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Disease Pathways

Disease Pathways
An Atlas of Human Disease Signaling Pathways

by Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev

  • Publisher : Elsevier
  • Release : 2019-10-18
  • Pages : 732
  • ISBN : 0128170875
  • Language : En, Es, Fr & De
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Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
A Book

by Pierre-Alain Clavien

  • Publisher : Springer Science & Business Media
  • Release : 2005
  • Pages : 442
  • ISBN : 9783540229346
  • Language : En, Es, Fr & De
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Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Innate Immunity Pathways in Autoimmune Diseases

Innate Immunity Pathways in Autoimmune Diseases
A Book

by Moncef Zouali,Antonio La Cava

  • Publisher : Frontiers Media SA
  • Release : 2019-12-10
  • Pages : 329
  • ISBN : 2889632369
  • Language : En, Es, Fr & De
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Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
A Book

by Jean-Francois Dufour,Pierre-Alain Clavien

  • Publisher : Springer Science & Business Media
  • Release : 2009-12-01
  • Pages : 526
  • ISBN : 9783642001505
  • Language : En, Es, Fr & De
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Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

Signal Transduction: Pathways, Mechanisms and Diseases

Signal Transduction: Pathways, Mechanisms and Diseases
A Book

by Ari Sitaramayya

  • Publisher : Springer Science & Business Media
  • Release : 2009-12-02
  • Pages : 437
  • ISBN : 9783642021121
  • Language : En, Es, Fr & De
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Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

The Jak-Stat Pathway in Hematopoiesis and Disease

The Jak-Stat Pathway in Hematopoiesis and Disease
A Book

by Alister C. Ward

  • Publisher : Springer Science & Business Media
  • Release : 2002-12-31
  • Pages : 140
  • ISBN : 9780306474248
  • Language : En, Es, Fr & De
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This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases
A Book

by Marek Los,Spencer B. Gibson

  • Publisher : Springer Science & Business Media
  • Release : 2006-06-20
  • Pages : 395
  • ISBN : 0387236953
  • Language : En, Es, Fr & De
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As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

What Your Doctor May Not Tell You about Heart Disease

What Your Doctor May Not Tell You about Heart Disease
A Book

by Mark Houston

  • Publisher : Grand Central Life & Style
  • Release : 2012-02-06
  • Pages : 320
  • ISBN : 1455506532
  • Language : En, Es, Fr & De
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Coronary heart disease has long been the number one killer in this country, and for decades, we have been told about five basic risk factors: elevated cholesterol, high blood pressure, diabetes, obesity, and smoking. But the truth is that heart disease is much more complex-- with close to 400 risk factors! In this innovative guide, Dr. Mark Houston helps readers discover the causes of heart disease, how to prevent and treat its debilitating effects via nutrition, nutritional supplements, exercise, weight management, and lays to rest to various myths (cholesterol is not the primary cause) based on scientific studies and medical publications. Readers will also learn how to indentify the risk factors most likely to endager them and construct an arsenal of non-pharmacological preventitive strategies that can counteract this most deadly disease.

Parkinson's Disease and Movement Disorders

Parkinson's Disease and Movement Disorders
A Book

by Joseph Jankovic,Eduardo Tolosa

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2007
  • Pages : 720
  • ISBN : 9780781778817
  • Language : En, Es, Fr & De
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Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders.

Molecular Pathology of Lung Diseases

Molecular Pathology of Lung Diseases
A Book

by Dani S. Zander,Helmut Popper,Jaishree Jagirdar,Abida Haque,Roberto Barrios

  • Publisher : Springer Science & Business Media
  • Release : 2010-05-26
  • Pages : 682
  • ISBN : 9780387724300
  • Language : En, Es, Fr & De
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This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Nonalcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease - E-Book

Nonalcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease - E-Book
A Book

by Arun J. Sanyal

  • Publisher : Elsevier Health Sciences
  • Release : 2012-08-12
  • Pages : 240
  • ISBN : 145574736X
  • Language : En, Es, Fr & De
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Dr. Sanyal's expertise as Chairman of the Division of Hepatology at Virginia Commonwealth University and the breadth of his published articles in hepatology make him the perfect person to compile state-of-the-art reviews on the topic of NASH/fatty liver. The articles in this issue address the following topics: The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease; Relevance of Liver Histology to Predict Clinically Meaningful Outcomes in NASH; Mechanisms of Simple Hepatic Steatosis; Cellular and Molecular Basis for Phenotype of Steatohepatitis; Mechanisms of Disease Progression in NASH: New Paradigms; Can NASH Be Diagnosed, Graded and Staged Non-Invasively?; Is NAFLD in Children the Same Disease as in Adults?; The Cardiovascular Link to NAFLD: A Critical Analysis; Impact of Behavioral Disturbances and Their Treatment on Obesity and NAFLD; and Management of NASH.

Atherothrombosis and Coronary Artery Disease

Atherothrombosis and Coronary Artery Disease
A Book

by Valentin Fuster,Eric J. Topol,Elizabeth G. Nabel

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2005
  • Pages : 1636
  • ISBN : 9780781735834
  • Language : En, Es, Fr & De
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Written by the world’s foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume. Coverage begins with a review of risk factors and prevention, emphasizing lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included.

Biotechnology Annual Review

Biotechnology Annual Review
A Book

by M. Raafat El-Gewely

  • Publisher : Elsevier
  • Release : 2005-09-12
  • Pages : 452
  • ISBN : 9780444519528
  • Language : En, Es, Fr & De
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Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists' knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, vehicles for the production of biotechnology products and methods for their detection, separation and analysis - to topics that are focused on the role of biotechnology in the health sciences. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training.

