Download Comparative Toxicogenomics Ebook PDF

Comparative Toxicogenomics

Comparative Toxicogenomics
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2008-07-11
  • Pages : 352
  • ISBN : 9780080560021
  • Language : En, Es, Fr & De
GET BOOK

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005
Hearings Before a Subcommittee of the Committee on Appropriations, House of Representatives, One Hundred Eighth Congress, Second Session

by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Environmental Health Perspectives

Environmental Health Perspectives
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations
Hearings Before a Subcommittee of the Committee on Appropriations, United States Senate

by United States. Congress. Senate. Committee on Appropriations

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Design, Management, and Quality Control of Toxicogenomic Experiments

Design, Management, and Quality Control of Toxicogenomic Experiments
A Book

by Lyle David Burgoon

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 338
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Bulletin of the Mount Desert Island Biological Laboratory

Bulletin of the Mount Desert Island Biological Laboratory
A Book

by Mount Desert Island Biological Laboratory

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments
A Book

by Helen Catherine Poynton

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 346
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Encyclopedia of Ecology

Encyclopedia of Ecology
A Book

by Sven Erik Jørgensen,Brian D. Fath

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 4122
  • ISBN : 9780080454009
  • Language : En, Es, Fr & De
GET BOOK

The Encyclopedia of Ecology contains contributions from international experts on a diverse array of topics related to ecology. It provides current and comprehensive information on many themes, including behavioral ecology, ecological processes, ecological modeling, ecological engineering, ecological indicators, ecological informatics, ecosystems, ecotoxicology, evolutionary ecology, general ecology, global ecology, human ecology, and systems ecology. The online version includes extensive internal cross-referencing and dynamic linking to journal articles and abstract databases.

Comparative Biochemistry and Physiology

Comparative Biochemistry and Physiology
Biochemistry & molecular biology

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Comparative Genomics

Comparative Genomics
Basic and Applied Research

by James R. Brown

  • Publisher : CRC Press
  • Release : 2007-12-03
  • Pages : 400
  • ISBN : 9781420008876
  • Language : En, Es, Fr & De
GET BOOK

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions. Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers— · Revolutionary advances in DNA-sequencing technology · Bold new approaches to the organization and analysis of large phylogenetic data sets · The impact of comparative genomics on our understanding of evolution · Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

Application of Toxicogenomic Approaches to Study Chemical-induced Effects on the Hypothalamic-pituitary-gonadal (HPG) Axis of the Japanese Medaka (Oryzias Latipes)

Application of Toxicogenomic Approaches to Study Chemical-induced Effects on the Hypothalamic-pituitary-gonadal (HPG) Axis of the Japanese Medaka (Oryzias Latipes)
A Book

by Xiaowei Zhang

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 218
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Genomic Approaches for Cross-Species Extrapolation in Toxicology

Genomic Approaches for Cross-Species Extrapolation in Toxicology
A Book

by William H. Benson,Richard T. Di Giulio

  • Publisher : CRC Press
  • Release : 2006-12-13
  • Pages : 216
  • ISBN : 9781420043648
  • Language : En, Es, Fr & De
GET BOOK

The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders
A Book

by Bingling Wang

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Bisphenol A (BPA) has been widely used in many industrial and consumer products and is known as an endocrine-disrupting chemical. To find the underlying genetic basis and molecular mechanisms of BPA-associated neurodevelopmental disorders (NDs), this chapter addressed the toxicogenomics of BPA with publicly accessed Comparative Toxicogenomics Database. The present results indicated that the key cellular components (CC) of the nervous system such as neuron, synapse, dendrite and axon are common in CC annotation; the commonly found molecular functions are neurotransmitter receptor or transducer binding or activity; and the main common biological processes include synaptic signalling, cognition, learning or memory, behaviour, the development of nervous system and brain. Neuroactive ligand-receptor interaction, dopaminergic, glutamatergic and serotonergic synapses, monoamine transport and synaptic vesicle pathway were the common pathways. Simultaneously, the BPA-disease may share the common pathways with drug addictions such as cocaine addiction. Unique pathways might also contribute to the BPA action in different NDs such as one carbon metabolism and detoxification of oxidative stress in Down syndrome. Although GO and pathway results indicate some common annotations, the predicted PPI molecular function clusters are quite different for each ND. In addition, some of the NDs share the same transcription factors (TFs) and miRNAs, which indicate these disorders have the similar expression profiles. Finally, chemicals having comparable interacting genes to BPA should be considered.

