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Cord Blood Stem Cells Medicine

Cord Blood Stem Cells Medicine
A Book

by Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete

  • Publisher : Elsevier
  • Release : 2014-12-03
  • Pages : 398
  • ISBN : 0124078362
  • Language : En, Es, Fr & De
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Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. Comprehensive coverage of the medical application of cord blood stem cells Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine Covers new applications of cord blood stem cells, particularly transplantation and HIV Introduces new technologies for cord blood stem cells and regenerative medicine

Cord Blood

Cord Blood
Establishing a National Hematopoietic Stem Cell Bank Program

by Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program

  • Publisher : National Academies Press
  • Release : 2005-10-26
  • Pages : 334
  • ISBN : 9780309165174
  • Language : En, Es, Fr & De
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With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Umbilical Cord Blood

Umbilical Cord Blood
A Future for Regenerative Medicine

by Suzanne Kadereit

  • Publisher : World Scientific
  • Release : 2010-03-01
  • Pages : 347
  • ISBN : 9812833293
  • Language : En, Es, Fr & De
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Umbilical cord blood, previously discarded after birth, has emerged over recent years as an alternative source of hematopoietic stem cells for hematological reconstitution, mainly for leukemia patients, as well as for some hematological deficiencies and bone marrow failures. In recent years, it has become increasingly clear that cord blood, as well as the surrounding tissue of the umbilical cord, contain additional stem cells which have been shown to be of great potential for regenerative medicine. Importantly, cord blood is abundant, it can be banked and shipped with ease, and thus has an indisputable potential for future medicines and regenerative therapies. Driven by a massive interest for regenerative medicine and alternative yet ethically acceptable stem cell sources, the scientific literature on umbilical cord and cord blood stem cells has increased tremendously. This book provides a consolidated, up-to-date overview of basic research on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently described stem and precursor cells of not yet fully elucidated potential. It also takes an in-depth look at basic and translational research efforts with stem cells from the umbilical cord in academic institutions and biotech companies. Suitable for use as a primer and reference book by medical fellows and researchers entering the research fields of stem cell biology and regenerative medicine, it can also be used by students (undergraduate and graduate) as a starting point for read-up on the literature on stem cells and their potential and applications, or as a teaching tool in graduate schools for biologists, particularly for students wanting to enter the emerging field of stem cell biology.

Frontiers of Cord Blood Science

Frontiers of Cord Blood Science
A Book

by Niranjan Bhattacharya,Phillip Stubblefield

  • Publisher : Springer Science & Business Media
  • Release : 2009-04-21
  • Pages : 400
  • ISBN : 9781848001671
  • Language : En, Es, Fr & De
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Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine
A Book

by Ana Colette Maurício

  • Publisher : BoD – Books on Demand
  • Release : 2017-01-11
  • Pages : 258
  • ISBN : 9535128655
  • Language : En, Es, Fr & De
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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Umbilical Cord Blood Banking and Transplantation

Umbilical Cord Blood Banking and Transplantation
A Book

by Karen Ballen

  • Publisher : Springer
  • Release : 2014-08-12
  • Pages : 286
  • ISBN : 3319064444
  • Language : En, Es, Fr & De
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This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Regenerative Therapy Using Blood-Derived Stem Cells

Regenerative Therapy Using Blood-Derived Stem Cells
A Book

by David S. Allan,Dirk Strunk

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-16
  • Pages : 220
  • ISBN : 9781617794711
  • Language : En, Es, Fr & De
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Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine.

