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Developmental and Fetal Origins of Differences in Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins
From Genetics to Environmental Factors

by Alexandra Matias,Isaac Blickstein

  • Publisher : Academic Press
  • Release : 2020-05-15
  • Pages : 386
  • ISBN : 0128203072
  • Language : En, Es, Fr & De
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Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout. Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis Features contributions from international experts in twin genetics and developmental biology

Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia

Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
A Book

by Henry Houlden,Alan Edward Renton,Francesca Luisa Conforti

  • Publisher : Frontiers Media SA
  • Release : 2021-06-28
  • Pages : 129
  • ISBN : 2889669041
  • Language : En, Es, Fr & De
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Gamete and Embryo-fetal Origins of Adult Diseases

Gamete and Embryo-fetal Origins of Adult Diseases
A Book

by He-Feng Huang,Jian-Zhong Sheng

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-19
  • Pages : 222
  • ISBN : 9400777728
  • Language : En, Es, Fr & De
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The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

RUNX Proteins in Development and Cancer

RUNX Proteins in Development and Cancer
A Book

by Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen

  • Publisher : Springer
  • Release : 2017-03-15
  • Pages : 515
  • ISBN : 9811032335
  • Language : En, Es, Fr & De
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This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Family Matters

Family Matters
Designing, Analysing and Understanding Family Based Studies in Life Course Epidemiology

by Gita D. Mishra

  • Publisher : Oxford University Press
  • Release : 2009-04-02
  • Pages : 341
  • ISBN : 0199231036
  • Language : En, Es, Fr & De
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Life course epidemiology considers how adult health is affected by a variety of factors and influences over the entire life-course. This book provides the reader with the knowledge and skills to design, analyse, and correctly interpret family-based studies, which are increasingly being used to explore life course epidemiology.

Chromosomal Translocations and Genome Rearrangements in Cancer

Chromosomal Translocations and Genome Rearrangements in Cancer
A Book

by Janet D. Rowley,Michelle M. Le Beau,Terence H. Rabbitts

  • Publisher : Springer
  • Release : 2015-12-09
  • Pages : 490
  • ISBN : 3319199838
  • Language : En, Es, Fr & De
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This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.

Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book

Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book
Diseases of the Fetus and Infant

by Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh

  • Publisher : Elsevier Health Sciences
  • Release : 2019-04-11
  • Pages : 1850
  • ISBN : 0323567096
  • Language : En, Es, Fr & De
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Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.

Fetal/Embryonic Hematopoietic Progenitors and Their Impact on Adult Diseases

Fetal/Embryonic Hematopoietic Progenitors and Their Impact on Adult Diseases
A Book

by Silvia Brunelli,Antonella Ellena Ronchi,Charlotta Boiers,Emanuele Azzoni

  • Publisher : Frontiers Media SA
  • Release : 2021-10-01
  • Pages : 129
  • ISBN : 2889714578
  • Language : En, Es, Fr & De
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BMJ

BMJ
British Medical Journal

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Handbook of Behavior Genetics

Handbook of Behavior Genetics
A Book

by Yong-Kyu Kim

  • Publisher : Springer Science & Business Media
  • Release : 2009-03-25
  • Pages : 564
  • ISBN : 0387767274
  • Language : En, Es, Fr & De
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This handbook provides research guidelines to study roles of the genes and other factors involved in a variety of complex behaviors. Utilizing methodologies and theories commonly used in behavior genetics, each chapter features an overview of the selected topic, current issues, as well as current and future research.

Principles of Sex-based Differences in Physiology

Principles of Sex-based Differences in Physiology
A Book

by Virginia M. Miller,Virginia L. Miller,Meredith Hay

  • Publisher : Gulf Professional Publishing
  • Release : 2004
  • Pages : 333
  • ISBN : 9780444514974
  • Language : En, Es, Fr & De
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Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers. This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.

