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Cord Blood Stem Cells Medicine

Cord Blood Stem Cells Medicine
A Book

by Catherine Stavropoulos-Giokas,Dominique Charron,Cristina Navarrete

  • Publisher : Elsevier
  • Release : 2014-12-03
  • Pages : 398
  • ISBN : 0124078362
  • Language : En, Es, Fr & De
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Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. Comprehensive coverage of the medical application of cord blood stem cells Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine Covers new applications of cord blood stem cells, particularly transplantation and HIV Introduces new technologies for cord blood stem cells and regenerative medicine

Umbilical Cord Blood

Umbilical Cord Blood
A Future for Regenerative Medicine

by Suzanne Kadereit

  • Publisher : World Scientific
  • Release : 2010-03-01
  • Pages : 347
  • ISBN : 9812833293
  • Language : En, Es, Fr & De
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Umbilical cord blood, previously discarded after birth, has emerged over recent years as an alternative source of hematopoietic stem cells for hematological reconstitution, mainly for leukemia patients, as well as for some hematological deficiencies and bone marrow failures. In recent years, it has become increasingly clear that cord blood, as well as the surrounding tissue of the umbilical cord, contain additional stem cells which have been shown to be of great potential for regenerative medicine. Importantly, cord blood is abundant, it can be banked and shipped with ease, and thus has an indisputable potential for future medicines and regenerative therapies. Driven by a massive interest for regenerative medicine and alternative yet ethically acceptable stem cell sources, the scientific literature on umbilical cord and cord blood stem cells has increased tremendously. This book provides a consolidated, up-to-date overview of basic research on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently described stem and precursor cells of not yet fully elucidated potential. It also takes an in-depth look at basic and translational research efforts with stem cells from the umbilical cord in academic institutions and biotech companies. Suitable for use as a primer and reference book by medical fellows and researchers entering the research fields of stem cell biology and regenerative medicine, it can also be used by students (undergraduate and graduate) as a starting point for read-up on the literature on stem cells and their potential and applications, or as a teaching tool in graduate schools for biologists, particularly for students wanting to enter the emerging field of stem cell biology.

Frontiers of Cord Blood Science

Frontiers of Cord Blood Science
A Book

by Niranjan Bhattacharya,Phillip Stubblefield

  • Publisher : Springer Science & Business Media
  • Release : 2009-04-21
  • Pages : 400
  • ISBN : 9781848001671
  • Language : En, Es, Fr & De
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Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Cord Blood

Cord Blood
Establishing a National Hematopoietic Stem Cell Bank Program

by Institute of Medicine,Board on Health Sciences Policy,Committee on Establishing a National Cord Blood Stem Cell Bank Program

  • Publisher : National Academies Press
  • Release : 2005-11-26
  • Pages : 334
  • ISBN : 0309095867
  • Language : En, Es, Fr & De
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With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Umbilical Cord Blood Banking and Transplantation

Umbilical Cord Blood Banking and Transplantation
A Book

by Karen Ballen

  • Publisher : Springer
  • Release : 2014-08-12
  • Pages : 286
  • ISBN : 3319064444
  • Language : En, Es, Fr & De
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This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine
A Book

by Ana Colette Maurício

  • Publisher : BoD – Books on Demand
  • Release : 2017-01-11
  • Pages : 258
  • ISBN : 9535128655
  • Language : En, Es, Fr & De
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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.

Fetal Stem Cells in Regenerative Medicine

Fetal Stem Cells in Regenerative Medicine
Principles and Translational Strategies

by Dario O. Fauza,Mahmud Bani

  • Publisher : Springer
  • Release : 2016-05-02
  • Pages : 453
  • ISBN : 149393483X
  • Language : En, Es, Fr & De
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This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

Regenerative Medicine Using Pregnancy-Specific Biological Substances

Regenerative Medicine Using Pregnancy-Specific Biological Substances
A Book

by Niranjan Bhattacharya,Phillip Stubblefield

  • Publisher : Springer Science & Business Media
  • Release : 2010-12-25
  • Pages : 460
  • ISBN : 9781848827189
  • Language : En, Es, Fr & De
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The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.

Stem Cell Banking

Stem Cell Banking
A Book

by Dusko Ilic

  • Publisher : Springer
  • Release : 2014-05-05
  • Pages : 168
  • ISBN : 1493905856
  • Language : En, Es, Fr & De
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This book exemplifies experience across the globe in banking of cord blood, mesenchymal, embryonic and induced pluripotent stem cells for clinical use from the United States, Canada, the European Union, Switzerland and Japan to Iran, India and Serbia. The concerns are similar regardless of stem cell type or origin. Implementing core values and common standards depend often on specific circumstances of political and economic setting, which makes flexibility as important as systematic planning. Banking of stem cells is not just building a repository and storing samples. The planning, design, construction and maintenance involve multiple skilled professionals. Stem cell banks are points where technology and medicine converge with ethics, laws and regulations. If properly designed and organized, their utilization will have a broad impact not only on the scientific community and medical professionals but also on the general public.

Cord Blood

Cord Blood
Establishing a National Hematopoietic Stem Cell Bank Program

by Institute of Medicine (U.S.). Committee on Establishing a National Cord Blood Stem Cell Bank Program,Emily Ann Meyer,Kathi E. Hanna,Kristine M. Gebbie

  • Publisher : National Academy Press
  • Release : 2005-01-01
  • Pages : 314
  • ISBN : 9780309096447
  • Language : En, Es, Fr & De
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With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. This book examines: The role of cord blood in stem cell transplantation; The current status of blood banks already in existence; The optimal structure for the cord blood program; The current use and utility of cord blood for stem cell transplants; The best way to advance the use of cord blood units and make them available for research.

