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Delivery of Drugs

Delivery of Drugs
Volume 2: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-02-01
  • Pages : 242
  • ISBN : 0128177772
  • Language : En, Es, Fr & De
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Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Drug Delivery Systems

Drug Delivery Systems
Characteristics and Biomedical Applications

by R. L. Juliano

  • Publisher : Oxford University Press, USA
  • Release : 1980
  • Pages : 320
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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TRANSDERMAL DELIVERY OF DRUGS

TRANSDERMAL DELIVERY OF DRUGS
A Book

by Agis F. Kydonieus,Bret Berner

  • Publisher : CRC-Press
  • Release : 1987
  • Pages : 168
  • ISBN : 9780849364860
  • Language : En, Es, Fr & De
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Controlled Drug Delivery

Controlled Drug Delivery
Challenges and Strategies

by Kinam Park

  • Publisher : Acs Professional Reference Boo
  • Release : 1997
  • Pages : 629
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal regulations.

Drug Delivery and Targeting

Drug Delivery and Targeting
For Pharmacists and Pharmaceutical Scientists

by Anya M. Hillery,Andrew W. Lloyd,James Swarbrick

  • Publisher : CRC Press
  • Release : 2003-09-02
  • Pages : 496
  • ISBN : 0203302761
  • Language : En, Es, Fr & De
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The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including: *Methods to optimize therapeutic efficacy, and the related commercial implications *Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination *Attempts to minimize toxicity or alter immunogenicity *Methods to achieve rate-controlled drug release and effective drug targeting *Novel and established routes of delivery *Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy This volume is indispensable for pharmaceutical students, scientists and researchers.

Drug Delivery Research Advances

Drug Delivery Research Advances
A Book

by Boris O. Mashkevich

  • Publisher : Nova Publishers
  • Release : 2007
  • Pages : 259
  • ISBN : 9781600217326
  • Language : En, Es, Fr & De
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Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.

Advanced Biopolymeric Systems for Drug Delivery

Advanced Biopolymeric Systems for Drug Delivery
A Book

by Amit Kumar Nayak,Md Saquib Hasnain

  • Publisher : Springer Nature
  • Release : 2020-07-11
  • Pages : 386
  • ISBN : 3030469239
  • Language : En, Es, Fr & De
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This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Computer-Aided Drug Design and Delivery Systems

Computer-Aided Drug Design and Delivery Systems
A Book

by Ahindra Nag,Baishakhi Dey

  • Publisher : McGraw Hill Professional
  • Release : 2010-10-06
  • Pages : 240
  • ISBN : 0071701257
  • Language : En, Es, Fr & De
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THE LATEST BREAKTHROUGHS IN COMPUTER-AIDED DRUG DESIGN AND DELIVERY This definitive text provides in-depth information on computer-assisted techniques for discovering, designing, and optimizing new, effective, and safe drugs. Computer-Aided Drug Design and Delivery Systems offers objective and quantitative data on the use and delivery of drugs in humans. Enabling technologies such as bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstruments are thoroughly discussed in this innovative work. Coverage includes: Computer-aided drug design (CADD) Drug delivery systems Bioinformatics of drug molecules and databases Lipase- and esterase-mediated drugs and drug intermediates Pharmacokinetics and pharmacodynamics of drugs Biomarkers, biosensors, and robotics in medicine Biomedical instrumentation

Controlled Drug Delivery

Controlled Drug Delivery
Fundamentals and Applications, Second Edition

by Joseph Robinson,Vincent H. L. Lee

  • Publisher : Informa Health Care
  • Release : 1987-01-30
  • Pages : 744
  • ISBN : 9780824775889
  • Language : En, Es, Fr & De
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Drugs and the pharmaceutical sciences.

Transdermal and Topical Drug Delivery from Theory to Clinical Practice

Transdermal and Topical Drug Delivery from Theory to Clinical Practice
A Book

by Adrian Williams

  • Publisher : Pharmaceutical Press
  • Release : 2003
  • Pages : 242
  • ISBN : 9780853694892
  • Language : En, Es, Fr & De
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The therapeutic benefits of administering drugs through the skin have been recognized for many years and have been capitalized upon in commercially successful and important transdermal delivery systems, such as estradiol patches for hormone replacement and nicotine patches as aids to smoking cessation. Transdermal and Topical Drug Delivery addresses all aspects of how to deliver drugs to the skin for local effects or across the skin for systemic therapy. Starting with a discussion of the principles underlying the area, the text expands into strategies used to deliver drugs effectively. This should be a valuable practical guide for the clinical delivery of drugs.

