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Cardiac regeneration and repair

Cardiac regeneration and repair
Pathology and therapies

by Ren-Ke Li,Richard D. Weisel

  • Publisher : Elsevier
  • Release : 2014-02-16
  • Pages : 440
  • ISBN : 0857096702
  • Language : En, Es, Fr & De
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Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Cardiac Regeneration

Cardiac Regeneration
A Book

by Masaki Ieda,Wolfram-Hubertus Zimmermann

  • Publisher : Springer
  • Release : 2017-10-27
  • Pages : 274
  • ISBN : 3319561065
  • Language : En, Es, Fr & De
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This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Stem Cells and Cardiac Regeneration

Stem Cells and Cardiac Regeneration
A Book

by Rosalinda Madonna

  • Publisher : Springer
  • Release : 2015-12-18
  • Pages : 205
  • ISBN : 3319254278
  • Language : En, Es, Fr & De
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This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration.

Heart Regeneration

Heart Regeneration
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 329
  • ISBN : 9814465259
  • Language : En, Es, Fr & De
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Cardiovascular Regeneration and Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy
A Book

by Annarosa Leri,Piero Anversa,William H. Frishman

  • Publisher : John Wiley & Sons
  • Release : 2008-04-15
  • Pages : 248
  • ISBN : 0470994304
  • Language : En, Es, Fr & De
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This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Biomaterials for Cardiac Regeneration

Biomaterials for Cardiac Regeneration
A Book

by Erik J. Suuronen,Marc Ruel

  • Publisher : Springer
  • Release : 2014-11-12
  • Pages : 323
  • ISBN : 3319109723
  • Language : En, Es, Fr & De
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This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.

Cardiac Regeneration in a Newborn: what Does this Mean for Future Cardiac Repair Research?.

Cardiac Regeneration in a Newborn: what Does this Mean for Future Cardiac Repair Research?.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Wound Healing, Tissue Repair and Regeneration in Diabetes

Wound Healing, Tissue Repair and Regeneration in Diabetes
A Book

by Debasis Bagchi,Amitava Das,Sashwati Roy

  • Publisher : Academic Press
  • Release : 2020-05
  • Pages : 656
  • ISBN : 0128164131
  • Language : En, Es, Fr & De
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Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.

Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine
Tissue Engineering and Clinical Applications

by Vahid Serpooshan,Sean M. Wu

  • Publisher : Springer
  • Release : 2019-06-29
  • Pages : 233
  • ISBN : 3030200477
  • Language : En, Es, Fr & De
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This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Myocardial Tissue Engineering

Myocardial Tissue Engineering
A Book

by Aldo R. Boccaccini,Sian Harding

  • Publisher : Springer Science & Business Media
  • Release : 2011-08-30
  • Pages : 270
  • ISBN : 9783642180569
  • Language : En, Es, Fr & De
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Myocardial tissue engineering (MTE), a concept that intends to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.

Regenerating the Heart

Regenerating the Heart
Stem Cells and the Cardiovascular System

by Ira S. Cohen,Glenn R. Gaudette

  • Publisher : Springer Science & Business Media
  • Release : 2011-03-23
  • Pages : 558
  • ISBN : 9781617790218
  • Language : En, Es, Fr & De
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Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.

The Journal of Cell Biology

The Journal of Cell Biology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Nanomedicine for Ischemic Cardiomyopathy

