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Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
Synthesis and Application

by Vinod K. Tiwari

  • Publisher : Elsevier
  • Release : 2020-07-31
  • Pages : 714
  • ISBN : 0128166762
  • Language : En, Es, Fr & De
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Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
A Book

by Chi-Huey Wong

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 980
  • ISBN : 3527605789
  • Language : En, Es, Fr & De
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Carbohydrates as Drugs

Carbohydrates as Drugs
A Book

by Peter H. Seeberger,Christoph Rademacher

  • Publisher : Springer
  • Release : 2014-11-14
  • Pages : 237
  • ISBN : 3319086758
  • Language : En, Es, Fr & De
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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Drug Design and Development

Drug Design and Development
A Book

by Chris Rostron

  • Publisher : Unknown Publisher
  • Release : 2020-05-15
  • Pages : 376
  • ISBN : 0198749317
  • Language : En, Es, Fr & De
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Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy.

Medicinal Chemistry and Drug Discovery: Drug discovery and drug development

Medicinal Chemistry and Drug Discovery: Drug discovery and drug development
A Book

by Alfred Burger

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Discovery from Nature

Drug Discovery from Nature
A Book

by S. Grabley,R. Thiericke

  • Publisher : Springer Science & Business Media
  • Release : 1998-11-26
  • Pages : 347
  • ISBN : 9783540648444
  • Language : En, Es, Fr & De
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This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Carbohydrate Recognition

Carbohydrate Recognition
Biological Problems, Methods, and Applications

by Binghe Wang,Geert-Jan Boons

  • Publisher : John Wiley & Sons
  • Release : 2011-09-09
  • Pages : 440
  • ISBN : 9781118017579
  • Language : En, Es, Fr & De
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This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Aminoglycoside Antibiotics

Aminoglycoside Antibiotics
From Chemical Biology to Drug Discovery

by Dev P. Arya

  • Publisher : John Wiley & Sons
  • Release : 2007-06-29
  • Pages : 336
  • ISBN : 047174302X
  • Language : En, Es, Fr & De
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Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.

Carbohydrate-Based Vaccines and Immunotherapies

Carbohydrate-Based Vaccines and Immunotherapies
A Book

by Zhongwu Guo,Geert-Jan Boons

  • Publisher : John Wiley & Sons
  • Release : 2009-06-17
  • Pages : 512
  • ISBN : 0470473274
  • Language : En, Es, Fr & De
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The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.

Research & Development

Research & Development
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002-07
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Influenza Virus Sialidase - A Drug Discovery Target

Influenza Virus Sialidase - A Drug Discovery Target
A Book

by Mark Itzstein

  • Publisher : Springer Science & Business Media
  • Release : 2011-09-01
  • Pages : 178
  • ISBN : 9783764389277
  • Language : En, Es, Fr & De
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Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.

Drug Discovery and Development

Drug Discovery and Development
Technology in Transition

by H. P. Rang,Daniel Vasella

  • Publisher : Churchill Livingstone
  • Release : 2006
  • Pages : 346
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Medicinal Chemistry and Drug Discovery: Nervous system agents

Medicinal Chemistry and Drug Discovery: Nervous system agents
A Book

by Alfred Burger

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Annual Report

Annual Report
A Book

by Central Drug Research Institute (India)

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chitin and Chitosan Derivatives

Chitin and Chitosan Derivatives
Advances in Drug Discovery and Developments

by Se-Kwon Kim

  • Publisher : CRC Press
  • Release : 2013-12-04
  • Pages : 527
  • ISBN : 1466566329
  • Language : En, Es, Fr & De
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A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field. Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing. A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

Jobs Almanac 1997

Jobs Almanac 1997
A Book

by Adams Publishing

  • Publisher : Unknown Publisher
  • Release : 1996-10
  • Pages : 954
  • ISBN : 9781558506480
  • Language : En, Es, Fr & De
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Describes each year's job outlook and provides the addresses of government and private sector employers grouped by industry.

BioScan

BioScan
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Index of Conference Proceedings

Index of Conference Proceedings
Annual cumulation

by British Library. Document Supply Centre

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Progress Towards the Development of Fully Synthetic Carbohydrate Based Cancer Vaccines

Progress Towards the Development of Fully Synthetic Carbohydrate Based Cancer Vaccines
A Book

by Tyler Edward Benedum

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 232
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Discovery and Evaluation

Drug Discovery and Evaluation
Safety and Pharmacokinetic Assays ; with 125 Tables

by H. Gerhard Vogel

  • Publisher : Springer Science & Business Media
  • Release : 2006-01-01
  • Pages : 889
  • ISBN : 9783540256380
  • Language : En, Es, Fr & De
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This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.