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Cellular Imaging Techniques for Neuroscience and Beyond

Cellular Imaging Techniques for Neuroscience and Beyond
A Book

by Floris G. Wouterlood

  • Publisher : Academic Press
  • Release : 2012-12-06
  • Pages : 296
  • ISBN : 0123858739
  • Language : En, Es, Fr & De
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The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc. Single and multiphoton confocal microscopy, and 4-pi confocal microscopy Obtaining nanoresolution via photoactivation localization microscopy (PALM) Several procedures that correlate observations in optical fluorescence microscopy and electron microscopy Study of morphology and function via high-resolution fluorescence procedures Additional high-resolution microscopic techniques

Cellular Imaging Techniques for Neuroscience and Beyond

Cellular Imaging Techniques for Neuroscience and Beyond
A Book

by Floris G. Wouterlood

  • Publisher : Academic Press
  • Release : 2012
  • Pages : 282
  • ISBN : 0123858720
  • Language : En, Es, Fr & De
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The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc. * The first comprehensive volume on cellular imaging with a focus for its application in neuroscience * Concluding chapter compares the merits of various techniques * Full color throughout, maximizing users comprehension of the results obtainable via various methods * Features outstanding and truly international scholarship, with chapters written by leading experts in neuroscience and cell biology * Discusses cutting edge methods such as STED, PALM/STORM, nonlinear microscopy and more

Advanced Optical Methods for Brain Imaging

Advanced Optical Methods for Brain Imaging
A Book

by Fu-Jen Kao,Gerd Keiser,Ankur Gogoi

  • Publisher : Springer
  • Release : 2018-05-14
  • Pages : 334
  • ISBN : 9811090203
  • Language : En, Es, Fr & De
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This book highlights the rapidly developing field of advanced optical methods for structural and functional brain imaging. As is known, the brain is the most poorly understood organ of a living body. It is indeed the most complex structure in the known universe and, thus, mapping of the brain has become one of the most exciting frontlines of contemporary research. Starting from the fundamentals of the brain, neurons and synapses, this book presents a streamlined and focused coverage of the core principles, theoretical and experimental approaches, and state-of-the-art applications of most of the currently used imaging methods in brain research. It presents contributions from international leaders on different photonics-based brain imaging modalities and techniques. Included are comprehensive descriptions of many of the technology driven spectacular advances made over the past few years that have allowed novel insights of the structural and functional details of neurons. The book is targeted at researchers, engineers and scientists who are working in the field of brain imaging, neuroscience and connectomics. Although this book is not intended to serve as a textbook, it will appeal to undergraduate students engaged in the specialization of brain imaging.

Single-Domain Antibodies: Biology, Engineering and Emerging Applications

Single-Domain Antibodies: Biology, Engineering and Emerging Applications

by Kevin A. Henry,C. Roger MacKenzie

  • Publisher : Frontiers Media SA
  • Release : 2018-03-19
  • Pages : 129
  • ISBN : 2889454320
  • Language : En, Es, Fr & De
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Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.

Bioinspired Approaches for Human-Centric Technologies

Bioinspired Approaches for Human-Centric Technologies
A Book

by Roberto Cingolani

  • Publisher : Springer
  • Release : 2014-06-04
  • Pages : 334
  • ISBN : 3319049240
  • Language : En, Es, Fr & De
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The present book discusses topics related to research and development of materials and devices at nanoscale size and their respective application in medicine and biomedicine. The individual chapters give a detailed state of the art overview to the distinct topic. Apparently disconnected fields - life sciences, biomedicine, chemistry, physics, medicine and engineering - will be bridged with a highly interdisciplinary view onto each subject.

Light and Video Microscopy

Light and Video Microscopy
A Book

by Randy O. Wayne

  • Publisher : Academic Press
  • Release : 2013-12-16
  • Pages : 366
  • ISBN : 0124115365
  • Language : En, Es, Fr & De
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The purpose of this book is to provide the most comprehensive, easy-to-use, and informative guide on light microscopy. Light and Video Microscopy will prepare the reader for the accurate interpretation of an image and understanding of the living cell. With the presentation of geometrical optics, it will assist the reader in understanding image formation and light movement within the microscope. It also provides an explanation of the basic modes of light microscopy and the components of modern electronic imaging systems and guides the reader in determining the physicochemical information of living and developing cells, which influence interpretation. Brings together mathematics, physics, and biology to provide a broad and deep understanding of the light microscope Clearly develops all ideas from historical and logical foundations Laboratory exercises included to assist the reader with practical applications Microscope discussions include: bright field microscope, dark field microscope, oblique illumination, phase-contrast microscope, photomicrography, fluorescence microscope, polarization microscope, interference microscope, differential interference microscope, and modulation contrast microscope

