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Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual
A Book

by Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD

  • Publisher : Demos Medical Publishing
  • Release : 2014-12-15
  • Pages : 110
  • ISBN : 1620700425
  • Language : En, Es, Fr & De
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This comprehensive yet practical guide covers botulinum toxin injections and the wide range of clinical applications for neurologic and other conditions. Intended as both as an introduction for new injectors and a handy reference guide for busy clinicians, the book opens with a brief review of pharmacology, product information and distinctions between the four toxins that are currently approved for use in the U.S. by the FDA, indications and doses for FDA-approved conditions, and accepted and emerging clinical applications. The remainder is an injection manual, organized anatomically and by condition and covering all applications. For each condition or site, information on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites and targeting techniques are provided in table format for quick look-up. Anatomic illustrations and cross-sections appear on facing pages to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin
A Book

by Keith A. Foster

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 196
  • ISBN : 149390261X
  • Language : En, Es, Fr & De
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Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin
A Book

by Lance Simpson

  • Publisher : Elsevier
  • Release : 2012-12-02
  • Pages : 436
  • ISBN : 0323141609
  • Language : En, Es, Fr & De
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Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin
A Book

by Keith A. Foster

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 345
  • ISBN : 1461494540
  • Language : En, Es, Fr & De
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Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxins

Botulinum Neurotoxins
A Book

by Andreas Rummel,Thomas Binz

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-14
  • Pages : 324
  • ISBN : 3642335705
  • Language : En, Es, Fr & De
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The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Botulinum toxins in dermatology

Botulinum toxins in dermatology
A Book

by Joel L. Cohen

  • Publisher : John Wiley & Sons
  • Release : 2013
  • Pages : 400
  • ISBN : 1444338250
  • Language : En, Es, Fr & De
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Botulinum Neurotoxins for Head and Neck Disorders

Botulinum Neurotoxins for Head and Neck Disorders
A Book

by Andrew Blitzer,Brian E. Benson,Joel Guss

  • Publisher : Thieme
  • Release : 2012-03-28
  • Pages : 248
  • ISBN : 1604065869
  • Language : En, Es, Fr & De
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Learn expert injection techniques with this multimedia reference guide to the therapeutic uses of botulinum neurotoxin Containing detailed injection instructions, Botulinum Neurotoxin for Head and Neck Disorders and the associated how-to videos offer otolaryngologists, neurologists, pain specialists, and others a complete guide to the management of motor, sensory and autonomic disorders of the head and neck region with botulinum neurotoxin. It covers treatment methods for conditions ranging from hyperfunctional motor disorders (dystonia, tremor, dysphagia), to afferent pain disorders (temporomandibular joint disorder, migraine, trigeminal neuralgia) to autonomic disorders (hypersalivation, Frey's syndrome). In each of the indications, the written material reviews the effects of the toxin on the nervous system, central pain thresholds, and central motor pathways. Special Features: Reviews the pharmacology, indications, mechanisms of action, and technique for each use of botulinum neurotoxin Provides detailed information on the anatomy, treatment methods, follow-up care, and possible complications for each disorder Includes online access to professionally produced videos in which Dr. Blitzer demonstrates injection techniques for the disorders in the book Contains vivid, full color illustrations and photographs that clarify information in the text Focusing specifically on injection techniques for the therapeutic uses of botulinum neurotoxin for treating head and neck disorders, this manual fills an important gap in the literature. It gives clinicians current, authoritative, and in-depth information on administering botulinum neurotoxin most effectively for the head and neck disorders of their patients.

Manual of Botulinum Toxin Therapy

Manual of Botulinum Toxin Therapy
A Book

by Daniel Truong,Mark Hallett,Dirk Dressler,Christopher Zachary

  • Publisher : Cambridge University Press
  • Release : 2014-01-23
  • Pages : 315
  • ISBN : 1107025354
  • Language : En, Es, Fr & De
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"This book tries to answer many of the questions posed above with the contributions of a team of international experts. As in the first edition, the emphasis in this book is on technique, so it is richly endowed with illustrations concerning accurate access techniques to help physicians become facile and fully competent"--Provided by publisher.

Botulinum and Tetanus Neurotoxins

Botulinum and Tetanus Neurotoxins
Neurotransmission and Biomedical Aspects

by B.R. DasGupta

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-11
  • Pages : 689
  • ISBN : 1475795424
  • Language : En, Es, Fr & De
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Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.

Botulinum Neurotoxin

Botulinum Neurotoxin
A Guide to Motor Point Injections

by Chong-Tae Kim

  • Publisher : Elsevier
  • Release : 2021-05-28
  • Pages : 174
  • ISBN : 9780323697156
  • Language : En, Es, Fr & De
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A practical, how-to guide for both new and experienced clinicians, Botulinum Neurotoxin: A Guide to Motor Point Injections identifies the correct motor points for botulinum neurotoxin (BoNT) injections for non-cosmetic purposes such as muscle dystonia, muscle spasticity, teeth grinding, or drooling. Dr. Chong-Tae Kim expertly guides readers through the efficient blocking of neurotransmitters using BoNT, identifying target muscles and clearly demonstrating how to identify optimal insertion points. Covers both the upper and lower extremities and how to select target muscles for specific deformities. Includes illustrations and photographs to illustrate muscle relationships and correct insertion points. Uses consistent labelling and coding throughout to provide an easy-to-follow, image-guided approach. Presents information in two parts: Part 1 covers BoNT injections to individual motor points of muscles of the face, neck, trunk, and extremities, along with superb visual guidance. Part 2 discusses how to select target muscles for BoNT injections to treat deformities caused by muscle hyperactivity. Consolidates today's available information on this timely topic into a single, convenient resource

