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Clinical and Translational Science

Clinical and Translational Science
Principles of Human Research

by David Robertson,Gordon H. Williams

  • Publisher : Academic Press
  • Release : 2016-11-25
  • Pages : 808
  • ISBN : 012802111X
  • Language : En, Es, Fr & De
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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

The CTSA Program at NIH

The CTSA Program at NIH
Opportunities for Advancing Clinical and Translational Research

by Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences

  • Publisher : National Academies Press
  • Release : 2013-10-09
  • Pages : 178
  • ISBN : 0309284740
  • Language : En, Es, Fr & De
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In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
From Bench to Bedside

by Martin Wehling

  • Publisher : Academic Press
  • Release : 2021-07-15
  • Pages : 494
  • ISBN : 032399962X
  • Language : En, Es, Fr & De
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Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Broadly Engaged Team Science in Clinical and Translational Research

Broadly Engaged Team Science in Clinical and Translational Research
A Book

by Debra Lerner,Marisha Palm,Thomas Concannon

  • Publisher : Springer
  • Release : 2021-10-13
  • Pages : 235
  • ISBN : 9783030830274
  • Language : En, Es, Fr & De
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Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.

Clinical and Translational Science in Sport Rehabilitation

Clinical and Translational Science in Sport Rehabilitation
A Book

by Mark A. Merrick,Michael G. Dolan

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 97
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Clinical and Translational Science

Clinical and Translational Science
Principles of Human Research

by David Robertson,Gordon H. Williams

  • Publisher : Academic Press
  • Release : 2009-03-02
  • Pages : 600
  • ISBN : 9780080920191
  • Language : En, Es, Fr & De
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Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Studyguide for Clinical and Translational Science

Studyguide for Clinical and Translational Science
Principles of Human Research by Robertson, David

by Cram101 Textbook Reviews

  • Publisher : Cram101
  • Release : 2013-05
  • Pages : 194
  • ISBN : 9781490239613
  • Language : En, Es, Fr & De
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Never HIGHLIGHT a Book Again Virtually all testable terms, concepts, persons, places, and events are included. Cram101 Textbook Outlines gives all of the outlines, highlights, notes for your textbook with optional online practice tests. Only Cram101 Outlines are Textbook Specific. Cram101 is NOT the Textbook. Accompanys: 9780521673761

Integrating Clinical and Translational Research Networks—Building Team Medicine

Integrating Clinical and Translational Research Networks—Building Team Medicine
A Book

by Ravi Salgia,Prakash Kulkarni

  • Publisher : MDPI
  • Release : 2021-01-29
  • Pages : 250
  • ISBN : 303650396X
  • Language : En, Es, Fr & De
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Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.

Translational Informatics

Translational Informatics
Realizing the Promise of Knowledge-Driven Healthcare

by Philip R.O. Payne,Peter J. Embi

  • Publisher : Springer
  • Release : 2014-08-23
  • Pages : 185
  • ISBN : 1447146468
  • Language : En, Es, Fr & De
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Integrative and translational methodologies and frameworks have transformed modern biomedical research and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate knowledge translation, and initial efforts to deliver personalized healthcare informed by the genomic profiles of patients. A common theme of reports and publications concerned with such transformative changes in the biomedical and healthcare domains is concerned with the challenges and opportunities related to the collection, management, integration, analysis, and dissemination of large-scale, heterogeneous biomedical data sets. In particular, the absence of well-established and adopted theoretical and practical frameworks intended to address such needs is a major impediment to the realization of translational and knowledge-driven healthcare, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. This book details for the first time the current state of this extremely potent area of healthcare innovation and policy and defines the interaction between clinical/translational science and biomedical informatics.​

Nih Administration of the Clinical and Translational Science Awards Program.

Nih Administration of the Clinical and Translational Science Awards Program.
A Book

by CreateSpace Independent Publishing Platform,Office of the Investigator General

  • Publisher : Createspace Independent Publishing Platform
  • Release : 2018-07-05
  • Pages : 36
  • ISBN : 9781722271473
  • Language : En, Es, Fr & De
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NIH Administration of the Clinical and Translational Science Awards Program.

CTSA Program at NIH

CTSA Program at NIH
Opportunities for Advancing Clinical and Translational Research

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Translating Expertise

Translating Expertise
The Librarian's Role in Translational Research

by Marisa L. Conte

  • Publisher : Rowman & Littlefield
  • Release : 2016-08-29
  • Pages : 280
  • ISBN : 1442262680
  • Language : En, Es, Fr & De
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Translating Expertise: The Librarian’s Role in Translational Research provides background and context on the CTSA program. Case studies detail routes to librarian involvement in translational research, including collection development, relationships with researchers and administrators, instruction and training, data management, and team science.

Clinical and Translational Medicine

Clinical and Translational Medicine
A Book

by Anna Garner

  • Publisher : Unknown Publisher
  • Release : 2019-06-12
  • Pages : 239
  • ISBN : 9781632428400
  • Language : En, Es, Fr & De
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Clinical and translational medicine refers to the therapeutic clinical potential and application of translational research that seeks to develop the understanding of mechanisms and treatments of human diseases. The clinical variation between diseases, biomarkers, pathogenesis and therapies are also highlighted through studies of clinical and translational medicine. This is a critical and core component of the full-spectrum of biomedical research. Translational medicine refers to an area of research that seeks to determine the relevance of novel discoveries in the biological science to human disease. It also integrates new knowledge in clinical practice and clinical observations into scientific knowledge. Hence, translational research, facilitates the generation of novel hypotheses and disease characterization based on direct human observation. Translational medicine can work to expedite the incorporation of novel endpoints into clinical testing, thus shortening the duration of clinical trials. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of clinical and translational medicine. The ever growing need of advanced technology is the reason that has fueled the research in this field in recent times. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study.

Outlines and Highlights for Clinical and Translational Science

Outlines and Highlights for Clinical and Translational Science
Principles of Human Research by David Robertson, ISBN

by Cram101 Textbook Reviews

  • Publisher : Academic Internet Pub Incorporated
  • Release : 2011-04
  • Pages : 354
  • ISBN : 9781614612001
  • Language : En, Es, Fr & De
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Never HIGHLIGHT a Book Again! Virtually all of the testable terms, concepts, persons, places, and events from the textbook are included. Cram101 Just the FACTS101 studyguides give all of the outlines, highlights, notes, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanys: 9780123736390 .

NIH Administration of the Clinical and Translational Science Awards Program

NIH Administration of the Clinical and Translational Science Awards Program
A Book

by United States. Department of Health and Human Services. Office of Inspector General

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 30
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Translational Medicine - What, Why and How: An International Perspective

Translational Medicine - What, Why and How: An International Perspective
A Book

by B. Alving,K. Dai,S.H.H. Chan

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2012-12-21
  • Pages : 134
  • ISBN : 3318022853
  • Language : En, Es, Fr & De
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This book is the first to provide an aerial view, as well as detailed information, on ‘how’ activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high-value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

2017 Pathways to Cures: Clinical and Translational Science Day at UCI

2017 Pathways to Cures: Clinical and Translational Science Day at UCI
A Book

by Institute for Clinical and Translational Science

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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2016 Pathways to Cures: Clinical and Translational Science Day at UCI

2016 Pathways to Cures: Clinical and Translational Science Day at UCI
A Book

by Institute for Clinical and Translational Science

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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2014 Pathways to Cures: Clinical and Translational Science Day at UCI

2014 Pathways to Cures: Clinical and Translational Science Day at UCI
A Book

by Institute for Clinical and Translational Science

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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2015 Pathways to Cures: Clinical and Translational Science Day at UCI

2015 Pathways to Cures: Clinical and Translational Science Day at UCI
A Book

by Institute for Clinical and Translational Science

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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