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Drug Delivery Aspects

Drug Delivery Aspects
Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Academic Press
  • Release : 2020-03-27
  • Pages : 266
  • ISBN : 0128218509
  • Language : En, Es, Fr & De
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Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses engineering and large-scale manufacturing of nanocarriers Considers preclinical, regulatory and ethical guidelines on nanoparticles Contains in-depth discussions on delivery of biologics, vaccines and sterilisation Industrial view on solid dispersions, milling techniques

Chemical Aspects of Drug Delivery Systems

Chemical Aspects of Drug Delivery Systems
A Book

by D R Karsa,R A Stephenson

  • Publisher : Royal Society of Chemistry
  • Release : 2007-10-31
  • Pages : 170
  • ISBN : 1847550371
  • Language : En, Es, Fr & De
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Despite advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects and can harm normal, as well as diseased, cells and organs, and for this reason it is vital that controlled release and the targeting of delivery systems must evolve in parallel to drug research. Chemical Aspects of Drug Delivery Systems reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field. Delivery systems described include carbohydrate derivatives, novel nonionic surfactant vesicles and various polymers, including polyacrylates and aqueous shellac solutions, as well as hydrogels. In addition, many of the key issues, such as the understanding of biosystems and targets and the development of materials to provide the deserved carrier and excipient properties for controlled, targeted drug delivery, are considered in depth. This book will be of equal interest to undergraduate, graduate, researcher and those in the pharmaceutical industries, and it complements two previous RSC Special Publications, Encapsulation and Controlled Release and Excipients and Delivery Systems for Pharmaceutical Formulations.

Chemical Aspects of Drug Delivery Systems

Chemical Aspects of Drug Delivery Systems
A Book

by D. R. Karsa,R. A. Stephenson,British Association for Chemical Specialties. Waterborne Polymers Group

  • Publisher : Royal Society of Chemistry
  • Release : 1996
  • Pages : 161
  • ISBN : 9780854047062
  • Language : En, Es, Fr & De
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This book reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field.

Site-specific Drug Delivery

Site-specific Drug Delivery
Cell Biology, Medical, and Pharmaceutical Aspects

by Eric Tomlinson,Stanley S. Davis

  • Publisher : John Wiley & Sons
  • Release : 1986
  • Pages : 164
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recent advances in cell and molecular biology are providing exciting opportunities for the rational design of novel highly specific and effective therapeutic agents. These opportunities will often only be turned into clinical success through strategies which ensure the delivery of such agents to the desired site of action. This is achieved via processes which prevent loss of drug activity, avoid toxicity and provide cost- effective and convenient therapy. This book addresses some of the biological opportunities and scientific challenges for the site-specific delivery of drugs, and indicates the formidable obstacles which face the pharmaceutical industry and academia alike.

Drug Delivery Approaches and Nanosystems, Volume 2

Drug Delivery Approaches and Nanosystems, Volume 2
Drug Targeting Aspects of Nanotechnology

by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani

  • Publisher : CRC Press
  • Release : 2017-11-15
  • Pages : 374
  • ISBN : 1351846663
  • Language : En, Es, Fr & De
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This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.

Drug Delivery Trends

Drug Delivery Trends
Volume 3: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-03-01
  • Pages : 246
  • ISBN : 012817871X
  • Language : En, Es, Fr & De
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Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses trends in drug delivery systems and selected dosage forms Illustrates regulatory, preclinical and quality principles Contains in-depth investigation of upcoming types of drug delivery systems

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Handbook of Non-Invasive Drug Delivery Systems

Handbook of Non-Invasive Drug Delivery Systems
Science and Technology

by Vitthal S. Kulkarni

  • Publisher : Elsevier
  • Release : 2009-12-31
  • Pages : 328
  • ISBN : 9780815520269
  • Language : En, Es, Fr & De
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With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Biophysical Aspects of Enhanced Transdermal Drug Delivery

Biophysical Aspects of Enhanced Transdermal Drug Delivery
Polar Compound Transport

by Cynthia Young Goates

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 502
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Delivery of Drugs

Delivery of Drugs
Volume 2: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-02-14
  • Pages : 244
  • ISBN : 9780128177761
  • Language : En, Es, Fr & De
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Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Encompasses the functional aspects of nano-micro carriers Demonstrates physical methods to improve drug efficacy Contains in-depth investigation on the specific aspects of drug delivery systems

Pharmaceutical Dosage Forms and Drug Delivery, Second Edition

Pharmaceutical Dosage Forms and Drug Delivery, Second Edition
A Book

by Ram I. Mahato,Ajit S. Narang

  • Publisher : CRC Press
  • Release : 2011-10-25
  • Pages : 512
  • ISBN : 1439849196
  • Language : En, Es, Fr & De
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In the second edition of Pharmaceutical Dosage Forms and Drug Delivery the authors integrate aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, emphasizing the increased attention that the recent spectacular advances in dosage form design and drug delivery, gene therapy, and nanotechnology have brought to the field. Highlights of the Second Edition: Additional author Ajit S. Narang brings an industrial practitioner perspective with increased focus on pharmacy math and statistics, and powders and granules Reorganized into three parts: Introduction, Physicochemical Principles, and Dosage Forms Chapters on pharmaceutical calculations, compounding principles, and powders and granules provide a complete spectrum of application of pharmaceutical principles Expansion of review questions and answers clarifies concepts for students and adds to their grasp of key concepts covered in the chapter Coverage of complexation and protein binding aspects of physical pharmacy includes the basic concepts as well as recent progress in the field Although there are numerous books on the science of pharmaceutics and dosage form design, most cover different areas of the discipline and do not provide an integrated approach to the topics. This book not only provides a singular perspective of the overall field, but it supplies a unified source of information for students, instructors, and professionals.

