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Concepts and Techniques in Genomics and Proteomics

Concepts and Techniques in Genomics and Proteomics
A Book

by N Saraswathy,P Ramalingam

  • Publisher : Elsevier
  • Release : 2011-07-01
  • Pages : 268
  • ISBN : 1908818050
  • Language : En, Es, Fr & De
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Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to illustrate ideas Important points to remember are noted

Fundamentals of Data Mining in Genomics and Proteomics

Fundamentals of Data Mining in Genomics and Proteomics
A Book

by Werner Dubitzky,Martin Granzow,Daniel P. Berrar

  • Publisher : Springer Science & Business Media
  • Release : 2007-04-13
  • Pages : 281
  • ISBN : 0387475095
  • Language : En, Es, Fr & De
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This book presents state-of-the-art analytical methods from statistics and data mining for the analysis of high-throughput data from genomics and proteomics. It adopts an approach focusing on concepts and applications and presents key analytical techniques for the analysis of genomics and proteomics data by detailing their underlying principles, merits and limitations.

Rechnergestützte Konstruktionsarbeit

Rechnergestützte Konstruktionsarbeit
humane und wirtschaftliche Gestaltung von Organisation, Technik und Qualifikation

by Siegfried Schreuder

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 187
  • ISBN : 9780387516608
  • Language : En, Es, Fr & De
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Yeast Functional Genomics and Proteomics

Yeast Functional Genomics and Proteomics
Methods and Protocols

by Igor Stagljar

  • Publisher : Humana Press
  • Release : 2014-11-26
  • Pages : 304
  • ISBN : 9781627039598
  • Language : En, Es, Fr & De
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Given the popularity and utility of Saccharomyces cerevisiae, yeast-based functional genomics and proteomics technologies, developed over the past decade, have contributed greatly to our understanding of bacterial, yeast, fly, worm and human gene functions. In Yeast Functional Genomics and Proteomics: Methods and Protocols, experts in the field contribute stand-alone protocols suitable for daily use in research laboratories. The volume examines methods from the most major and fundamental techniques to more cutting-edge, advanced concepts. As part of the highly successful Methods in Molecular BiologyTM series, the chapters are clearly formatted with introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Yeast Functional Genomics and Proteomics: Methods and Protocols is an ideal reference for both yeast researchers and those who wish to use yeast as a model system for the further study of functional genomics and proteomics.

Statistical Bioinformatics

Statistical Bioinformatics
For Biomedical and Life Science Researchers

by Jae K. Lee

  • Publisher : John Wiley & Sons
  • Release : 2011-09-20
  • Pages : 364
  • ISBN : 1118211529
  • Language : En, Es, Fr & De
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This book provides an essential understanding of statistical concepts necessary for the analysis of genomic and proteomic data using computational techniques. The author presents both basic and advanced topics, focusing on those that are relevant to the computational analysis of large data sets in biology. Chapters begin with a description of a statistical concept and a current example from biomedical research, followed by more detailed presentation, discussion of limitations, and problems. The book starts with an introduction to probability and statistics for genome-wide data, and moves into topics such as clustering, classification, multi-dimensional visualization, experimental design, statistical resampling, and statistical network analysis. Clearly explains the use of bioinformatics tools in life sciences research without requiring an advanced background in math/statistics Enables biomedical and life sciences researchers to successfully evaluate the validity of their results and make inferences Enables statistical and quantitative researchers to rapidly learn novel statistical concepts and techniques appropriate for large biological data analysis Carefully revisits frequently used statistical approaches and highlights their limitations in large biological data analysis Offers programming examples and datasets Includes chapter problem sets, a glossary, a list of statistical notations, and appendices with references to background mathematical and technical material Features supplementary materials, including datasets, links, and a statistical package available online Statistical Bioinformatics is an ideal textbook for students in medicine, life sciences, and bioengineering, aimed at researchers who utilize computational tools for the analysis of genomic, proteomic, and many other emerging high-throughput molecular data. It may also serve as a rapid introduction to the bioinformatics science for statistical and computational students and audiences who have not experienced such analysis tasks before.

