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Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
Medicinal Chemistry 2.0

by Pierfausto Seneci

  • Publisher : Elsevier
  • Release : 2018-06-05
  • Pages : 194
  • ISBN : 008099928X
  • Language : En, Es, Fr & De
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Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

Information and Communications

Information and Communications
Challenges for the Chemical Sciences in the 21st Century

by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century,Organizing Committee for the Workshop on Information and Communications

  • Publisher : National Academies Press
  • Release : 2003-11-28
  • Pages : 208
  • ISBN : 030908721X
  • Language : En, Es, Fr & De
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Since publication of the National Research Council (NRC) reports on chemistry in 1985 and chemical engineering in 1988,1,2 dramatic advances in information technology (IT) have totally changed these communities. During this period, the chemical enterprise and information technology have enjoyed both a remarkably productive and mutually supportive set of advances. These synergies sparked unprecedented growth in the capability and productivity of both fields including the definition of entirely new areas of the chemical enterprise. The chemical enterprise provided information technology with device fabrication processes, new materials, data, models, methods, and (most importantly) people. In turn, information technology provided chemical science and technology with truly remarkable and revolutionary resources for computations, communications, and data management. Indeed, computation has become the strong third component of the chemical science research and development effort, joining experiment and theory. Sustained mutual growth and interdependence of the chemical and information communities should take account of several unique aspects of the chemical sciences. These include extensive and complex databases that characterize the chemical disciplines; the importance of multiscale simulations that range from molecules to technological processes; the global economic impact of the chemical industry; and the industry's major influence on the nation's health, environment, security, and economic well-being. In planning the future of the chemical sciences and technology, it is crucial to recognize the benefits already derived from advances in information technology as well as to point the way to future benefits that will be derived.

Pharmaceutical Process Development

Pharmaceutical Process Development
Current Chemical and Engineering Challenges

by A. John Blacker,Mike T. Williams

  • Publisher : Royal Society of Chemistry
  • Release : 2011
  • Pages : 354
  • ISBN : 1849731462
  • Language : En, Es, Fr & De
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This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

Chemical Biology

Chemical Biology
Concepts, Methods and Tools for Drug Discovery

by Tomi K. Sawyer,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers

  • Publisher : Wiley-VCH
  • Release : 2010-07-28
  • Pages : 400
  • ISBN : 9783527322985
  • Language : En, Es, Fr & De
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Compiled by one of the pioneers in the industrial use of chemical biology, this is the first stand-alone publication to systematically address its application to the drug discovery process. The three main parts cover the concepts, methods, and tools, taking in such a wide variety of technologies as chemical genetics, high-throughput screening, bioengineering and bioinformatics. Backed by the key players in the global pharmaceutical market, with the editor and authors relating their first-hand experience.

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery
A Book

by Zoran Rankovic,Richard Morphy

  • Publisher : Wiley
  • Release : 2010-04-07
  • Pages : 304
  • ISBN : 0470584165
  • Language : En, Es, Fr & De
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An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

High Throughput Analysis for Early Drug Discovery

High Throughput Analysis for Early Drug Discovery
A Book

by James Kyranos

  • Publisher : Elsevier
  • Release : 2004-09-18
  • Pages : 204
  • ISBN : 0080472923
  • Language : En, Es, Fr & De
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High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis

Health and Medicine

Health and Medicine
Challenges for the Chemical Sciences in the 21st Century

by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century,Organizing Committee for the Workshop on Health and Medicine

  • Publisher : National Academies Press
  • Release : 2004-03-02
  • Pages : 76
  • ISBN : 0309087201
  • Language : En, Es, Fr & De
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The report assesses the current state of chemistry and chemical engineering within the context of drug discovery, disease diagnosis, and disease prevention. Also addressed are chemical and chemical engineering challenges in pharmaceutical synthesis, delivery, and manufacture.

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set
A Book

by Donald J. Abraham

  • Publisher : Wiley-Interscience
  • Release : 2003-03-07
  • Pages : 5568
  • ISBN : 9780471370321
  • Language : En, Es, Fr & De
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This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development. With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including: * Proteomics * Genomics * Bioinformatics * Combinatorial Chemistry * High-Throughput Screening * Blood Substitutes * Allosteric Effectors as Potential Drugs * COX Inhibitors * Statins * High-Throughput Pharmacology * and More. The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.

