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Design and Development of New Nanocarriers

Design and Development of New Nanocarriers
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2017-12-12
  • Pages : 766
  • ISBN : 0128136286
  • Language : En, Es, Fr & De
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Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Nanocarriers for Drug Delivery

Nanocarriers for Drug Delivery
Nanoscience and Nanotechnology in Drug Delivery

by Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar Mishra,Sabu Thomas

  • Publisher : Elsevier
  • Release : 2018-10-05
  • Pages : 694
  • ISBN : 0128140348
  • Language : En, Es, Fr & De
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Nano-carriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery presents recent discoveries in research on the pharmaceutical applications of the various types of nanosystem-based drug delivery systems. As many nanosystems have reached the market over the past decade, this book proves their benefits to patients. It explores these new carriers and the advances in drug delivery they have facilitated. Reflecting the interdisciplinary nature of the subject matter, the book includes experts from different fields, and with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. Coverage includes industrial applications that bridge the gap between lab-based research and practical industrial use. The resulting work is a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Includes sections on nanocarrier systems

Nanomedicines

Nanomedicines
Design, Delivery and Detection

by Martin Braddock

  • Publisher : Royal Society of Chemistry
  • Release : 2016-04-14
  • Pages : 370
  • ISBN : 1782622535
  • Language : En, Es, Fr & De
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Nanomedicines and nanopharmacology is a rapidly developing and evolving field with new techniques and applications under constant development. This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Providing an understanding of the relationship of nanocarrier, drug and targetting moieties and physico-chemical properties, this title will provide an accurate and current representation of the field by addressing the promises, prospects and pitfalls of nanomedicine. Covering a wide range of areas in detail, this book will provide an excellent companion for medicinal chemists, pharmacologists and biochemists working in industry or academia.

Pharmaceutical Quality by Design

Pharmaceutical Quality by Design
Principles and Applications

by Sarwar Beg,Md Saquib Hasnain

  • Publisher : Academic Press
  • Release : 2019-03-27
  • Pages : 448
  • ISBN : 0128163720
  • Language : En, Es, Fr & De
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Pharmaceutical Quality by Design: Principles and Applications discusses the Quality by Design (QbD) concept implemented by regulatory agencies to ensure the development of a consistent and high-quality pharmaceutical product that safely provides the maximum therapeutic benefit to patients. The book walks readers through the QbD framework by covering the fundamental principles of QbD, the current regulatory requirements, and the applications of QbD at various stages of pharmaceutical product development, including drug substance and excipient development, analytical development, formulation development, dissolution testing, manufacturing, stability studies, bioequivalence testing, risk and assessment, and clinical trials. Contributions from global leaders in QbD provide specific insight in its application in a diversity of pharmaceutical products, including nanopharmaceuticals, biopharmaceuticals, and vaccines. The inclusion of illustrations, practical examples, and case studies makes this book a useful reference guide to pharmaceutical scientists and researchers who are engaged in the formulation of various delivery systems and the analysis of pharmaceutical product development and drug manufacturing process. Discusses vital QbD precepts and fundamental aspects of QbD implementation in the pharma, biopharma and biotechnology industries Provides helpful illustrations, practical examples and research case studies to explain QbD concepts to readers Includes contributions from global leaders and experts from academia, industry and regulatory agencies

Lipid Nanocarriers for Drug Targeting

Lipid Nanocarriers for Drug Targeting
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-04-16
  • Pages : 674
  • ISBN : 012813688X
  • Language : En, Es, Fr & De
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Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment Assesses the pros and cons of using different lipid nanocarriers for different therapies

Organic Materials as Smart Nanocarriers for Drug Delivery

Organic Materials as Smart Nanocarriers for Drug Delivery
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-03-26
  • Pages : 768
  • ISBN : 0128136642
  • Language : En, Es, Fr & De
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Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems

Design of Nanostructures for Theranostics Applications

Design of Nanostructures for Theranostics Applications
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-01-15
  • Pages : 692
  • ISBN : 0128136707
  • Language : En, Es, Fr & De
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Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment

Nanostructured Biomaterials for Overcoming Biological Barriers

Nanostructured Biomaterials for Overcoming Biological Barriers
A Book

by Maria Jose Alonso,Noemi S. Csaba

  • Publisher : Royal Society of Chemistry
  • Release : 2012
  • Pages : 622
  • ISBN : 1849733635
  • Language : En, Es, Fr & De
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Overcoming biological barriers is of importance for solving the problems of many current drugs and vaccines, and is especially relevant in the commerical exploitation of new therapeutic strategies. This book focuses on the mechanistic issues related to the interaction between drug delivery systems and biological barriers.

