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Diagnostic Molecular Biology

Diagnostic Molecular Biology
A Book

by Chang-Hui Shen

  • Publisher : Academic Press
  • Release : 2019-04-02
  • Pages : 471
  • ISBN : 012802867X
  • Language : En, Es, Fr & De
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Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding. The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes as well as the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations. This book also covers the applications of the principles and techniques currently employed in the clinical laboratory. • Provides an understanding of which techniques are used in diagnosis at the molecular level • Explains the basic principles of molecular biology and their application in the clinical diagnosis of diseases • Places protocols in context with practical applications

Molecular Diagnostics

Molecular Diagnostics
A Book

by George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson

  • Publisher : Academic Press
  • Release : 2016-10-27
  • Pages : 520
  • ISBN : 0128029889
  • Language : En, Es, Fr & De
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Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Diagnostic Molecular Biology

Diagnostic Molecular Biology
A Book

by Theodore Mifflin,Thomas W. Prior,Mark Lovell

  • Publisher : McGraw-Hill
  • Release : 1993-01-01
  • Pages : 129
  • ISBN : 9780070419339
  • Language : En, Es, Fr & De
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Fundamentals of Diagnostic Molecular Biology

Fundamentals of Diagnostic Molecular Biology
A Book

by Thirumalairaj Vinoth Kumar

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2015-05-13
  • Pages : 192
  • ISBN : 9783659595790
  • Language : En, Es, Fr & De
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Advances in molecular and cell biology have provided us with an understanding of the mechanisms of disease at the molecular and genetic levels. Diagnostic Molecular Biology is a class of diagnostic tests that assess a person's health literally at a molecular level, detecting and measuring specific genetic sequences in DNA or RNA or the proteins they express. Molecular diagnostics identify gene, RNA, and protein variations that shed light on whether a specific person is predisposed to have a disease, whether they actually have a disease, or whether a certain treatment option is likely to be effective for a specific disease. Molecular diagnostic tests detect specific sequences in DNA or RNA that may or may not be associated with disease, including single nucleotide polymorphism (SNP), deletions, rearrangements, insertions and others. These tests also can detect and quantify the presence of specific viruses, bacteria, or types of cells. It is a dynamic and transformative area of diagnostics that revolutionizes health care. It helps to uncover the underlying mechanisms of disease. It enables clinicians to care at an individual level and impede the practice of personalized medicine.

Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging

Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging
A Book

by W. Semmler,M. Schwaiger

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 268
  • ISBN : 3642608442
  • Language : En, Es, Fr & De
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New developments in the field of high resolution imaging focus on functional parameters pertaining to disease-specific medical imaging. Such new diagnostic strategies are possible using scintigraphic techniques and, more recently, by MRI and US. In addition, new therapeutic concepts, including gene therapy, require specific tracers or contrast media for therapy monitoring, for example, enzyme activity and changes in receptor expression. For this purpose scientists conducting basic research, expecially molecular biologists, and clinicians must collaborate in order to exploit the available interdisciplinary knowledge in the development of new imaging technologies so as to incorporate the molecular signals of diseases.

Molecular Diagnostics: Promises and Possibilities

Molecular Diagnostics: Promises and Possibilities
A Book

by Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen

  • Publisher : Springer Science & Business Media
  • Release : 2010-01-29
  • Pages : 520
  • ISBN : 9789048132614
  • Language : En, Es, Fr & De
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A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Mycobacteria

Mycobacteria
Molecular Biology and Virulence

by C. Ratledge,J. W. Dale

  • Publisher : John Wiley & Sons
  • Release : 2009-04-01
  • Pages : 416
  • ISBN : 1444311441
  • Language : En, Es, Fr & De
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Tuberculosis continues to kills more people than any other single infective agent. The resurgence of the disease in many countries has produced a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis. This book provides an up-to-date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature, such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but also will find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis. Comprehensively covers recent advances in the molecular biology of the mycobacteria. First book to be published on this subject since the publishing of the complete genome for the tubercle bacillus (M. tuberculosis). Coincides with a worldwide resurgence of tuberculosis.