Stem Cell Repair and Regeneration

Stem Cell Repair and Regeneration
Volume 3

by Nataša Levičar,Nagy A Habib,Myrtle Y Gordon,Ioannis Dimarakis

  • Publisher : World Scientific
  • Release : 2008-04-29
  • Pages : 320
  • ISBN : 190897902X
  • Language : En, Es, Fr & De
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Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. The third book in the Stem Cell Repair and Regeneration series offers contributions from numerous areas bridging medicine and the life sciences. Significant research activities in the tissue engineering or regenerative medicine (the term recently used) field started in the 1970s, and there is currently great excitement over the possibility of replacing damaged body parts through regenerative medicine. Potential strategies to replace, repair and restore the function of damaged tissues or organs include stem cell transplantation, transplantation of tissues engineered in the laboratory, and the induction of regeneration by the body's own cells. It is believed that novel cellular therapeutics outperform any medical device, recombinant protein or chemical compound. This volume explores novel stem cell therapeutic strategies for myriad diseases, including renal failure, retinal disease and myocardial infarction. Contents:The Biology of Human Mesenchymal Stem Cells (C Westwood & M O Clements)Mesenchymal Stem Cells: From Culture to Clinic (C A Gregory)Stem Cell Bioprocessing for Clinical Applications of Regenerative Medicine (A Mantalaris et al.)Defining and Overcoming the Immunological Barriers to Stem Cell Therapies (N J Robertson et al.)Activation of the Immune System: A Corollary of Transplantation with ES Cell-Derived Tissues (A S Boyd et al.)Suppression of HLA Expression by Lentivirus-Mediated Gene Transfer of siRNA Cassettes (N Kasahara)Cord Blood Cells for Myocardial Regeneration (C Stamm & M Nan)Clinical Trials in Cardiac Stem Cell Therapy: An Update (R Kam & I Dimarakis)Stem Cell Therapy in Neurodegenerative Disease (C T Flores & M Y Gordon)Adult Human Stem Cell Therapy for Ischemic Stroke (D Williamson et al.)Cell Therapy in Renal Disease (H D Humes)Regenerative Medicine of the Eye: A Short Review (D T Harris et al.)A Clearer View of Stem Cells in Retinal Disease (M D Hodges et al.)Limbal Epithelial Stem Cells: Biology and Therapeutic Potential (M Notara et al.)The Use of Mesenchymal Stem Cells for Bone and Cartilage Repair (R Behan et al.) Readership: Life science scientists; biomedical researchers; academics, postgraduate students and advanced undergraduate students in cell biology, biochemistry and genetics; surgeons; clinicians; biotechnology and pharmaceutical industry professionals. Keywords:Stem Cell;Cardiac;Renal;RetinalKey Features:Comprehensive and up-to-date overview for clinicians and scientistsContains chapters by the field's leading scientists from some of the world's top research institutions and universitiesChapters cover basic stem cell science and topics related to many areas of translational “from bench to bedside” stem cell researchInformation presented in a form accessible to all interested students, clinicians and scientists

Regenerative Medicine and Cell Therapy

Regenerative Medicine and Cell Therapy
A Book

by Hossein Baharvand,Nasser Aghdami

  • Publisher : Springer Science & Business Media
  • Release : 2012-08-09
  • Pages : 318
  • ISBN : 1627030980
  • Language : En, Es, Fr & De
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Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases. Regenerative Medicine and Cell Therapy discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors’ goal is that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Umbilical Cord Stem Cell Therapy

Umbilical Cord Stem Cell Therapy
The Gift of Healing from Healthy Newborns

by David A. Steenblock,Anthony G. Payne

  • Publisher : Basic Health Publications, Inc.
  • Release : 2006
  • Pages : 178
  • ISBN : 9781591201250
  • Language : En, Es, Fr & De
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Examines the potential for stem cells gleaned from umbilical cords to generate a wealth of new therapy and healing medicines for neurological conditions and blood problems.

United States Congressional Serial Set

United States Congressional Serial Set
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Stem Cells and Tissue Engineering

Stem Cells and Tissue Engineering
A Book

by Mirjana Pavlovic,Bela Balint

  • Publisher : Springer Science & Business Media
  • Release : 2012-11-07
  • Pages : 154
  • ISBN : 1461455057
  • Language : En, Es, Fr & De
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Stem cells are the building blocks for all other cells in an organism. The human body has about 200 different types of cells and any of those cells can be produced by a stem cell. This fact emphasizes the significance of stem cells in transplantational medicine, regenerative therapy and bioengineering. Whether embryonic or adult, these cells can be used for the successful treatment of a wide range of diseases that were not treatable before, such as osteogenesis imperfecta in children, different forms of leukemias, acute myocardial infarction, some neural damages and diseases, etc. Bioengineering, e.g. successful manipulation of these cells with multipotential capacity of differentiation toward appropriate patterns and precise quantity, are the prerequisites for successful outcome and treatment. By combining in vivo and in vitro techniques, it is now possible to manage the wide spectrum of tissue damages and organ diseases. Although the stem-cell therapy is not a response to all the questions, it provides more and more answers every day. Stem Cells and Tissue Engineering is a concise review on the functional, phenotypic, regenerative, transplantational and curative aspects of a stem cell’s entity. It is critical and encouraging at the same time, providing truthful and appropriate samples from the practice and research that can lead toward optimal use of this immense source of adjuvant and curative therapy in human pathology. Written by a clinician and a researcher, who are currently teaching what they are doing, it is recommended as a teaching tool along with an original textbook.

