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Drug-Biomembrane Interaction Studies

Drug-Biomembrane Interaction Studies
The Application of Calorimetric Techniques

by Rosario Pignatello

  • Publisher : Elsevier
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 1908818344
  • Language : En, Es, Fr & De
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The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
5. DSC: history, instruments and devices

by A. Fortunato

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091800
  • Language : En, Es, Fr & De
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In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
3. Analytical methods for studying drug–biomembrane interactions

by R. Pignatello

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091789
  • Language : En, Es, Fr & De
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DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
8. DSC applications: nucleic acids and membrane interactions

by S. Giatrellis,G. Nounesis

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091835
  • Language : En, Es, Fr & De
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DSC is a non-invasive experimental technique, which, besides other numerous applications, has been extensively applied in investigating the thermodynamic properties of synthetic and biological membranes. The calorimetric profiles of phase transitions of self-organized lipid membranes can provide valuable information about membrane interactions with biomolecules, pharmaceutical agents, other membranes, etc. The scope of this chapter is to review specific applications of DSC in studying membrane– nucleic acid interactions, which have attracted scientific attention for their biological relevance, as well as for their potential for biotechnological and pharmaceutical advances.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
6. DSC in drug–biomembrane interaction studies

by C. Carbone,R. Pignatello

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091819
  • Language : En, Es, Fr & De
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Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of different biomolecules and biomembrane models, which will be presented more thoroughly in the succeeding chapters. In particular, a detailed description of the DSC technique for studying the interaction of surfactants, genetic materials, polymers, and DDSs with biomembrane models and biomolecule toxicity studies will be provided, taking into consideration the most recent literature.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
10. Antimicrobial agents

by T. Musumeci,G. Puglisi

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091851
  • Language : En, Es, Fr & De
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Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the effects of such drugs. We discuss interaction studies in the recent literature that use calorimetric techniques, regarding the mechanism of action or side effects of antimicrobial agents. For interaction studies with mimetic membrane models using DSC analysis, we will try to answer some key questions: (a) Does lipid composition affect the interaction? (b) Does the composition of bilayers influence the secondary structure of a peptide antimicrobial? (c) Does lipid polymorphism influence the activity and toxicity of the molecules? We underline the importance of phospholipids (neutral or anionic) chosen to produce biomembrane vesicles as models for the different studies.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
2. Biomembrane models

by A. Wiśniewska-Becker,W.I. Gruszecki

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091770
  • Language : En, Es, Fr & De
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Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical techniques are used with these models to study membrane properties and their changes under different environmental factors. This chapter describes common membrane models and some of their applications. There are two groups of models: vesicular models (micelles, bicelles and liposomes) and planar ones (lipid monolayers, supported lipid bilayers, black lipid membranes). The advantages and disadvantages of both types are discussed as well as their usefulness for particular biophysical techniques.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
9. Non-steroidal anti-inflammatory drugs

by C. Carbone,T. Musumeci,R. Pignatello

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091843
  • Language : En, Es, Fr & De
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Several DSC studies have given a better understanding of the molecular mechanisms of interaction of many non-steroidal anti-inflammatory agents (NSAIDs), such as indomethacin, ibuprofen, naproxen, nimesulide, ketoprofen and oxicam drugs with cell membranes or with simplified phospholipid-based biomembrane models. The consequent changes in the organization, fluidity and permeability of these membranes can, in some instances, be related to the pharmacological profile and toxicology of this drug class. The literature also attests the usefulness of DSC methods in studying the interaction of NSAID-loaded delivery systems (polymeric micro- and nanoparticles, micelles, lipid nanoparticles and prodrugs) with biomembrane models. DSC is also a valid tool for following the release of an anti-inflammatory drug from its carrier.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
1. Biological membranes and their role in physio-pathological conditions

by R. Pignatello

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091762
  • Language : En, Es, Fr & De
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This chapter will summarize recent information on cell membranes. Their structure, functions and the role of the various components are discussed, considering both their physiological tasks, such as mechanisms of drug internalization into cells, as well as membrane changes associated with or caused by particular disease states. Later chapters will discuss the possibility of testing biomembrane models to study their interaction with drugs and biological compounds.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
4. Differential scanning calorimetry (DSC): theoretical fundamentals

by A. Raudino,M.G. Sarpietro,M. Pannuzzo

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091797
  • Language : En, Es, Fr & De
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In this chapter we briefly introduce the main physical principles of DSC as well as related techniques. After a quick survey of the more common experimental techniques, we describe the thermodynamics and kinetics of events accompanying a heating/cooling process. We focus on lipid membranes of one or more components. Both the thermotropic and the barotropic behaviours are investigated, as well as the water/lipid ratio. The effect of foreign impurities (hydrophobic molecules, proteins) dissolved in the lipid matrix on DSC thermotropic behaviour is also investigated, either in the ideal mixing model or for non-ideal miscibility. In the poor miscibility limit, lipids and hydrophobic impurities may undergo phase separation. The mechanisms of phase separation are discussed and related to experimental DSC features. Out-of-equilibrium phenomena, such as the different thermotropic behaviour between heating and cooling modes or the kinetics of lipid/water partitioning, are explained using simple models for phase transitions.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
11. Drug delivery systems: drug nanocarriers

