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Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Drug Discovery, Drug Delivery, and Disease Prevention

by Rupinder K. Sodhi

  • Publisher : Unknown Publisher
  • Release : 2019-05
  • Pages : 600
  • ISBN : 9780128157626
  • Language : En, Es, Fr & De
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Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Drug Discovery, Drug Delivery, and Disease Prevention

by Rupinder K. Sodhi,Jitender Madan

  • Publisher : Academic Press
  • Release : 2020-10-15
  • Pages : 432
  • ISBN : 0128157631
  • Language : En, Es, Fr & De
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Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Origin of Cancers

Origin of Cancers
Clinical Perspectives and Implications of a Stem-Cell Theory of Cancer

by Shi-Ming Tu

  • Publisher : Springer Science & Business Media
  • Release : 2010-07-20
  • Pages : 237
  • ISBN : 9781441959683
  • Language : En, Es, Fr & De
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Précis This book is a treatise about the origin of cancers. I would like to convince readers that the basic tenets of the theory of a stem-cell origin of cancers also constitute a unified theory of cancer. Stem-cell origin of normal (and cancer) cells: Vitruvian version Every truth passes through three stages before it is recognized. In the first it is ridiculed, in the second, it is opposed, in the third, it is regarded as self-evident. – Arthur Schopenhauer v vi Preface Every person has a unique story to tell. My story is about cancer. Cancer touches the lives of countless people. Often enough, it leaves indelible tracks. Many lives have been lost; others are forever changed. For those who confront this deadly scourge, there is a sense of urgency, if not of desperation. For those who face im- nent death, life becomes even more precious and carries a special meaning. As an oncologist, I am touched daily by cancer. I feel its inception, evolution, and aft- math. It seems as though we are fighting an incessant war against cancer at the front line in the trenches. This is my story about cancer. Some people are terrific storytellers. Others have incredible tales to tell.

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives
A Book

by Jorge Morales Montor,Mariana Segovia

  • Publisher : Academic Press
  • Release : 2020-10-01
  • Pages : 286
  • ISBN : 0128220295
  • Language : En, Es, Fr & De
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Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Alternative and Complementary Therapies for Cancer

Alternative and Complementary Therapies for Cancer
Integrative Approaches and Discovery of Conventional Drugs

by Moulay Alaoui-Jamali

  • Publisher : Springer Science & Business Media
  • Release : 2010-09-02
  • Pages : 722
  • ISBN : 9781441900203
  • Language : En, Es, Fr & De
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Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient’s survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and alleviate the disease. Typically, herbal preparations contain single or multiple plant ingredients, including a number of potential active components. Yet, they remain classified as food supplements and thus are exempt from regulations on quality control and proof of efficacy that govern standard pharmaceuticals. Clinical evidence for many preparations is often based on non-documented or anecdotal evidence. In consequence, several preparations with unproven efficacy are circulating in the market with the fear of interference with standard cancer therapies and/or severe toxicity that some can generate, in addition to the unjustified economical burden to patients. Despite inconsistent and conflicting clinical results single molecules have been isolated from herbal preparations and many are exploited to develop potential novel agents. This has fostered the need to organize a set of timely, in-depth and up-to-date review covering the latest developments in alternative cancer management from a scientific and clinical perspective dedicated to the medical community and health care providers, as well as to patients and their families. This book brings the latest comprehensive cancer information and practical recommendations on the best documented practice of alternative therapies for cancer management put together by recognized experts in the fields of medical oncology, traditional medicine, and cancer pharmacology. It goes hand-in-hand with the patient’s medical treatment options, quality of life issues, and more. The book is organized into four major sections: The first is an overview of the cancer syndrome by renowned medical oncologists from the USA and Europe. The second is a comprehensive description of traditional medicine by renowned experts from China and Germany. The third is an overview on the pharmacological impact of herb-based formulations on standard chemotherapy agents used in clinical practice. The fourth is a survey of cases reports from several hospitals with approved practice of alternative medicine. The book will feature simple definitions and essential information grouped in both medical and lay-term terminology, and straightforward illustrations related to human physiology, disease definition, scientific data on know and potential mechanisms of action, and preventive approaches. Finally, the book will feature collaboration of experts from China, India, USA, Canada, Germany, France, and other centres with recognized expertise in alternative/traditional medicine. This international cooperation is crucial to cover the complex topic of alternative therapies for cancer.

