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Bone: A Treatise is a series of seven volumes devoted to providing the most up-to-date, comprehensive, and authoritative coverage of all aspects of bone. Seventy-four chapters have been written by 127 respected authors, all of whom are actively engaged in basic, applied, and clinical bone research. The seven volumes in this unique series are organized thematically; each volume integrates structure, function, biochemistry, metabolism, and the molecular and clinical aspects of a particular aspect of the biology of bone. Bone-forming cells are treated in Volume I. Bone resorbing cells are covered in Volume II. Volumes III and IV examine the extracellular matrix of bone, with Volume III concentrating on the structure of bone matrix and on bone-specific proteins, while Volume IV focuses on the mineralization (calcification) of that matrix. Volume V addresses the repair and regeneration of bone. Volumes VI and VII explore bone growth and development.

Cory Doctorow's Attack Surface is a standalone novel set in the world of New York Times bestsellers Little Brother and Homeland. Most days, Masha Maximow was sure she'd chosen the winning side. In her day job as a counterterrorism wizard for an transnational cybersecurity firm, she made the hacks that allowed repressive regimes to spy on dissidents, and manipulate their every move. The perks were fantastic, and the pay was obscene. Just for fun, and to piss off her masters, Masha sometimes used her mad skills to help those same troublemakers evade detection, if their cause was just. It was a dangerous game and a hell of a rush. But seriously self-destructive. And unsustainable. When her targets were strangers in faraway police states, it was easy to compartmentalize, to ignore the collateral damage of murder, rape, and torture. But when it hits close to home, and the hacks and exploits she’s devised are directed at her friends and family--including boy wonder Marcus Yallow, her old crush and archrival, and his entourage of naïve idealists--Masha realizes she has to choose. And whatever choice she makes, someone is going to get hurt. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

A discussion of bone cancer and treatments for it.

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, antiresorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.

The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source dedicated to better understanding this group of conditions that have significant consequences for health in both past and present communities on a global scale. This edition presents an updated introduction to the biology and metabolism of mineralised tissues that are fundamental to understanding the expression of the metabolic bone diseases in skeletal remains. The extensive advances in understanding of these conditions in both bioarchaeological and biomedical work are brought together for the reader. Dedicated chapters focussing on each disease emphasise the integration of up-to-date clinical background with the biological basis of disease progression to give guidance on identification. New chapters covering anaemia and approaches to recognising the co-occurrence of pathological conditions have been included, reflecting recent advances in research. Boxes highlighting significant issues, use of information from sources such as texts and nonhuman primates, and theoretical approaches are included in the text. Each chapter closes with ‘Core Concepts’ that summarise key information. The final chapter reviews current challenges in bioarchaeology and provides directions for future research. This is a must-have resource for users at all career stages interested in integrating information on the metabolic bone diseases into bioarchaeological projects. Covers deficiencies of vitamin C and D, osteoporosis (age-related and secondary), Paget’s disease of bone, anaemia and approaches to disease co-occurrence Contains clear and user-friendly guidance for macroscopic, radiological and microscopic diagnoses Highlights current inquiries and debates in biological anthropology, bioarchaeology, palaeopathology, medical history and clinical/biomedical research Extensive figures, most new or updated, provide invaluable information on biological processes and lesion expression through diagrams and photographs

This is a comprehensive, lavishly illustrated review of orthopaedic oncology that is multi-disciplinary, integrative and highly practical. Introductory chapters cover overviews of the basics of bone and soft tissue tumors – the pathology, radiology and surgical and oncologic management. These are followed by chapters covering all tumor types organized according to the 2013 WHO classification of bone and soft tissue tumors. Each class of tumor is dealt with in detail, with case presentations illustrating how they would be diagnosed and managed in a clinical setting. The range of variation of each tumor type is indicated with appropriate radiological and pathological images. Detailed tables and flow charts provide quick access to vital diagnosis and staging information for each tumor type. This book provides an expert, case-based approach to orthopaedic oncology and patient care for trainees and practising orthopaedic surgeons, pathologists and radiologists. A practical and comprehensive review of orthopaedic oncology Covers all tumor types and their range of variation Organized according to the 2013 WHO classification of bone and soft tissue tumours Tables and flow charts provide diagnosis and staging information for each tumor type

Examines the parts, organization, and development of the musculoskeletal system, including information on diseases and injuries of bones, muscles, and joints.

