pramod Agrawal

  • Publisher : Springer
  • Release : 1984
  • Pages : 202
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bespreking van fysische en chemische parameters met betrekking tot microbiele groei; analyses van diverse regelprocessen voor "continu" bioreactor (continue toevoer van voedingsstoffen gedurende het proces en ter afvoer van gedeeltes van het medium ter instandhouding van een constant volume); modelstudie en simulatie van bioreactor-procestechniek; bewerkingstechnieken in microbiele processen (toevoeging van voedingsstoffen in de bioreactor, gedurende het proces), waarbij het produkt tot aan het eind van het proces in de reactor aanwezig blijft