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics
A Book

by Yi Lu,Ram I. Mahato

  • Publisher : Springer Science & Business Media
  • Release : 2009-06-23
  • Pages : 694
  • ISBN : 9781441901316
  • Language : En, Es, Fr & De
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Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.

Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges

Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges

by Thomas G. P. Grünewald,Simone Fulda

  • Publisher : Frontiers Media SA
  • Release : 2016-04-05
  • Pages : 129
  • ISBN : 2889198197
  • Language : En, Es, Fr & De
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Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and be relevant for a broad readership. This Frontiers Research Topic intended to provide a platform for active and interdisciplinary discussion, to summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and to offer new perspectives on how to further promote and accelerate the translational process. It comprises high-quality original articles and timely reviews.

Targeted Therapies

Targeted Therapies
Mechanisms of Resistance

by Daniel Gioeli

  • Publisher : Springer Science & Business Media
  • Release : 2011-06-02
  • Pages : 202
  • ISBN : 9781607614784
  • Language : En, Es, Fr & De
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This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
A Book

by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson,Maurie Markman

  • Publisher : John Wiley & Sons
  • Release : 2015-12-21
  • Pages : 400
  • ISBN : 1118468570
  • Language : En, Es, Fr & De
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Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
New Perspectives and Opportunities

by Christopher D. Gregory

  • Publisher : Springer
  • Release : 2016-08-24
  • Pages : 247
  • ISBN : 3319394061
  • Language : En, Es, Fr & De
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This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Gastric Cancer In The Precision Medicine Era

Gastric Cancer In The Precision Medicine Era
Diagnosis and Therapy

by Vincenzo Canzonieri,Antonio Giordano

  • Publisher : Springer
  • Release : 2019-04-15
  • Pages : 256
  • ISBN : 3030048616
  • Language : En, Es, Fr & De
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Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Lysosomes

Lysosomes
Biology, Diseases, and Therapeutics

by Frederick R. Maxfield,James M. Willard,Shuyan Lu

  • Publisher : John Wiley & Sons
  • Release : 2016-05-31
  • Pages : 544
  • ISBN : 1118978307
  • Language : En, Es, Fr & De
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Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
A Book

by Stephen Neidle

  • Publisher : Academic Press
  • Release : 2013-09-30
  • Pages : 640
  • ISBN : 0123972280
  • Language : En, Es, Fr & De
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Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources

Nanomaterials for Tumor Targeting Theranostics

Nanomaterials for Tumor Targeting Theranostics
A Proactive Clinical Perspective

by Mingqian Tan,Aiguo Wu

  • Publisher : World Scientific
  • Release : 2016-02-22
  • Pages : 432
  • ISBN : 981463543X
  • Language : En, Es, Fr & De
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Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use. Contents:Nanomaterials as Therapeutic/Imaging Agent Delivery Vehicles for Tumor Targeting Theranostics (Mingqian Tan, Yanfang Wang, Xiaojie Song, and Yaqi Wu)Basics of Theranostics in Tumor (Huichao Zou, Yaohua Liu, and Shiguang Zhao)Magnetic Nanomaterials for Tumor Targeting Theranostics (Leyong Zeng, Zheyu Shen, and Aiguo Wu)Quantum Dots (QDs) for Tumor Targeting Theranostics (Yufei Ma, He Shen, Mengxin Zhang, and Zhijun Zhang)Mesoporous Silica Nanoparticles (MSNs) for Cancer Theranostics (Yu Hsia, Maharajan Sivasubramanian, Nai-Tzu Chen, and Leu-Wei Lo)Surface Enhanced Raman Scattering (SERS) Nanoprobes as Cancer Theranostics (Meikun Fan)Polymeric Nanosystems for Targeted Theranostics (Yongyong Li, Huiyun Wen, Haiqing Dong, Aijun Shen, Tianbin Ren, and Donglu Shi)Carbon Nanomaterials for Tumor Targeting Theranostics (João M M Leitão, Eliana F C Simões, and Joaquim C G Esteves da Silva)Lipopolyplex Nanoparticles for Tumor Targeting Theranostics (Fengying Dai and Xin Zhang)Microbubbles for Tumor Targeting Theranostics (Daming Yong, Xuejing Wang, Lei Wang, and Xiaojun Han)Upconversion Nanomaterials for Tumor Targeting Theranostics (Wei Wang)Functional Dendrimers as Nanoscale Theranostic Vehicles for Cancer Treatment (Kui Luo and Zhongwei Gu)Protein-based Nanoparticles for Tumor Targeting Theranostics (Yang Liu, Hao Wu, and Huihui Wang)Conclusions and Future Perspectives (Shanmin Gao and Narayan S Hosmane) Readership: Advanced undergraduates, graduate students, chemists, materials scientists, biomedical engineers, pharmacologists, biologists, doctors and oncologists in nanomaterials, nanobiotechnology, nanomedicine, tumor theranostics, tumor targeting, tumor diagnosis, tumor imaging, and tumor therapy. Key Features:One of the first books to comprehensively describe main nanomaterials for tumor targeting theranosticsFocuses on the combination of therapeutic and diagnostic applications of current principal nanomaterials, providing descriptions of cutting-edge discoveries along with perspectivesChapter contributors are internationally renowned scientists who are experts in their own research arena of nanomaterialsKeywords:Nanomaterials;Tumor Theranostics;Tumor Targeting;Tumor Diagnosis;Tumor Imaging;Tumor Therapy

