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Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-07-30
  • Pages : 226
  • ISBN : 012816574X
  • Language : En, Es, Fr & De
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Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Research Awards Index

Research Awards Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human Genome Editing

Human Genome Editing
Science, Ethics, and Governance

by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations

  • Publisher : National Academies Press
  • Release : 2017-08-13
  • Pages : 328
  • ISBN : 0309452880
  • Language : En, Es, Fr & De
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Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Research Grants Index

Research Grants Index
A Book

by National Institutes of Health (U.S.). Division of Research Grants

  • Publisher : Unknown Publisher
  • Release : 1971
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Kumar and Clark's Clinical Medicine E-Book

Kumar and Clark's Clinical Medicine E-Book
A Book

by Parveen Kumar,Michael L Clark

  • Publisher : Elsevier Health Sciences
  • Release : 2012-06-04
  • Pages : 1352
  • ISBN : 070205304X
  • Language : En, Es, Fr & De
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Kumar & Clark’s Clinical Medicine 8 builds on the prize-winning formula that won the first prize in the BMA Book Awards Medicine Category in 2010 (7th edition) and 2006 (6th edition). ‘This book is comprehensive, student friendly (if still intimidating in size!) and covers such a vast breadth of knowledge. It still remains the primary ‘must-have’ text book of any budding doctor, or qualified one at that. This book is stunning in its breadth and in its ease of use. It still remains as the ‘gold-standard’ thorough guide to clinical medicine its forefathers were.’ BMA Judges 2010 'This is one of a select few books that deserves to be in most doctors' personal possession and it's as simple as that. ...’ Dr Harry Brown. New to this edition: New chapter on palliative medicine. Five times the number of margin clinical photos. New echocardiography images. Double the number of dermatological images; including all the major lesion morphologies covered in a single page. 16 new authors. New sections on protein synthesis, energy production and stem cells. New members of the International Advisory Board from India, South Africa, Poland and the Middle East. 7 new online chapters from the International Advisory Board. Key online features: 30 extra short chapters online, written by members of the International Advisory Board to cover key international issues, such as malaria, envenoming and HIV. Animated practical procedures, including lumbar puncture, central venous and bladder catheterization, arterial cannulation etc. heart and lung sounds, and interactive surface anatomy available online. Full text online through StudentConsult. Add your own notes and bookmarks. Search across all the StudentConsult resources you own online in one place. New to this edition: New chapter on palliative medicine. Five times the number of margin clinical photos. New echocardiography images. Double the number of dermatological images; including all the major lesion morphologies covered in a single page. 16 new authors. New sections on protein synthesis, energy production and stem cells. New members of the International Advisory Board from India, South Africa, Poland and the Middle East. 7 new online chapters from the International Advisory Board.

Handbook of Laboratory Animal Science, Volume III

Handbook of Laboratory Animal Science, Volume III
Animal Models

by Jann Hau,Steven J. Schapiro

  • Publisher : CRC Press
  • Release : 2013-12-26
  • Pages : 334
  • ISBN : 1466555130
  • Language : En, Es, Fr & De
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While replacing and reducing the use of laboratory animals are integral parts of the 3Rs-replace, reduce, refine-which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestsel

The Laboratory Fish

The Laboratory Fish
A Book

by Gary Ostrander

  • Publisher : Elsevier
  • Release : 2000-09-12
  • Pages : 678
  • ISBN : 9780125296502
  • Language : En, Es, Fr & De
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This reference series provides researchers of all kinds with comprehensive practical information on different species of laboratory animals, for daily laboratory use. Each title in the series in devoted to a different species. and draws together all available data in one easily accessible source. Each has similar format, with sections on the strains available, their husbandry and special diets. This leads to sections on gross anatomy, endocrinology and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout, with copious color histology microphotographs. Key Features * Comprehensive reference source for anybody working with laboratory fish * 2-color, user-friendly format * Copious high quality illustrations included throughout * Color plate section * Glossary * Appendix of useful addresses

Functional Analysis of the Human Genome

Functional Analysis of the Human Genome
A Book

by F. Farzaneh,D. N. Cooper

  • Publisher : Garland Science
  • Release : 2020-09-11
  • Pages : 256
  • ISBN : 1000140962
  • Language : En, Es, Fr & De
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An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.

Etiology of Breast and Gynecological Cancers

Etiology of Breast and Gynecological Cancers
A Book

by C. Marcelo Aldaz,Michael N. Gould,J. C. McLachlan,Thomas J. Slaga

  • Publisher : John Wiley & Sons
  • Release : 1997-03-21
  • Pages : 296
  • ISBN : 9780471169017
  • Language : En, Es, Fr & De
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Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29–December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including: recent advances in the molecular genetics of hereditary breast and ovarian cancer molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia genotoxicity of environmental agents in human mammary epithelial cells rodent model of reproductive tract leiomyomata estrogens and the genetic control of tumor growth Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
A Book

by P. Michael Conn

  • Publisher : Academic Press
  • Release : 2013-05-29
  • Pages : 1108
  • ISBN : 0124159125
  • Language : En, Es, Fr & De
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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials
A Book

by Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam

  • Publisher : Frontiers Media SA
  • Release : 2019-12-23
  • Pages : 329
  • ISBN : 2889632490
  • Language : En, Es, Fr & De
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This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice.