Design of Nanostructures for Versatile Therapeutic Applications

Design of Nanostructures for Versatile Therapeutic Applications
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-02-03
  • Pages : 690
  • ISBN : 0128136685
  • Language : En, Es, Fr & De
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Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry. Assesses the most recently developed nanostructures that have potential antimicrobial properties, explaining their novel mechanical aspects Shows how nanoantibiotics can be used to more effectively treat disease Provides a cogent summary of recent developments in nanoantimicrobial discovery, allowing readers to quickly familiarize themselves with the topic

Medicinal Chemistry with Pharmaceutical Product Development

Medicinal Chemistry with Pharmaceutical Product Development
A Book

by Debarshi Kar Mahapatra,Sanjay Kumar Bharti

  • Publisher : CRC Press
  • Release : 2019-02-04
  • Pages : 368
  • ISBN : 0429947151
  • Language : En, Es, Fr & De
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This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.

Nanostructures for Drug Delivery

Nanostructures for Drug Delivery
A Book

by Ecaterina Andronescu,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-03-24
  • Pages : 1024
  • ISBN : 0323461492
  • Language : En, Es, Fr & De
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Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes
A Book

by Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer

  • Publisher : Academic Press
  • Release : 2017-05-23
  • Pages : 552
  • ISBN : 0128097183
  • Language : En, Es, Fr & De
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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Design of Nanostructures for Theranostics Applications

Design of Nanostructures for Theranostics Applications
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-01-15
  • Pages : 692
  • ISBN : 0128136707
  • Language : En, Es, Fr & De
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Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment

Nanomaterials for Clinical Applications

Nanomaterials for Clinical Applications
Case Studies in Nanomedicines

by Costas Demetzos,Natassa Pippa

  • Publisher : Elsevier
  • Release : 2020-02-14
  • Pages : 322
  • ISBN : 0128168765
  • Language : En, Es, Fr & De
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Nanomaterials in Clinical Medicine: Case Studies in Nanomedicines focuses on the nanomaterials that can be formulated as drug delivery vehicles, such as liposomes, micelles, nanoemulsions and nanogels. Their physicochemical, morphological, thermo-dynamical and nanotoxicological properties are analyzed with respect to the design and development of drug delivery nanosystems for the encapsulation of an active pharmaceutical ingredient and its controlled release. Each chapter covers basic properties, the nanosystem (e.g., liposomes), the added value in drug delivery and targeting, and future perspectives. Case studies and examples of how nanomaterials are being used in clinical medicine, including marketed liposomal medicines and medical utility and regimens are also included. Particular attention is given to new nanocarriers, such as elastic liposomes, lipid polymeric hybrid nanoparticles, organogel, nanofibers carbon nanomaterials, quantum dots and inorganic nanoparticles. This book is an important information source for those wanting to increase their understanding of what major nanomaterials are being used to create more effective drug delivery systems. Summarizes the major nanomaterials used in clinical medicine, explaining how their properties make them suitable for this purpose Explains how nanomaterials are used to create increasingly efficient drug delivery vehicles Includes real-life examples, demonstrating how nanomaterials are being used in medical practice

Nanomaterials for Drug Delivery and Therapy

Nanomaterials for Drug Delivery and Therapy
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2019-03-14
  • Pages : 580
  • ISBN : 0128166290
  • Language : En, Es, Fr & De
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Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers

Emerging Nanotechnologies in Immunology

Emerging Nanotechnologies in Immunology
The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines

by Ranjita Shegokar,Eliana B. Souto

  • Publisher : William Andrew
  • Release : 2018-05-17
  • Pages : 290
  • ISBN : 0323401139
  • Language : En, Es, Fr & De
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Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanopharmaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The book's contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes. In addition, regulation and risk are also covered since the safety of these nanopharmaceuticals still represents a barrier to their wide and innovative use. Provides a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research Focuses on the characterization and quantification of nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects Includes a thorough overview of legal and regulatory aspects and a discussion of the ethical issues related to the R&D of nanopharmaceuticals

Nanostructures for Antimicrobial Therapy

Nanostructures for Antimicrobial Therapy
A Book

by Anton Ficai,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-05-29
  • Pages : 722
  • ISBN : 0323461514
  • Language : En, Es, Fr & De
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Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Nanocarriers for Brain Targeting

Nanocarriers for Brain Targeting
Principles and Applications

by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani

  • Publisher : CRC Press
  • Release : 2019-08-27
  • Pages : 512
  • ISBN : 0429877536
  • Language : En, Es, Fr & De
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This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery
A Book

by Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin

  • Publisher : Morgan & Claypool Publishers
  • Release : 2015-12-01
  • Pages : 155
  • ISBN : 1681740109
  • Language : En, Es, Fr & De
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The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics
A Book

by Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye

  • Publisher : Academic Press
  • Release : 2019-07-08
  • Pages : 432
  • ISBN : 0128173319
  • Language : En, Es, Fr & De
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Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles