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Focal Controlled Drug Delivery

Focal Controlled Drug Delivery
A Book

by Abraham J. Domb,Wahid Khan

  • Publisher : Springer Science & Business Media
  • Release : 2014-02-17
  • Pages : 700
  • ISBN : 1461494346
  • Language : En, Es, Fr & De
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The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Treatise on Controlled Drug Delivery

Treatise on Controlled Drug Delivery
Fundamentals-optimization-applications

by Agis F. Kydonieus

  • Publisher : Routledge
  • Release : 2017-10-02
  • Pages : 568
  • ISBN : 1351406876
  • Language : En, Es, Fr & De
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An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Fundamentals of Drug Delivery

Fundamentals of Drug Delivery
A Book

by Heather A. E. Benson,Michael S. Roberts,Adrian C. Williams,Xiaowen Liang

  • Publisher : John Wiley & Sons
  • Release : 2021-10-26
  • Pages : 592
  • ISBN : 1119769604
  • Language : En, Es, Fr & De
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A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Encyclopedia of Controlled Drug Delivery

Encyclopedia of Controlled Drug Delivery
A Book

by Edith Mathiowitz

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 1057
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Controlled Release Veterinary Drug Delivery

Controlled Release Veterinary Drug Delivery
Biological and Pharmaceutical Considerations

by M.J. Rathbone,R. Gurny

  • Publisher : Elsevier
  • Release : 2000-07-20
  • Pages : 392
  • ISBN : 9780080529974
  • Language : En, Es, Fr & De
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Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months). The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field. Controlled Release Veterinary Drug Delivery comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems. The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Polymers for Controlled Drug Delivery

Polymers for Controlled Drug Delivery
A Book

by Peter J. Tarcha

  • Publisher : CRC Press
  • Release : 1990-11-21
  • Pages : 296
  • ISBN : 9780849356520
  • Language : En, Es, Fr & De
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Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Towards New Frontiers in Patient Care

by Filippo Rossi,Giuseppe Perale,Maurizio Masi

  • Publisher : Springer
  • Release : 2016-01-19
  • Pages : 100
  • ISBN : 3319022881
  • Language : En, Es, Fr & De
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This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
A Book

by Emmanuel C. Opara

  • Publisher : CRC Press
  • Release : 2020-02-28
  • Pages : 351
  • ISBN : 0429582757
  • Language : En, Es, Fr & De
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This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Controlled Drug Release Of Oral Dosage Forms

Controlled Drug Release Of Oral Dosage Forms
A Book

by Jean-Maurice Vergnaud

  • Publisher : CRC Press
  • Release : 1993-07-31
  • Pages : 410
  • ISBN : 9780131749542
  • Language : En, Es, Fr & De
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Numerical analysis of matter transfer is an area that pharmacists find difficult, but which is a technique frequently used in preparing controlled drug release and oral dosage forms. This book provides clear and straightforward information enabling the reader to carry out numerical analysis of matter transfer - a vital processs when looking at the formulation of oral dosage forms with controlled drug release. The drug is dispersed in a polymeric matrix either biodegradable or not, the basis of which is the transfer of the liquid and the drug through dosage form. Information on this diffusion is found either through mathematical treatment when the problem is simple, or through numerical analysis for more complex problems. Professor Vergnaud demonstrates and clarifies these, modelling the process of drug delivery by using numerical analysis and computerization. A simulation of the process is provided, together with a determination of the effects of all parameters, and the author uses both mathematical and numerical models to predict the preparation of new dosage forms able to fulfil specific conditions.

Controlled Drug Delivery

Controlled Drug Delivery
Challenges and Strategies

by Kinam Park

  • Publisher : Acs Professional Reference Boo
  • Release : 1997
  • Pages : 629
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal regulations.