by M. Grazia Sarpietro,F. Castelli

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 012809186X
  • Language : En, Es, Fr & De
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This chapter describes a method for evaluating the release of a drug by different delivery systems to biomembrane models made of multilamellar and unilamellar vesicles, using DSC techniques. First, different delivery systems as well as biomembrane models are described followed by a detailed description of the experimental protocols that are the basis of the technique. A drug-loaded delivery system is incubated with the biomembrane model and drug release is evaluated by considering the effect of the drug on the biomembrane’s thermotropic behaviour, and comparing the experimental data with those of the free drug. Finally, examples of the application of this technique are given.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
7. DSC applications: macromolecules

by M.H. Chiu,N.S. Berezowski,E.J. Prenner

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-10-31
  • Pages : 440
  • ISBN : 0128091827
  • Language : En, Es, Fr & De
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DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug-Membrane Interactions

Drug-Membrane Interactions
Analysis, Drug Distribution, Modeling

by Joachim K. Seydel,Michael Wiese

  • Publisher : John Wiley & Sons
  • Release : 2009-07-10
  • Pages : 367
  • ISBN : 3527616497
  • Language : En, Es, Fr & De
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Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Electrochemical Studies on Drug-Membrane Interaction

Electrochemical Studies on Drug-Membrane Interaction
A Book

by Subramaniam Rameshkumar,Muthunan Thevar Vijayan

  • Publisher : Unknown Publisher
  • Release : 2018-04-17
  • Pages : 224
  • ISBN : 9783659977725
  • Language : En, Es, Fr & De
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Laser Raman and Infrared Spectral Studies on Drug-membrane Interaction

Laser Raman and Infrared Spectral Studies on Drug-membrane Interaction
A Book

by Sohyoung Choo

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 100
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization
A Book

by Fatma N. Kök,Ahu Arslan Yildiz,Fatih Inci

  • Publisher : Springer
  • Release : 2019-04-16
  • Pages : 306
  • ISBN : 3030115968
  • Language : En, Es, Fr & De
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This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.

Soft Matter Systems for Biomedical Applications

Soft Matter Systems for Biomedical Applications
A Book

by Leonid Bulavin,Nikolai Lebovka

  • Publisher : Springer Nature
  • Release : 2021-09-27
  • Pages : 452
  • ISBN : 3030809242
  • Language : En, Es, Fr & De
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This book addresses new challenges in soft matter and colloids. It presents timely reports on colloidal self-assembly, soft matters from liquid crystals, nanoparticles in liquid crystals, hydrocolloids, hybrid nanosystems, nanosuspensions, and dispersion of nanoparticles in different media, soft matter processing and modern experiments related with soft matters.

Transdermal Drug Delivery

Transdermal Drug Delivery
Concepts and Application

by Kevin Ita

  • Publisher : Academic Press
  • Release : 2020-06-12
  • Pages : 324
  • ISBN : 0128225513
  • Language : En, Es, Fr & De
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Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems

Nanostructures for Drug Delivery

Nanostructures for Drug Delivery
A Book

by Ecaterina Andronescu,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-03-24
  • Pages : 1024
  • ISBN : 0323461492
  • Language : En, Es, Fr & De
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Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Experimental and Numerical Studies in Biomedical Engineering

Experimental and Numerical Studies in Biomedical Engineering
A Book

by Spiros V. Paras,Athanasios G. Kanaris

  • Publisher : MDPI
  • Release : 2019-08-26
  • Pages : 130
  • ISBN : 3039212478
  • Language : En, Es, Fr & De
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The term ‘biomedical engineering’ refers to the application of the principles and problem-solving techniques of engineering to biology and medicine. Biomedical engineering is an interdisciplinary branch, as many of the problems health professionals are confronted with have traditionally been of interest to engineers because they involve processes that are fundamental to engineering practice. Biomedical engineers employ common engineering methods to comprehend, modify, or control biological systems, and to design and manufacture devices that can assist in the diagnosis and therapy of human diseases. This Special Issue of Fluids aims to be a forum for scientists and engineers from academia and industry to present and discuss recent developments in the field of biomedical engineering. It contains papers that tackle, both numerically (Computational Fluid Dynamics studies) and experimentally, biomedical engineering problems, with a diverse range of studies focusing on the fundamental understanding of fluid flows in biological systems, modelling studies on complex rheological phenomena and molecular dynamics, design and improvement of lab-on-a-chip devices, modelling of processes inside the human body as well as drug delivery applications. Contributions have focused on problems associated with subjects that include hemodynamical flows, arterial wall shear stress, targeted drug delivery, FSI/CFD and Multiphysics simulations, molecular dynamics modelling and physiology-based biokinetic models.