Download Chitosan in Drug Delivery Ebook PDF

Functional Chitosan

Functional Chitosan
Drug Delivery and Biomedical Applications

by Sougata Jana,Subrata Jana

  • Publisher : Springer Nature
  • Release : 2020-04-10
  • Pages : 489
  • ISBN : 9811502633
  • Language : En, Es, Fr & De
GET BOOK

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Chitosan in Drug Delivery

Chitosan in Drug Delivery
A Book

by Md Saquib Hasnain,Amit Kumar Nayak,Sarwar Beg

  • Publisher : Academic Press
  • Release : 2020-12-01
  • Pages : 420
  • ISBN : 0128193379
  • Language : En, Es, Fr & De
GET BOOK

Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Modeling of Controlled Drug Delivery from a Chitosan Microparticle

Modeling of Controlled Drug Delivery from a Chitosan Microparticle
A Book

by Niloofar Alipourasiabi

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 77
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Nowadays, advanced controlled drug delivery systems have been attracted the pharmaceutical research studies. As several experiments have to be done for pharmaceutical approaches, mathematical modeling becomes important. Mathematical modeling of drug release provides better understanding of controlled drug delivery system and would help to optimize the system without huge number of expensive experiments. Diffusion is the predominant transport phenomena of the drug delivery systems. Therefore, optimizing the parameters related to diffusional mass transport, such as diffusion coefficient and porosity, would be the essential key to get better controlled drug release profile. One of the challenges of controlled drug delivery systems is the initial burst, which decreases the effective lifetime of drug and would cause toxicity. This challenge has been solved by using a coating layer to control the drug release. Regarding to this issue, promising modeling results have been shown in this study and all the modeling data have been fitted with available experimental set of data. The mathematical modeling results in a partial differential equation. The analytical solution for the simplified equation is provided in this study. However, the boundary condition for the outer layer is complicated and the solution for the real problem would be available by using numerical methods. Finite difference method provided the numerical solution to the real problem and MATLAB software facilitate the process of solving the equation numerically.

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems
A Book

by Lăcrămioara Popa

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.

Preparation of Chitosan Nanoparticles as a Drug Delivery System for Perindopril Erbumine

Preparation of Chitosan Nanoparticles as a Drug Delivery System for Perindopril Erbumine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Chitosan and Its Derivatives as Promising Drug Delivery Carriers

Chitosan and Its Derivatives as Promising Drug Delivery Carriers
A Book

by M. Prabaharan

  • Publisher : Momentum Press
  • Release : 2012-10-19
  • Pages : 84
  • ISBN : 1606504134
  • Language : En, Es, Fr & De
GET BOOK

Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents.

Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery

Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Abstract: A series of thermo/pH sensitive N ‐succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 °C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery. Abstract : Thermo/pH‐sensitive N ‐succinyl hydroxybutyl chitosan (NSHBC) hydrogels are first prepared and investigated for drug delivery. NSHBC hydrogels exhibit outstanding ability to load the model drug of BSA and trigger release it at simulated intestinal conditions, which can be a promising carrier in oral drug delivery applications.

Chitin and Chitosan Derivatives

Chitin and Chitosan Derivatives
Advances in Drug Discovery and Developments

by Se-Kwon Kim

  • Publisher : CRC Press
  • Release : 2013-12-04
  • Pages : 527
  • ISBN : 1466566280
  • Language : En, Es, Fr & De
GET BOOK

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field. Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing. A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

Modified-chitosan Nanoparticles for Drug Delivery Through the Blood-brain Barrier

Modified-chitosan Nanoparticles for Drug Delivery Through the Blood-brain Barrier
A Book

by Éva Molnár

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 494
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Chitosan Based Materials and its Applications

Chitosan Based Materials and its Applications
A Book

by Guilherme Luiz Dotto, Sergio Paulo Campana-Filho and Luiz Antonio de Almeida Pinto

  • Publisher : Bentham Science Publishers
  • Release : 2017-06-07
  • Pages : 345
  • ISBN : 1681084856
  • Language : En, Es, Fr & De
GET BOOK

This volume presents 10 reviews contributed by eminent researchers around the world on chitosan based materials. The introductory chapters present information on general characteristics of chitosan and various types of materials which are based on it such as nanofibers, nanoparticles, nanocapsules and other chemically modified chitosans. This is followed by an explanation of chitosan characterization and extraction techniques. Concluding chapters describe the applications of chitosan products in water treatment, drug delivery, edible films and pervaporation membranes. Readers will therefore gain an understanding about chitosan and materials derived from this polymer and their practical applications. The volume serves as a simple reference for chemical engineering students and professionals interested in the basic and applied chemistry of chitosan and chitosan-derived products.

