Download Computational Toxicology Ebook PDF

Computational Toxicology

Computational Toxicology
Risk Assessment for Chemicals

by Sean Ekins

  • Publisher : John Wiley & Sons
  • Release : 2018-02-13
  • Pages : 432
  • ISBN : 111928256X
  • Language : En, Es, Fr & De
GET BOOK

A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. • Provides a perspective of what is currently achievable with computational toxicology and a view to future developments • Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment • Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference • Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling • Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

Advances in Computational Toxicology

Advances in Computational Toxicology
Methodologies and Applications in Regulatory Science

by Huixiao Hong

  • Publisher : Springer
  • Release : 2019-05-21
  • Pages : 412
  • ISBN : 3030164438
  • Language : En, Es, Fr & De
GET BOOK

This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.

Computational Toxicology

Computational Toxicology
A Book

by Brad Reisfeld,Arthur N. Mayeno

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 648
  • ISBN : 9781627030595
  • Language : En, Es, Fr & De
GET BOOK

Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology provides biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. Divided into four sections, Volume I covers a wide array of methodologies and topics. Opening with an introduction to the field of computational toxicology and its current and potential applications, the volume continues with 'best practices' in mathematical and computational modeling, followed by chemoinformatics and the use of computational techniques and databases to predict chemical properties and toxicity, as well as an overview of molecular dynamics. The final section is a compilation of the key elements and main approaches used in pharmacokinetic and pharmacodynamic modeling, including the modeling of absorption, compartment and non-compartmental modeling, physiologically based pharmacokinetic modeling, interspecies extrapolation, and population effects. Written in the successful Methods in Molecular Biology series format where possible, chapters include introductions to their respective topics, lists of the materials and software tools used, methods, and notes on troubleshooting. Authoritative and easily accessible, Computational Toxicology will allow motivated readers to participate in this exciting field and undertake a diversity of realistic problems of interest.

ORD's Computational Toxicology Research Program Implementation Plan (FY 2006-2008)

ORD's Computational Toxicology Research Program Implementation Plan (FY 2006-2008)
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Computational Toxicology

Computational Toxicology
Methods and Applications for Risk Assessment

by Bruce A. Fowler

  • Publisher : Academic Press
  • Release : 2013-06-04
  • Pages : 274
  • ISBN : 012396508X
  • Language : En, Es, Fr & De
GET BOOK

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Computational Toxicology

Computational Toxicology
Methods and Protocols

by Orazio Nicolotti

  • Publisher : Humana Press
  • Release : 2018-06-24
  • Pages : 439
  • ISBN : 9781493978984
  • Language : En, Es, Fr & De
GET BOOK

This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply with both scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.

Computational Toxicology

Computational Toxicology
Chapter 12. Translation of Computational Model Results for Risk Decisions

by William Mendez,Bruce A. Fowler

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-06-04
  • Pages : 274
  • ISBN : 0128060530
  • Language : En, Es, Fr & De
GET BOOK

The focus of the chapter is on the development and application of computational toxicology methods to human risk assessment. The various CompTox methods are defined, and a brief history of their development and applications in risk assessment is provided. The technological, economic, and public health concerns driving the development of the methods are described, along with how the specific forces shaped the historical and current use of CompTox methods in risk assessment. Translation research programs in the United States and OECD are briefly reviewed, and current applications of CompTox to risk assessment in the areas of screening, priority setting for testing and regulation, and the elucidation of adverse outcome pathways are discussed. Potential future directions for the application of computational toxicology in a wider range of risk applications are identified, along with ongoing research needs.

Computational Toxicology

Computational Toxicology
Chapter 6. Computational Translation and Integration of Test Data to Meet Risk Assessment Goals

by Luis G. Valerio

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-06-04
  • Pages : 274
  • ISBN : 0128060476
  • Language : En, Es, Fr & De
GET BOOK

The remarkable advances of high-performance computing to facilitate and increase efficiency in helping to resolve or support assessments on the toxic effects of chemicals on tissues and genomic material have led to development of novel in silico methods. These methods can support risk assessment via integration of study data that can be translated into meaningful predictive information. This chapter describes some methods in computational toxicology and how to integrate experimental data with computational assessments for supporting risk assessment.