Drug Delivery Systems

Drug Delivery Systems
A Book

by Kewal K. Jain

  • Publisher : Springer Science & Business Media
  • Release : 2008-03-07
  • Pages : 251
  • ISBN : 1588298914
  • Language : En, Es, Fr & De
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In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Drug Delivery Systems

Drug Delivery Systems
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-10-23
  • Pages : 792
  • ISBN : 0128145080
  • Language : En, Es, Fr & De
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Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs
A Book

by Dionysios Douroumis,Alfred Fahr

  • Publisher : John Wiley & Sons
  • Release : 2012-12-19
  • Pages : 648
  • ISBN : 1118444671
  • Language : En, Es, Fr & De
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Many newly proposed drugs suffer from poor water solubility,thus presenting major hurdles in the design of suitableformulations for administration to patients. Consequently, thedevelopment of techniques and materials to overcome these hurdles is a major areaof research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs providesa comprehensive overview of currently used formulation strategiesfor hydrophobic drugs, including liposome formulation, cyclodextrindrug carriers, solid lipid nanoparticles, polymeric drugencapsulation delivery systems, self–microemulsifying drugdelivery systems, nanocrystals, hydrosol colloidal dispersions,microemulsions, solid dispersions, cosolvent use, dendrimers,polymer- drug conjugates, polymeric micelles, and mesoporous silicananoparticles. For each approach the book discusses the maininstrumentation, operation principles and theoretical background,with a focus on critical formulation features and clinical studies. Finally, the bookincludes some recent and novel applications, scale-upconsiderations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is anessential multidisciplinary guide to this important area of drugformulation for researchers in industry and academia working indrug delivery, polymers and biomaterials.

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Controlled Release in Oral Drug Delivery

Controlled Release in Oral Drug Delivery
A Book

by Clive G. Wilson,Patrick J. Crowley

  • Publisher : Springer Science & Business Media
  • Release : 2011-09-22
  • Pages : 414
  • ISBN : 9781461410041
  • Language : En, Es, Fr & De
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Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.

Peptide Drug Delivery to the Brain

Peptide Drug Delivery to the Brain
A Book

by William M. Pardridge

  • Publisher : Raven Press (ID)
  • Release : 1991
  • Pages : 357
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques.

Controlled Pulmonary Drug Delivery

Controlled Pulmonary Drug Delivery
A Book

by Hugh D.C. Smyth,Anthony J. Hickey

  • Publisher : Springer Science & Business Media
  • Release : 2011-06-24
  • Pages : 558
  • ISBN : 9781441997456
  • Language : En, Es, Fr & De
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The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Current Technologies To Increase The Transdermal Delivery Of Drugs

Current Technologies To Increase The Transdermal Delivery Of Drugs
A Book

by José Juan Escobar-Chávez

  • Publisher : Bentham Science Publishers
  • Release : 2010
  • Pages : 146
  • ISBN : 1608051919
  • Language : En, Es, Fr & De
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This e-book provides an overview of current technologies used to increase the topical/transdermal delivery of drugs, its protocols, advantages and limitations. It includes exclusive chapters on chemical enhancers, Iontophoresis, Sonophoresis, Electroporation, Microneedles and the more recent use of micro/nanoparticles to deliver drugs throughout the skin. The e-book's generalized approach on the topic is aimed to be helpful in drug discovery, drug delivery and toxicological research and to provide a broader perspective on the topic to readers with respect to current literature available on the.

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
A Book

by Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak

  • Publisher : CRC Press
  • Release : 2007-03-30
  • Pages : 376
  • ISBN : 1000654745
  • Language : En, Es, Fr & De
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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer
A Book

by Prashant Kesharwani

  • Publisher : Academic Press
  • Release : 2019-01-26
  • Pages : 340
  • ISBN : 0128163674
  • Language : En, Es, Fr & De
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Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers