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Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
A Book

by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta

  • Publisher : Academic Press
  • Release : 2020-05-15
  • Pages : 432
  • ISBN : 0128184817
  • Language : En, Es, Fr & De
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Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
A Book

by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta

  • Publisher : Academic Press
  • Release : 2020-05-15
  • Pages : 432
  • ISBN : 0128184817
  • Language : En, Es, Fr & De
GET BOOK

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Antibacterial Drug Discovery to Combat MDR

Antibacterial Drug Discovery to Combat MDR
Natural Compounds, Nanotechnology and Novel Synthetic Sources

by Iqbal Ahmad,Shamim Ahmad,Kendra P. Rumbaugh

  • Publisher : Springer Nature
  • Release : 2019-11-09
  • Pages : 680
  • ISBN : 9811398712
  • Language : En, Es, Fr & De
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This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Sustainable Agriculture Reviews 46

Sustainable Agriculture Reviews 46
Mitigation of Antimicrobial Resistance Vol 1 Tools and Targets

by Harsh Panwar

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030530248
  • Language : En, Es, Fr & De
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Antibiotic Discovery and Development

Antibiotic Discovery and Development
A Book

by Thomas J. Dougherty,Michael J. Pucci

  • Publisher : Springer Science & Business Media
  • Release : 2011-12-18
  • Pages : 1127
  • ISBN : 1461414008
  • Language : En, Es, Fr & De
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This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery

Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery
A Book

by Busi Siddhardha,Madhu Dyavaiah,Asad Syed

  • Publisher : Springer Nature
  • Release : 2020-03-28
  • Pages : 684
  • ISBN : 9811516952
  • Language : En, Es, Fr & De
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This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Drug Discovery and Development

Drug Discovery and Development
From Molecules to Medicine

by Omboon Vallisuta,Suleiman Olimat

  • Publisher : BoD – Books on Demand
  • Release : 2015-06-03
  • Pages : 330
  • ISBN : 9535121286
  • Language : En, Es, Fr & De
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It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Antimicrobials—Advances in Research and Application: 2012 Edition

Antimicrobials—Advances in Research and Application: 2012 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-26
  • Pages : 464
  • ISBN : 146499305X
  • Language : En, Es, Fr & De
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Antimicrobials—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Antimicrobials. The editors have built Antimicrobials—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimicrobials in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimicrobials—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Frontiers in Anti-Cancer Drug Discovery

Frontiers in Anti-Cancer Drug Discovery
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2018-12-06
  • Pages : 340
  • ISBN : 1681087014
  • Language : En, Es, Fr & De
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Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The ninth volume of the series features chapters covering the following topics: - New research on the therapeutic intervention of cancer and cancer drug delivery - Dabrafenib usage in melanoma therapy - Targeting autophagy in cancer therapy - Pro-apoptotic and anti-telomerase activity of naturally occurring compounds - CDK inhibitors - Oral nanostructure drug delivery for anti-cancer treatment

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer
A Book

by Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia

  • Publisher : Springer
  • Release : 2017-03-21
  • Pages : 630
  • ISBN : 3319486837
  • Language : En, Es, Fr & De
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This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Antibiotic Resistant Bacteria: A Challenge to Modern Medicine

Antibiotic Resistant Bacteria: A Challenge to Modern Medicine
A Book

by Sadhana Sagar,Shilpa Kaistha,Amar Jyoti Das,Rajesh Kumar

  • Publisher : Springer Nature
  • Release : 2019-11-14
  • Pages : 179
  • ISBN : 9811398798
  • Language : En, Es, Fr & De
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This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
Facts, Challenges, Technologies and Future Perspectives

by Marc Stadler,Petra Dersch

  • Publisher : Springer
  • Release : 2016-12-21
  • Pages : 496
  • ISBN : 3319492845
  • Language : En, Es, Fr & De
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This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
A Book

by Mohmmad Younus Wani,Aijaz Ahmad

  • Publisher : Academic Press
  • Release : 2020-04-30
  • Pages : 268
  • ISBN : 0128205784
  • Language : En, Es, Fr & De
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Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antiparasitic and Antibacterial Drug Discovery

Antiparasitic and Antibacterial Drug Discovery
From Molecular Targets to Drug Candidates

by Paul M. Selzer

  • Publisher : John Wiley & Sons
  • Release : 2009-06-08
  • Pages : 489
  • ISBN : 3527323279
  • Language : En, Es, Fr & De
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria
A Book

by Natalia V. Kirienko,Laurence Rahme,You-Hee Cho

  • Publisher : Frontiers Media SA
  • Release : 2019-12-24
  • Pages : 329
  • ISBN : 2889632563
  • Language : En, Es, Fr & De
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Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Emerging Strategies

by George Tegos,Eleftherios Mylonakis

  • Publisher : CABI
  • Release : 2012
  • Pages : 357
  • ISBN : 1845939433
  • Language : En, Es, Fr & De
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Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Microbial Genomics and Drug Discovery

Microbial Genomics and Drug Discovery
A Book

by Thomas J. Dougherty,Steven J. Projan

  • Publisher : CRC Press
  • Release : 2003-05-14
  • Pages : 264
  • ISBN : 9780203911464
  • Language : En, Es, Fr & De
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Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition

Antimicrobial Resistance in Agriculture

Antimicrobial Resistance in Agriculture
Perspective, Policy and Mitigation

by Indranil Samanta,Samiran Bandyopadhyay

  • Publisher : Academic Press
  • Release : 2019-09-25
  • Pages : 392
  • ISBN : 0128165235
  • Language : En, Es, Fr & De
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Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans. Explores all the genera of livestock and fish originated pathogenic bacteria associated with antimicrobial resistance Presents cutting-edge research on epigenetics, nanotechnology and intervention technologies Discusses transmission dynamics of resistance gene pools from different reservoirs, including food animals, poultry, fishes and the environment

Frontiers in Anti-Infective Drug Discovery

Frontiers in Anti-Infective Drug Discovery
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2013-09-15
  • Pages : 360
  • ISBN : 160805912X
  • Language : En, Es, Fr & De
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This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The third volume of this series features 6 chapters that cover a variety of topics including: - Drug Discovery for TB - Therapeutic Limitations due to Antibiotic Drug Resistance - Applications for Virus Vaccine Vectors in Infectious Disease Research - NewCastle Disease Virus - Anti-Infective Therapy Against Leishmaniasis - Anti-Viral Activity of Proanthocyanidins.

New edge of antibiotic development: antimicrobial peptides and corresponding resistance

New edge of antibiotic development: antimicrobial peptides and corresponding resistance

by Octavio L. Franco,Nádia S. Parachin

  • Publisher : Frontiers E-books
  • Release : 2014-09-26
  • Pages : 329
  • ISBN : 2889193012
  • Language : En, Es, Fr & De
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Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.