Chitosan-Based Hydrogels

Chitosan-Based Hydrogels
Functions and Applications

by Kangde Yao,Junjie Li,Fanglian Yao,Yuji Yin

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 521
  • ISBN : 1439821151
  • Language : En, Es, Fr & De
GET BOOK

Due to their unique properties, chitosan-based materials have emerged as useful resources in a variety of medicines, drug controlled-release carriers, tissue engineering scaffolds, and immobilized enzymes. But many of these materials have yet to reach the commercial market. Therefore, more work must be completed to fill the gap between research and production. Exploring the state of the field, Chitosan-Based Hydrogels: Functions and Applications details the latest progress in the research and development of chitosan-based biomaterials. The book introduces the formation and chemical structure of chitosan-based hydrogels. It also discusses the relationship between their structure and functions, which provides a theoretical basis for the design of biomaterials. In addition, many real-world examples illustrate the potential application of chitosan-based hydrogels in various areas, including materials science, biotechnology, pharmaceuticals, regenerative medicine, and cell engineering. By examining the structure and functions of chitosan-based hydrogels in living systems, this book provides the foundation for future research. It encourages readers to contribute to further research and development of these unique biomaterials.

Plasticized Chitosan-based Xerogel Nanocomposite for Controlled Drug Delivery

Plasticized Chitosan-based Xerogel Nanocomposite for Controlled Drug Delivery
A Book

by Feiran Li

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 80
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Chitosan for Biomaterials I

Chitosan for Biomaterials I
A Book

by R. Jayakumar,M. Prabaharan,Riccardo A. A. Muzzarelli

  • Publisher : Springer Science & Business Media
  • Release : 2011-09-15
  • Pages : 236
  • ISBN : 3642231136
  • Language : En, Es, Fr & De
GET BOOK

Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H. Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima, J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnürch.- Chitosan-Based Particulate Systems for Non-Invasive Vaccine Delivery, by S. Şenel.- Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.- Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.- Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-

Developing Novel Mucoadhesive Chitosan Based Formulations for Drug Delivery to the Urinary Bladder

Developing Novel Mucoadhesive Chitosan Based Formulations for Drug Delivery to the Urinary Bladder
A Book

by Oluwadamilola Miriam Kolawole

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Sustainable Agriculture Reviews 36

Sustainable Agriculture Reviews 36
Chitin and Chitosan: Applications in Food, Agriculture, Pharmacy, Medicine and Wastewater Treatment

by Grégorio Crini,Eric Lichtfouse

  • Publisher : Springer
  • Release : 2019-06-04
  • Pages : 428
  • ISBN : 3030165817
  • Language : En, Es, Fr & De
GET BOOK

This book reviews recent research and applications of chitin and chitosan, as natural alternatives of fossil fuel products, in medicine and pharmacy, agriculture, food science and water treatment. Chitin and chitosan products are polysaccharides derived from food waste of crustaceans and fungi, and thus are cheap, abundant, sustainable, non-toxic, recyclable and biocompatible. Remarkable applications include food additives and preservation, packaging materials, biopesticides and fertilisers, drug delivery, tissue engineering, bioflocculation and dye removal.

Curcumin Containing Chitosan-pectinate Nanoparticulate Drug Delivery System for Colon Cancer Treatment

Curcumin Containing Chitosan-pectinate Nanoparticulate Drug Delivery System for Colon Cancer Treatment
A Book

by Enas Ali Alkhader

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Index Medicus

Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Chitosan-Based Systems for Biopharmaceuticals

Chitosan-Based Systems for Biopharmaceuticals
Delivery, Targeting and Polymer Therapeutics

by Bruno Sarmento,Jose das Neves

  • Publisher : John Wiley & Sons
  • Release : 2012-02-16
  • Pages : 600
  • ISBN : 1119964075
  • Language : En, Es, Fr & De
GET BOOK

Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.

Peptide and Protein Drug Delivery

Peptide and Protein Drug Delivery
Proceedings of a Symposium Held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997

by Sven Frøkjær

  • Publisher : Munksgaard International Publishers
  • Release : 1998
  • Pages : 483
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Handbook of Pharmaceutical Excipients

Handbook of Pharmaceutical Excipients
A Book

by Raymond C. Rowe,Paul J. Sheskey,Paul J. Weller

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 776
  • ISBN : 9780853694724
  • Language : En, Es, Fr & De
GET BOOK

Describes the chemical and physical properties of pharmaceutical excipients. Each monograph contains nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology, description, pharmacopeial specifications, typical propertics, stability and storage conditions, incompatibilities, method of manufacture, safety, handling precautions, regulatory status, pharmacopeias, related substances, comments, specific references, general references, and authors.