Computational Toxicology

Computational Toxicology
A Book

by Brad Reisfeld,Arthur N. Mayeno

  • Publisher : Humana Press
  • Release : 2012-09-26
  • Pages : 613
  • ISBN : 9781627030496
  • Language : En, Es, Fr & De
GET BOOK

Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology provides biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. Divided into four sections, Volume I covers a wide array of methodologies and topics. Opening with an introduction to the field of computational toxicology and its current and potential applications, the volume continues with ’best practices’ in mathematical and computational modeling, followed by chemoinformatics and the use of computational techniques and databases to predict chemical properties and toxicity, as well as an overview of molecular dynamics. The final section is a compilation of the key elements and main approaches used in pharmacokinetic and pharmacodynamic modeling, including the modeling of absorption, compartment and non-compartmental modeling, physiologically based pharmacokinetic modeling, interspecies extrapolation, and population effects. Written in the successful Methods in Molecular BiologyTM series format where possible, chapters include introductions to their respective topics, lists of the materials and software tools used, methods, and notes on troubleshooting. Authoritative and easily accessible, Computational Toxicology will allow motivated readers to participate in this exciting field and undertake a diversity of realistic problems of interest.

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology

by Rudy J Richardson,Dale E Johnson

  • Publisher : Royal Society of Chemistry
  • Release : 2017-03-03
  • Pages : 347
  • ISBN : 1782623329
  • Language : En, Es, Fr & De
GET BOOK

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Modeling of Biomembranes: from Computational Toxicology to Simulations of Neurodegenerative Diseases

Modeling of Biomembranes: from Computational Toxicology to Simulations of Neurodegenerative Diseases
A Book

by Inna Ermilova

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 90
  • ISBN : 9789177975847
  • Language : En, Es, Fr & De
GET BOOK

Principles of Toxicology

Principles of Toxicology
Environmental and Industrial Applications

by Stephen M. Roberts,Robert C. James,Phillip L. Williams

  • Publisher : John Wiley & Sons
  • Release : 2015-01-12
  • Pages : 496
  • ISBN : 0470907916
  • Language : En, Es, Fr & De
GET BOOK

A fully updated and expanded edition of the bestselling guide on toxicology and its practical application • Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards • New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology • Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems • Includes case histories and examples from industry demonstrate the application of toxicological principles • Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms

Big-Data and Machine Learning to Revamp Computational Toxicology and Its Use in Risk Assessment

Big-Data and Machine Learning to Revamp Computational Toxicology and Its Use in Risk Assessment
A Book

by Thomas Luechtefeld,Craig Rowlands,Thomas Hartung

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Environmental Toxicology and Chemistry

Environmental Toxicology and Chemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

AMSTAT News

AMSTAT News
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Computational Systems Toxicology

Computational Systems Toxicology
A Book

by Julia Hoeng,Manuel C. Peitsch

  • Publisher : Humana Press
  • Release : 2015-09-14
  • Pages : 430
  • ISBN : 9781493927777
  • Language : En, Es, Fr & De
GET BOOK

This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment. Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.

Department of the Interior and Related Agencies Appropriations for ...

Department of the Interior and Related Agencies Appropriations for ...
Hearings Before a Subcommittee of the Committee on Appropriations, United States Senate

by United States. Congress. Senate. Committee on Appropriations

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Big Data in Predictive Toxicology

Big Data in Predictive Toxicology
A Book

by Andrea-Nicole Richarz,Daniel Neagu

  • Publisher : Royal Society of Chemistry
  • Release : 2019-12-10
  • Pages : 394
  • ISBN : 1839160829
  • Language : En, Es, Fr & De
GET BOOK

The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the opportunities of new techniques encountered in data science. It addresses the nature of toxicological big data, their storage, analysis and interpretation. It also details how these data can be applied in toxicity prediction, modelling and risk assessment. This title is of particular relevance to researchers and postgraduates working and studying in the fields of computational methods, applied and physical chemistry, cheminformatics, biological sciences, predictive toxicology and safety and hazard assessment.

Design, Management, and Quality Control of Toxicogenomic Experiments

Design, Management, and Quality Control of Toxicogenomic Experiments
A Book

by Lyle David Burgoon

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 338
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Casarett and Doull's Toxicology

Casarett and Doull's Toxicology
The Basic Science of Poisons

by Louis J. Casarett

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 1236
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Annotation.