Principles and Applications of Molecular Diagnostics

Principles and Applications of Molecular Diagnostics
A Book

by Nader Rifai,A. Rita Horvath,Carl T. Wittwer

  • Publisher : Unknown Publisher
  • Release : 2018-06-08
  • Pages : 436
  • ISBN : 9780128160619
  • Language : En, Es, Fr & De
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Principles and Aspects of Molecular Diagnostics is an accessible guide for clinical chemists and biologists applying molecular technology to clinical diagnosis. The book consists of two parts, with Part One covering principles and analytical concepts in molecular diagnostics, such as genomes and variants, nucleic acids isolation and techniques, circulating tumor cells and DNA, and cellular DNA. Part Two presents clinical applications of molecular diagnostics in solid tumors, prenatal diagnosis, infectious disease, genetic disease, hematopoietic malignancies, pharmacogenetics and identity testing. This book is ideal for those who need a thorough, yet succinct, guide on the use of this technology for molecular testing. Explains the principles and tools of molecular biology, along with the modern analytical tools that can be used to obtain the best results Offers authoritative information written and edited by the top experts in molecular diagnostics Provides references to seminal books, review articles and technical articles that go into greater depth, thus serving as the basis for further study

Diagnostic Techniques in Genetics

Diagnostic Techniques in Genetics
A Book

by Jean-Louis Serre

  • Publisher : John Wiley & Sons
  • Release : 2007-01-11
  • Pages : 270
  • ISBN : 0470870265
  • Language : En, Es, Fr & De
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Recent developments within molecular biology and genetic engineering have led to huge advances and changes within the biological sciences especially within the field of human genetics. Diagnostic Techniques in Genetics offers an important overview of how DNA or RNA technology may be applied to a large set of genetic diagnoses. The first part of the book focuses on DNA/RNA applications and includes many of the latest developments in the field combined with routine procedures of genetic diagnoses, for example cloning and sequencing DNA. The DNA applications presented in the first chapter are then each applied to a specific kind of genetic diagnosis and the text concludes with a chapter devoted to population genetics. First published in French by Dunod in 2002, this book is an excellent reference for students taking courses in molecular biology, medicine and medical genetics. It is also a useful introduction for postgraduate students and researchers in the field who require a general overview of genetic diagnoses.

Practical and Laboratory Diagnosis of Tuberculosis

Practical and Laboratory Diagnosis of Tuberculosis
From Sputum Smear to Molecular Biology

by Guadalupe García-Elorriaga,Guillermo del Rey-Pineda

  • Publisher : Springer
  • Release : 2015-07-29
  • Pages : 75
  • ISBN : 3319204785
  • Language : En, Es, Fr & De
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The present work focuses on the diagnosis of TB, covering all its possible ways. Content ranges from clinical diagnosis, which is the first instance in approaching tuberculosis, until the gold standard microbiological and molecular diagnostic tools, which are useful due to its speed and high sensitivity. Additionally, diagnosis of latent TB infection, which is key feature to controlling TB under a public health perspective, is also addressed. This book is intended to be a quick and useful reference for the diagnosis of TB, being of special use for clinicians, pulmonologists and microbiologists, but also to every professional, professors and students involved in research and practice on TB diagnosis. In addition, it is intended to be of interest to professionals all over the world, but especially in countries with high TB endemicity, where the proper diagnosis of TB is a topic of major importance.

Fundamentals of Molecular Diagnostics

Fundamentals of Molecular Diagnostics
A Book

by David E. Bruns,Edward R. Ashwood,Carl A. Burtis

  • Publisher : Saunders
  • Release : 2007
  • Pages : 267
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Veterinary Infection Biology: Molecular Diagnostics and High-Throughput Strategies

Veterinary Infection Biology: Molecular Diagnostics and High-Throughput Strategies
A Book

by Mónica V. Cunha,João Inácio

  • Publisher : Humana Press
  • Release : 2016-08-23
  • Pages : 536
  • ISBN : 9781493948123
  • Language : En, Es, Fr & De
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This volume provides an overview of molecular biology tools for pathogen detection and characterization. Focusing on biobanking, biosafety, good laboratory practices, biological specimen collection and processing, quality assurance and control, validation of molecular diagnostic assays for veterinary use; molecular detection and identification of animal pathogens using a wide range of established techniques and covering, also, emerging diagnosis approaches; genotyping tools for assessing the genetic landscape and epidemiology of pathogens; and integrative omics and high-throughput technologies as powerful research tools. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Veterinary Infection Biology: Molecular Diagnostics and High-Throughput Strategies aids scientists in continuing to study a broad range of molecular approaches, from simple and affordable to emerging and sophisticate.

