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Comparative Toxicogenomics

Comparative Toxicogenomics
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2008-07-11
  • Pages : 352
  • ISBN : 9780080560021
  • Language : En, Es, Fr & De
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Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

The Comparative Toxicogenomics Database

The Comparative Toxicogenomics Database
A Book

by Mount Desert Island Biological Laboratory

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The database identifies interactions between chemicals and genes in diverse organisms to advance understanding of how environmental chemicals affect human health.

Information Resources in Toxicology

Information Resources in Toxicology
Volume 1: Background, Resources, and Tools

by Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes

  • Publisher : Academic Press
  • Release : 2020-05-16
  • Pages : 1054
  • ISBN : 0128137258
  • Language : En, Es, Fr & De
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This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources. Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles. Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals. Explores recent internet trends, web-based databases, and software tools in a section on the online environment. Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents. Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field.

Toxicogenomics

Toxicogenomics
A Powerful Tool for Toxicity Assessment

by Saura C. Sahu

  • Publisher : John Wiley & Sons
  • Release : 2008-11-20
  • Pages : 422
  • ISBN : 0470699647
  • Language : En, Es, Fr & De
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Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.

Toxicogenomics

Toxicogenomics
Principles and Applications

by Hisham K. Hamadeh,Cynthia A. Afshari

  • Publisher : John Wiley & Sons
  • Release : 2004-09-06
  • Pages : 361
  • ISBN : 9780471434177
  • Language : En, Es, Fr & De
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Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.

OMICS

OMICS
Biomedical Perspectives and Applications

by Debmalya Barh,Kenneth Blum,Margaret A. Madigan

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 622
  • ISBN : 1439850097
  • Language : En, Es, Fr & De
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A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Toxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models
Alternatives to Animal Testing for Safety Assessment

by Jos Kleinjans

  • Publisher : Academic Press
  • Release : 2014-01-02
  • Pages : 362
  • ISBN : 0123978718
  • Language : En, Es, Fr & De
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Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays Includes an overview of current testing methods and risk assessment frameworks Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders
A Book

by Bingling Wang

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bisphenol A (BPA) has been widely used in many industrial and consumer products and is known as an endocrine-disrupting chemical. To find the underlying genetic basis and molecular mechanisms of BPA-associated neurodevelopmental disorders (NDs), this chapter addressed the toxicogenomics of BPA with publicly accessed Comparative Toxicogenomics Database. The present results indicated that the key cellular components (CC) of the nervous system such as neuron, synapse, dendrite and axon are common in CC annotation; the commonly found molecular functions are neurotransmitter receptor or transducer binding or activity; and the main common biological processes include synaptic signalling, cognition, learning or memory, behaviour, the development of nervous system and brain. Neuroactive ligand-receptor interaction, dopaminergic, glutamatergic and serotonergic synapses, monoamine transport and synaptic vesicle pathway were the common pathways. Simultaneously, the BPA-disease may share the common pathways with drug addictions such as cocaine addiction. Unique pathways might also contribute to the BPA action in different NDs such as one carbon metabolism and detoxification of oxidative stress in Down syndrome. Although GO and pathway results indicate some common annotations, the predicted PPI molecular function clusters are quite different for each ND. In addition, some of the NDs share the same transcription factors (TFs) and miRNAs, which indicate these disorders have the similar expression profiles. Finally, chemicals having comparable interacting genes to BPA should be considered.

Toxicogenomics in Predictive Carcinogenicity

Toxicogenomics in Predictive Carcinogenicity

by Michael D. Waters,Russell S. Thomas

  • Publisher : Royal Society of Chemistry
  • Release : 2016-06-10
  • Pages : 524
  • ISBN : 1782621628
  • Language : En, Es, Fr & De
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Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.

