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Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
Synthesis and Application

by Vinod K. Tiwari

  • Publisher : Elsevier
  • Release : 2020-07-31
  • Pages : 714
  • ISBN : 0128166762
  • Language : En, Es, Fr & De
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Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
A Book

by Chi-Huey Wong

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 980
  • ISBN : 3527605789
  • Language : En, Es, Fr & De
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics

Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics
A Book

by Laura Cipolla

  • Publisher : World Scientific
  • Release : 2015-07-23
  • Pages : 536
  • ISBN : 1783267216
  • Language : En, Es, Fr & De
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The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Carbohydrate-based Drug Discovery, 2 Volume Set

Carbohydrate-based Drug Discovery, 2 Volume Set
A Book

by Chi-Huey Wong

  • Publisher : John Wiley & Sons
  • Release : 2003-10-17
  • Pages : 980
  • ISBN : 3527306323
  • Language : En, Es, Fr & De
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Carbohydrate Recognition

Carbohydrate Recognition
Biological Problems, Methods, and Applications

by Binghe Wang,Geert-Jan Boons

  • Publisher : John Wiley & Sons
  • Release : 2011-09-09
  • Pages : 440
  • ISBN : 9781118017579
  • Language : En, Es, Fr & De
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This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Carbohydrates 2018

Carbohydrates 2018
A Book

by Amélia Pilar Rauter,Nuno Manuel Xavier

  • Publisher : MDPI
  • Release : 2020-03-25
  • Pages : 172
  • ISBN : 3039283162
  • Language : En, Es, Fr & De
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This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Carbohydrates in Drug Design and Discovery

Carbohydrates in Drug Design and Discovery
A Book

by Jesus Jimenez-Barbero,F. Javier Canada,Sonsoles Martin-Santamaria

  • Publisher : Royal Society of Chemistry
  • Release : 2015-03-30
  • Pages : 320
  • ISBN : 1849739994
  • Language : En, Es, Fr & De
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In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

