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Considering the Patient in Pediatric Drug Development

Considering the Patient in Pediatric Drug Development
How Good Intentions Turned Into Harm

by Klaus Rose

  • Publisher : Academic Press
  • Release : 2020-11-19
  • Pages : 414
  • ISBN : 0128242051
  • Language : En, Es, Fr & De
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Considering the Patient in Pediatric Drug Development: How Good Intentions Turned into Harm addresses a fundamental challenge in drug development and healthcare for young patients. In clinical trials and clinical practice, the term "children" is used ambiguously to confer physiological characteristics to a chronological age limit, which in reality does not exist. This book outlines why the United States (US) and European Union's (EU) regulatory authorities, pediatric academia, and the pharmaceutical industry demand, support and perform pediatric drug studies, along with the key flaws of this demand that blurs the different administrative and physiological meanings of the term "child." In addition, the book covers why most pediatric regulatory studies lack medical sense and many even harm young patients and the conflicts of interest behind pediatric drug studies. It includes relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs as well as key differences between newborns, infants, older children and adolescents. Explains relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs, including key differences between newborns, infants, older children and adolescents Discusses historical roots of separate drug approval in officially labeled "children" and conflicts of interest in performing and publishing "pediatric" research Helps to decipher justifications for pediatric studies to help people navigate the relevance of the information

Pediatric Drug Development

Pediatric Drug Development
A Book

by Andrew E. Mulberg,Dianne Murphy,Julia Dunne,Lisa L. Mathis

  • Publisher : John Wiley & Sons
  • Release : 2013-05-20
  • Pages : 624
  • ISBN : 1118312058
  • Language : En, Es, Fr & De
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Pediatric Drug Development, Second Edition, encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of pediatric drug development.

Clinical Research in Paediatric Psychopharmacology

Clinical Research in Paediatric Psychopharmacology
A Practical Overview of the Ethical, Scientific, and Regulatory Aspects

by Philippe Auby

  • Publisher : Woodhead Publishing
  • Release : 2019-09-15
  • Pages : 218
  • ISBN : 0081006179
  • Language : En, Es, Fr & De
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Clinical Research in Paediatric Psychopharmacology: An Overview of the Ethical, Scientific and Regulatory Aspects provides a practical guide and overview of the ethical, scientific and regulatory aspects of clinical research in pediatric psychopharmacology, also discussing practical points to consider when developing clinical research in this field. The book is ideal for professionals involved in clinical research in pediatric psychopharmacology, i.e., including, but not limited to pediatricians, health care professionals, researchers, investigators, pharmaceutical company personals and potentially ethics committee members. Topics discussed include the role of patient organization and advocacy groups in research, the role of families and patients: ‘should I involve my kid in clinical research, and historical, ethical, regulatory, clinical, scientific, intercultural and practical aspects of clinical research in child and adolescent psychopharmacology. Covers both theoretical and practical aspects of clinical research in paediatric psychopharmacology Approaches the topic from different angles from the regulatory framework to the patient perspective Discusses ethical and safety considerations for research in paediatric psychopharmacology Offers future perspective for paediatric development

Fundamentals of Pediatric Drug Dosing

Fundamentals of Pediatric Drug Dosing
A Book

by Iftekhar Mahmood,Gilbert Burckart

  • Publisher : Springer
  • Release : 2016-10-28
  • Pages : 146
  • ISBN : 3319437542
  • Language : En, Es, Fr & De
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Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not ‘small adults’, and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.

Applications of Pharmacokinetic Principles in Drug Development

Applications of Pharmacokinetic Principles in Drug Development
A Book

by Rajesh Krishna

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 550
  • ISBN : 1441992162
  • Language : En, Es, Fr & De
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This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become an important component understanding the drug action on the body and is becoming increasingly important in drug labeling due to it's potential for predicting drug behavior in populations that may be difficult to study in adequate numbers during drug development. The ability to correlate drug exposure to effect and model it during the drug development value chain provides valuable insight into optimizing the next steps to derive maximum information from each study. These principles and modeling techniques have resulted in an expanded and integrated view of PK and PO and have led to the expectations that we may be able to optimally design clinical trials and eventually lead us to identifying the optimal therapy for the patient, while minimizing cost and speeding up drug development. There is wide utility for the book both as a text and as a reference.