Bionanotechnology

Bionanotechnology
Principles and Applications

by Anil Kumar Anal

  • Publisher : CRC Press
  • Release : 2018-02-02
  • Pages : 189
  • ISBN : 1351643630
  • Language : En, Es, Fr & De
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This book deals with a subject of high interest and importance in all sectors, including biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology, and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The aim of the text is to provide the reader with broader knowledge of biological methods for signal transduction and molecular recognitions systems and how they can be replicated in bio-sensing applications. The reader will learn the basic structures and interactions of biomacromolecules for developing biocompatible and eco-friendly devices.

Essentials of Medical Genomics

Essentials of Medical Genomics
A Book

by Stuart M. Brown,John G. Hay,Harry Ostrer

  • Publisher : John Wiley & Sons
  • Release : 2008-12-29
  • Pages : 456
  • ISBN : 0470334495
  • Language : En, Es, Fr & De
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Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays New edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market! Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook NEW: PowerPoint slides of images available at instructor website

An Advanced Textbook on Genomic and Proteomic Sciences

An Advanced Textbook on Genomic and Proteomic Sciences
A Book

by Charlie Hodgman,Chungui Lu,Sandra Kirk

  • Publisher : Unknown Publisher
  • Release : 2016-05-28
  • Pages : 200
  • ISBN : 9781848167865
  • Language : En, Es, Fr & De
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This book aims to equip readers with modern molecular biology concepts and techniques including genomics, transcriptomics, proteomics, bioinformatics, metabolomics and systems biology. It will provide students, researchers and lecturers with a core understanding of a newly emerging field that is of relevance to the industrial/academic arenas. As a result, they can create insightful and inventive solutions to common problems, and describe and explore the current field of post-genomic ('omics') technologies.

Automation in Proteomics and Genomics

Automation in Proteomics and Genomics
An Engineering Case-Based Approach

by Gil Alterovitz,Roseann M. Benson,Marco Ramoni

  • Publisher : John Wiley & Sons
  • Release : 2009-03-16
  • Pages : 340
  • ISBN : 9780470741177
  • Language : En, Es, Fr & De
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In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.

Biological Concepts and Techniques in Toxicology

Biological Concepts and Techniques in Toxicology
An Integrated Approach

by Jim E. Riviere

  • Publisher : CRC Press
  • Release : 2006-03-06
  • Pages : 416
  • ISBN : 1420018442
  • Language : En, Es, Fr & De
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Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol

Fundamentals of Molecular Biology

Fundamentals of Molecular Biology
A Book

by Jayanta K. Pal,Saroj S. Ghaskadbi

  • Publisher : Oxford University Press, USA
  • Release : 2009
  • Pages : 374
  • ISBN : 9780195697810
  • Language : En, Es, Fr & De
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Fundamentals of Molecular Biology focuses on explaining the basic concepts and techniques in molecular biology and their applications.

Introduction to Data Mining for the Life Sciences

Introduction to Data Mining for the Life Sciences
A Book

by Rob Sullivan

  • Publisher : Springer Science & Business Media
  • Release : 2012-01-07
  • Pages : 638
  • ISBN : 1597452904
  • Language : En, Es, Fr & De
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Data mining provides a set of new techniques to integrate, synthesize, and analyze tdata, uncovering the hidden patterns that exist within. Traditionally, techniques such as kernel learning methods, pattern recognition, and data mining, have been the domain of researchers in areas such as artificial intelligence, but leveraging these tools, techniques, and concepts against your data asset to identify problems early, understand interactions that exist and highlight previously unrealized relationships through the combination of these different disciplines can provide significant value for the investigator and her organization.

Automation in Proteomics and Genomics

Automation in Proteomics and Genomics
An Engineering Case-Based Approach

by Gil Alterovitz,Roseann M. Benson,Marco Ramoni

  • Publisher : Wiley
  • Release : 2009-04-20
  • Pages : 340
  • ISBN : 9780470727232
  • Language : En, Es, Fr & De
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In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.