Carbohydrate-based Synthetic Methodology and Polymer Development

Carbohydrate-based Synthetic Methodology and Polymer Development
A Book

by Vishwanath Venkatesh Gaitonde

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 165
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Carbohydrates are some of the most abundant organic molecules on earth. They are ubiquitous compounds, most commonly known for providing energy for working and are biologically stockpiled as glycogen. Modern Era advancement in disciplines of glycomics, glycobiology, and bio-renewable studies has played a pivotal role in generating robust interest in the study of carbohydrate chemistry. The advances in the field have progressed to cover an expansive range of scientific areas. For example, there is strong interest in i) developing synthetic methodology, ii) understanding reactivity, iii) performing structural studies, iv) exploring enzyme catalysis, v) biological and medical applications, as well as exploiting their use in food and polymer industries. From a biological perspective it is recognized that carbohydrates play a fundamental role in cell recognition, cell-cell interaction, cell differentiation, cell growth, survival of living cells and organisms. Synthetically, a variety of natural products and antibiotics contains carbohydrate moieties, providing a vast platform for glyco-based synthesis. In addition, biochemical inquiries over last few decades have established the association of carbohydrates with various disease conditions and identified glycan(s) as untapped tools in drug discovery. Development of the carbohydrate-based drug discovery can be categorized by one of the following approaches. i) producing native glycans with desired biological activity, ii) structural modification via glycomimetic approaches, iii) generating a glyco-scaffold for achieving carbohydrate diversity, and iv) developing glyco-fused therapeutics. The scope of work covered in this dissertation covers several carbohydrate-related areas. First, we desired to i) develop a series of ß-glycosyl amide linkages demonstrating the use of ß-glycosyl-2,4-dinitrobenzenesulfonamides as key intermediates in the chemoselective formation of these motifs, ii) produce glycosyl fluoride moieties to study their potential inhibitory activity against Mycobacterium tuberculosis (Mtb) GlgE, iii) generate oligosaccharides to study their interaction with the glucan binding site of Mtb GlgE, and iv) demonstrate the utilization of furfural (degradation product of pentose sugars from hemicellulose, bio-resource) to access a bisfuran monomer, in order to generate furan based polymeric materials. Glycosyl amide linkages are key motifs found in glycosyl amino acids, N-linked glycopeptides besides several natural products. Some of the popular strategies to access these linkages include Lansbury aspartylation involving direct coupling of glycosylamine with activated aspartic acid on protected amino acid. Alternatively, a route to access ß-glycosyl amide linkage is via Staudinger reduction-acylation or traceless Staudinger ligation of ß-glycosyl azide. This method ends up producing a mixture of a/ß glycosyl amides. 2,4-Dinitrobenzenesulfonyl chloride (dNBS-Cl) has been used to protect the primary amines producing the 2,4-dinitrobenzenesulfonamides (dNBS-NH2, dNBS). dNBS can be used to produce secondary amines and diamines as noted by Fukuyama et al. dNBS were later explored for producing amides, thioamides, ureas, and thioureas, and only very recently this strategy has been taken as a possible chemoselective approach to form peptide linkage and neoglycoconjugates. To further this chemistry in our chemoselective studies producing the ß-glycosyl amides, we explored the scope of this methodology by reacting a series of ß-dNBS glycosides with thioacetic acid. The N-glycosyl-2,4-dinitrobenzenesulfonamides were accessed via benzoyl-protected ß-glycosyl azides. The azides were i) reduced with Adams' catalyst to the corresponding amines, ii) the glycosylamines were sulfonated with 2,4-dinitrobenzenesulfonyl chloride to form N-glycosyl-2,4-dinitrobenzenesulfonamides in moderate yields, and iii) the ß-glycosyl amides were then prepared in 67 - 81 % yields by treatment of the sulfonamides with thioacetic acid and cesium carbonate. The conversion of the glycosylsulfonamide to the glycosyl amide proceeded with high stereoselectivity. A second project area involved new approaches to preapare oligosaccharide. Mtb is the causative agent of tuberculosis (TB), which is one of the leading cause of death due to an infectious disease. Designing susbtrates, inhibitors and biochemical probes to understand and overcome this disease condition is of significant interest. Mtb GlgE an a-1,4-glucan: phosphate maltosyltransferase is a genetically validated tuberculosis target. Underlining this target, we designed glycosyl fluoride derivatives, as biochemical probes to determine the active-site residues and better understand the Mtb GlgE catalytic mechanism. 5-fluoro-L-idosyl fluoride, an epimer of 5-fluoro-D-glucosyl fluoride has been synthesized over 5-steps. Starting with D-glucose a key step was photobromination at the C-5 using NBS and AIBN followed by substituting the bromide with fluoride using AgF. Mtb GlgE transfers the maltosyl units on to the elongating the a-1,4-glucan polymer. As a concurrent project we sought to access the oligosaccharide units mimicking the a-glucan polymer in the Mtb GlgE. The oligosaccharides are envisioned to be useful for probing the a-glucan binding site. During the oligosaccharide synthesis, we propose a stereoselective glycosylation strategy was pursued applying a preactivation methodology. Starting with D-maltose, the building blocks for the a-1,4-glucan oligosaccharide were accessed via a divergent synthetic route by creating the donor (4',6'-O-benzylidene-ß-maltosyl thioglycoside) and the acceptor (4'-OH-ß-maltosyl thioglycoside) substrates. During synthesis the donor is first accessed, which was further regioselectively reduced at the 4',6'-O-benzylidene to create 4'-OH (non-reducing end), generating the acceptor substrate. Glycosylation between the donor and acceptor substrate is then envisioned to proceed using a [2+2] preactivated method to build the tetrasachharide unit. This tetrasaccharide on regioselective reduction at the 4',6'-O-benzylidene creates the 4'-OH (non-reducing end), which then acts as a template to produce [4+2] hexasaccharide and/or [4+4] octasaccharide, and so on to access a-1,4-glucan oligosaccharide units of desired length. In a final area of research, carbohydrates were explored as feedstocks for polymer synthesis Starch is commonly understood as a first generation biorenewable feedstock and lignocellulose as second generation biorenewable. Lignocellulose consists of cellulose (40 -- 45 %), hemicellulose (24 -- 40 %), and lignin (18 -- 25 %). Hemicellulose consists chiefly of the pentose sugar xylose and arabinose. The degradation of these pentose sugars yields furfural. The latter is considered to be a leading candidate for bio-renewable building blocks and as a platform chemical for its application in diverse commercial sectors. In the same direction there is a substantial interest and progress in the utilization of this bio-based feedstock to fulfill the growing demands in the sector of fuel, chemical, pharmaceutical and polymer industries. As a part of our preliminary investigation, starting with commercial furfural, we have designed a four steps synthetic route to access a bisfuran diol (BFD)

Carbohydrate-Based Vaccines and Immunotherapies

Carbohydrate-Based Vaccines and Immunotherapies
A Book

by Zhongwu Guo,Geert-Jan Boons

  • Publisher : John Wiley & Sons
  • Release : 2009-06-09
  • Pages : 442
  • ISBN : 0470197560
  • Language : En, Es, Fr & De
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The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.

