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Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
Fundamentals of Design and Operation

by David A. Mitchell,Nadia Krieger,Marin Berovic

  • Publisher : Springer Science & Business Media
  • Release : 2006-08-02
  • Pages : 448
  • ISBN : 3540312862
  • Language : En, Es, Fr & De
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This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

On-line Estimation and Adaptive Control of Bioreactors

On-line Estimation and Adaptive Control of Bioreactors
A Book

by G. Bastin

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 394
  • ISBN : 1483290980
  • Language : En, Es, Fr & De
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This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques. The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

Disposable Bioreactors II

Disposable Bioreactors II
A Book

by Dieter Eibl,Regine Eibl

  • Publisher : Springer
  • Release : 2013-12-17
  • Pages : 292
  • ISBN : 3642451586
  • Language : En, Es, Fr & De
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Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up, by Christian Löffelholz, Stephan C. Kaiser, Matthias Kraume, Regine Eibl , Dieter Eibl. Orbitally Shaken Single-Use Bioreactors, by Wolf Klöckner, Sylvia Diederichs, Jochen Büchs. Therapeutic Human Cells: Manufacture for Cell Therapy/Regenerative Medicine by Christian van den Bos, Robert Keefe, Carmen Schirmaier, Michael McCaman. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study by Regine Eibl, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, Dieter Eibl. Microbial High Cell Density Fermentations in a Stirred Single-Use Bioreactor by Thomas Dreher, Bart Walcarius, Ute Husemann, Franziska Klingenberg, Christian Zahnow, Thorsten Adams, Davy de Wilde, Peter Casteels, Gerhard Greller. Quorus Bioreactor: A New Perfusion-Based Technology for Microbial Cultivation by Sheena J. Fraser, Christian Endres. Cultivation of Marine Microorganisms in Single-Use Systems by Friederike Hillig, Maciej Pilarek, Stefan Junne, Peter Neubauer. Flexible Biomanufacturing Processes that Address the Needs of the Future by Bernhard Diel, Christian Manzke, Thorsten Peuker. An Approach to Quality and Security of Supply for Single-Use Bioreactors by Magali Barbaroux, Susanne Gerighausen, Heiko Hackel. A Risk Analysis for Production Processes with Disposable Bioreactors by Tobias Merseburger, Ina Pahl, Daniel Müller, Markus Tanner.

Bioreactors for Tissue Engineering

Bioreactors for Tissue Engineering
Principles, Design and Operation

by Julian Chaudhuri,Mohamed Al-Rubeai

  • Publisher : Springer Science & Business Media
  • Release : 2006-01-16
  • Pages : 376
  • ISBN : 1402037414
  • Language : En, Es, Fr & De
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For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Membrane Bioreactors for Municipal Wastewater Treatment

Membrane Bioreactors for Municipal Wastewater Treatment
A Book

by H. F. van der Roest,D. P. Lawrence,A. G. N. van Bentem

  • Publisher : IWA Publishing
  • Release : 2002-11-01
  • Pages : 150
  • ISBN : 9781843390114
  • Language : En, Es, Fr & De
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Recent technical innovations and significant cost reductions have sharply increased the potential for using Membrane Bioreactor (MBR) technology in municipal wastewater treatment. MBR technology displays several advantages compared to the traditional activated sludge processes, such as high effluent quality, limited space requirement and with the possibility of a flexible and phased extension of existing waste water treatment plants. Membrane Bioreactors for Municipal Wastewater Treatment describes the results of a comparative research programme involving four leading membrane suppliers: Kubota (Japan), Mitsubishi (Japan), X-Flow (Netherlands) and Zenon (Canada). Each supplier provided a pilot to represent a suitable scale - right up to full scale. These pilots were operated and optimised in the course of the research programme to achieve the best operating window under different operating regimes. The research focussed on the functionality of the membrane, the biological treatment, membrane fouling, achieved effluent quality, and system operability as well as other factors. In a number of side studies the required pre-treatment, membrane fouling/cleaning, energy usage, effluent quality and sludge processing were also addressed. The comparative pilot research was carried out by DHV Water on location at the wastewater treatment plant at Beverwijk in the Netherlands.