Challenges in Chemistry Graduate Education

Challenges in Chemistry Graduate Education
A Workshop Summary

by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges in Chemistry Graduate Education; Board on Chemical Sciences

  • Publisher : National Academies Press
  • Release : 2012-08-21
  • Pages : 96
  • ISBN : 0309257115
  • Language : En, Es, Fr & De
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Chemistry graduate education is under considerable pressure. Pharmaceutical companies, long a major employer of synthetic organic chemists, are drastically paring back their research divisions to reduce costs. Chemical companies are opening new research and development facilities in Asia rather than in the United States to take advantage of growing markets and trained workforces there. Universities, especially public universities, are under significant fiscal constraints that threaten their ability to hire new faculty members. Future federal funding of chemical research may be limited as the federal budget tightens. All of these trends have major consequences for the education of chemistry graduate students in U.S. universities. To explore and respond to these intensifying pressures, the Board on Chemical Sciences and Technology held a workshop in Washington, DC, on January 23-24 2012, titled "Graduate Education in Chemistry in the Context of a Changing Environment." The workshop brought together representatives from across the chemical enterprise, representing leaders and future leaders of academia, industry, and government. The goal of the workshop was not to come to conclusions, but to have an open and frank discussion about critical issues affecting chemistry graduate education, such as the attraction and retainment of the most able students to graduate education, financial stressors on the current support model and their implications for the future model, competencies needed in the changing job market for Ph.D. chemists, and competencies needed to address societal problems such as energy and sustainability. Challenges in Chemistry Graduate Education: A Workshop Summary is organized into six chapters and summarizes the workshop on "Graduate Education in Chemistry in the Context of a Changing Environment."

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
Ligand-protein Interactions

by Robert M. Stroud,Janet Finer-Moore

  • Publisher : Royal Society of Chemistry
  • Release : 2008
  • Pages : 382
  • ISBN : 0854043659
  • Language : En, Es, Fr & De
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This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

Comprehensive Medicinal Chemistry II, Volume 1

Comprehensive Medicinal Chemistry II, Volume 1
GLOBAL PERSPECTIVE

by Peter Kennewell

  • Publisher : Elsevier Science
  • Release : 2006-11-15
  • Pages : 881
  • ISBN : 9780080445144
  • Language : En, Es, Fr & De
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This volume provides and educative and authoriative discussions on the drug discovery and development process. It is divided into ten sections and starts with personal recollections on the history and evolution of the drug discovery process. To illustrate the end result of the drug discovery process, a large chapter reviews the major drug introductions over 1993-2003. Subsequent chapters examine the impact of genomic technologies, new sources of drugs and alternatives to animal testing. The next section reviews the roles of enterprise and pharamaceuticals companies, venture capitalists and academic-industrial relations in the drug discovery process. Social and ethical issues are reviewed in the context of assessing health demands in developed, developing countries and also in relation to smaller scale diseases (orphan drugs). Two chapters then review the bioethical and ethical issues facing the pharmaceutical industry. The volume concludes with reviews on funding and regulartion and how intellectual property rights and patents are protected. With such a wide variety of topics this volume will appeal to both scientists and non-scientists who need to understand how and why the pharmaceutical industry works. * valuable content available from May 2009 as an individual volume * provides a global overview of the drug discovery process

Physico Chemical Methods in Drug Discovery and Development

Physico Chemical Methods in Drug Discovery and Development
A Book

by Zoran Mandic

  • Publisher : IAPC Publishing
  • Release : 2012
  • Pages : 482
  • ISBN : 9535694200
  • Language : En, Es, Fr & De
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A Handbook for DNA-Encoded Chemistry

A Handbook for DNA-Encoded Chemistry
Theory and Applications for Exploring Chemical Space and Drug Discovery

by Robert A. Goodnow, Jr.