Nanomedicine for Ischemic Cardiomyopathy
Progress, Opportunities, and Challenges

by Morteza Mahmoudi

  • Publisher : Academic Press
  • Release : 2020-05-05
  • Pages : 214
  • ISBN : 0128174358
  • Language : En, Es, Fr & De
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Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges provides an overview on the recent advances in diagnostic and treatment of ischemic cardiomyopathy diseases including myocardial infarction. Shortcomings of the current methods and how nanomedicine can address those obstacles in the field are discussed including the limitations of newly developed cell therapy approaches to clinical translation and how nanomedicine may overcome crucial issues and facilitate the successful and efficient clinical translation of cell therapy. Biomolecular therapy is also explored as another powerful approach for regeneration of heart tissue including available methods and systematic delivery of biomolecules using nanocarriers to the injured part of myocardium through active targeting. Finally, coverage of major tissue engineering advances for myocardial regeneration, including use of epicardial nanostructured patches for regeneration of injured epicardium and the highly conductive patches for enhancing cross talks between the cardiomyocytes, is explored. This concise, yet rigorous coverage, of the field of cardiac nanotechnology outlines the innovative and necessary role of nanomedicine in regenerative medicine for cardiac repair allowing researchers, clinicians, and nanotechnologists to examine the strengths and limitations of current findings and predict future trends to advance the applications of nanotechnology in cardiovascular biomedical research. Introduces concepts of the unique capacities of cardiac-nanotechnology Points to potential and promising applications of engineering nanotechnologies on revolutionizing cell therapy and biomolecular therapy approaches for cardiac regeneration Bridges the knowledge gap between cardiologists and cardiac regenerative nanomedicine experts

Concepts and Applications of Stem Cell Biology

Concepts and Applications of Stem Cell Biology
A Guide for Students

by Gabriela Rodrigues,Bernard A. J. Roelen

  • Publisher : Springer Nature
  • Release : 2020-06-30
  • Pages : 267
  • ISBN : 3030439399
  • Language : En, Es, Fr & De
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This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Enhancing Myocardial Repair with CardioClusters

Enhancing Myocardial Repair with CardioClusters
A Book

by Megan Michele Mendes Monsanto

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 167
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Heart disease leading to cardiovascular failure is a major public health issue in the United States with a considerable burden for the health care system. Despite recent progress to advance stem cell-based therapy for patients, heart failure carries a five-year mortality that rivals most cancers. This proposal describes an approach to control and pattern three distinct stem cell populations derived from the human heart to promote superior repair and regeneration after myocardial infarction. Regenerative capacity of the heart is mediated through multiple distinct populations of stem cell types that are the subject of ongoing intense study. In the past decade, isolation and characterization of c-kit+ cardiac progenitor cells (CPCs), mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) have provided substantial insight to the capabilities of stem cells to rebuild the damaged heart and advance clinical therapy. Clinical trials have proven the efficacy and safety of autologous and allogeneic cell delivery to human patients, yet improvements in cardiac function and reduction in scar tissue remain modest and far below that needed for restoration of normal functional output. The work presented in this dissertation project overcomes these current cell-based limitations by using a novel method for improving myocardial repair: CardioClusters, a three-dimensional microenvironment consisting of CPCs, MSCs and EPCs. The innovation of this project is the creation of CardioClusters with the ability to capitalize upon beneficial attributes of multiple human stem cells from a single human heart providing a clinically relevant translational strategy. Collectively, studies in this dissertation will pave the way for interventional approaches to selectively adapt stem cell behavior and merge beneficial attributes of stem cell populations found within the human heart for prevention of heart failure after cardiomyopathic injury.

Endocrine Frailty in the Elderly

Endocrine Frailty in the Elderly
A Book

by Sandro La Vignera,Antonio Aversa,Fabio Monzani

  • Publisher : Frontiers Media SA
  • Release : 2019-12-04
  • Pages : 329
  • ISBN : 2889632342
  • Language : En, Es, Fr & De
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Stem Cell Therapy for Myocardial Repair

Stem Cell Therapy for Myocardial Repair
Functional and Bioenergetic Modulations in the Infarct Border Zone

by Julia M. Feygin

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 362
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cardiovascular Healing - Focus on Inflammation

Cardiovascular Healing - Focus on Inflammation
Leopoldina Symposium, Wuerzburg, June 23 to 24, 2006

by Johann Bauersachs

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 122
  • ISBN : 9783804724655
  • Language : En, Es, Fr & De
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Biomaterial-based Tissue Engineering Approaches to Repair Myocardial Infarction

Biomaterial-based Tissue Engineering Approaches to Repair Myocardial Infarction
A Book

by Jiashing Yu

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 286
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Untitled

Untitled
A Book

by Anonim

  • Publisher : Elsevier España
  • Release : 2021
  • Pages : 329
  • ISBN : 8490220654
  • Language : En, Es, Fr & De
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