Disposable Bioreactors

Disposable Bioreactors
A Book

by Regine Eibl,Dieter Eibl

  • Publisher : Springer Science & Business Media
  • Release : 2009-11-27
  • Pages : 226
  • ISBN : 3642018718
  • Language : En, Es, Fr & De
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Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

Bioreactors

Bioreactors
Design, Operation and Novel Applications

by Carl-Fredrik Mandenius

  • Publisher : John Wiley & Sons
  • Release : 2016-05-16
  • Pages : 520
  • ISBN : 3527337687
  • Language : En, Es, Fr & De
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In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Bioreactors

Bioreactors
Sustainable Design and Industrial Applications in Mitigation of Ghg Emissions

by Lakhveer Singh,Abu Yousuf,Durga Madhab Mahapatra

  • Publisher : Academic Press
  • Release : 2020-04
  • Pages : 368
  • ISBN : 0128212640
  • Language : En, Es, Fr & De
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Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.

Bioreactors

Bioreactors
Animal Cell Culture Control for Bioprocess Engineering

by Goutam Saha,Alok Barua,Satyabroto Sinha

  • Publisher : CRC Press
  • Release : 2017-12-01
  • Pages : 136
  • ISBN : 1498736017
  • Language : En, Es, Fr & De
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Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation
A Book

by Joaquim M.S. Cabral,Claudia Lobato da Silva

  • Publisher : CRC Press
  • Release : 2018-09-03
  • Pages : 334
  • ISBN : 0429841825
  • Language : En, Es, Fr & De
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An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research

Eco-Engineered Bioreactors

Eco-Engineered Bioreactors
Advanced Natural Wastewater Treatment

by James Higgins,Al Mattes,William Stiebel,Brent Wootton

  • Publisher : CRC Press
  • Release : 2017-11-22
  • Pages : 385
  • ISBN : 1351681109
  • Language : En, Es, Fr & De
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This book provides a comprehensive understanding of a highly innovative method of natural wastewater treatment using advanced in-groundbioreactors called Eco-Engineered Bioreactors (EEBs), and traces their evolution from the earliest aerated gravel bed versions once known as Engineered Wetlands (EWs) and now known as BREW Bioreactors (BBRs) all the way to today’s wide slate of aerobic and anaerobic varieties. Treatment using EEBs involves passing wastewaters through excavated basins in which they contact fixed films of microbial consortia on permeable substrate media. Written from the perspective of ecological engineers designing EEBs, this guide covers updated information on the state-of-the-art for EEBs, covering their morphologies, testing methods, designs, operations, and microbiology.

Fundamentals of Membrane Bioreactors

Fundamentals of Membrane Bioreactors
Materials, Systems and Membrane Fouling

by Bradley Ladewig,Muayad Nadhim Zemam Al-Shaeli

  • Publisher : Springer
  • Release : 2016-10-22
  • Pages : 150
  • ISBN : 9811020140
  • Language : En, Es, Fr & De
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This book provides a critical, carefully researched, up-to-date summary of membranes for membrane bioreactors. It presents a comprehensive and self-contained outline of the fundamentals of membrane bioreactors, especially their relevance as an advanced water treatment technology. This outline helps to bring the technology to the readers’ attention, and positions the critical topic of membrane fouling as one of the key impediments to its more widescale adoption. The target readership includes researchers and industrial practitioners with an interest in membrane bioreactors.

Bioreactors for Microbial Biomass and Energy Conversion

Bioreactors for Microbial Biomass and Energy Conversion
A Book

by Qiang Liao,Jo-shu Chang,Christiane Herrmann,Ao Xia

  • Publisher : Springer
  • Release : 2018-04-20
  • Pages : 468
  • ISBN : 9811076774
  • Language : En, Es, Fr & De
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This book discusses recent trends and developments in the microbial conversion process, which serves as an important route for biofuel production, with particular attention to bioreactors. It combines microbial conversion with multiphase flow and mass transfer, providing an alternative perspective for the understanding of microbial biomass and energy production process as well as enhancement strategy. This book is relevant to students and researchers who work in the fields of renewable energy, engineering and biotechnology. Policymakers, economists and industry engineers also benefit from this book, as it can be used as a resource for the implementation of renewable energy technologies.