Stem Cell Banking

Stem Cell Banking
A Book

by Dusko Ilic

  • Publisher : Springer
  • Release : 2014-05-05
  • Pages : 168
  • ISBN : 1493905856
  • Language : En, Es, Fr & De
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This book exemplifies experience across the globe in banking of cord blood, mesenchymal, embryonic and induced pluripotent stem cells for clinical use from the United States, Canada, the European Union, Switzerland and Japan to Iran, India and Serbia. The concerns are similar regardless of stem cell type or origin. Implementing core values and common standards depend often on specific circumstances of political and economic setting, which makes flexibility as important as systematic planning. Banking of stem cells is not just building a repository and storing samples. The planning, design, construction and maintenance involve multiple skilled professionals. Stem cell banks are points where technology and medicine converge with ethics, laws and regulations. If properly designed and organized, their utilization will have a broad impact not only on the scientific community and medical professionals but also on the general public.

The Regeneration Promise: The Facts behind Stem Cell Therapies

The Regeneration Promise: The Facts behind Stem Cell Therapies
A Book

by Peter Hollands

  • Publisher : Bentham Science Publishers
  • Release : 2020-12-03
  • Pages : 126
  • ISBN : 981148211X
  • Language : En, Es, Fr & De
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The Regeneration Promise is a reader-friendly guide to the world of regenerative medicine and stem cell technology. It covers the history of stem cell technology as a general introduction to the subject and then continues with a description of the many known types of stem cells and how these can potentially be used to treat disease. The author explains the pros and cons of using stem cell technology to treat patients in simple and factual terms throughout the book while clarifying many stem cell myths. There is valuable advice for people considering undergoing stem cell therapy and also for those who are considering stem cell storage such as umbilical cord blood storage at the birth of a baby. The book also covers information on current research in stem cell technology and how this may be useful in the clinic, as promising regenerative medicine treatments emerge in the near future. The simple use of language with a clear explanation of scientific terms, where applicable, makes this book an accessible source of information for anyone interested in enhancing their general knowledge about regenerative medicine when considering such treatment options and understanding the debate surrounding stem cell technology and its use in disease therapy.

Perinatal Stem Cells

Perinatal Stem Cells
Biology, Manufacturing and Translational Medicine

by Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li

  • Publisher : Springer
  • Release : 2019-04-06
  • Pages : 173
  • ISBN : 9811327033
  • Language : En, Es, Fr & De
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This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Perinatal Stem Cells

Perinatal Stem Cells
A Book

by Kyle Cetrulo,Curtis L. Cetrulo, Jr.,Rouzbeh R. Taghizadeh

  • Publisher : John Wiley & Sons
  • Release : 2013-02-04
  • Pages : 320
  • ISBN : 1118497945
  • Language : En, Es, Fr & De
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Perinatal Stem Cells, 2nd Edition builds on the firstedition to provide an updated tutorial on perinatal stem cells,including stem cells harvested from the amniotic fluid, placenta,maternal blood supply, umbilical cord and Wharton's Jelly. As inthe first edition, coverage includes the underlying biology of eachof the sources of pregnancy related stem cells, cell culture, andpotential therapeutic uses, as well as insights on the impact ofthese stem cells from obstetricians and gynecologists,cardiologists, hematologists, tissue engineers, and cord bloodbankers. Normally discarded as medical waste, perinatal stem cells offera powerful therapeutic tool box alternative to the controversialembryonic stem cells. Since publication of the first edition, aburgeoning commerical industry has developed around various sourcesof perinatal cells, and the second edition now includes an overviewof this growing industry. With contributions from some of the top academic stem celllaboratories in the United States as well as new chapters frominternational stem cell scientists, Perinatal StemCells presents an update onthe cutting-edge research in the field whilemaintaining its signature clinical focus.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
A Book

by Robert J. Soiffer

  • Publisher : Springer Science & Business Media
  • Release : 2008-11-14
  • Pages : 736
  • ISBN : 9781597454384
  • Language : En, Es, Fr & De
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Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Stem Cells & Regenerative Medicine

Stem Cells & Regenerative Medicine
From Molecular Embryology to Tissue Engineering

by Krishnarao Appasani,Raghu K. Appasani

  • Publisher : Springer Science & Business Media
  • Release : 2010-11-01
  • Pages : 629
  • ISBN : 9781607618607
  • Language : En, Es, Fr & De
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Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Essential Current Concepts in Stem Cell Biology

Essential Current Concepts in Stem Cell Biology
A Book

by Beate Brand-Saberi

  • Publisher : Springer Nature
  • Release : 2020-01-03
  • Pages : 242
  • ISBN : 3030339238
  • Language : En, Es, Fr & De
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This textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Regenerative Medicine Using Pregnancy-Specific Biological Substances

Regenerative Medicine Using Pregnancy-Specific Biological Substances
A Book

by Niranjan Bhattacharya,Phillip Stubblefield

  • Publisher : Springer Science & Business Media
  • Release : 2010-12-25
  • Pages : 460
  • ISBN : 9781848827189
  • Language : En, Es, Fr & De
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The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.