Research in Computational Molecular Biology

Research in Computational Molecular Biology
14th Annual International Conference, RECOMB 2010, Lisbon, Portugal, April 25-28, 2010, Proceedings

by Bonnie Berger

  • Publisher : Springer Science & Business Media
  • Release : 2010-04-20
  • Pages : 582
  • ISBN : 3642126820
  • Language : En, Es, Fr & De
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This volume contains the papers presented at RECOMB 2010: the 14th Annual International Conference on Research in Computational Molecular Biology held in Lisbon, Portugal, during April 25–28, 2010. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. RECOMB 2010 was hosted by INESC-ID and Instituto Superior Tecnico, or- nized by a committee chaired by Arlindo Oliveira and took place at the Int- national Fair of Lisbon Meeting Centre. This year, 36 papers were accepted for presentation out of 176 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed by three members of the PC, or by external reviewers, and there was an extensive Web-based discussion over a period of two weeks, leading to the ?nal decisions. RECOMB 2010 also introduced a Highlights Track, in which six additional presentations by senior authors were chosen from papers published in 2009. The RECOMB conferenceseriesiscloselyassociatedwiththeJournalofComputational Biology, which traditionally publishes special issues devoted to presenting full versions of selected conference papers.

Critical Pathways to Success in CNS Drug Development

Critical Pathways to Success in CNS Drug Development
A Book

by Neal R. Cutler,John J. Sramek,Michael F. Murphy,Henry Riordan,Peter Biek,Angelico Carta

  • Publisher : John Wiley & Sons
  • Release : 2010-01-22
  • Pages : 272
  • ISBN : 9781444318586
  • Language : En, Es, Fr & De
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Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations

Pathways for Sustainable Sanitation

Pathways for Sustainable Sanitation
Achieving the Millennium Development Goals

by Anonim

  • Publisher : IWA Publishing
  • Release : 2008-01-01
  • Pages : 56
  • ISBN : 1843391961
  • Language : En, Es, Fr & De
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The report is a product arising from the work of t

Clinical Pathways in Vitreoretinal Disease

Clinical Pathways in Vitreoretinal Disease
A Book

by Scott Steidl

  • Publisher : Thieme Medical Pub
  • Release : 2003
  • Pages : 442
  • ISBN : 9781588901194
  • Language : En, Es, Fr & De
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Using evidence-based medicine to develop management strategies and featuring pathway diagrams and decision-making trees, the book links specific symptoms to the appropriate diagnosis and most effective treatment.

The Involvement of the Three Main Inflammatory Bowel Disease Pathways and the Secretion of Trypsin Proteolytic Activity on Intestinal Epithelial Cells

The Involvement of the Three Main Inflammatory Bowel Disease Pathways and the Secretion of Trypsin Proteolytic Activity on Intestinal Epithelial Cells
A Book

by Núria Solà Tapias

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 217
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Crohn's disease (CD) and Ulcerative colitis (UC) are two forms of Inflammatory Bowel Disease (IBD), a chronic inflammatory pathology affecting the digestive tract. Patients suffer from relapsing flares, diarrhea, abdominal pain and bleeding. Although the molecular mechanisms of IBD are poorly understood, recent data suggest that IBD occurs in genetically predisposed individuals developing an abnormal immune response to intestinal microbes after, being exposed to specific environmental triggers. Genetic studies have reported more than 170 polymorphisms susceptible to be involved in IBD pathogenesis. The strongest associations have highlighted three main pathways altered in IBD including bacterial sensing (NOD2, CD), autophagy (ATG16L1 and IRGM, CD) and endoplasmic reticulum stress (ER-Stress) (XBP1, UC). The role of intestinal barrier function is also strongly implicated in IBD pathogenesis, and is modulated by factors present in the lumen derived from microbiota, food or at a molecular level, by factors such as proteases. In IBD pathophysiology, the inflammatory process is characterized by impaired intestinal biology including disruption of tight junctions and leaky gut, decreased amount of Paneth and Goblet cells, and translocation of luminal antigens triggering inflammation. Previous studies have demonstrated an increased level of active serine proteases in the stools and tissues of IBD patients, supposing that proteases originate from infiltrated immune cells, pancreatic secretion or microbiota. However, our team has reported that intestinal epithelial cells are a major source of serine proteases, in particular trypsin-like enzymes, are released by a stressed epithelium in pathogenic context such as irritable bowel syndrome. In this project, we aimed at better understanding whether the three main pathways involved in IBD (Nod2, autophagy, ER-stress) could be linked to an epithelial release of trypsin and reciprocally, if epithelial trypsin is able to induce or modulate these three IBD pathways. We confirmed that trypsin-like activity was significantly higher in biopsies from UC and CD patients compared to healthy controls. In Caco-2 monolayers cultured in transwells, secreted trypsin-like proteolytic activity remained stable upon NOD2 stimulation but decreased under autophagy induction. Thapsigargin (Tg) stimulation a well-known ER-stress inducer, enhanced the apical release of trypsin-like activity in Caco2 cells. [...].

Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
A Book

by Jean-Francois Dufour,Pierre-Alain Clavien

  • Publisher : John Wiley & Sons
  • Release : 2015-08-24
  • Pages : 520
  • ISBN : 1118663365
  • Language : En, Es, Fr & De
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Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Neurological Disease: New Insights for the Healthcare Professional: 2012 Edition

Neurological Disease: New Insights for the Healthcare Professional: 2012 Edition
ScholarlyPaper

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-10
  • Pages : 32
  • ISBN : 1464978352
  • Language : En, Es, Fr & De
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Neurological Disease: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Neurological Disease in a compact format. The editors have built Neurological Disease: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurological Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurological Disease: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.