Characterization of Nanoencapsulated Food Ingredients

Characterization of Nanoencapsulated Food Ingredients
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-03-07
  • Pages : 696
  • ISBN : 0128156686
  • Language : En, Es, Fr & De
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Characterization of Nanoencapsulated Food Ingredients, Volume Four in the Nanoencapsulation in the Food Industry series, introduces some of the common instrumental analysis and characterization methods for the evaluation of nanocarriers and nanoencapsulated ingredients in terms of their morphology, size distribution, surface charge and composition, appearance, physicochemical and rheological properties, and antioxidant activity. Divided in five sections, the book covers the qualitative and quantitative properties of nanoencapsulated food ingredients by different characterization techniques, besides correlating nanocarrier behavior to their physicochemical and functional properties. Authored by a team of global experts in the fields of nano- and microencapsulation of food, nutraceutical, and pharmaceutical ingredients, this title is of great value to those engaged in the various fields of nanoencapsulation and nanodelivery systems. Shows how different properties of nanoencapsulated food ingredients can be analyzed Presents the mechanism of each characterization technique Investigates how the analytical results can be understood with nanoencapsulated ingredients

50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus and beyond

50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus and beyond

by Alino Martinez-Marcos,José L.Trejo,Laura López-Mascaraque

  • Publisher : Frontiers Media SA
  • Release : 2016-09-21
  • Pages : 129
  • ISBN : 2889199630
  • Language : En, Es, Fr & De
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In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.

Encyclopedia of Neuroscience, Volume 1

Encyclopedia of Neuroscience, Volume 1
A Book

by Larry R. Squire

  • Publisher : Academic Press
  • Release : 2009-06-12
  • Pages : 12505
  • ISBN : 0080963935
  • Language : En, Es, Fr & De
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The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.

Cellular Imaging and Emerging Technologies for Adult Neurogenesis Research

Cellular Imaging and Emerging Technologies for Adult Neurogenesis Research
A Book

by Silvia De Marchis,Adam C. Puche

  • Publisher : Frontiers Media SA
  • Release : 2012-05-01
  • Pages : 129
  • ISBN : 2889190293
  • Language : En, Es, Fr & De
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Adult Neurogenesis: Beyond Rats and Mice

Adult Neurogenesis: Beyond Rats and Mice
A Book

by Luca Bonfanti,Irmgard Amrein

  • Publisher : Frontiers Media SA
  • Release : 2019-02-11
  • Pages : 129
  • ISBN : 2889457613
  • Language : En, Es, Fr & De
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Researchers working on adult neurogenesis have focused largely on inbred laboratory rodents. While this provides a strong advantage of restricting genetic variation in the group, it also narrows our perspective on adult neurogenesis as a biological phenomenon. Many unsolved issues and open questions cannot be resolved without the contribution of comparative studies spanning through widely different species: how did adult neurogenesis evolve, what is the link between adult neurogenesis and brain complexity, how do adult neurogenesis and animal behavior influence each other, how does adult neurogenesis contribute to brain plasticity, cognition and, possibly, repair, and how do experimental conditions affect adult neurogenesis. The main message from the comparative approach to adult neurogenesis is that the relative exclusive focus on laboratory rodents can result in a bias on how we think about this biological process.

Seeing Beyond the Eye: The Brain Connection

Seeing Beyond the Eye: The Brain Connection
A Book

by Christine Nguyen,Monica Liliana Acosta,Silvia Di Angelantonio,Thomas Salt

  • Publisher : Frontiers Media SA
  • Release : 2021-09-02
  • Pages : 129
  • ISBN : 2889712591
  • Language : En, Es, Fr & De
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Multimodal Brain Tumor Segmentation and Beyond

Multimodal Brain Tumor Segmentation and Beyond
A Book

by Bjoern Menze,Spyridon Bakas

  • Publisher : Frontiers Media SA
  • Release : 2021-08-10
  • Pages : 129
  • ISBN : 2889711706
  • Language : En, Es, Fr & De
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Advanced Neuroimaging Methods for Studying Autism Disorder

Advanced Neuroimaging Methods for Studying Autism Disorder

by Alessandro Grecucci,Roma Siugzdaite,Remo Job

  • Publisher : Frontiers Media SA
  • Release : 2017-11-16
  • Pages : 129
  • ISBN : 2889453162
  • Language : En, Es, Fr & De
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In the last twenty years, many attempts have been made to provide neurobiological models of autism. Functional, structural and connectivity analyses have highlighted reduced responses in key social areas, such as amygdala, medial prefrontal cortex, cingulate cortex, and superior temporal sulcus. However, these studies present discrepant results and some of them have been questioned for methodological limitations. The aim of this research topic is to present advanced neuroimaging methods able to capture the complexity of the neural deficits displayed in autism. This special issue presents new studies using structural and functional MRI, as well as magnetoencephalography, and novel protocols to analyze data (Analysis of Cluster Variability, Noise Reduction Strategies, Source-based Morphometry, Functional Connectivity Density, Restriction Spectrum Imaging and the others). We believe it is time to integrate data provided by different techniques and methodologies in order to have a better understanding of autism.