  • Publisher : John Wiley & Sons
  • Release : 2014-04-28
  • Pages : 480
  • ISBN : 1118487680
  • Language : En, Es, Fr & De
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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

Drug Discovery and Development, Volume 2

Drug Discovery and Development, Volume 2
Drug Development

by Mukund S. Chorghade

  • Publisher : John Wiley & Sons
  • Release : 2007-02-16
  • Pages : 416
  • ISBN : 9780470085219
  • Language : En, Es, Fr & De
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From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Graduate Education in the Chemical Sciences

Graduate Education in the Chemical Sciences
Issues for the 21st Century: Report of a Workshop

by National Research Council,Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Board on Chemical Sciences and Technology,Chemical Sciences Roundtable

  • Publisher : National Academies Press
  • Release : 2000-07-31
  • Pages : 186
  • ISBN : 9780309171724
  • Language : En, Es, Fr & De
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Graduate Education in the Chemical Sciences is a summary of the December 1999 workshop, "Graduate Education in the Chemical Sciences: Issues for the 21st Century,"This workshop discussed the various features of graduate education in chemical science and technology. Using case histories and their individual experiences, speakers examined the current status of graduate education in the chemical sciences, identified problems and opportunities, and discussed possible strategies for improving the system. The discussion was oriented toward the goal of generating graduates who are well prepared to advance the chemical sciences in academia, government, and industry in the next 5 to 10 years.

Reducing the Time from Basic Research to Innovation in the Chemical Sciences

Reducing the Time from Basic Research to Innovation in the Chemical Sciences
A Workshop Report to the Chemical Sciences Roundtable

by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Chemical Sciences Roundtable

  • Publisher : National Academies Press
  • Release : 2003-05-18
  • Pages : 142
  • ISBN : 0309087341
  • Language : En, Es, Fr & De
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Innovation, the process by which fundamental research becomes a commercial product, is increasingly important in the chemical sciences and is changing the nature of research and development efforts in the United States. The workshop was held in response to requests to speed the R&D process and to rapidly evolve the patterns of interaction among industry, academe, and national laboratories. The report contains the authors' written version of the workshop presentations along with audience reaction.

Medicinal Chemistry

Medicinal Chemistry
An Introduction

by Gareth Thomas

  • Publisher : Wiley
  • Release : 2000-12-27
  • Pages : 568
  • ISBN : 9780471489351
  • Language : En, Es, Fr & De
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Medicinal Chemistry: An Introduction, provides a comprehensive, balanced introduction to this exciting, evolving and multi-disciplinary field. This text assumes little prior knowledge of medicinal chemistry and keeps the approach as simple as possible. Focusing on the chemical principles used for drug discovery and design, it also covers human biology where relevant. Each chapter has a summary of its contents, self-assessment questions, numerous examples and applications.

Proceedings of 8th Edition of International Conference on Chemistry Science and Technology 2018

Proceedings of 8th Edition of International Conference on Chemistry Science and Technology 2018
Journal of Archives in Chemical Research : Volume 2

by EuroScicon

  • Publisher : EuroScicon
  • Release : 2018-06-01
  • Pages : 68
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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June 14-15, 2018 London, UK Key Topics : Chemistry Of Compounds, Organic Chemistry And Inorganic Chemistry, Physical And Theoretical Chemistry, Heterocyclic Chemistry, Electrochemistry, Electrolysis And Corrosion, Geochemistry, Nuclear Chemistry/Radiochemistry, Biochemistry, Pharmaceutical/Medicinal Chemistry, Polymer Chemistry, Forensic Chemistry, Environmental Chemistry, Bio Based Chemistry, Analytical Chemistry, Multi-Scale And/Or Multi-Disciplinary Approach To Process-Product Innovation, Sustainable Process-Product Development Through Green Chemistry, ,

Biotechnology and Biopharmaceuticals

Biotechnology and Biopharmaceuticals
Transforming Proteins and Genes into Drugs

by Rodney J. Y. Ho,Milo Gibaldi

  • Publisher : John Wiley & Sons
  • Release : 2004-09-21
  • Pages : 576
  • ISBN : 0471450278
  • Language : En, Es, Fr & De
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Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies.

Mass Spectrometry in Medicinal Chemistry

Mass Spectrometry in Medicinal Chemistry
Applications in Drug Discovery

by Klaus Wanner,Georg Höfner

  • Publisher : John Wiley & Sons
  • Release : 2007-06-27
  • Pages : 460
  • ISBN : 352761091X
  • Language : En, Es, Fr & De
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This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.