From Genes to Genomes

From Genes to Genomes
Concepts and Applications of DNA Technology

by Jeremy W. Dale,Malcolm von Schantz

  • Publisher : John Wiley & Sons
  • Release : 2008-03-11
  • Pages : 394
  • ISBN : 0470518707
  • Language : En, Es, Fr & De
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“... an excellent book... achieves all of its goals with style, clarity and completeness... You can see the power and possibilities of molecular genetics as you read...” –Human Genetics "This volume hits an outstanding balance among readability, coverage, and detail." –Biochemistry and Molecular Biology Education Rapid advances in a collection of techniques referred to as gene technology, genetic engineering, recombinant DNA technology and gene cloning have pushed molecular biology to the forefront of the biological sciences. This new edition of a concise, well-written textbook introduces key techniques and concepts involved in cloning genes and in studying their expression and variation. The book opens with a brief review of the basic concepts of molecular biology, before moving on to describe the key molecular methods and how they fit together. This ranges from the cloning and study of individual genes to the sequencing of whole genomes, and the analysis of genome-wide information. Finally, the book moves on to consider some of the applications of these techniques, in biotechnology, medicine and agriculture, as well as in research that is causing the current explosion of knowledge across the biological sciences. From Genes to Genomes: Concepts and Applications of DNA Technology, Second Edition includes full two-colour design throughout. Specific changes for the new edition include: Strengthening of gene to genome theme Updating and reinforcing of material on proteomics, gene therapy and stem cells More eukaryotic/mammalian examples and less focus on bacteria This textbook is must-have for all undergraduates studying intermediate molecular genetics within the biological and biomedical sciences. It is also of interest for researchers and all those needing to update their knowledge of this rapidly moving field.

Grid and Cloud Computing: Concepts, Methodologies, Tools and Applications

Grid and Cloud Computing: Concepts, Methodologies, Tools and Applications
Concepts, Methodologies, Tools and Applications

by Management Association, Information Resources

  • Publisher : IGI Global
  • Release : 2012-04-30
  • Pages : 2134
  • ISBN : 1466608803
  • Language : En, Es, Fr & De
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"This reference presents a vital compendium of research detailing the latest case studies, architectures, frameworks, methodologies, and research on Grid and Cloud Computing"--

Chemical Genomics and Proteomics, Second Edition

Chemical Genomics and Proteomics, Second Edition
A Book

by Ferenc Darvas,András Guttman,György Dormán

  • Publisher : CRC Press
  • Release : 2013-01-11
  • Pages : 243
  • ISBN : 1439830525
  • Language : En, Es, Fr & De
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Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics. The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lipodomics, such as steroidomics. The book also discusses biomarker discovery applications of microarray technologies using DNA, RNA, and protein and glycan arrays. Chapters cover further applications of biomolecular biomarkers for disease diagnosis, in small molecule drug R&D, and during therapeutic use of medicines. These include prognostic, disease specific, response (surrogate), and toxicity biomarkers. In addition, the text explores the principles of contemporary systems biology and genomics in experimental medicine—a new paradigm that demonstrates a network-oriented view and advanced statistical and informatics data management, opening the way toward personalized medicine. Finally, various in silico chemogenomics approaches are addressed for predicting binding of drug candidates to undesirable targets, which would help in designing better clinical candidates with fewer side effects. This new edition benefits a broad range of readers from industrial and academic researchers in drug discovery, medicinal chemistry, and molecular and cell biology to physicians in clinical diagnostics and students in related fields of study.

