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Bioreactors in Biotechnology

Bioreactors in Biotechnology
A Practical Approach

by Alan H. Scragg

  • Publisher : Ellis Horwood Limited
  • Release : 1991
  • Pages : 330
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Discusses many aspects of bioreactor use and design in biotechnology. There is coverage of conventional and airlift bioreactor design, instrumentation, control and simulation of bioreactor runs, bioreactors for plant and animal culture and a descriptions of experiments.

Animal Cell Bioreactors

Animal Cell Bioreactors
A Book

by Chester S. Ho

  • Publisher : Butterworth-Heinemann
  • Release : 2013-10-22
  • Pages : 512
  • ISBN : 1483289478
  • Language : En, Es, Fr & De
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Animal Cell Bioreactors provides an introduction to the underlying principles and strategies in the in vitro cell culture biotechnology. It addresses engineering aspects such as mass transfer, instrumentation, and control ensuring successful design and operation of animal cell bioreactors. The goal is to provide a comprehensive analysis and review in the advancement of the bioreactor systems for large-scale animal cell cultures. The book is organized into four parts. Part I traces the historical development of animal cell biotechnology. It presents examples of work in progress that seeks to make animal cell biotechnology processes as productive on a cost per unit of product basis as that achieved by other microbial systems. Part II includes chapters dealing with the implications of cell biology in animal cell biotechnology; protein-bound oligosaccharides and their structures; the development of serum-free media and its use in the production of biologically active substances; and the metabolism of mammalian cells. Part III focuses on animal cell cultivation, covering topics such as the fixed bed immobilized culture; three-dimensional microcarriers; and hydrodynamic phenomena in microcarrier cultures. Part IV discusses the design, operation, and control of animal cell bioreactors.

Disposable Bioreactors

Disposable Bioreactors
A Book

by Regine Eibl,Dieter Eibl

  • Publisher : Springer Science & Business Media
  • Release : 2009-11-27
  • Pages : 226
  • ISBN : 3642018718
  • Language : En, Es, Fr & De
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Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

On-line Estimation and Adaptive Control of Bioreactors

On-line Estimation and Adaptive Control of Bioreactors
A Book

by G. Bastin

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 394
  • ISBN : 1483290980
  • Language : En, Es, Fr & De
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This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques. The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
Fundamentals of Design and Operation

by David A. Mitchell,Nadia Krieger,Marin Berovic

  • Publisher : Springer Science & Business Media
  • Release : 2006-08-02
  • Pages : 448
  • ISBN : 3540312862
  • Language : En, Es, Fr & De
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This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Airlift Bioreactors

Airlift Bioreactors
A Book

by M. Y. Chisti

  • Publisher : Springer
  • Release : 1989-02-28
  • Pages : 345
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Production of Potato Microtubers in Bioreactors

Production of Potato Microtubers in Bioreactors
A Book

by Wan-Chin Yu

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 296
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioreactors

Bioreactors
Animal Cell Culture Control for Bioprocess Engineering

by Goutam Saha,Alok Barua,Satyabroto Sinha

  • Publisher : CRC Press
  • Release : 2017-12-01
  • Pages : 136
  • ISBN : 1498736025
  • Language : En, Es, Fr & De
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Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Reductive Dechlorination of Chlorinated Phenols in Anaerobic Upflow Bioreactors

Reductive Dechlorination of Chlorinated Phenols in Anaerobic Upflow Bioreactors
A Book

by Mary Luise Krumme

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 258
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Resealed erythrocytes as carriers and bioreactors

Resealed erythrocytes as carriers and bioreactors
proceedings of the Third International Meeting held at the Gwinn Estate, Cleveland, Ohio, USA, 18-20 October, 1989

by Ralph Green,John R. DeLoach

  • Publisher : Pergamon
  • Release : 1991
  • Pages : 252
  • ISBN : 9780080411569
  • Language : En, Es, Fr & De
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Bioreactors - Downstream Processing - Process and Reactor Modelling - Bioprocesses

Bioreactors - Downstream Processing - Process and Reactor Modelling - Bioprocesses
Lectures Held at ACHEMA 88, June 5/11, 1988

by Dieter Behrens,P. Krämer,DECHEMA

  • Publisher : Wiley-VCH
  • Release : 1988
  • Pages : 467
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Use of Dinoflagellates to Characterize Cell Stimulation in Bioreactors

