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Collective Behavior In Systems Biology

Collective Behavior In Systems Biology
A Primer on Modeling Infrastructure

by Assaf Steinschneider

  • Publisher : Academic Press
  • Release : 2019-09-04
  • Pages : 260
  • ISBN : 0128173378
  • Language : En, Es, Fr & De
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Collective Behavior In Systems Biology: A Primer on Modeling Infrastructure offers a survey of established and emerging methods for quantifying process behavior in cellular systems. It introduces and applies mathematics and related abstract methods to processes in biological systems - why they are used, how they work, and what they mean. Emphasizing differential equations in an interdisciplinary approach, this book discusses infrastructure for kinetic modeling, technological system and control theories, optimization, and process behavior in cellular networks. The knowledge that the reader gains will be valuable for entering and keeping up with a rapidly developing discipline. Introduces basics of mathematical and abstract methods for understanding, predicting, and modifying collective behavior in cellular systems Targets biomedical professionals as well as computational specialists who are willing to take advantage of novel high-throughput data acquisition technologies

Systems Biology

Systems Biology
A Book

by Mariano Bizzarri

  • Publisher : Humana Press
  • Release : 2018-08-30
  • Pages : 364
  • ISBN : 9781493984916
  • Language : En, Es, Fr & De
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This volume focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective behavior, metabolic, dynamic profiling, and quantitative morphological studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Systems Biology aims to ensure successful results in the further study of this vital field.

Computational Methods in Systems Biology

Computational Methods in Systems Biology
18th International Conference, CMSB 2020, Konstanz, Germany, September 23-25, 2020, Proceedings

by Alessandro Abate,Tatjana Petrov,Verena Wolf

  • Publisher : Springer Nature
  • Release : 2020
  • Pages : 387
  • ISBN : 303060327X
  • Language : En, Es, Fr & De
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This book constitutes the refereed proceedings of the 18th International Conference on Computational Methods in Systems Biology, CMSB 2020, held in Konstanz, Germany, in September 2020.* The 17 full papers and 5 tool papers were carefully reviewed and selected from 30 submissions. In addition 3 abstracts of invited talks and 2 tutorials have been included in this volume. Topics of interest include formalisms for modeling biological processes; models and their biological applications; frameworks for model verification, validation, analysis, and simulation of biological systems; high-performance computational systems biology and parallel implementations; model inference from experimental data; model integration from biological databases; multi-scale modeling and analysis methods; computational approaches for synthetic biology; and case studies in systems and synthetic biology. * The conference was held virtually due to the COVID-19 pandemic.

Proc. of the Third Brazilian Symp. on Mathematical and Computational Biology - v1

Proc. of the Third Brazilian Symp. on Mathematical and Computational Biology - v1
A Book

by RUBEM MONDAINI

  • Publisher : Editora E-papers
  • Release : 2021
  • Pages : 454
  • ISBN : 8587922882
  • Language : En, Es, Fr & De
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Anais do III Simpósio Brasileiro de Biologia Matemática e Computacional

Systems and Synthetic Biology

Systems and Synthetic Biology
A Book

by Vikram Singh,Pawan K. Dhar

  • Publisher : Springer
  • Release : 2014-12-15
  • Pages : 385
  • ISBN : 9401795142
  • Language : En, Es, Fr & De
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This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Life: An Introduction to Complex Systems Biology

Life: An Introduction to Complex Systems Biology
A Book

by Kunihiko Kaneko

  • Publisher : Springer
  • Release : 2006-09-14
  • Pages : 374
  • ISBN : 3540326677
  • Language : En, Es, Fr & De
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This book examines life not from the reductionist point of view, but rather asks the questions: what are the universal properties of living systems, and how can one construct from there a phenomenological theory of life that leads naturally to complex processes such as reproductive cellular systems, evolution and differentiation? The presentation is relatively non-technical to appeal to a broad spectrum of students and researchers.

Theoretical and Applied Aspects of Systems Biology

Theoretical and Applied Aspects of Systems Biology
A Book

by Fabricio Alves Barbosa da Silva,Nicolas Carels,Floriano Paes Silva Junior

  • Publisher : Springer
  • Release : 2018-06-21
  • Pages : 259
  • ISBN : 3319749749
  • Language : En, Es, Fr & De
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This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.

Handbook of Research on Systems Biology Applications in Medicine

Handbook of Research on Systems Biology Applications in Medicine
A Book

by Daskalaki, Andriani

  • Publisher : IGI Global
  • Release : 2008-11-30
  • Pages : 982
  • ISBN : 1605660779
  • Language : En, Es, Fr & De
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"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Systems Biology of Metabolic and Signaling Networks

Systems Biology of Metabolic and Signaling Networks
Energy, Mass and Information Transfer

by Miguel A. Aon,Valdur Saks,Uwe Schlattner

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-22
  • Pages : 375
  • ISBN : 3642385052
  • Language : En, Es, Fr & De
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Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Systems Biology

Systems Biology
A Book

by Robert A. Meyers

  • Publisher : John Wiley & Sons
  • Release : 2012-12-05
  • Pages : 726
  • ISBN : 3527668594
  • Language : En, Es, Fr & De
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Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.

