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Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
From Biomarker Discovery to Clinical Implementation

by Jan Trøst Jørgensen

  • Publisher : Academic Press
  • Release : 2019-05-08
  • Pages : 508
  • ISBN : 0128135409
  • Language : En, Es, Fr & De
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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
From Biomarker Discovery to Clinical Implementation

by Jan Trøst Jørgensen

  • Publisher : Academic Press
  • Release : 2019-04-15
  • Pages : 305
  • ISBN : 9780128135396
  • Language : En, Es, Fr & De
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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine
A Book

by Il-Jin Kim

  • Publisher : CRC Press
  • Release : 2019-03-06
  • Pages : 256
  • ISBN : 1000007219
  • Language : En, Es, Fr & De
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There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Drug-Diagnostics Co-Development in Oncology

Drug-Diagnostics Co-Development in Oncology

by Jan Trøst Jørgensen

  • Publisher : Frontiers E-books
  • Release : 2014-11-07
  • Pages : 329
  • ISBN : 2889193322
  • Language : En, Es, Fr & De
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The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen receptor modulator tamoxifen was developed in the 1970’s for the treatment of breast cancer a positive correlation between receptor status and treatment outcome was found. As a result of this research, it was suggested to use the estrogen-receptor assay as a diagnostic test for selection of patients for tamoxifen treatment. Despite this suggestion was put forward nearly 40 years ago the adaptation of the drug-diagnostic co-development model has been relatively slow and it is only within the last decade that it has gained more widespread acceptance. The parallel development of the monoclonal antibody trastuzumab (Herceptin®, Roche/Genentech) and the immunohistochemistry assay for HER2 protein overexpression (HercepTest™, Dako) seems to have served as an inspiration to a number of stakeholders such as pharma and diagnostic companies, regulatory agencies, and academia. In recent years we have seen an increasing number of oncology drug development projects that have taken advantage of the drug-diagnostic co-development model, as outline below. Most of the new targeted anti-cancer drugs that have been introduced in recent years, such as BRAF-, ALK-, EGFR- and HER2-inhibitors, are more or less all a product of the drugdiagnostic co-development model. These drugs have shown remarkable high response rates in selected groups of patients within cancer diseases with great unmet medical needs. This Research Topic on Drug-Diagnostic Co-Development in Oncology aims to provide you with an insight into some of the diverse activities that constitute this new research area.

Predictive Biomarkers in Oncology

Predictive Biomarkers in Oncology
Applications in Precision Medicine

by Sunil Badve,George Louis Kumar

  • Publisher : Springer
  • Release : 2018-12-06
  • Pages : 642
  • ISBN : 3319952285
  • Language : En, Es, Fr & De
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“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

An R Companion to Applied Regression

An R Companion to Applied Regression
A Book

by John Fox,Sanford Weisberg

  • Publisher : SAGE Publications
  • Release : 2018-09-27
  • Pages : 608
  • ISBN : 1544336454
  • Language : En, Es, Fr & De
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An R Companion to Applied Regression is a broad introduction to the R statistical computing environment in the context of applied regression analysis. John Fox and Sanford Weisberg provide a step-by-step guide to using the free statistical software R, an emphasis on integrating statistical computing in R with the practice of data analysis, coverage of generalized linear models, and substantial web-based support materials. The Third Edition includes a new chapter on mixed-effects models, new and updated data sets, and a de-emphasis on statistical programming, while retaining a general introduction to basic R programming. The authors have substantially updated both the car and effects packages for R for this new edition, and include coverage of RStudio and R Markdown.

Diagnostic Molecular Biology

Diagnostic Molecular Biology
A Book

by Chang-Hui Shen

  • Publisher : Academic Press
  • Release : 2019-04-02
  • Pages : 471
  • ISBN : 012802867X
  • Language : En, Es, Fr & De
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Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding. The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes as well as the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations. This book also covers the applications of the principles and techniques currently employed in the clinical laboratory. • Provides an understanding of which techniques are used in diagnosis at the molecular level • Explains the basic principles of molecular biology and their application in the clinical diagnosis of diseases • Places protocols in context with practical applications