Carbohydrates 2018

Carbohydrates 2018
A Book

by Nuno Manuel Xavier,Amélia Pilar Rauter

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 172
  • ISBN : 9783039283170
  • Language : En, Es, Fr & De
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This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer's disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Carbohydrates as Drugs

Carbohydrates as Drugs
A Book

by Peter H. Seeberger,Christoph Rademacher

  • Publisher : Springer
  • Release : 2014-11-14
  • Pages : 237
  • ISBN : 3319086758
  • Language : En, Es, Fr & De
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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The Organic Chemistry of Sugars

The Organic Chemistry of Sugars
A Book

by Taylor & Francis Group

  • Publisher : CRC Press
  • Release : 2021-06-30
  • Pages : 904
  • ISBN : 9781032099903
  • Language : En, Es, Fr & De
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Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonstrating the methods and strategies that apply mainstream organic chemistry to the chemical modification of sugars. The book first describes the discovery, development, and impact of carbohydrates, followed by a discussion of protecting group strategies, glycosylation techniques, and oligosaccharide syntheses. Several chapters focus on reactions that convert sugars and carbohydrates to non-carbohydrate molecules including the substitution of sugar hydroxyl groups to new groups of synthetic or biological interest, cyclitols and carbasugars, as well as endocyclic heteroatom substitutions. Subsequent chapters demonstrate the use of sugars in chiral catalysis, their roles as convenient starting materials for complex syntheses involving multiple stereogenic centers, and syntheses for monosaccharides. The final chapters focus on new and emerging technologies, including approaches to combinatorial carbohydrate chemistry, the biological importance and chemical synthesis of glycopeptides, and the medicinally significant concept of glycomimetics. Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, The Organic Chemistry of Sugars provides a comprehensive treatment of the manipulation of sugars and their importance in mainstream organic chemistry. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Anti-Obesity Drug Discovery and Development

Anti-Obesity Drug Discovery and Development
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2014-08-08
  • Pages : 295
  • ISBN : 1608059146
  • Language : En, Es, Fr & De
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Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Carbohydrate Chemistry Volume 45

Carbohydrate Chemistry Volume 45
A Book

by Yves Queneau,Thisbe K. Lindhorst,Amelia Pilar Rauter

  • Publisher : Royal Society of Chemistry
  • Release : 2021-12-22
  • Pages : 664
  • ISBN : 1839163909
  • Language : En, Es, Fr & De
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Carbohydrate Chemistry is an invaluable volume demonstrating the interdisciplinary nature of modern carbohydrate research and containing analysed, evaluated and distilled information on the latest research in the area.

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
Natural Product Drug Discovery

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2016-10-11
  • Pages : 332
  • ISBN : 0128096926
  • Language : En, Es, Fr & De
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Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Kinase Drug Discovery

Kinase Drug Discovery
Modern Approaches

by Richard A. Ward,Frederick W. Goldberg

  • Publisher : Royal Society of Chemistry
  • Release : 2018-10-10
  • Pages : 414
  • ISBN : 1788010833
  • Language : En, Es, Fr & De
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Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

Anti-fibrotic Drug Discovery

Anti-fibrotic Drug Discovery
A Book

by Jehrod Brenneman,Malliga R. Iyer

  • Publisher : Royal Society of Chemistry
  • Release : 2020-02-28
  • Pages : 340
  • ISBN : 178801510X
  • Language : En, Es, Fr & De
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Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Antibiotic Drug Discovery

Antibiotic Drug Discovery
New Targets and Molecular Entities

by Steven M. Firestine,Troy Lister

  • Publisher : Royal Society of Chemistry
  • Release : 2017-05-30
  • Pages : 271
  • ISBN : 1782624244
  • Language : En, Es, Fr & De
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This book identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities.

Drug Discovery for Leishmaniasis

Drug Discovery for Leishmaniasis

by Carmen Gil

  • Publisher : Royal Society of Chemistry
  • Release : 2017-11-02
  • Pages : 402
  • ISBN : 1782628894
  • Language : En, Es, Fr & De
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Peptide-based Drug Discovery

Peptide-based Drug Discovery
Challenges and New Therapeutics

by Ved Srivastava

  • Publisher : Royal Society of Chemistry
  • Release : 2017-06-22
  • Pages : 588
  • ISBN : 1788011716
  • Language : En, Es, Fr & De
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With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.