Proteomics

Proteomics
Concepts, Techniques and Applications

by Aubhishek Zaman

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2012-07
  • Pages : 100
  • ISBN : 9783659181399
  • Language : En, Es, Fr & De
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With the advent of potein sequence data the world has experienced a remarkable leap in scientist's interest to study proteins in a time dependent and stress dependent manner. With sequence and structural information rolling up newer mysteries regarding cellular milieu, whole protein study has become important in numerous applications such as exploring new biomarkers, diagnising diseases in vitro, identifying interaction partners, establishing cellular signaling pathways etc. Already significant advancements has been achieved in cancer research and toxicological study. In order to make up to the growing demand for proteomic studies, techniques such as 2-DE, ICAT, ESI, MALDI, SELDI and newer modifications of these techniques has too evolved in both technicalities and specific applications. The scopes of this book rest in elucidating the current developments in proteomic approach, techniques and applications. Today the burgeoning field of proteomics augurs a massive push in the limits as far as technological sensitivity, specificity and efficiency is concerned; proteomics will find its extensive application in Genomics, Transcriptomics and Metabolomics more and more for sure.

Genomics, Proteomics and Vaccines

Genomics, Proteomics and Vaccines
A Book

by Guido Grandi

  • Publisher : John Wiley & Sons
  • Release : 2004-08-13
  • Pages : 336
  • ISBN : 0470093927
  • Language : En, Es, Fr & De
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While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly. Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens. This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions

Data Mining Technique: Fundamental Concept and Statistical Analysis

Data Mining Technique: Fundamental Concept and Statistical Analysis

by Dr. Sagar S. Jambhorkar & Mr. Vijay S. Jondhale

  • Publisher : Horizon Books ( A Division of Ignited Minds Edutech P Ltd)
  • Release : 2021
  • Pages : 119
  • ISBN : 9384044962
  • Language : En, Es, Fr & De
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Data Mining and Data Warehousing is the recent trend in IT field but still it is widely used in various areas. This book introduces basic as well as advanced techniques of data mining & brief information about data warehousing. The book also contains some advanced software tools which are really helpful for students. In this book I tried to explain all the techniques and concepts of the data mining & data warehousing, in very simplified & descriptive way which can help to the student for there examination preparation as well as technical improvement.

Population Genomics

Population Genomics
Concepts, Approaches and Applications

by Om P. Rajora

  • Publisher : Springer
  • Release : 2019-01-07
  • Pages : 822
  • ISBN : 3030045897
  • Language : En, Es, Fr & De
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Population genomics has revolutionized various disciplines of biology including population, evolutionary, ecological and conservation genetics, plant and animal breeding, human health, medicine and pharmacology by allowing to address novel and long-standing questions with unprecedented power and accuracy. It employs large-scale or genome-wide genetic information and bioinformatics to address various fundamental and applied aspects in biology and related disciplines, and provides a comprehensive genome-wide perspective and new insights that were not possible before. These advances have become possible due to the development of new and low-cost sequencing and genotyping technologies and novel statistical approaches and software, bioinformatics tools, and models. Population genomics is tremendously advancing our understanding the roles of evolutionary processes, such as mutation, genetic drift, gene flow, and natural selection, in shaping up genetic variation at individual loci and across the genome and populations; improving the assessment of population genetic parameters or processes such as adaptive evolution, effective population size, gene flow, admixture, inbreeding and outbreeding depression, demography, and biogeography; resolving evolutionary histories and phylogenetic relationships of extant, ancient and extinct species; understanding the genomic basis of fitness, adaptation, speciation, complex ecological and economically important traits, and disease and insect resistance; facilitating forensics, genetic medicine and pharmacology; delineating conservation genetic units; and understanding the genetic effects of resource management practices, and assisting conservation and sustainable management of genetic resources. This Population Genomics book discusses the concepts, approaches, applications and promises of population genomics in addressing most of the above fundamental and applied crucial aspects in a variety of organisms from microorganisms to humans. The book provides insights into a range of emerging population genomics topics including population epigenomics, landscape genomics, seascape genomics, paleogenomics, ecological and evolutionary genomics, biogeography, demography, speciation, admixture, colonization and invasion, genomic selection, and plant and animal domestication. This book fills a vacuum in the field and is expected to become a primary reference in Population Genomics world-wide.