Ensuring Innovation in Diagnostics for Bacterial Infection

Ensuring Innovation in Diagnostics for Bacterial Infection
Implications for Policy

by Chantal Morel,Lindsay McClure,Suzanne Edwards,Dale Sandberg

  • Publisher : World Health Organization
  • Release : 2016
  • Pages : 317
  • ISBN : 9289050365
  • Language : En, Es, Fr & De
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The inappropriate use of antibiotics is a primary cause of the ongoing increase in drug resistance among pathogenic bacteria. The resulting decrease in the efficacy of antibiotics threatens our ability to combat infectious diseases. Rapid, point-of-care tests to identify pathogens and better target the appropriate treatment could greatly improve the use of antibiotics. Yet there are few such tests currently available or being developed despite the rapid pace of medical innovation. Clearly something is inhibiting the much-needed development of new and more convenient diagnostic tools. This study delineates priorities for developing diagnostics to improve antibiotic prescription and use with the goal of managing and curbing the expansion of drug resistance. It calls for new approaches, particularly in the provision of diagnostic devices, and, in doing so, outlines some of the inadequacies in health, science and policy initiatives that have led to the dearth of such devices. The authors make the case that there is a clear and urgent need for innovation, not only in the technology of diagnosis, but also in public policy and medical practice to support the availability and use of better diagnostic tools. This book explores the complexities of the diagnostics market from the perspective of both supply and demand, unearthing interesting bottlenecks, some obvious, some more subtle. It calls for a multifaceted and broad policy response, and an overhaul of current practice, so that the growth of bacterial resistance can be stemmed.

Diagnosis and Management of Lameness in the Horse - E-Book

Diagnosis and Management of Lameness in the Horse - E-Book
A Book

by Michael W. Ross,Sue J. Dyson

  • Publisher : Elsevier Health Sciences
  • Release : 2010-11-11
  • Pages : 1424
  • ISBN : 1437711766
  • Language : En, Es, Fr & De
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Covering many different diagnostic tools, this essential resource explores both traditional treatments and alternative therapies for conditions that can cause gait abnormalities in horses. Broader in scope than any other book of its kind, this edition describes equine sporting activities and specific lameness conditions in major sport horse types, and includes up-to-date information on all imaging modalities. This title includes additional digital media when purchased in print format. For this digital book edition, media content may not be included. Cutting-edge information on diagnostic application for computed tomography and magnetic resonance imaging includes the most comprehensive section available on MRI in the live horse. Coverage of traditional treatment modalities also includes many aspects of alternative therapy, with a practical and realistic perspective on prognosis. An examination of the various types of horses used in sports describes the lameness conditions to which each horse type is particularly prone, as well as differences in prognosis. Guidelines on how to proceed when a diagnosis cannot easily be reached help you manage conditions when faced with the limitations of current diagnostic capabilities. Clinical examination and diagnostic analgesia are given a special emphasis. Practical, hands-on information covers a wide range of horse types from around the world. A global perspective is provided by a team of international authors, editors, and contributors. A full-color insert shows thermography images. Updated chapters include the most current information on topics such as MRI, foot pain, stem cell therapy, and shock wave treatment. Two new chapters include The Biomechanics of the Equine Limb and its Effect on Lameness and Clinical Use of Stem Cells, Marrow Components, and Other Growth Factors. The chapter on the hock has been expanded substantially, and the section on lameness associated with the foot has been completely rewritten to include state-of-the-art information based on what has been learned from MRI. Many new figures appear throughout the book.

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders
A Book

by Paul C. Guest

  • Publisher : Springer
  • Release : 2019-02-12
  • Pages : 328
  • ISBN : 3030055426
  • Language : En, Es, Fr & De
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This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Innovations for Next-Generation Antibody-Drug Conjugates

Innovations for Next-Generation Antibody-Drug Conjugates
A Book

by Marc Damelin

  • Publisher : Springer
  • Release : 2018-05-29
  • Pages : 357
  • ISBN : 3319781545
  • Language : En, Es, Fr & De
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Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
A Book

by Aiden Abidov,Isabel Oliva,Frank I Marcus

  • Publisher : Academic Press
  • Release : 2016-03-18
  • Pages : 212
  • ISBN : 0128014350
  • Language : En, Es, Fr & De
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Cardiac MRI in Diagnosis, Clinical Management and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia provides up-to-date information regarding the most effective diagnostic protocols and CMR sequences for the evaluation of patients with suspected or known ARVC/D. It includes CMR protocol summaries and clinical algorithms presented as flow diagrams, many of which have never been previously published. The book contains case reports from the practice and database of Dr. Frank I. Marcus, world renowned ARVC/D expert; as well as input from imaging experts from a large academic center with unique RV pathology imaging experience. This title is the perfect pocket companion for cardiologists, pediatric cardiologists, cardiac imaging and electrophysiology specialists as well as cardiology researchers. The only comprehensive MRI reference focused and dedicated on the utilization of MRI in screening, diagnosis, therapeutic guidance and prognostic assessment of ARVC/D. Provides evidence based diagnostic and prognostic algorithms for management of patients with known and suspected ARVC/D. Contains concise clinical CMR acquisition protocol and evidence-based summaries of recommendations and multiple practical tips and tricks shared by experts in the field. Includes practical guidelines helping to determine pre-test and post-test likelihood of ARVC/D; as well as CMR evidence of the disease progression. Accompanying website provides complementary videos important for the understanding of ARVC diagnosis.

