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Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
A Book

by Klara Valko

  • Publisher : Elsevier Science
  • Release : 2020-07-07
  • Pages : 788
  • ISBN : 0444640703
  • Language : En, Es, Fr & De
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Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Preparative Chromatography for Separation of Proteins

Preparative Chromatography for Separation of Proteins
A Book

by Arne Staby,Anurag S. Rathore,Satinder Ahuja

  • Publisher : John Wiley & Sons
  • Release : 2017-03-06
  • Pages : 608
  • ISBN : 1119031109
  • Language : En, Es, Fr & De
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"Preparative Chromatography for Separation of Proteins addresses a wide range of the most current modeling techniques, strategies, and case studies of industrial separation of proteins and peptides to aid in the efficiency and efficacy of this broadly-used technique in the purification of biopharmaceuticals"--

Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis
A Book

by Lena Ohannesian,Anthony Streeter

  • Publisher : CRC Press
  • Release : 2001-11-09
  • Pages : 608
  • ISBN : 9780824741945
  • Language : En, Es, Fr & De
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Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
A Book

by Klara Valko

  • Publisher : Elsevier
  • Release : 2000-10-13
  • Pages : 612
  • ISBN : 9780080541099
  • Language : En, Es, Fr & De
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Separation Methods in Drug Synthesis and Purification

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS
A Book

by Swapan Chowdhury

  • Publisher : Elsevier
  • Release : 2005-11-04
  • Pages : 354
  • ISBN : 9780080456065
  • Language : En, Es, Fr & De
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As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

HPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists
A Book

by Yuri V. Kazakevich,Rosario LoBrutto

  • Publisher : John Wiley & Sons
  • Release : 2007-02-16
  • Pages : 1080
  • ISBN : 0470087943
  • Language : En, Es, Fr & De
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HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Chiral Chromatography

Chiral Chromatography
A Book

by Thomas E. Beesley,Raymond P. W. Scott

  • Publisher : John Wiley & Sons
  • Release : 1999-01-26
  • Pages : 522
  • ISBN : 9780471974277
  • Language : En, Es, Fr & De
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Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included: * chiral separations involving both gas and liquid chromatography * descriptions of the apparatus used for both techniques * detailed discussion on the retention mechanism that results in chiral selectivity * the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography * preparative applications for large scale purification of enantiomers * applications of capillary electrophoresis and capillary electrochromatography. In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

Advances in Chromatography

Advances in Chromatography
A Book

by Eli Grushka,Nelu Grinberg

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 328
  • ISBN : 1466569662
  • Language : En, Es, Fr & De
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For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 51, the series editors have invited established, well-known chemists from across the globe to offer cutting-edge reviews on their areas of expertise—from theoretical aspects to novel and established applications of chromatographic techniques. Featured topics include Nonequilibrium Thermodynamics in Nonlinear Chromatography and Electrophoresis: Theory and Applications Biomimetic Chromatography: A Useful Tool in the Drug Discovery Process Solid-Phase Microextraction for In Vivo Pharmacokinetics and Other Stages of Drug Development Identification and Detection of Antibiotic Drugs and Their Degradation Products in Aquatic Samples Sample Preparation for Chromatographic Analysis Development of HPLC Retention Index QSAR Models for Nontargeted Metabolomics Thin Layer Chromatography with a Controlled Gas Phase Influencing on the Separation The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Preparative Chromatography

Preparative Chromatography
A Book

by H. Schmidt-Traub,Michael Schulte,Andreas Seidel-Morgenstern

  • Publisher : John Wiley & Sons
  • Release : 2012-09-27
  • Pages : 566
  • ISBN : 3527649301
  • Language : En, Es, Fr & De
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Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
A Book

by Satinder Ahuja

  • Publisher : John Wiley & Sons
  • Release : 2011-03-31
  • Pages : 400
  • ISBN : 9781118097755
  • Language : En, Es, Fr & De
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Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Preparative Chromatography

Preparative Chromatography
of Fine Chemicals and Pharmaceutical Agents

by H. Schmidt-Traub

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 485
  • ISBN : 3527605908
  • Language : En, Es, Fr & De
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This interdisciplinary approach combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. The book covers recent developments in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on solid materials and packed columns process concepts. Final chapters on modeling and determination of model parameters, the design and optimization of preparative chromatographic processes and chromatographic reactors allow for the optimum selection of chromatographic systems. Essential for chemists and engineers working in the chemicals and pharmaceutical industries as well as for food technologies, due to the interdisciplinary nature of these processes.