On account of its unrivalled imaging capabilities and sensitivity, magnetic resonance imaging (MRI) is considered the modality of choice for the investigation of physiologic and pathologic processes affecting the bone marrow. This book describes the MRI appearances of both the normal bone marrow, including variants, and the full range of bone marrow disorders. Detailed discussion is devoted to malignancies, including multiple myeloma, lymphoma, chronic myeloproliferative disorders, leukemia, and bone metastases. Among the other conditions covered are benign and malignant compression fractures, osteonecrosis, hemolytic anemia, Gaucher’s disease, bone marrow edema syndrome, trauma, and infective and non-infective inflammatory disease. Further chapters address the role of MRI in assessing treatment response, the use of contrast media, and advanced MRI techniques. Magnetic Resonance Imaging of the Bone Marrow represents an ideal reference for both novice and experienced practitioners.

Digital models based on data from medical images have recently become widespread in the field of biomechanics. This book summarizes medical imaging techniques and processing procedures, both of which are necessary for creating bone models with finite element methods. Chapter 1 introduces the main principles and the application of the most commonly used medical imaging techniques. Chapter 2 describes the major methods and steps of medical image analysis and processing. Chapter 3 presents a brief review of recent studies on reconstructed finite element bone models, based on medical images. Finally, Chapter 4 reveals the digital results obtained for the main bone sites that have been targeted by finite element modeling in recent years.

Bone Resorption: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Additional Research in a compact format. The editors have built Bone Resorption: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Resorption: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

A Review of the Radiosensitivity of the Tissues in Bone is a report prepared by the Task Group for the International Commission on Radiological Protection Committees 1 and 2. The book reviews a biological indicator of the maximum permissible radiation dose. Data shows that an induction of malignant change should be considered as the limiting factor in maximum permissible levels for the bone. The risk of carcinogenesis in cells is connected with the proliferative potential of the cells. These cells are on bone marrow surfaces, in hematopoietic marrow, and in certain epithelial cells close to bone surfaces. The text also reviews the changes in the patterns of distribution resulting from growth and remodeling of bone. The book examines the effect of distribution of alkaline earth, of plutonium, of thorium, of americium, and of phosphorus in bone growth. The book also evaluates the comparative tumorigenic effects of external and internal irradiation of bone and the factors to be considered in determining the dose limitation from bone-seeking radionuclides. This book can prove beneficial to researchers and practitioners in the fields of radiology, internal medicine, or oncology.

"Peking Man," a cave man once thought a great hunter who had first tamed fire, actually was a composite of the gnawed remains of some fifty women, children, and men unfortunate enough to have been the prey of the giant cave hyena. Researching the famous fossil site of Dragon Bone Hill in China, scientists Noel T. Boaz and Russell L. Ciochon retell the story of the cave's unique species of early human, Homo erectus. Boaz and Ciochon take readers on a gripping scientific odyssey. New evidence shows that Homo erectus was an opportunist who rode a tide of environmental change out Africa and into Eurasia, puddle-jumping from one gene pool to the next. Armed with a shaky hold on fire and some sharp rocks, Homo erectus incredibly survived for over 1.5 million years, much longer than our own species Homo sapiens has been on Earth. Tell-tale marks on fossil bones show that the lives of these early humans were brutal, ruled by hunger and who could strike the hardest blow, yet there are fleeting glimpses of human compassion as well. The small brain of Homo erectus and its strangely unchanging culture indicate that the species could not talk. Part of that primitive culture included ritualized aggression, to which the extremely thick skulls of Homo erectus bear mute witness. Both a vivid recreation of the unimagined way of life of a prehistoric species, so similar yet so unlike us, and a fascinating exposition of how modern multidisciplinary research can test hypotheses in human evolution, Dragon Bone Hill is science writing at its best.

Bone Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Bone Cancer in a compact format. The editors have built Bone Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.