Molecular Diagnostics: Promises and Possibilities

Molecular Diagnostics: Promises and Possibilities
A Book

by Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen

  • Publisher : Springer Science & Business Media
  • Release : 2010-01-29
  • Pages : 520
  • ISBN : 9789048132614
  • Language : En, Es, Fr & De
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A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
A Book

by Yuichi Takiguchi

  • Publisher : Springer
  • Release : 2017-01-24
  • Pages : 327
  • ISBN : 9811020027
  • Language : En, Es, Fr & De
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This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Innovations for Next-Generation Antibody-Drug Conjugates

Innovations for Next-Generation Antibody-Drug Conjugates
A Book

by Marc Damelin

  • Publisher : Springer
  • Release : 2018-05-29
  • Pages : 357
  • ISBN : 3319781545
  • Language : En, Es, Fr & De
GET BOOK

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Precision Molecular Pathology of Liver Cancer

Precision Molecular Pathology of Liver Cancer
A Book

by Chen Liu

  • Publisher : Springer
  • Release : 2018-01-09
  • Pages : 271
  • ISBN : 331968082X
  • Language : En, Es, Fr & De
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This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.

Bayesian Ideas and Data Analysis

Bayesian Ideas and Data Analysis
An Introduction for Scientists and Statisticians

by Ronald Christensen,Wesley Johnson,Adam Branscum,Timothy E Hanson

  • Publisher : CRC Press
  • Release : 2011-07-07
  • Pages : 516
  • ISBN : 1439803552
  • Language : En, Es, Fr & De
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Emphasizing the use of WinBUGS and R to analyze real data, Bayesian Ideas and Data Analysis: An Introduction for Scientists and Statisticians presents statistical tools to address scientific questions. It highlights foundational issues in statistics, the importance of making accurate predictions, and the need for scientists and statisticians to collaborate in analyzing data. The WinBUGS code provided offers a convenient platform to model and analyze a wide range of data. The first five chapters of the book contain core material that spans basic Bayesian ideas, calculations, and inference, including modeling one and two sample data from traditional sampling models. The text then covers Monte Carlo methods, such as Markov chain Monte Carlo (MCMC) simulation. After discussing linear structures in regression, it presents binomial regression, normal regression, analysis of variance, and Poisson regression, before extending these methods to handle correlated data. The authors also examine survival analysis and binary diagnostic testing. A complementary chapter on diagnostic testing for continuous outcomes is available on the book’s website. The last chapter on nonparametric inference explores density estimation and flexible regression modeling of mean functions. The appropriate statistical analysis of data involves a collaborative effort between scientists and statisticians. Exemplifying this approach, Bayesian Ideas and Data Analysis focuses on the necessary tools and concepts for modeling and analyzing scientific data. Data sets and codes are provided on a supplemental website.

Withrow and MacEwen's Small Animal Clinical Oncology - E-Book

Withrow and MacEwen's Small Animal Clinical Oncology - E-Book
A Book

by Stephen J. Withrow,Rodney Page,David M. Vail

  • Publisher : Elsevier Health Sciences
  • Release : 2013-08-07
  • Pages : 768
  • ISBN : 0323241972
  • Language : En, Es, Fr & De
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With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats — what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet’s pain and nutritional complications as well as the pet owner’s grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.

Nanotheranostics for Cancer Applications

Nanotheranostics for Cancer Applications
A Book

by Prakash Rai,Stephanie A. Morris

  • Publisher : Springer
  • Release : 2018-11-12
  • Pages : 480
  • ISBN : 3030017753
  • Language : En, Es, Fr & De
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This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

The Circuit Designer’s Companion

The Circuit Designer’s Companion
A Book

by Tim Williams

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 310
  • ISBN : 1483102505
  • Language : En, Es, Fr & De
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The Circuit Designer’s Companion covers the theoretical aspects and practices in analogue and digital circuit design. Electronic circuit design involves designing a circuit that will fulfill its specified function and designing the same circuit so that every production model of it will fulfill its specified function, and no other undesired and unspecified function. This book is composed of nine chapters and starts with a review of the concept of grounding, wiring, and printed circuits. The subsequent chapters deal with the passive and active components of circuitry design. These topics are followed by discussions of the principles of other design components, including linear integrated circuits, digital circuits, and power supplies. The remaining chapters consider the vital role of electromagnetic compatibility in circuit design. These chapters also look into safety, design of production, testability, reliability, and thermal management of the designed circuit. This book is of great value to electrical and design engineers.