Environmental Epigenetics

Environmental Epigenetics
A Book

by L. Joseph Su,Tung-chin Chiang

  • Publisher : Springer
  • Release : 2015-05-18
  • Pages : 321
  • ISBN : 1447166787
  • Language : En, Es, Fr & De
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This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Twin Mythconceptions

Twin Mythconceptions
False Beliefs, Fables, and Facts about Twins

by Nancy L. Segal

  • Publisher : Academic Press
  • Release : 2017-02-08
  • Pages : 334
  • ISBN : 0128039957
  • Language : En, Es, Fr & De
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Twin Mythconceptions: False Beliefs, Fables, and Facts about Twins sheds new light on over 70 commonly held ideas and beliefs about the origins and development of identical and fraternal twins. Using the latest scientific findings from psychology, psychiatry, biology, and education, the book separates fact from fiction. Each idea about twins is described, followed by both a short answer about the truth, and then a longer, more detailed explanation. Coverage includes embryology of twins, twin types, intellectual growth, personality traits, sexual orientation of twins, marital relationships, epigenetic analyses, and more. Five appendices cover selected topics in greater depth, such as the frequency of different twin types and the varieties of polar body twin pairs. This book will inform and entertain behavioral and life science researchers, health professionals, twins, parents of twins, and anyone interested in the fascinating topic of twins. Identifies common misunderstandings about twins Provides scientific answers to questions about twins Encompasses the biology, psychology, genetics, and personality of twins Includes discussion of identical, fraternal same-sex, and fraternal opposite-sex twins Allows for quick answers to common questions and more detailed explanations

The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology

The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Obstetrics & Maternal-Fetal Medicine

by Tahir Mahmood,Charles Savona Ventura,Ioannis Messinis,Sambit Mukhopadhyay

  • Publisher : Cambridge University Press
  • Release : 2021-10-31
  • Pages : 480
  • ISBN : 1108495788
  • Language : En, Es, Fr & De
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An essential, up-to-date textbook for postgraduate trainees preparing for the EBCOG Fellowship exam.

Human Malformations and Related Anomalies

Human Malformations and Related Anomalies
A Book

by Roger E. Stevenson,Judith G. Hall

  • Publisher : Oxford University Press
  • Release : 2005-10-27
  • Pages : 1520
  • ISBN : 019974808X
  • Language : En, Es, Fr & De
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This widely acclaimed reference work gives a comprehensive survey of all significant human malformations and related anomalies from the perspective of the clinician. The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. When known, the molecular or other pathogenetic basis for the malformation is given. Most anomalies are illustrated by photographs or drawings. Specific malformations are linked to syndromes through the extensive use of differential diagnosis tables. Over a decade has passed since the first edition of this book was published, and the revised edition fully incorporates the advances made in the field during the intervening years.. It reflects new understanding of human developmental biology that has emerged from molecular, cytogenetic, and biochemical studies; new observations by clinicians as well as enhanced diagnostic and prevention capacities; and more accurate and comprehensive epidemiology. By condensing much of the information presented in the first volume of the previous edition, and exercising rigorous editorial control, Drs. Stevenson and Hall and their contributors have managed to update the book while reducing its size to that of a single volume. All clinicians and scientists interested in birth defects, including pediatricians, geneticists, genetic counselors, obstetricians, and pediatric pathologists, will find this book to be an invaluable source of information.

Epigenetics in Human Disease

Epigenetics in Human Disease
A Book

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2012-07-26
  • Pages : 592
  • ISBN : 0123884160
  • Language : En, Es, Fr & De
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
A Book

by Shuai Li,John Hopper

  • Publisher : Academic Press
  • Release : 2021-08-31
  • Pages : 374
  • ISBN : 0128209526
  • Language : En, Es, Fr & De
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Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Obesity

Obesity
Genomics and Postgenomics

by Karine Clement,Thorkild I. A. Sorensen

  • Publisher : CRC Press
  • Release : 2007-09-12
  • Pages : 600
  • ISBN : 1420020137
  • Language : En, Es, Fr & De
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This book comprehensively accounts the current understanding of genetic mechanisms of obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and mutations, and current results from animal model research and genetic studies in human models. By presenting the impact of genetic factors in the development of obesity and key molec

Epigenetics and Human Health

Epigenetics and Human Health
Linking Hereditary, Environmental and Nutritional Aspects

by Alexander Haslberger,Sabine Greßler

  • Publisher : John Wiley & Sons
  • Release : 2011-08-24
  • Pages : 316
  • ISBN : 352764475X
  • Language : En, Es, Fr & De
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After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.