Small Bioreactors for Management of Biodegradable Waste

Small Bioreactors for Management of Biodegradable Waste
A Book

by Pranas Baltrėnas,Edita Baltrėnaitė

  • Publisher : Springer
  • Release : 2018-06-01
  • Pages : 364
  • ISBN : 3319782118
  • Language : En, Es, Fr & De
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This volume discusses how small bioreactors can produce useful biogas and compost from biodegradable waste. The authors identify which biodegradable wastes are optimal for small bioreactors, and how these choices can be used to increase bioreactor productivity. Additionally, readers will learn about how the amount and composition of biogas is estimated, the concentration of biodegradable waste that needs to be supplied to a bioreactor, the development of small bioreactors including the ratio of cost to the obtained benefits, and the nature of biodegradable wastes generated by both small farms and large food industry enterprises. The beginning chapters explain what biodegradable waste is, show how to predict how much waste an enterprise will produce, and elaborate the characteristics of the biogas which is generated from biodegradable waste in small bioreactors. Then the book discusses the types of small bioreactors and how to select the optimal bioreactor for a given case. Bioreactor performance is analyzed on both an economical and production efficiency basis, with experimental results provided on the quantity and quality of the biogas produced. The final chapters address how small bioreactors can be incorporated into small biogas plants, and the potential use of small bioreactors in countries with high demand for alternative energy using the case of Lithuania. The audience for this work includes specialists in biodegradable waste management and utilization enterprises, designers, and academics, researchers and students engaged in environmental engineering.

Animal Cells as Bioreactors

Animal Cells as Bioreactors
A Book

by Terence Cartwright

  • Publisher : Cambridge University Press
  • Release : 1994-08-26
  • Pages : 184
  • ISBN : 0521412587
  • Language : En, Es, Fr & De
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Gives an integrated view of how cultured animal cells are used for biopharmaceutical production, and of the new technical developments contributing to the improvements in safety, economics, and approach to drug production.

Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors

Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2018-05-21
  • Pages : 320
  • ISBN : 0444640657
  • Language : En, Es, Fr & De
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Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors, Volume 81, describes the novelty of membrane bioreactors for the treatment of wastewater and the removal of specific contaminants that affect water quality or pose harm to humans. Topics of note in the updated release include Water Chemistry and Microbiology, Quorum Sensing as Bacterial Communication Language, the Effects of Quorum Sensing, Quorum Quenching, Membrane Bioreactors for Wastewater Treatment, Removal of Specific Contaminants, Microextraction Techniques, and the Determination of Quorum Sensing Chemicals. The contents of this updated volume will be appealing to a wide range of researchers as the authors of most chapters are experts in their respective fields with numerous published studies. Gives an overview of quorum sensing as a communication language for bacteria and quorum quenching mediated approaches to mitigate or eliminate the effects of quorum sensing Presents various sensitive determination methods where a variety of microextraction strategies is used for preconcentration of analyte(s)

Producing Biomolecular Substances with Fermenters, Bioreactors, and Biomolecular Synthesizers

Producing Biomolecular Substances with Fermenters, Bioreactors, and Biomolecular Synthesizers
A Book

by William L. Hochfeld

  • Publisher : CRC Press
  • Release : 2006-06-22
  • Pages : 408
  • ISBN : 1420021311
  • Language : En, Es, Fr & De
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Containing authoritative and in-depth coverage, Producing Biomolecular Materials Using Fermenters, Bioreactors, and Biomolecular Synthesizers examines the bioproduction systems that support the controlled, automated, and quantity growth of proteins. The book discusses the substance, character, makeup, and quality of the basic materials used in the production and downstream processing of boimolecular materials: raw materials, reagents, intermediates, and consumables. Dr. Hochfield gets right to the point, explaining just what must be done and how to do it effectively, then providing the formula necessary for reaching the required value, allowing you to simply plug-in your data and make protein. However, if you actually do need the origin and derivation of any given formula, you can go right to the extensive reference section in the Appendix, find the formula you need in the exact form that you need it, without having to wade through numerous pages of extraneous material. This classic work presents unparalled, detailed, and cutting-edge information on bioprocessing systems. A working reference and formulary for producing recombinant, bioactive, or other exotic proteins, peptides, and nucleic acids to specification, the text provides coverage of the related technologies, coupled with the extensive biotechnology glossary, manufacturer’s directories, extensive references, important formulae, charts, illustrations, comprehensive index, emphasis on practical techniques, time-proven methods, and essential applications. These features combine with its ingenious, easy-to-use layout to make it the resource you will consult on a regular basis.

Advances and Applications of Partitioning Bioreactors

Advances and Applications of Partitioning Bioreactors
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-05-21
  • Pages : 385
  • ISBN : 0128149973
  • Language : En, Es, Fr & De
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Advances and Applications of Partitioning Bioreactors, Volume 54, presents an updated reference in the field of partitioning bioreactors, addressing the relevance of kinetic determination, cell deactivation and transport phenomena from an engineering point-of-view. Topics covered in this new release include Mass transport phenomena in partitioning bioreactors, Modelling and design of partitioning bioreactors, Population balances for partitioning bioreactors, Solid-liquid partitioning bioreactors for industrial wastewater treatment, Multiphase bioreactors in the Food Industry, Multiphase bioreactors in the pharmaceutical industry, Biological treatment of gas pollutants in partitioning bioreactors, Hydrocarbon biodegradation using airlift bioreactors, and more. Contains contributions from experts in their respective areas Updated, state-of-the-art work on partitioning bioreactors

Animal Cell Bioreactors

Animal Cell Bioreactors
A Book

by Chester S. Ho

  • Publisher : Butterworth-Heinemann
  • Release : 2013-10-22
  • Pages : 512
  • ISBN : 1483289478
  • Language : En, Es, Fr & De
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Animal Cell Bioreactors provides an introduction to the underlying principles and strategies in the in vitro cell culture biotechnology. It addresses engineering aspects such as mass transfer, instrumentation, and control ensuring successful design and operation of animal cell bioreactors. The goal is to provide a comprehensive analysis and review in the advancement of the bioreactor systems for large-scale animal cell cultures. The book is organized into four parts. Part I traces the historical development of animal cell biotechnology. It presents examples of work in progress that seeks to make animal cell biotechnology processes as productive on a cost per unit of product basis as that achieved by other microbial systems. Part II includes chapters dealing with the implications of cell biology in animal cell biotechnology; protein-bound oligosaccharides and their structures; the development of serum-free media and its use in the production of biologically active substances; and the metabolism of mammalian cells. Part III focuses on animal cell cultivation, covering topics such as the fixed bed immobilized culture; three-dimensional microcarriers; and hydrodynamic phenomena in microcarrier cultures. Part IV discusses the design, operation, and control of animal cell bioreactors.

Principles of Membrane Bioreactors for Wastewater Treatment

Principles of Membrane Bioreactors for Wastewater Treatment
A Book

by Hee-Deung Park,In-Soung Chang,Kwang-Jin Lee

  • Publisher : CRC Press
  • Release : 2015-04-17
  • Pages : 445
  • ISBN : 1466590386
  • Language : En, Es, Fr & De
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Principles of Membrane Bioreactors for Wastewater Treatment covers the basic principles of membrane bioreactor (MBR) technology, including biological treatment, membrane filtration, and MBR applications. The book discusses concrete principles, appropriate design, and operational aspects. It covers a wide variety of MBR topics, including filtration theory, membrane materials and geometry, fouling phenomena and properties, and strategies for minimizing fouling. Also covered are the practical aspects such as operation and maintenance. Case studies and examples in the book help readers understand the basic concepts and principles clearly, while problems presented help advance relevant theories more deeply. Readers will find this book a helpful resource to understand the state of the art in MBR technology.