Controlled Drug Delivery

Controlled Drug Delivery
Fundamentals and Applications Sustained and Controlled Release Drug Delivery Systems

by Joseph R. Robinson

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
A Book

by Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone

  • Publisher : Springer Science & Business Media
  • Release : 2011-12-14
  • Pages : 592
  • ISBN : 1461408806
  • Language : En, Es, Fr & De
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Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Treatise on Controlled Drug Delivery

Treatise on Controlled Drug Delivery
Fundamentals-optimization-applications

by Agis F. Kydonieus

  • Publisher : CRC Press
  • Release : 2017-10-02
  • Pages : 568
  • ISBN : 1351406884
  • Language : En, Es, Fr & De
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An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Electronically Controlled Drug Delivery

Electronically Controlled Drug Delivery
A Book

by Bret Berner,Steven M. Dinh

  • Publisher : CRC-Press
  • Release : 1998-06-01
  • Pages : 241
  • ISBN : 9780849376818
  • Language : En, Es, Fr & De
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Developments in microelectronics, micromachining, and medical device design show great promise for creating electronically-assisted intelligent therapeutic systems for home use diagnostics and out-patient care. The costs of therapeutic development and distribution have been prohibitive, however, important strides are being made. Electronically Controlled Drug Delivery provides an overview of advances in drug delivery using electronics to regulate the delivery profile and optimize therapy. Electronically Controlled Drug Delivery offers students, researchers, and industrial scientists current broad-ranged coverage of novel electronic drug delivery technologies. The therapeutic rationale, underlying principles, basics of critical technologies, and application to potential commercial products and novel technologies are all addressed in this state-of-the-art reference.

Targeted & Controlled Drug Delivery: Novel Carrier Systems (HB)

Targeted & Controlled Drug Delivery: Novel Carrier Systems (HB)
A Book

by Vyas; Khar

  • Publisher : Unknown Publisher
  • Release : 2006-02-01
  • Pages : 594
  • ISBN : 9788123907994
  • Language : En, Es, Fr & De
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Controlled Release in Oral Drug Delivery

Controlled Release in Oral Drug Delivery
A Book

by Clive G. Wilson,Patrick J. Crowley

  • Publisher : Springer Science & Business Media
  • Release : 2011-09-22
  • Pages : 414
  • ISBN : 9781461410041
  • Language : En, Es, Fr & De
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Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.

Controlled Drug Delivery

Controlled Drug Delivery
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Controlled Pulmonary Drug Delivery

Controlled Pulmonary Drug Delivery
A Book

by Hugh D.C. Smyth,Anthony J. Hickey

  • Publisher : Springer Science & Business Media
  • Release : 2011-06-24
  • Pages : 558
  • ISBN : 1441997458
  • Language : En, Es, Fr & De
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The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Utilization of Microspheres in Controlled Drug Delivery

Utilization of Microspheres in Controlled Drug Delivery
Microspheres Prepared by the Emulsion Solvent Removal Methods in Controlled Delivery of Drugs

by Wasfy Obeidat

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2011-06
  • Pages : 304
  • ISBN : 9783844397857
  • Language : En, Es, Fr & De
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This book initially provides a review of controlled drug delivery systems and an overview of microencapsulation methods with emphasis on the emulsion solvent removal methods. The book then presents studies conducted on producing microspheres containing commonly used drugs such as Theophylline, Piroxicam and Propylthiouracil. The book also discusses various formulation and processing parameters affecting microsphere-drug products. Such factors include the effects of polymer solution phase viscosity and molecular weight the on the properties microspheres. It also discusses the use of single and combinations of polymers of different properties that are manipulated in a way to achieve goals such as controlled release, enteric properties, masking taste or drug and body protection. Interesting results were found in many preparations and many are published in international journals.

A Novel Approach For Controlled Drug Delivery - Microparticles

A Novel Approach For Controlled Drug Delivery - Microparticles
Formulation And Evaluation Of Microparticles For Controlled Delivery Of Tramadol Hydrochloride

by Shrujal Patel,Sandip Teraiya,Bhargav Jayswal

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2012
  • Pages : 108
  • ISBN : 9783659124488
  • Language : En, Es, Fr & De
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Microparticles are one of the key novel drug delivery systems has been widely used to precisely modulate release rate. Microparticles based polymeric systems fabricated using suitable carrier has been extensively explored as an effective matrix for controlled and sustained release delivery of many drugs. With the controlled release systems, the rate of drug release matches the rate of drug elimination, and therefore the drug concentration is within the therapeutic window for the majority of the 24-hr period.The aim of this study was to prepare Eudragit microspheres containing Tramadol HCl by solvent evaporation method to achieve a controlled drug release profile. Investigation of the effect of various processing and formulation factors such as polymer type, drug: polymer ratio, stirring speed to obtain spherical particles. Then yield of production, shape, and mean particle size, particle size distribution, encapsulation efficiency, surface properties and release rate of drug from the microspheres were performed.