A Practical Handbook of Preparative HPLC

A Practical Handbook of Preparative HPLC
A Book

by Donald A Wellings

  • Publisher : Elsevier
  • Release : 2011-04-18
  • Pages : 176
  • ISBN : 9780080458854
  • Language : En, Es, Fr & De
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This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA. This book... •Provides practical, hands-on advice based on years of experience •Will help ensure optimal design, equipment and separation results for your particular task •Presents system layouts from laboratory to process scale •Will help you to devise or improve record-keeping and documentation systems ·Provides practical, hands-on advice based on years of experience ·Will help ensure optimal design, equipment and separation results for your particular task ·Presents system layouts from laboratory to process scale ·Will help you to devise or improve record-keeping and documentation systems

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
Advances and Applications in Pharmaceutical Analysis

by Gregory K. Webster

  • Publisher : CRC Press
  • Release : 2014-02-04
  • Pages : 418
  • ISBN : 9814463000
  • Language : En, Es, Fr & De
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Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis. Supercritical Fluid Chromatography reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.

Molecular Basis of Chromatographic Separation

Molecular Basis of Chromatographic Separation
A Book

by Esther Forgacs,Tibor Cserhati

  • Publisher : CRC Press
  • Release : 1997-07-03
  • Pages : 256
  • ISBN : 9780849376962
  • Language : En, Es, Fr & De
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Chromatographic separation is widely used in many scientific disciplines today, having an ever increasing number of scientific and technological applications. The widespread use of this rapid and powerful technique requires that it be fully understood, so that the most suitable may be determined for each possible separation problem in each possible domain of scientific research and technology. Molecular Basis of Chromatographic Separation provides complete coverage of the practical and molecular aspects of this popular technique. It compiles and evaluates recent results, outlines available methods, and discusses how to select the best method for a particular application.

Handbook of Pharmaceutical Analysis by HPLC

Handbook of Pharmaceutical Analysis by HPLC
A Book

by Satinder Ahuja,Michael Dong

  • Publisher : Elsevier
  • Release : 2005-02-09
  • Pages : 600
  • ISBN : 9780080455181
  • Language : En, Es, Fr & De
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High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening). A complete reference guide to HPLC Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling

Practical HPLC Methodology and Applications

Practical HPLC Methodology and Applications
A Book

by Brian A. Bidlingmeyer

  • Publisher : John Wiley & Sons
  • Release : 1993-04-19
  • Pages : 464
  • ISBN : 9780471572466
  • Language : En, Es, Fr & De
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Of related interest. Trace and Ultratrace Analysis by HPLC Satinder Ahuja Written by a leading scientist in the field, this monograph provides the first definitive and technically up-to-date treatment of the theory, equipment, and applications of chemistry's most powerful reliable analytical technique. Coverage includes an encyclopedic compendium of common substances that require trace and ultratrace analysis, and features clear discussion of such important topics as considerations for HPLC equipment, sensitive detectors, sample preparation, method development, selectivity and computer-based optimizations, optimizing detectability, and much more. 1991 (0 471-51419-5) 432 pp. High Performance Liquid Chromatography in Biotechnology Edited by William S. Hancock Analytical chemists, biochemists, and chemical engineers will find this up-to-date guide to HPLC's recent developments essential for enhancing on-the-job technical expertise. Extensive coverage includes the broad applications of HPLC, ranging from major chromatographic techniques (including reversed phase, ion exchange, affinity and hydrophobic interaction chromatography) to specific separations such as those in monoclonal antibody and nucleic acid purification. Techniques for quality control programs and advanced technology are also discussed. 1990 (0 471-82584-0) 564 pp. Unified Separation Science J. Calvin Giddings This advanced text/monograph brings together for the first time the variety of techniques used for chemical separations by outlining their common underlying mechanisms. The mass transport phenomena underlying all separation processes are developed in a simple physical-mathematical form, facilitating analysis of alternative separation techniques and the factors integral to separation power. The first six chapters provide background material applicable to a wide range of separation methods, while the final five chapters illustrate specific techniques and methods. 1991 (0 471-52089-6) 320 pp.