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses
A Book

by Darrell Ralph Boverhof

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 476
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Science

Science
A Book

by John Michels (Journalist)

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Casarett & Doull's Essentials of Toxicology, Third Edition

Casarett & Doull's Essentials of Toxicology, Third Edition
A Book

by Curtis D. Klaassen,John B. Watkins

  • Publisher : McGraw Hill Professional
  • Release : 2015-11-22
  • Pages : 528
  • ISBN : 007184709X
  • Language : En, Es, Fr & De
GET BOOK

Understand the essential principles of toxicology and how poisons affect the human body with this accessible and engaging summary A Doody's Core Title for 2017! General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text. Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material. Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections: Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Ninth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Ninth Edition
A Book

by Curtis D. Klaassen

  • Publisher : McGraw Hill Professional
  • Release : 2018-11-23
  • Pages : 1696
  • ISBN : 1259863751
  • Language : En, Es, Fr & De
GET BOOK

Toxicology’s gold-standard text - completely updated to reflect the latest breakthroughs and discoveries Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:•General Principles of Toxicology•Disposition of Toxicants•Non-Organ Directed Toxicity•Target Organ Toxicity•Toxic Agents•Environmental Toxicology•Applications of Toxicology Many new contributors capture the progress made in toxicology over the past few years:This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book. Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals. A true “essential”If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology - written by experts, and presented in full color, your search ends here.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
A Book

by Curtis Klaassen

  • Publisher : McGraw Hill Professional
  • Release : 2013-04-25
  • Pages : 1473
  • ISBN : 0071769226
  • Language : En, Es, Fr & De
GET BOOK

The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references. NEW to the Eighth Edition FULL-COLOR design to allow for a clearer interpretation of the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals are updated with state-of-the-art standards that makes this edition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories" and "Toxic Effects of Nanoparticles"

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
A Book

by Louis J. Casarett,John Doull

  • Publisher : McGraw Hill Professional
  • Release : 2013-06-19
  • Pages : 1454
  • ISBN : 0071769234
  • Language : En, Es, Fr & De
GET BOOK

Casarett and Doull's has set the standard for toxicology reference texts for years, and is the market leading title to this day. It serves the general toxicology market, and is to the field what Goodman and Gilman is to pharmacology. The books are often purchased together, and form a knock-out punch along with our DiPiro textbook; combined, these three titles produce millions of dollars in revenue and more than 100,000 in unit sales. Casarett & Doull's is, in other words, one part of a triad that forms the best pharmacology/pharmacy/toxicology collection in all of medical publishing

Drug Information: A Guide for Pharmacists, Sixth Edition

Drug Information: A Guide for Pharmacists, Sixth Edition
A Book

by Patrick M. Malone,Meghan J. Malone,Sharon K. Park

  • Publisher : McGraw Hill Professional
  • Release : 2017-12-13
  • Pages : 1456
  • ISBN : 125983798X
  • Language : En, Es, Fr & De
GET BOOK

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The guide pharmacists and students turn to first for cutting-edge coverage of drug information A Doody’s Core Title for 2019! The goal of Drug Information: A Guide for Pharmacists, Sixth Edition is to teach students and practitioners how to effectively research, interpret, evaluate, collate, and disseminate drug information in the most efficient and effective manner possible. Updated to reflect the realities of today’s practice, the book also addresses important issues such as the legal and ethical considerations of providing drug information. Drug Information: A Guide for Pharmacists begins by introducing the concept of drug information, including its history, and provides details on the various places drug information specialists may find employment. This is followed by information on how to answer a question, from the process of gathering necessary background information through determining the actual informational need, to answering the question. The chapter on drug information resources includes descriptions of the most commonly used references and contains new information on apps available to practitioners. As with past editions, practical examples are also provided. The Sixth Edition has been updated throughout, with chapters from previous editions rearranged to make the subject flow better. This edition is also enhanced by the addition of new chapters on journal clubs and counterfeit drugs/drug shortages. In addition, coverage of Policy Development, Project Design and Implementation has been greatly expanded.