Botulinum Neurotoxin Complex

Botulinum Neurotoxin Complex
A Structural and Biophysical Characterization

by Jiarong Flora Chen

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 300
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use
A Book

by Michael Charles Goodnough

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 424
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Botulinum Toxin in Clinical Dermatology

Botulinum Toxin in Clinical Dermatology
A Book

by Anthony V. Benedetto

  • Publisher : CRC Press
  • Release : 2006-01-13
  • Pages : 326
  • ISBN : 0203495055
  • Language : En, Es, Fr & De
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Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree
A Book

by Sherly Bellevue

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 102
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Botulinum Neurotoxins and Nervous System

Botulinum Neurotoxins and Nervous System
Future Challenges for Novel Indications

by Siro Luvisetto

  • Publisher : MDPI
  • Release : 2020-11-06
  • Pages : 368
  • ISBN : 303943456X
  • Language : En, Es, Fr & De
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This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum
A Book

by Sean S. Dineen

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 142
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Treatments from Toxins

Treatments from Toxins
The Therapeutic Potential of Clostridial Neurotoxins

by Keith Alan Foster,Peter Hambleton,Clifford C. Shone

  • Publisher : CRC Press
  • Release : 2006-11-02
  • Pages : 312
  • ISBN : 1420004158
  • Language : En, Es, Fr & De
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As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies based on the endopeptidase activity of the toxins, vaccine development, protection against botulism, and vectors for neuronal drug delivery. Based on recent scientific and clinical information from top international authorities, Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins reviews the status of current research and development and identifies significant developments. Drawing on their vast experience in this field, the editors present the basic background of the bacteriology and genetics of the neurotoxigenic clostridia, a history of the discovery of the neurotoxins, and an overview of the tetanus and botulism diseases. The chapters detailing common medical applications of the toxins cover side effects and novel uses, including neuronal drug delivery strategies, and provide a fresh look at what can still be achieved. They also explore the toxins as potential threat agents and the advent of the therapeutic use of botulinum toxins. Highlighting the pitfalls, successes, and challenges that exist when engineering complex proteins, the book brings together the clinical and theoretical worlds. It presents a broad overview of the current status of botulinum research and its clinical applications.

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity
A Book

by Min Dong

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 192
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Botulinum Neurotoxins for Head and Neck Disorders

Botulinum Neurotoxins for Head and Neck Disorders
A Book

by Andrew Blitzer,Brian E. Benson,Diana N. Kirke

  • Publisher : Thieme
  • Release : 2020-03-21
  • Pages : 226
  • ISBN : 1684200962
  • Language : En, Es, Fr & De
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The most comprehensive, state-of-the-art guide available on the use of botulinum neurotoxin for head & neck disorders! Senior author Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by esteemed co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea. Key Features A 30-year review of spasmodic dysphonia data includes new insights encompassing comprehensive treatment, management and outcomes results, and neuropathophysiology A new chapter details the emerging role of botulinum neurotoxin to treat radiation-induced spasm and pain Updates on the management of palatal myoclonus, temporomandibular joint disorder, and sialorrhea An impressive compendium of professional injection videos, including a new video on sialorrhea and an updated migraine video Clinical pearls throughout the book focus on best practices, how to avoid pitfalls, and achieving the most optimal outcomes This is a must-have resource for otolaryngologists–head and neck surgeons, neurologists, dentists, pain specialists, physical medicine and rehabilitation specialists, and others health professionals who use botulinum neurotoxin to treat motor, sensory, and autonomic disorders of the head and neck region.

Botulinum Toxin Treatment

Botulinum Toxin Treatment
What Everyone Should Know

by Bahman Jabbari

  • Publisher : Springer
  • Release : 2018-11-13
  • Pages : 217
  • ISBN : 3319999451
  • Language : En, Es, Fr & De
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Very few therapeutic agents in clinical medicine have found indication for so many clinical conditions, and in such a short time as did botulinum neurotoxins (Botox and others). Chronic migraine, bladder dysfunction , dystonia, hemifacial spasm , blepharospasm , drooling, excessive sweating and spasticity are all approved by FDA and many other indications are in the near horizon . The aesthetic/cosmetic use of Botox and other BoNTs already has a huge market worldwide. Stroke, Multiple sclerosis, Parkinson’s disease, Cerebral palsy as well as brain and spinal injury are among clinical conditions in which some of patients’ major symptoms can respond to botulinum toxin therapy Several books have been written on the subject of Botox and other neurotoxins for treatment of medical disorders ( including two books by Jabbari both published by Springer 2015 & 2017). However, despite the huge interest and enthusiasm of the public to learn more about Botox and other toxins, there is currently no book in the market on this subject which is specifically designed to inform and educate the public on botulinum toxin therapy. Botulinum Toxin Treatment explains and discusses in simple language the structure and function of botulinum toxin and other neurotoxins as well as the rational for its utility in different disease conditions. Safety, factors affecting efficacy and duration of action, as well as cost and insurance issues are also addressed.