Advances in Targeted Cancer Therapy

Advances in Targeted Cancer Therapy
A Book

by Richard M. Schultz

  • Publisher : Springer Science & Business Media
  • Release : 2006-01-24
  • Pages : 303
  • ISBN : 3764374144
  • Language : En, Es, Fr & De
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There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

Targeted Therapies in Cancer:

Targeted Therapies in Cancer:
Myth or Reality?

by Francesco Colotta,Alberto Mantovani

  • Publisher : Springer Science & Business Media
  • Release : 2007-12-05
  • Pages : 191
  • ISBN : 9780387738987
  • Language : En, Es, Fr & De
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Billions of dollars are spent every year on research into targeted therapies for cancer. That’s why it’s more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a forum for scientists and clinicians working in cancer drug discovery and therapy to share their opinions and experiences. The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.

Targeted Therapies in Oncology

Targeted Therapies in Oncology
A Book

by Giuseppe Giaccone,Jean-Charles Soria

  • Publisher : CRC Press
  • Release : 2013-10-21
  • Pages : 498
  • ISBN : 1842145460
  • Language : En, Es, Fr & De
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Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edi

Metastases to the Central Nervous System, An Issue of Neurosurgery Clinics of North America, E-Book

Metastases to the Central Nervous System, An Issue of Neurosurgery Clinics of North America, E-Book
A Book

by Edjah K. Nduom,Jeff Olson

  • Publisher : Elsevier Health Sciences
  • Release : 2020-09-24
  • Pages : 240
  • ISBN : 0323761933
  • Language : En, Es, Fr & De
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This issue of Neurosurgery Clinics, guest edited by Drs. Edjah Nduom and Jeff Olson, will focus on Metastases to the Central Nervous System. This issue is one of four selected each year by our series consulting editors, Dr. Russell R. Lonser and Dr. Daniel K. Resnick. Topics discussed in this issue will include: Epidemiology of metastatic CNS disease, Initial approach to the patient with a newly diagnosed solitary brain metastasis, Initial approach to the patient with multiple newly diagnosed brain metastases, When to consider a stereotactic biopsy for brain metastases, Techniques for open surgical resection of cerebral metastases, Laser ablation for cerebral metastases, Histopathological features and laboratory markers of common brain metastases, Recurrence vs radiation necrosis – evaluation and treatment, Anti-epileptic drugs for the management of cerebral metastases, Chemotherapy for the management of cerebral metastases, Approach to the management of metastatic leptomeningeal disease, Immune therapy for CNS metastases, Novel therapeutic targets for the treatment of cerebral metastases, Skull base metastases – diagnosis and management, and more.

Extracellular Targeting of Cell Signaling in Cancer

Extracellular Targeting of Cell Signaling in Cancer
Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways

by James W. Janetka,Roseann M. Benson

  • Publisher : John Wiley & Sons
  • Release : 2018-07-23
  • Pages : 488
  • ISBN : 1119300185
  • Language : En, Es, Fr & De
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International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics
A Book

by Ramj Mahato,Yi Lu

  • Publisher : Springer
  • Release : 2016-04-01
  • Pages : 712
  • ISBN : 9781493939565
  • Language : En, Es, Fr & De
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Pharmaceutical Perspectives of Cancer Therapeutics covers a wide range of therapeutic approaches. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, and the use of imaging in cancer therapy are discussed.