Genomic Approaches for Cross-Species Extrapolation in Toxicology

Genomic Approaches for Cross-Species Extrapolation in Toxicology
A Book

by William H. Benson,Richard T. Di Giulio

  • Publisher : CRC Press
  • Release : 2006-12-13
  • Pages : 216
  • ISBN : 1420043641
  • Language : En, Es, Fr & De
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The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

Environmental Health Perspectives

Environmental Health Perspectives
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009-07
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005
Hearings Before a Subcommittee of the Committee on Appropriations, House of Representatives, One Hundred Eighth Congress, Second Session

by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

Reducing, Refining and Replacing the Use of Animals in Toxicity Testing
A Book

by Dave Allen,Mike D. Waters

  • Publisher : Royal Society of Chemistry
  • Release : 2013
  • Pages : 369
  • ISBN : 1849736529
  • Language : En, Es, Fr & De
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Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence." By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
A Book

by Darrell R. Boverhof,B. Bhaskar Gollapudi

  • Publisher : John Wiley & Sons
  • Release : 2011-10-11
  • Pages : 392
  • ISBN : 9781118008980
  • Language : En, Es, Fr & De
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This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Principles of Toxicology Testing, Second Edition

Principles of Toxicology Testing, Second Edition
A Book

by Frank A Barile

  • Publisher : CRC Press
  • Release : 2013-04-02
  • Pages : 362
  • ISBN : 1842145282
  • Language : En, Es, Fr & De
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Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.

Comprehensive Toxicology

Comprehensive Toxicology
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2010-06-01
  • Pages : 6448
  • ISBN : 0080468845
  • Language : En, Es, Fr & De
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An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations
Hearings Before a Subcommittee of the Committee on Appropriations, United States Senate

by United States. Congress. Senate. Committee on Appropriations

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 2005

Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 2005
Hearing Before a Subcommittee of the Committee on Appropriations, United States Senate, One Hundred Eighth Congress, Second Session, on H.R. 5006/S. 2810, an Act Making Appropriations for the Departments of Labor, Health and Human Services, and Education, and Related Agencies, for the Fiscal Year Ending September 30, 2005, and for Other Purposes

by U S Government Printing Office,United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 456
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Quality of Life Through Quality of Information

Quality of Life Through Quality of Information
Proceedings of MIE2012

by John Mantas,European Federation for Medical Informatics

  • Publisher : IOS Press
  • Release : 2012
  • Pages : 1251
  • ISBN : 1614991006
  • Language : En, Es, Fr & De
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Medical informatics and electronic healthcare have many benefits to offer in terms of quality of life for patients, healthcare personnel, citizens and society in general. But evidence-based medicine needs quality information if it is to lead to quality of health and thus to quality of life. This book presents the full papers accepted for presentation at the MIE2012 conference, held in Pisa, Italy, in August 2012. The theme of the 2012 conference is aeQuality of Life through Quality of InformationAE. As always, the conference provides a unique platform for the exchange of ideas and experiences among the actors and stakeholders of ICT supported healthcare. The book incorporates contributions related to the latest achievements in biomedical and health informatics in terms of major challenges such as interoperability, collaboration, coordination and patient-oriented healthcare at the most appropriate level of care.It also offers new perspectives for the future of biomedical and health informatics, critical appraisal of strategies for user involvement, insights for design, deployment and the sustainable use of electronic health records, standards, social software, citizen centred e-health, and new challenges in rehabilitation and social care informatics. The topics presented are interdisciplinary in nature and will be of interest to a variety of professionals; physicians, nurses and other allied health providers, health informaticians, engineers, academics and representatives from industry and consultancy in the various fields.

Concepts in Pharmacogenomics

Concepts in Pharmacogenomics
A Book

by Martin M. Zdanowicz

  • Publisher : ASHP
  • Release : 2010
  • Pages : 414
  • ISBN : 1585282340
  • Language : En, Es, Fr & De
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The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time. If you are pharmacist, resident, or student curious about this new field, start with Concepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation. Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.