Download Bursting Neurons and Fading Memories Ebook PDF

Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
An Alternative Hypothesis of the Pathogenesis of Alzheimer’s Disease

by Michael R. D'Andrea

  • Publisher : Academic Press
  • Release : 2014-10-10
  • Pages : 170
  • ISBN : 0128019883
  • Language : En, Es, Fr & De
GET BOOK

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
A Book

by Michael R. D'Andrea

  • Publisher : Academic Press
  • Release : 2016-02-21
  • Pages : 220
  • ISBN : 012804330X
  • Language : En, Es, Fr & De
GET BOOK

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Aging

Aging
A Book

by Harold Cox

  • Publisher : Dushkin Publishing Group
  • Release : 2005-07
  • Pages : 191
  • ISBN : 9780073515939
  • Language : En, Es, Fr & De
GET BOOK

This eighteenth edition of ANNUAL EDITIONS: AGING (2006 UPDATE) provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.dushkin.com/online.

Annual Editions

Annual Editions
Human Development 03/04

by Karen L. Freiberg

  • Publisher : McGraw-Hill/Dushkin
  • Release : 2002-12
  • Pages : 205
  • ISBN : 9780072548198
  • Language : En, Es, Fr & De
GET BOOK

This annually updated reader is a compilation of carefully selected articles from magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others. This title is supported by Dushkin Online (www.dushkin.com/online/), a student Web site that provides study support and tools and links to related Web sites.

Annual Editions

Annual Editions
Aging 04/05

by Harold Cox

  • Publisher : Annual Editions: Aging
  • Release : 2003-07
  • Pages : 223
  • ISBN : 9780072845570
  • Language : En, Es, Fr & De
GET BOOK

This collection of public press articles were chosen because they address the most relevant and current problems in the field of aging and they present a variety of divergent views on the appropriate solutions to these problems. The well-illustrated articles are written by gerontologists, educators, researchers, and writers, and provide an effective and useful perspective on today's important topics in the study of aging. This title is supported by the student Web site, Dushkin Online (www.dushkin.com/online).

Society for Neuroscience Abstracts

Society for Neuroscience Abstracts
Volume 7, 11th Annual Meeting, Los Angeles, Calif., October 18-23, 1981

by Society for Neuroscience. Annual Meeting

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 1011
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Science Reporter

Science Reporter
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Annual Editions: Aging

Annual Editions: Aging
A Book

by Harold Cox

  • Publisher : McGraw-Hill/Dushkin
  • Release : 2006-04
  • Pages : 207
  • ISBN : 9780073516141
  • Language : En, Es, Fr & De
GET BOOK

Using an interdisciplinary approach, provides current articles selected from the best of the public press, including articles from medicine, nursing, psychology, sociology, social work, and the biological sciences.

Annual Editions: Aging 08/09

Annual Editions: Aging 08/09
A Book

by Harold Cox

  • Publisher : McGraw-Hill/Dushkin
  • Release : 2008-03-17
  • Pages : 224
  • ISBN : 9780073397603
  • Language : En, Es, Fr & De
GET BOOK

This Twenty-First Edition of ANNUAL EDITIONS: AGING provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM, ISBN 0073301906, is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.mhcls.com/online.

Newsweek

Newsweek
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
A Book

by Peter Whittle

  • Publisher : World Scientific
  • Release : 2010
  • Pages : 230
  • ISBN : 1848165900
  • Language : En, Es, Fr & De
GET BOOK

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels.Design is based on the criterion that an associative memory must be able to cope with ?fading data?, i.e., to form an inference from the data even as its memory of that data degrades. The resultant net shows striking biological parallels. When these principles are combined with the Freeman specification of a neural oscillator, some remarkable effects emerge. For example, the commonly-observed phenomenon of neuronal bursting appears, with gamma-range oscillation modulated by a low-frequency square-wave oscillation (the ?escapement oscillation?). Bridging studies and new results of artificial and biological neural networks, the book has a strong research character. It is, on the other hand, accessible to non-specialists for its concise exposition on the basics.

Index to IEEE Publications

Index to IEEE Publications
A Book

by Institute of Electrical and Electronics Engineers

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

The Ape That Spoke

The Ape That Spoke
Language and the Evolution of the Human Mind

by John McCrone

  • Publisher : Avon Books
  • Release : 1992-04
  • Pages : 288
  • ISBN : 9780380713998
  • Language : En, Es, Fr & De
GET BOOK

Aerospace Medicine and Biology

Aerospace Medicine and Biology
A Continuing Bibliography with Indexes

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1966
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Science Frontiers

Science Frontiers
Some Anomalies and Curiosities of Nature

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 350
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

PETER M. MILNER

PETER M. MILNER
A Book

by PHYSIOLOGICAL PSYCHOLOGY

  • Publisher : Unknown Publisher
  • Release : 1970
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Epilepsy Abstracts

Epilepsy Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1980
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

The Dentate Gyrus and Its Role in Seizures

The Dentate Gyrus and Its Role in Seizures
A Book

by Charles E. Ribak,Christine M. Gall,Istvan Mody

  • Publisher : Elsevier Science Limited
  • Release : 1992
  • Pages : 317
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

The chapters of this book are grouped to provide a logical sequence for the reader. The first section, entitled Cell Types and Innervation Patterns brings together six presentations that address different aspects of the detailed anatomy of the dentate gyrus. Particular emphasis is placed on the three major cell types, granule cells, basket cells and the heterogeneous cells of the hilus. In addition, two of the chapters focus on the termination pattern of chemically-identified afferents to this region. The section concludes with a paper that bridges the gap between anatomy and the next section: Cellular Physiology and Functional Plasticity of neurons in the dentate gyrus. The five chapters in the second section are devoted to the electrophysiology of different neuronal types of the dentate gyrus. The middle section, entitled Seizures and the Regulation of Gene Expression and Protein Content, demonstrates some remarkable alterations in the expression of neuropeptides, growth factors and intracellular calcium-regulating proteins in experimental models of epilepsy.