Clinical Drug Trials and Tribulations, Revised and Expanded, Second Edition

Clinical Drug Trials and Tribulations, Revised and Expanded, Second Edition
A Book

by Allen Cato,Lynda Sutton,Allen Cato III

  • Publisher : CRC Press
  • Release : 2002-03-26
  • Pages : 368
  • ISBN : 0824744802
  • Language : En, Es, Fr & De
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Aimed at those already involved in drug development or those considering entering the field, Clinical Drug Trials and Tribulations, Second Edition comprehensibly addresses the new, day-to-day challenges of drug development with valuable assessments of the areas affecting the conduction of nonclinical and clinical studies. Addressing which decisions should be made during drug development, this updated and expanded text/reference carefully guides readers through the various trials and tribulations that emerge phase-by-phase and are pertinent to all levels of pharmaceutical or clinical drug management. Bringing together the latest information on drug development, the Second Edition contains: new material on... international regulation and deregulation venture capitalist investment the IND process informed consent changes in manufacturing and updated and extended coverage of... pediatric drug trial design the advantages and disadvantages of orphan drug designations the maximization of package inserts for marketing post approval safety surveillance withdrawals from the drug market Clinical Drug Trials and Tribulations, Second Edition will prove an invaluable reference for pharmacologists, pharmacists, clinical chemists, clinical coordinators, clinical monitors, government drug regulatory personnel, and bioethicists as well as a useful text for medical or pharmacy school courses on pharmaceutical development and research.

Pediatric Formulations

Pediatric Formulations
A Roadmap

by Daniel Bar-Shalom,Klaus Rose

  • Publisher : Springer Science & Business Media
  • Release : 2014-01-30
  • Pages : 439
  • ISBN : 1489980113
  • Language : En, Es, Fr & De
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Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.

A Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development
A Book

by Ali S. Faqi

  • Publisher : Academic Press
  • Release : 2012-11-16
  • Pages : 885
  • ISBN : 0123878152
  • Language : En, Es, Fr & De
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A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source

Drug Therapy in Nursing

Drug Therapy in Nursing
A Book

by Diane S. Aschenbrenner,Samantha J. Venable

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2009
  • Pages : 1306
  • ISBN : 9780781765879
  • Language : En, Es, Fr & De
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This text presents a totally nursing-focused framework for teaching and learning nursing pharmacology, and "places the patient" at the center of all drug administration decisions and considerations. The book presents core drug knowledge using prototypes of different drug classes and emphasizes core patient variables that influence the patient's response to therapy. This thoroughly updated Third Edition covers newly approved drugs, has separate chapters on drugs affecting fungal and viral infections, and includes more pathophysiology information. FDA Black Box warnings have been added to the discussion of each prototype when applicable, and safety alerts have been added to emphasize prevention of common medication errors. A companion Website offers student and instructor ancillaries including NCLEX®-style questions, pathophysiology animations, medication administration videos, and dosage calculation quizzes.

Guide to Paediatric Drug Development and Clinical Research

Guide to Paediatric Drug Development and Clinical Research
A Book

by Klaus Rose,John N. Van den Anker

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2010-01-01
  • Pages : 221
  • ISBN : 3805593627
  • Language : En, Es, Fr & De
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Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better understanding of how the child's body develops as well as recent legislation in the USA and in Europe, this comprises dosing, ethics, age-appropriate pharmaceutical forms and clinical trials, to name just a few aspects.A wide spectrum of readers will profit from this book, including paediatricians, pharmacists, general practitioners and health care professionals involved in child care and paediatric research, clinical trial personnel, patient advocacy groups, ethics committees, politicians, parents and interested lay persons.

ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
Applications in Drug Discovery and Development

by Honghui Zhou,Frank-Peter Theil

  • Publisher : John Wiley & Sons
  • Release : 2015-10-26
  • Pages : 472
  • ISBN : 111889880X
  • Language : En, Es, Fr & De
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With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Drug Discovery and Development

Drug Discovery and Development
New Advances

by Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi

  • Publisher : BoD – Books on Demand
  • Release : 2020-03-11
  • Pages : 164
  • ISBN : 1789239753
  • Language : En, Es, Fr & De
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The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Clinical Trials

Clinical Trials
What Patients and Volunteers Need to Know

by Lorna Speid, Ph.D

  • Publisher : Oxford University Press
  • Release : 2010-07-30
  • Pages : 208
  • ISBN : 9780199752805
  • Language : En, Es, Fr & De
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Every year, hundreds of thousands of healthy volunteers and patients worldwide undertake the journey through the maze that can be clinical trials. Research participants take part in clinical trials for a variety of reasons. The healthy volunteers may be seeking extra money to pay off college tuition, or they may know someone who is suffering and would potentially benefit from the results of the trial. The patient who is terminally ill might participate in a clinical trial simply as a last hope for a cure. Whatever the goals, though, most participants will experience the same sense of bewilderment as they encounter the jargon and medical terminology that they will hear and have to read about and understand during the course of the clinical trial. Clinical Trials: What Patients and Volunteers Need to Know demystifies the entire process, focusing on the process of drug development, and the clinical trial itself. Writing from a lifetime of experience, the author provides important questions to ask those running a clinical trial, key definitions and terms for a participant to know and understand, as well as anecdotes illustrating the clinical trial process. The author also grapples with the idea of "informed consent," providing mechanisms for patients and volunteers to feel fully informed before signing up for the trial. A vital resource for those who are considering enrolling in a clinical trial, or for the parents, friends, or relatives of those involved in a clinical trial, this book takes away the mystery and allows the participant to enter a clinical trial feeling both informed and confident.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
A Book

by Ali S. Faqi

  • Publisher : Academic Press
  • Release : 2016-11-03
  • Pages : 986
  • ISBN : 0128036214
  • Language : En, Es, Fr & De
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A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Drug Development

Drug Development
A Case Study Based Insight into Modern Strategies

by Chris Rundfeldt

  • Publisher : BoD – Books on Demand
  • Release : 2011-12-07
  • Pages : 656
  • ISBN : 9533072571
  • Language : En, Es, Fr & De
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This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.

Current Topics in Nonclinical Drug Development

Current Topics in Nonclinical Drug Development
Volume 1

by Pritam S. Sahota,Philip Bentley,Zbigniew Wojcinski

  • Publisher : CRC Press
  • Release : 2020-12-23
  • Pages : 318
  • ISBN : 0429648499
  • Language : En, Es, Fr & De
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The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Dermatological Drug Development

Dermatological Drug Development
A Book

by Tomoko Maeda-Chubachi,Elizabeth Kernodle Hussey,Sylvia Furst

  • Publisher : Cambridge Scholars Publishing
  • Release : 2020-09-18
  • Pages : 146
  • ISBN : 152755967X
  • Language : En, Es, Fr & De
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This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the complexities of dermatological drug development, covering topical, oral, and biologic drugs. This book fills an important gap, as there is currently no other textbook addressing dermatological drug development, explaining and illustrating why unique nonclinical and clinical studies are necessary and how they are typically designed and conducted. The drug development process is also an evolving strategy that is characterized by communicating, negotiating, and agreeing with regulatory agencies, such as FDA (US), EMA (EU), and PMDA (Japan).

Nelson Textbook of Pediatrics, 2-Volume Set

Nelson Textbook of Pediatrics, 2-Volume Set
A Book

by Robert M. Kliegman, MD,Bonita M.D. Stanton, MD,Joseph St. Geme, MD,Nina F Schor, MD, PhD