Techniques in Quantification and Localization of Gene Expression

Techniques in Quantification and Localization of Gene Expression
A Book

by Bruce K. Patterson

  • Publisher : Springer Science & Business Media
  • Release : 2000-01-24
  • Pages : 150
  • ISBN : 9780817640347
  • Language : En, Es, Fr & De
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The molecular basis of disease is the driving force in biomedical reserach. Gene detection, quantification, and localization are required to determine disease pathogenesis. In as much as DNA is the genetic potential in a particular organism, RNA and protein expression are the functional result of our genetic program. "Techniques in Localization of Gene Expression" describes in great detail the methods used to quantify and localize gene expression. Sensitive detection of gene expression is hindered by poor recovery or preservation of target sequences. "Techniques" emphasizes optimized methods to ensure full recovery and preservaiton of targets from specimen acquisition through detection of specific targets and final analysis. Situ Analyses of cells and tissues are also discussed. One of the weaknesses in biomedical research has been the use of in vitro model systems consisting of cell lines that may or may not mimic the in vivo conditions. These model systems are necessary to ask several questions on cell s and tissues with controllled variables int he absense of strategies to ask many questions at the same time. Multiparameter analysis can cirmcumvent the necessity fo in vitro model systems by allowing many quesitons to be answered on a cell or tissue at a single point in time. Using fluorescent dyes, on can answer many questions about a particular cell or tissue. One color, one question is an overriding theme of this book. The limitations of this approach are the number of colors in the spectrum and our ability to resolve them. Readers will find working protocols that have been developed and used routinely in the author's laboratory. Representative applications will be described using the various gene quantification and localization protocols to illustrate the utility of the techniques.

Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens

Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens
A Book

by Larry Nathanson

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 176
  • ISBN : 1461539382
  • Language : En, Es, Fr & De
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journal are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass ofoncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelfor by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.;and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Recent Advances in Otolaryngology

Recent Advances in Otolaryngology
Head & Neck Surgery

by Anil K Lalwani,Markus HF Pfister

  • Publisher : JP Medical Ltd
  • Release : 2014-04-30
  • Pages : 406
  • ISBN : 9351521451
  • Language : En, Es, Fr & De
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Third volume of annual series bringing clinicians and trainees up to date with latest developments in otolaryngology. Complete chapter dedicated to emerging subspecialty, geriatric otolaryngology.

Human Genetics

Human Genetics
Race, Population, and Disease

by Russ Hodge

  • Publisher : Infobase Publishing
  • Release : 2010-01-01
  • Pages : 228
  • ISBN : 0816066825
  • Language : En, Es, Fr & De
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Describes modern developments in the field of genetics, discussing the mapping of the human genome, the genetic causes of afflictions, and genetic modification.

The Mouse in Animal Genetics and Breeding Research

The Mouse in Animal Genetics and Breeding Research
A Book

by Eugene J Eisen

  • Publisher : World Scientific
  • Release : 2005-06-27
  • Pages : 376
  • ISBN : 1783260262
  • Language : En, Es, Fr & De
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The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields. Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB) Contents:The Beginnings: Ode to a Wee Mouse (E J Eisen)Testing Quantitative Genetic Selection Theory (E J Eisen)Maternal Effects, Genomic Imprinting and Evolution (J Funk-Keenan & W R Atchley)Inbreeding and Crossbreeding (G A Brockmann)Genotype by Environment Interaction: Lessons From the Mouse (W D Hohenboken)Genetics of Growth in the Mouse (J M Cheverud)Genetics of Body Composition and Metabolic Rate (L Bünger & W G Hill)Genetics of Reproduction (M K Nielsen)Genetics of Behavior (R J Hitzemann)Genetics of Disease Resistance (S L Ewart & R A Ramadas)Genomic Dissection of Complex Trait Predisposition (D Pomp)Mouse Mutagenesis (D R Beier)Embryo Biotechnologies (C A Pinkert & M J Martin)Transgenics (J D Murray & E A Maga)The Mouse in Biomedical Research (R B Roberts & D W Threadgill)The Mouse Genome Sequencing Project: An Overview (M C Wendl et al.) Readership: Researchers, teachers, graduate students and advanced undergraduates in genetics, genomics, biotechnology, bioinformatics, animal breeding and zoology. Key Features:Covers the methods used to find genes in the mouse that affect complex genetic traitsCuts across biomedical and bioagricultural applicationsNo competing titles availableKeywords:Genetics;Mouse;Biotechnology;Genome Sequencing;Quantitative Genetics;Transgenics;Growth;Reproduction;Biomedical Genetics;Biomedical Genetics;Behavior;Maternal Genetics;ENU Mutagenesis

Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
A Practical Guide

by Eleftheria Zeggini,Andrew Morris

  • Publisher : Academic Press
  • Release : 2010-11-17
  • Pages : 340
  • ISBN : 9780123751430
  • Language : En, Es, Fr & De
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According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks

Animal Models and Human Reproduction

Animal Models and Human Reproduction
A Book

by Heide Schatten,Gheorghe M. Constantinescu

  • Publisher : John Wiley & Sons
  • Release : 2017-01-13
  • Pages : 600
  • ISBN : 1118881346
  • Language : En, Es, Fr & De
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Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.

Human Genetics and Genomics

Human Genetics and Genomics
A Practical Guide

by Bahar Taneri,Esra Asilmaz,Türem Delikurt,Pembe Savas,Seniye Targen,Yagmur Esemen

  • Publisher : John Wiley & Sons
  • Release : 2020-02-12
  • Pages : 160
  • ISBN : 3527682651
  • Language : En, Es, Fr & De
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Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.

International Review Of Cytology

International Review Of Cytology
A Survey of Cell Biology

by Kwang W. Jeon

  • Publisher : Elsevier
  • Release : 2005-05-04
  • Pages : 368
  • ISBN : 0080457789
  • Language : En, Es, Fr & De
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International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address the Keratins of the human hair follicle; calcium channels and Ca2+ fluctuations in sperm physiology; genomic imprinting: cis-acting sequences and regional control; insulin-like growth factor signaling in fishes; cell biology of cardiac cushion development.