Nanopharmaceuticals

Nanopharmaceuticals
Volume 1: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-01-10
  • Pages : 244
  • ISBN : 0128177799
  • Language : En, Es, Fr & De
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Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 Encompasses functional aspects of nanocarriers Discusses Intellectual Property landscapes of micro-nano drug carriers Contains in-depth investigation of specific aspects of drug delivery systems

Transdermal and Topical Drug Delivery from Theory to Clinical Practice

Transdermal and Topical Drug Delivery from Theory to Clinical Practice
A Book

by Adrian Williams

  • Publisher : Pharmaceutical Press
  • Release : 2003
  • Pages : 242
  • ISBN : 9780853694892
  • Language : En, Es, Fr & De
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The therapeutic benefits of administering drugs through the skin have been recognized for many years and have been capitalized upon in commercially successful and important transdermal delivery systems, such as estradiol patches for hormone replacement and nicotine patches as aids to smoking cessation. Transdermal and Topical Drug Delivery addresses all aspects of how to deliver drugs to the skin for local effects or across the skin for systemic therapy. Starting with a discussion of the principles underlying the area, the text expands into strategies used to deliver drugs effectively. This should be a valuable practical guide for the clinical delivery of drugs.

Drug Delivery Nanoparticles Formulation and Characterization

Drug Delivery Nanoparticles Formulation and Characterization
A Book

by Yashwant Pathak,Deepak Thassu

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 416
  • ISBN : 1420078054
  • Language : En, Es, Fr & De
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Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Molecular Biopharmaceutics

Molecular Biopharmaceutics
Aspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation

by Bente Steffansen,Birger Brodin,Carsten Uhd Nielsen

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 371
  • ISBN : 9780853697220
  • Language : En, Es, Fr & De
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This book covers a complex and developing academic scientific area. It focuses on describing the interplay between the chemistry of drug molecules and membrane transporters. It also aims to guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery. Starting with an introduction to the topic, Molecular Biopharmaceutics then considers the following: physico-chemical characterisation of drug candidates; membrane transport of drug candidates; describing and predicting bioavailability.

Drug Delivery and Development of Anti-HIV Microbicides

Drug Delivery and Development of Anti-HIV Microbicides
A Book

by José das Neves,Bruno Sarmento

  • Publisher : CRC Press
  • Release : 2014-10-16
  • Pages : 706
  • ISBN : 9814463566
  • Language : En, Es, Fr & De
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The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug dosage forms and/or drug delivery systems is an indispensable aspect for the success of microbicides. Different groups strived over the last decade to optimize the biophysical and technological performance of traditional dosage forms (gels, tablets, and suppositories) to fulfill the specificities of microbicides use, without neglecting users’ preferences and affordability issues. Moreover, new formulation approaches, such as vaginal rings and films, nanotechnology-based systems, stimuli-sensitive formulations, targeted drug delivery systems, among others have been proposed and are currently undergoing pre-clinical or even clinical testing.

Bioadhesives in Drug Delivery

Bioadhesives in Drug Delivery
A Book

by K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang

  • Publisher : John Wiley & Sons
  • Release : 2020-05-12
  • Pages : 432
  • ISBN : 1119640253
  • Language : En, Es, Fr & De
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Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Drug Delivery Systems

Drug Delivery Systems
A Book

by Vasant V. Ranade,Mannfred A. Hollinger,John B. Cannon

  • Publisher : CRC Press
  • Release : 2003-08-26
  • Pages : 464
  • ISBN : 9781420040142
  • Language : En, Es, Fr & De
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Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both

Handbook of Pharmaceutical Controlled Release Technology

Handbook of Pharmaceutical Controlled Release Technology
A Book

by Donald L. Wise

  • Publisher : CRC Press
  • Release : 2000-08-24
  • Pages : 902
  • ISBN : 9780824703691
  • Language : En, Es, Fr & De
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The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!

Polysaccharide Carriers for Drug Delivery

Polysaccharide Carriers for Drug Delivery
A Book

by Sabyasachi Maiti,Sougata Jana

  • Publisher : Woodhead Publishing
  • Release : 2019-06-14
  • Pages : 802
  • ISBN : 0081025548
  • Language : En, Es, Fr & De
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Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter. Focuses on biopolysaccharide-based, distinct approaches for drug delivery applications Illustrates new concepts and highlights future scope for clinical development Provides comprehensive, up-to-date information on different aspects of drug delivery technology