Perinatal Stem Cells

Perinatal Stem Cells
Biology, Manufacturing and Translational Medicine

by Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li

  • Publisher : Springer
  • Release : 2019-04-06
  • Pages : 173
  • ISBN : 9811327033
  • Language : En, Es, Fr & De
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This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

The Regeneration Promise: The Facts behind Stem Cell Therapies

The Regeneration Promise: The Facts behind Stem Cell Therapies
A Book

by Peter Hollands

  • Publisher : Bentham Science Publishers
  • Release : 2020-12-03
  • Pages : 126
  • ISBN : 981148211X
  • Language : En, Es, Fr & De
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The Regeneration Promise is a reader-friendly guide to the world of regenerative medicine and stem cell technology. It covers the history of stem cell technology as a general introduction to the subject and then continues with a description of the many known types of stem cells and how these can potentially be used to treat disease. The author explains the pros and cons of using stem cell technology to treat patients in simple and factual terms throughout the book while clarifying many stem cell myths. There is valuable advice for people considering undergoing stem cell therapy and also for those who are considering stem cell storage such as umbilical cord blood storage at the birth of a baby. The book also covers information on current research in stem cell technology and how this may be useful in the clinic, as promising regenerative medicine treatments emerge in the near future. The simple use of language with a clear explanation of scientific terms, where applicable, makes this book an accessible source of information for anyone interested in enhancing their general knowledge about regenerative medicine when considering such treatment options and understanding the debate surrounding stem cell technology and its use in disease therapy.

Regenerative Medicine and Cell Therapy

Regenerative Medicine and Cell Therapy
A Book

by Hossein Baharvand,Nasser Aghdami

  • Publisher : Springer Science & Business Media
  • Release : 2012-08-09
  • Pages : 318
  • ISBN : 1627030980
  • Language : En, Es, Fr & De
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Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases. Regenerative Medicine and Cell Therapy discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors’ goal is that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research
A Book

by Atta-ur-Rahman,Shazia Anjum

  • Publisher : Bentham Science Publishers
  • Release : 2017-04-03
  • Pages : 285
  • ISBN : 168108435X
  • Language : En, Es, Fr & De
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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The fourth volume of this series features reviews on the use of stem cells through retrodifferentiation, mesodermal regeneration, hematopoiesis and mesenchymal stem cells. The volume also features a chapter on current knowledge on cell-based therapy in veterinary medicine.

Advances in Stem Cell Therapy

Advances in Stem Cell Therapy
Bench to Bedside

by Nagwa El-Badri

  • Publisher : Humana Press
  • Release : 2016-11-18
  • Pages : 310
  • ISBN : 3319291491
  • Language : En, Es, Fr & De
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The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies.

Umbilical Cord Stem Cell Therapy

Umbilical Cord Stem Cell Therapy
The Gift of Healing from Healthy Newborns

by David A. Steenblock,Anthony G. Payne

  • Publisher : Basic Health Publications, Inc.
  • Release : 2006
  • Pages : 178
  • ISBN : 9781591201250
  • Language : En, Es, Fr & De
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Examines the potential for stem cells gleaned from umbilical cords to generate a wealth of new therapy and healing medicines for neurological conditions and blood problems.

Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy

Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy
A Book

by W. Holzgreve,M. Lessl

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-09
  • Pages : 229
  • ISBN : 3662044692
  • Language : En, Es, Fr & De
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The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex perimental and only investigated in medical centers with the appropri ate background. It is, however, not only justified, but helpful to com bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".

Human Cord Blood-Derived Stem Cells in Transplantation and Regenerative Medicine

Human Cord Blood-Derived Stem Cells in Transplantation and Regenerative Medicine
A Book

by Cornel Iancu

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human Cord Blood-Derived Stem Cells in Transplantation and Regenerative Medicine.

Perinatal Stem Cells

Perinatal Stem Cells
Research and Therapy

by Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy

  • Publisher : Academic Press
  • Release : 2018-06-14
  • Pages : 418
  • ISBN : 0128120630
  • Language : En, Es, Fr & De
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Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Peripheral Blood Stem Cell Autografts

Peripheral Blood Stem Cell Autografts
A Book

by Eckart W. Wunder,Philippe R. Henon

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 276
  • ISBN : 3642757170
  • Language : En, Es, Fr & De
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The monograph edited by Drs. Wunder and Henon on "Peripheral Blood Stem Cell Autogtafts" is extremely useful as well as timely. It covers the "state of the arts" with respect to the use of hemopoietic stem cells collected from the peripheral blood for the reconstitution of hematopoiesis after myeloablative therapy. If is is accepted that hematopoietic function in the mammalian organism is the result of stem cell seeding of an appropriate stromal matrix, then the use of blood derived stem cells for hematopoietic reconstitution represents the "physiological form" of the (re) establishment of a hematopoietic bone marrow. All observations to date are compatible with the assumption that stem cells migrate via the blood stream from extraembryonic hematopoietic tissue to the fetal liver to establish there a first intraembryonic site of blood cell formation and especially of stem cell replication and proliferation. This fetal liver tissue appears then to be the major source for the seeding offetal bone marrow stroma as it develops sequentially in all the bones of the skeleton - in other words during most of the entire embryonic development. There is a very high concentration of stem cells in the blood of the embryo (more than 20000 CFU-GM per ml in the 22nd week) and the stem cells in cord blood seem to be the "tail end" of a dramatic "stem cell traffic" in the embryo to establish the hemopoietic as well as lymphopoietic tissue.