The Use of Dinoflagellates to Characterize Cell Stimulation in Bioreactors
A Book

by Antony Kuang-Shih Chen

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 114
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Immobilization of Bacterial and Yeast Cells in Hollow-fiber Membrane Bioreactors

Immobilization of Bacterial and Yeast Cells in Hollow-fiber Membrane Bioreactors
A Book

by Douglas Scott Inloes

  • Publisher : Unknown Publisher
  • Release : 1982
  • Pages : 368
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Design Implications for Anaerobic Membrane Bioreactors and the Metabolic Influence of Cycle Time for the Treatment of Liquid Dairy Manure

Design Implications for Anaerobic Membrane Bioreactors and the Metabolic Influence of Cycle Time for the Treatment of Liquid Dairy Manure
A Book

by James M Wallace

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 386
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Physiological Studies of Hybridoma Cultivation in Hollow Fiber Bioreactors

Physiological Studies of Hybridoma Cultivation in Hollow Fiber Bioreactors
A Book

by Linda Marie Custer

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 470
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bubble Coalescence and Mass Transfer in Air Sparged Bioreactors

Bubble Coalescence and Mass Transfer in Air Sparged Bioreactors
A Book

by Timothy Oolman

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 426
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Membrane Bioreactors for Wastewater Treatment

Membrane Bioreactors for Wastewater Treatment
A Book

by Ruoyu David Chen

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 238
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioreaction Engineering, Characteristic Features of Bioreactors

Bioreaction Engineering, Characteristic Features of Bioreactors
A Book

by Karl Schügerl

  • Publisher : Wiley
  • Release : 1990
  • Pages : 418
  • ISBN : 9780471925934
  • Language : En, Es, Fr & De
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Covers not only the basic theories and principles behind reaction engineering of cells and microorganisms but also the types of reactor which can be built from such principles. The different parameters which control each type of reactor are described.

Optimization and scale-up of animal cell bioreactors

Optimization and scale-up of animal cell bioreactors
A Book

by Donald J. Kirwan

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioreactors: Process and Analysis

Bioreactors: Process and Analysis
A Book

by Tapobrata Panda

  • Publisher : Tata McGraw-Hill Education
  • Release : 2011
  • Pages : 491
  • ISBN : 9780070704244
  • Language : En, Es, Fr & De
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6. Bioreactor modeling -- Model - what is it? -- Definition of lumped and distributed parameter models -- Introduction to a few terminologies and theorems -- Modeling principles -- Steps in modeling -- Fundamental laws used in process modeling -- First-order systems -- Second-order systems -- Complexity of the model -- Parameter sensitivity -- Exercises -- References -- Appendix 6 -- 7. Transport processes in bioreactors -- Introduction -- Heat transfer -- Other parameters influencing transfer operations -- Exercises -- References -- 8. Controls in bioreactors -- Introduction -- Control tasks in a bioreactor system -- Instrumentation to control a bioreactor -- Controlled variables and measurement devices -- Procedure for design of efficient control systems -- Conventional control techniques -- Advanced control techniques -- Consistency checks on measurements -- Adaptive online optimizing control of bioreactor system -- Exercises -- References -- Appendix 8 -- 9. Case studies -- Introduction -- Design of packed bed bioreactor -- Airlift bioreactors -- Hollow fiber bioreactor (HFBR) -- Plant cell bioreactor -- Design of bioreactors for solid state fermentation (SSF) -- Mammalian cell bioreactor design -- Exercises -- References -- Appendix 9 -- 10. Application of computational fluid dynamics in bioreactor analysis and design -- Introduction -- Fluid dynamic modeling -- Simulation -- Exercises -- References -- Appendix 10 -- 11. Scale-up of bioreactors -- Introduction -- Additional scale-up problems in bioreactors -- Criteria of scale-up -- Similarity criteria -- Scale-up methods -- Generalized approaches to scale-up in combination of methods -- Examples -- Exercises -- References -- 12. Mechanical aspects of bioreactor design -- Introduction -- Requirements for construction of a bioreactor -- Guidelines for bioreactor design -- Bioreactor vessels -- Agitator assembly -- Exercises -- References -- Appendix 12