  • Publisher : Elsevier Health Sciences
  • Release : 2015-04-22
  • Pages : 3888
  • ISBN : 1455775665
  • Language : En, Es, Fr & De
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After more than 75 years, Nelson Textbook of Pediatrics remains your indispensable source for definitive, state-of-the-art answers on every aspect of pediatric care. Embracing the new advances in science as well as the time-honored art of pediatric practice, this classic reference provides the essential information that practitioners and other care providers involved in pediatric health care throughout the world need to understand to effectively address the enormous range of biologic, psychologic, and social problems that our children and youth may face. Brand-new chapters and comprehensive revisions throughout ensure that you have the most recent information on diagnosis and treatment of pediatric diseases based on the latest recommendations and methodologies. "The coverage of such a wide range of subjects relating to child health makes this textbook still the gold standard and companion for all pediatricians across the world." Reviewed by Neel Kamal, Sept 2015 "All in all, this is an excellent and detailed paediatric review textbook which represents excellent value for money..truly a textbook for the global community" Reviewed by glycosmedia.com, Sept 2015 Form a definitive diagnosis and create the best treatment plans possible using evidence-based medicine and astute clinical experiences from leading international authors-many new to this edition. A NEW two-volume layout provides superior portability and exceptional ease of use. Gain a more complete perspective. Along with a broader emphasis on imaging and molecular diagnoses and updated references, the new edition includes an increased focus on international issues to ensure relevance in pediatrics practice throughout the world. Effectively apply the latest techniques and approaches with complete updates throughout 35 new chapters, including: Innovations in Addressing Child Health and Survival in Low Income Settings; Developmental Domains and Theories of Cognition; The Reggio Emilia Educational Approach Catatonia ; Refeeding Syndrome; Altitude-associated Illness; Genetic Approaches to Rare and Undiagnosed Diseases; Healthcare?Associated Infections; Intrapartum and Peripartum Infections; Bath salts and other drugs of abuse; Small Fiber Polyneuropathy; Microbiome; Kingella kingae; Mitochondrial Neurogastrointestinal Encephalomyopathy; Nonalcoholic Fatty Liver Disease; Plagiocephaly; CNS Vasculitis; Anterior Cruciate Ligament Rupture; and Sports-Related Traumatic Brain Injury. Recognize, diagnose, and manage genetic and acquired conditions more effectively. A new Rehabilitation section with 10 new chapters, including: Evaluation of the Child for Rehabilitative Services; Severe Traumatic Brain Injury; Spinal Cord Injury and Autonomic Crisis Management; Spasticity; Birth Brachial Plexus Palsy; Traumatic and Sports-Related Injuries; Meningomyelocele; Health and Wellness for Children with Disabilities. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
A Book

by Michelle A. Rudek,Cindy H. Chau,William D. Figg,Howard L. McLeod

  • Publisher : Springer Science & Business Media
  • Release : 2014-01-10
  • Pages : 836
  • ISBN : 1461491355
  • Language : En, Es, Fr & De
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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Nelson Textbook of Pediatrics E-Book

Nelson Textbook of Pediatrics E-Book
A Book

by Robert M. Kliegman,Bonita M.D. Stanton,Joseph St. Geme,Nina F Schor,Richard E. Behrman

  • Publisher : Elsevier Health Sciences
  • Release : 2011-06-01
  • Pages : 2680
  • ISBN : 1437735894
  • Language : En, Es, Fr & De
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Nelson Textbook of Pediatrics has been the world’s most trusted pediatrics resource for nearly 75 years. Drs. Robert Kliegman, Bonita Stanton, Richard Behrman, and two new editors—Drs. Joseph St. Geme and Nina Schor—continue to provide the most authoritative coverage of the best approaches to care. This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Locate key content easily and identify clinical conditions quickly thanks to a full-color design and full-color photographs. Stay current on recent developments and hot topics such as melamine poisoning, long-term mechanical ventilation in the acutely ill child, sexual identity and adolescent homosexuality, age-specific behavior disturbances, and psychosis associated with epilepsy. Tap into substantially enhanced content with world-leading clinical and research expertise from two new editors—Joseph St. Geme, III, MD and Nina Schor, MD—who contribute on the key subspecialties, including pediatric infectious disease and pediatric neurology. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Recognize, diagnose, and manage genetic conditions more effectively using an expanded section that covers these diseases, disorders, and syndromes extensively. Find information on chronic and common dermatologic problems more easily with a more intuitive reorganization of the section.