Chromatography

Chromatography
A Science of Discovery

by Robert L. Wixom,Charles W. Gehrke

  • Publisher : John Wiley & Sons
  • Release : 2011-01-31
  • Pages : 410
  • ISBN : 1118060296
  • Language : En, Es, Fr & De
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Leading researchers discuss the past and present of chromatography More than one hundred years after Mikhail Tswett pioneered adsorption chromatography, his separation technique has developed into an important branch of scientific study. Providing a full portrait of the discipline, Chromatography: A Science of Discovery bridges the gap between early, twentieth-century chromatography and the cutting edge of today’s research. Featuring contributions from more than fifty award-winning chromatographers, Chromatography offers a multifaceted look at the development and maturation of this field into its current state, as well as its importance across various scientific endeavors. The coverage includes: Consideration of chromatography as a unified science rather than just a separation method Key breakthroughs, revolutions, and paradigm shifts in chromatography Profiles of Nobel laureates who used chromatography in their research, and the role it played Recent advances in column technology Chromatography’s contributions to the agricultural, space, biological/medical sciences; pharmaceutical science; and environmental, natural products, and chemical analysis Future trends in chromatography With numerous references and an engaging series of voices, Chromatography: A Science of Discovery offers a diverse look at an essential area of science. It is a unique and invaluable resource for researchers, students, and other interested readers who seek a broader understanding of this field.

HPLC Method Development for Pharmaceuticals

HPLC Method Development for Pharmaceuticals
A Book

by Satinder Ahuja,Henrik Rasmussen

  • Publisher : Elsevier
  • Release : 2011-09-21
  • Pages : 532
  • ISBN : 0080554199
  • Language : En, Es, Fr & De
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High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

Chromatographic Fingerprint Analysis of Herbal Medicines

Chromatographic Fingerprint Analysis of Herbal Medicines
Thin-layer and High Performance Liquid Chromatography of Chinese Drugs

by Hildebert Wagner,Rudolf Bauer,Dieter Melchart,Pei-Gen Xiao,Anton Staudinger

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-24
  • Pages : 1024
  • ISBN : 3709107636
  • Language : En, Es, Fr & De
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This manual, to be published in two volumes, provides a condensed overview of the analytical investigation of 80 Chinese Herbal Drugs which are most frequently in use. Thin layer chromatographic-, high pressure liquid chromatographic- and gas chromatographic-fingerprint analytical techniques allow the detection of all main low-molecular constituents of a plant drug and even single constituents can be visualized. Analytical results thereof are shown in numerous color figures. The quality proof of the investigation meets the standard of the European Drug Regulatory Authority. Furthermore, this volume gives a detailed description of the analytical methods used for several drugs. Bioactive constituents, pharmacological and biological activities of several single herbal drugs as well as their therapeutic applications are discussed.

Bioanalysis of Pharmaceuticals

Bioanalysis of Pharmaceuticals
Sample Preparation, Separation Techniques and Mass Spectrometry

by Steen Honoré Hansen

  • Publisher : John Wiley & Sons
  • Release : 2015-07-20
  • Pages : 336
  • ISBN : 1118716825
  • Language : En, Es, Fr & De
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Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.