Foundations of Theoretical Approaches in Systems Biology

Foundations of Theoretical Approaches in Systems Biology
A Book

by Alberto Marin-Sanguino,Julio Vera,Rui Alves

  • Publisher : Frontiers Media SA
  • Release : 2019-01-11
  • Pages : 129
  • ISBN : 2889456838
  • Language : En, Es, Fr & De
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If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that attempt to systematize and explain the abundance of available data. As we live through the consolidation of a new paradigm where experimental data goes hand in hand with computational analysis, we contemplate the challenge of fusing these two aspects of the new biology into a consistent theoretical framework. Whether systems biology will survive as a field or be washed away by the tides of future fads will ultimately depend on its success to achieve this type of synthesis. The famous quote attributed to Kurt Lewin comes to mind: "there is nothing more practical than a good theory". This book presents a wide assortment of articles on systems biology in an attempt to capture the variety of current methods in systems biology and show how they can help to find answers to the challenges of modern biology.

Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology

Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology
A Book

by Mariano Vázquez,Peter V. Coveney,Hernan Edgardo Grecco,Alfons Hoekstra,Bastien Chopard

  • Publisher : Frontiers Media SA
  • Release : 2019-04-04
  • Pages : 449
  • ISBN : 2889458172
  • Language : En, Es, Fr & De
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Handbook of Collective Intelligence

Handbook of Collective Intelligence
A Book

by Thomas W. Malone

  • Publisher : MIT Press
  • Release : 2015-10-30
  • Pages : 232
  • ISBN : 0262029812
  • Language : En, Es, Fr & De
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Experts describe the latest research in a rapidly growing multidisciplinary field, the study of groups of individuals acting collectively in ways that seem intelligent.

Systems Biology

Systems Biology
A Book

by Jens Nielsen,Stefan Hohmann

  • Publisher : John Wiley & Sons
  • Release : 2017-03-15
  • Pages : 600
  • ISBN : 3527696172
  • Language : En, Es, Fr & De
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Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.

BIOMAT 2009

BIOMAT 2009
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9814464961
  • Language : En, Es, Fr & De
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Kinetic Equations of Active Soft Matter

Kinetic Equations of Active Soft Matter
A Book

by Viktor Gerasimenko

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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We consider a new approach to the description of the collective behavior of complex systems of mathematical biology based on the evolution equations for observables of such systems. This representation of the kinetic evolution seems, in fact, the direct mathematically fully consistent formulation modeling the collective behavior of biological systems since the traditional notion of the state in kinetic theory is more subtle and it is an implicit characteristic of the populations of living creatures.

Complex Fluids in Biological Systems

Complex Fluids in Biological Systems
Experiment, Theory, and Computation

by Saverio E. Spagnolie

  • Publisher : Springer
  • Release : 2014-11-27
  • Pages : 440
  • ISBN : 1493920650
  • Language : En, Es, Fr & De
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This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solutions in the numerical simulation of biologically relevant complex fluid flows This volume will be accessible to advanced undergraduate and beginning graduate students in engineering, mathematics, biology, and the physical sciences, but will appeal to anyone interested in the intricate and beautiful nature of complex fluids in the context of living systems.

Novel Technological and Methodological Tools for the Understanding of Collective Behaviors

Novel Technological and Methodological Tools for the Understanding of Collective Behaviors
A Book

by Elio Tuci,Vito Trianni,Simon Garnier,Andrew King

  • Publisher : Frontiers Media SA
  • Release : 2020-01-23
  • Pages : 129
  • ISBN : 2889634248
  • Language : En, Es, Fr & De
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Systems Biology of Tumor Microenvironment

Systems Biology of Tumor Microenvironment
Quantitative Modeling and Simulations

by Katarzyna A. Rejniak

  • Publisher : Springer
  • Release : 2016-10-13
  • Pages : 249
  • ISBN : 3319420232
  • Language : En, Es, Fr & De
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This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

Computational Methods in Systems Biology

Computational Methods in Systems Biology
International Conference CMSB 2004, Paris, France, May 26-28, 2004, Revised Selected Papers

by Vincent Danos,Vincent Schachter

  • Publisher : Springer Science & Business Media
  • Release : 2005-03-24
  • Pages : 282
  • ISBN : 3540253750
  • Language : En, Es, Fr & De
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The Computational Methods in Systems Biology (CMSB) workshop series was established in 2003 by Corrado Priami. The purpose of the workshop series is to help catalyze the convergence between computer scientists interested in language design, concurrency theory, software engineering or program verification, and physicists, mathematicians and biologists interested in the systems-level understanding of cellular processes. Systems biology was perceived as being increasingly in search of sophisticated modeling frameworks whether for representing and processing syst- level dynamics or for model analysis, comparison and refinement. One has here a clear-cut case of a must-explore field of application for the formal methods developed in computer science in the last decade. This proceedings consists of papers from the CMSB 2003 workshop. A good third of the 24 papers published here have a distinct formal methods origin; we take this as a confirmation that a synergy is building that will help solidify CMSB as a forum for cross-community exchange, thereby opening new theoretical avenues and making the field less of a potential application and more of a real one. Publication in Springer's new Lecture Notes in Bioinformatics (LNBI) offers particular visibility and impact, which we gratefully acknowledge. Our keynote speakers, Alfonso Valencia and Trey Ideker, gave challenging and somewhat humbling lectures: they made it clear that strong applications to systems biology are still some way ahead. We thank them all the more for accepting the invitation to speak and for the clarity and excitement they brought to the conference.