Neuroimaging

Neuroimaging
Methods

by Peter Bright

  • Publisher : BoD – Books on Demand
  • Release : 2012-02-17
  • Pages : 374
  • ISBN : 9535100971
  • Language : En, Es, Fr & De
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Neuroimaging methodologies continue to develop at a remarkable rate, providing ever more sophisticated techniques for investigating brain structure and function. The scope of this book is not to provide a comprehensive overview of methods and applications but to provide a 'snapshot' of current approaches using well established and newly emerging techniques. Taken together, these chapters provide a broad sense of how the limits of what is achievable with neuroimaging methods are being stretched.

Optogenetics

Optogenetics
A Book

by Hiromu Yawo

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 9811587639
  • Language : En, Es, Fr & De
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EBOOK: Pioneering Studies In Cognitive Neuroscience

EBOOK: Pioneering Studies In Cognitive Neuroscience
A Book

by Richard Roche,Sean Commins

  • Publisher : McGraw-Hill Education (UK)
  • Release : 2009-10-16
  • Pages : 136
  • ISBN : 0335240356
  • Language : En, Es, Fr & De
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This edited collection presents seven recent studies in contemporary cognitive neuroscience which have come to be viewed as classic experiments. the contributing authors are renowned in their field for producing intelligent and innovative research, and together they cover each of the main sub-disciplines of cognitive neuroscience.

Biomarkers in Drug Discovery and Development

Biomarkers in Drug Discovery and Development
A Handbook of Practice, Application, and Strategy

by Ramin Rahbari,Jonathan Van Niewaal,Michael R. Bleavins

  • Publisher : John Wiley & Sons
  • Release : 2020-02-28
  • Pages : 608
  • ISBN : 1119187524
  • Language : En, Es, Fr & De
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This book continues the legacy of a well-established reference within the pharmaceutical industry – providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development. • Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection of better compounds and reduce late stage attrition, and facilitate personalized medicine • Helps readers get a better understanding of biomarkers and how to use them, for example which are accepted by regulators and which still non-validated and exploratory • Updates developments in genomic sequencing, and application of large data sets into pre-clinical and clinical testing; and adds new material on data mining, economics, and decision making, personal genetic tools, and wearable monitoring • Includes case studies of biomarkers that have helped and hindered decision making • Reviews of the first edition: “If you are interested in biomarkers, and it is difficult to imagine anyone reading this who wouldn't be, then this book is for you." (ISSX) and “...provides a good introduction for those new to the area, and yet it can also serve as a detailed reference manual for those practically involved in biomarker implementation.” (ChemMedChem)

Neuroscience and Neurotechnology of Neuronal Cell Surface Molecules in Neural Circuits

Neuroscience and Neurotechnology of Neuronal Cell Surface Molecules in Neural Circuits
A Book

by Masahito Yamagata,Hiroko Bannai

  • Publisher : Frontiers Media SA
  • Release : 2021-08-05
  • Pages : 129
  • ISBN : 2889711498
  • Language : En, Es, Fr & De
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Methods in Insect Sensory Neuroscience

Methods in Insect Sensory Neuroscience
A Book

by Thomas A. Christensen

  • Publisher : CRC Press
  • Release : 2004-12-20
  • Pages : 464
  • ISBN : 1420039423
  • Language : En, Es, Fr & De
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Insects are among the most diverse and adaptable organisms on Earth. They have long been our chief competitors for food and are responsible for spreading devastating afflictions such as malaria and encephalitis. The insects’ ability to thrive is due in large part to their well-developed sensory systems, which present a host of novel physiological, biochemical, and behavioral attributes that underlie their remarkable feats of sensory performance. Methods in Insect Neuroscience is the first text to showcase the tremendous variety of methods that are available to study the sensory capabilities of insects. It covers the complete spectrum of sensory modalities in insects, from vision and audition, to chemoreception and multimodal processing. The book is designed to serve as a how to guide for putting into practice a wide range of techniques, including behavioral observation, brain imaging, single- and multi-unit electrophysiology, computer modeling/signal processing, and robotics to address innumerable questions. A truly multidisciplinary synthesis of neurobiological, behavioral, and computational approaches to sensory-information processing is most likely to yield our richest understanding of the mechanisms that underlie sensation and perception. In that spirit, this book contains chapters by leading neuroethologists, comparative biologists, neuroscientists, computational biologists, geneticists, and bioengineers who have adopted insects as their models. Their hard work and dedication is evident in the quality of detail contained in every chapter. This book is intended for seasoned neuroscientists looking for state-of-the-art information, as well as discussions on the open-ended questions facing sensory neuroscience today. It is also intended as a primer for newcomers utilizing insects to embark on a study of sensory mechanisms.The opening section provides background information and references about the basic organization of the insect brain and the behavioral strategies used by insects to navigate their complex and varied environments. The latter sections are designed to provide more detailed information about specific sensory modalities and the tools that are used to study them.