Molecular Diagnostics

Molecular Diagnostics
Fundamentals, Methods and Clinical Applications

by Lela Buckingham

  • Publisher : F.A. Davis
  • Release : 2019-02-22
  • Pages : 576
  • ISBN : 0803699549
  • Language : En, Es, Fr & De
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Meet the challenges of this rapidly expanding field with a solid understanding of the fundamentals of nucleic acid biochemistry as well as the advanced concepts integral to practice in today’s laboratories. With a focus on the application of molecular concepts to the diagnosis of disease, the 3rd Edition of this popular resource encompasses microbiology, virology, genetics, oncology, and human identification.

Basic Concepts of Molecular Pathology

Basic Concepts of Molecular Pathology
A Book

by Philip T. Cagle,Timothy Craig Allen

  • Publisher : Springer Science & Business Media
  • Release : 2009-06-10
  • Pages : 190
  • ISBN : 9780387896267
  • Language : En, Es, Fr & De
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Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Diagnostic Molecular Pathology

Diagnostic Molecular Pathology
A Guide to Applied Molecular Testing

by William B. Coleman,Gregory J. Tsongalis

  • Publisher : Academic Press
  • Release : 2016-10-05
  • Pages : 582
  • ISBN : 0128011572
  • Language : En, Es, Fr & De
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Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Diagnostic Molecular Pathology

Diagnostic Molecular Pathology
A Book

by Debra G. B. Leonard

  • Publisher : Saunders
  • Release : 2003
  • Pages : 208
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This practical guide provides information essential to understanding the significance of molecular biology and its application to everyday practice. Coverage focuses on the spectrum of currently used molecular tests in the areas of hematopathology, solid tumors, genetics, and identify testing. Examples of both molecular and cytogenetic assays demonstrate how these tests are used in today's pathology labs to detect a wide range of infectious diseases and inherited and metabolic conditions. Presents the full range of molecular diagnostic methods from the standpoint of their clinical applications and diagnostic value. Provides full-chapter coverage of each type of molecular testing, including genetics · carcinomas · sarcomas · leukemias and lymphomas · and identity testing. Concisely covers all areas of molecular pathology-making it the single source for all aspects of this field. Features the contributions of 12 leading experts in molecular pathology. Offers a complete introduction to molecular biology as well as common molecular methods of testing. Focuses on test utility as well as test interpretation and significance. With 11 additional contributors.

Diagnostic Virology Protocols

Diagnostic Virology Protocols
A Book

by John R. Stephenson,Alan Warnes

  • Publisher : Humana Press
  • Release : 2010-12-02
  • Pages : 470
  • ISBN : 9781607618164
  • Language : En, Es, Fr & De
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Recent outbreaks of swine influenza and avian influenza, along with the remaining and in some cases expanding threats from HIV, dengue virus, and the viruses causing hepatitis, have reinforced the need for rapid, accurate and cost-effective diagnosis of viral disease. Diagnostic Virology Protocols, Second Edition brings the field fully up-to-date with a focus on protocols involving nucleic acid detection, most often through some form of the polymerase chain reaction (PCR). The expert contributors also delve into the key technology of robotics as well as future prospects, such as further refined point-of-care testing and the increasing importance of mathematical modelling. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Diagnostic Virology Protocols, Second Edition captures the dramatic changes in the virus diagnostic laboratory in order to better prepare scientists to combat the inevitable threats to public health from future and present infectious diseases.

Molecular Biology : Diagnostic Principles and Practice

Molecular Biology : Diagnostic Principles and Practice
A Book

by David H. (Ed. in Chief) Persing,Fred C. (Ed.) Tenover,James (Ed.) Versalovic,Yi-Wet (Ed.) and etc Tang

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 724
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Application of Molecular Biology Tools Within Diagnostic Mycobacteriology

Application of Molecular Biology Tools Within Diagnostic Mycobacteriology
A Book

by Vibeke Østergaard Thomsen

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 198
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Diagnostics

Molecular Diagnostics
Current Research and Applications

by Jim Huggett,Justin O'Grady

  • Publisher : Unknown Publisher
  • Release : 2014-05-01
  • Pages : 260
  • ISBN : 9781908230416
  • Language : En, Es, Fr & De
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The application of molecular technology in clinical diagnosis is a rapidly developing area and is predicted to greatly improve the speed, efficiency, and accuracy of diagnostic medicine. The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic, and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial, and fungal pathogens, as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases. This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories. [Subject: Medicine, Molecular Biology, Epidemiology, Life Science, Oncology]